Dating of the Udin Boršt conglomerate terrace and implication for tectonic uplift in the northern part of the Ljubljana Basin (Slovenia)

EN:The northwestern part of the Ljubljana Basin is filled mostly with fluvioglacial sediments deposited by rivers coming from Alpine mountain groups. The Tržiška Bistrica River, flowing from the Karavanke Mountains, has deposited a large alluvial fan consisting predominantly of carbonate pebbles with subordinate amounts of siliciclastic pebbles. The oldest infill, cemented into a conglomerate terrace named Udin Boršt, overlies an erosional surface on Oligocene mudstone. The thickness of the conglomerate terrace is up to 50 m. The conglomerate terrace is well karstified; the surface is dissected by numerous dolines and covered with a thick soil sequence. There are several caves. The most important are spring caves formed on the contact with the underlying impermeable basement. Samples of quartz pebbles were taken from the walls and ceiling in the 815 m long spring Arneševa Luknja Cave for cosmogenic nuclides burial age dating. The calculated burial age yielded an age of 1.86 ± 0.19 Ma that gives (i) the age of the oldest known infill in the Ljubljana Basin and (ii) indicates the time of change of the sedimentary system in the Basin from erosion to deposition. The age of the Udin Boršt karst and caves is significantly younger. The age dates provide grounds for a first relatively firm estimate of the long-term tectonic uplift of the Udin Boršt terrace to be between 0.06 and 0.04 mm/yr. This tectonic uplift rate may be related to the activity of the regional Sava Fault.SLO:Severozahodni del Ljubljanske kotline pokrivajo večinoma fluvioglacialni sedimenti, ki so jih odložile reke iz alpskih gorskih skupin. Tržiška Bistrica, ki priteka iz Karavank je odložila velik vršaj. V njem prevladujejo karbonatni prodniki z manjšim deležem siliciklastičnih prodnikov. Ta najstarejša zapolnitev, sprijeta v konglomeratno teraso Udin boršt, leži na erozijskem površju oblikovanem v oligocenskih glinovcih. Debelina konglomeratne terase je do 50 m. Konglomeratna terasa je dobro zakrasela, površje pa je razčlenjeno z vrtačami in pokrito z debelo plastjo prsti. V njej je več jam, med katerimi so najpomembnejše izvirne jame, ki so se oblikovale na stiku z neprepustno podlago. V 815 m dolgi Arneševi luknji smo vzeli iz sten in stropa jame vzorec iz kremenovih prodnikov za določitev pokopne starosti prodnega zasipa s kozmičnimi nuklidi. Izračunana starost prekritja sedimentov je 1.86 ± 0.19 Ma. Ta datacija določa (i) starost najstarejše sedimentne zapolnitve v Ljubljanski kotlini in (ii) čas spremembe v sedimentacijskem sistemu kotline iz erozije v sedimentacijo. Starost kraških oblik in jam v Udin borštu je znatno mlajša. Starost sedimenta daje tudi osnovo za relativno trdno določitev tektonskega dviga terase Udin boršta na 0,06 do 0,04 mm/yr. Ta tektonski dvig je verjetno povezan z premiki ob regionalnem savskem prelomu

Bone Mineral Density in Young Women on Methadone Substitution

Little is known about bone mineral density (BMD) in patients with heroin addiction and subsequent methadone substitution. The goal of this study was to compare bone mass density of young HIV-negative women on long-term methadone treatment to a local group of young healthy women. Eleven women (aged 20-29) with previous heroin dependence and current methadone substitution (20-140mg, median 60, daily) for 1.5-9 (median 3) years were compared to 30 healthy women (aged 20-28). Participants were examined with dual-energy X-ray absorptiometry of the lumbar spine (L2-L4), of the total proximal hip area, and of the femoral neck. Patients and controls had neither current nor lifetime underweight condition, had comparable ages at menarche, and did not differ significantly in current body mass index (21.9±4.0, respectively, 20.5±1.5kg/m2) in spite of a largely unhealthy lifestyle (cigarette, alcohol, and cocaine consumption in patients). Patients' total-hip parameters were marginally lower than those of controls (BMD P=0.054, T score P=0.049), whereas the femoral neck and lumbar spine parameters did not differ significantly between the two groups. Long-term methadone substitution in HIV-negative women seems to slightly affect bone mass densit

