Activist art vs. public performances as sources of activism for black South African lesbians

A Research Report submitted to the Department of History of Art, Faculty of Humanities, University of the Witwatersrand in partial fulfilment of the requirements for the Degree of Master of Arts, 2016Statistics indicate that over the past 16 years (since the year 2000), there have been over 30 black lesbians in South Africa, who have been victims of rape (and in some cases, brutal murder as well) as a result of