Bone mineral density in young women on methadone substitution

Little is known about bone mineral density (BMD) in patients with heroin addiction and subsequent methadone substitution. The goal of this study was to compare bone mass density of young HIV-negative women on long-term methadone treatment to a local group of young healthy women. Eleven women (aged 20-29) with previous heroin dependence and current methadone substitution (20-140 mg, median 60, daily) for 1.5-9 (median 3) years were compared to 30 healthy women (aged 20-28). Participants were examined with dual-energy X-ray absorptiometry of the lumbar spine (L2-L4), of the total proximal hip area, and of the femoral neck. Patients and controls had neither current nor lifetime underweight condition, had comparable ages at menarche, and did not differ significantly in current body mass index (21.9 ± 4.0, respectively, 20.5 ± 1.5 kg/m(2)) in spite of a largely unhealthy lifestyle (cigarette, alcohol, and cocaine consumption in patients). Patients' total-hip parameters were marginally lower than those of controls (BMD P = 0.054, T score P = 0.049), whereas the femoral neck and lumbar spine parameters did not differ significantly between the two groups. Long-term methadone substitution in HIV-negative women seems to slightly affect bone mass density

Linking the northern Alps with their foreland: The latest exhumation history resolved by low-temperature thermochronology

The evolution of the Central Alpine deformation front (Subalpine Molasse) and its undeformed foreland is recently debated because of their role for deciphering the late orogenic evolution of the Alps. Its latest exhumation history is poorly understood due to the lack of late Miocene to Pliocene sediments. We constrain the late Miocene to Pliocene history of this transitional zone with apatite fission track and (U-Th)/He data. We used laser ablation inductively coupled mass spectrometry for apatite fission track dating and compare this method with previously published and unpublished external detector method fission track data. Two investigated sections across tectonic slices show that the Subalpine Molasse was tectonically active after the onset of folding of the Jura Mountains. This is much younger than hitherto assumed. Thrusting occurred at 10, 8, 6–5 Ma and potentially thereafter. This is contemporaneous with reported exhumation of the External Crystalline Massifs in the central Alps. The Jura Mountains and the Subalpine Molasse used the same detachments as the External Crystalline Massifs and are therefore kinematically coupled. Estimates on the amount of shortening and thrust displacement corroborate this idea. We argue that the tectonic signal is related to active shortening during the late stage of orogenesis

Nitroxyl (HNO) Stimulates Soluble Guanylyl Cyclase to Suppress Cardiomyocyte Hypertrophy and Superoxide Generation

Background: New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox sibling of NON attracting considerable attention for the treatment of cardiovascular disorders, eliciting cGMP-dependent vasodilatation yet cGMP-independent positive inotropy. The impact of HNO on cardiac hypertrophy (which is negatively regulated by cGMP) however has not been investigated. Methods: Neonatal rat cardiomyocytes were incubated with angiotensin II (Ang II) in the presence and absence of the HNO donor Angeli’s salt (sodium trioxodinitrate) or B-type natriuretic peptide, BNP (all 1 mmol/L). Hypertrophic responses and its triggers, as well as cGMP signaling, were determined. Results: We now demonstrate that Angeli’s salt inhibits Ang II-induced hypertrophic responses in cardiomyocytes, including increases in cardiomyocyte size, de novo protein synthesis and b-myosin heavy chain expression. Angeli’s salt also suppresses Ang II induction of key triggers of the cardiomyocyte hypertrophic response, including NADPH oxidase (on both Nox2 expression and superoxide generation), as well as p38 mitogen-activated protein kinase (p38MAPK). The antihypertrophic, superoxide-suppressing and cGMP-elevating effects of Angeli’s salt were mimicked by BNP. We also demonstrate that the effects of Angeli’s salt are specifically mediated by HNO (with no role for NON or nitrite), with subsequent activation of cardiomyocyte soluble guanylyl cyclase (sGC) and cGMP signaling (on both cGMP-dependen

DTB - Deutsche Terminboerse: die Bilanzierung und Besteuerung von Optionen und Futures

SIGLEAvailable from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel A 181683 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman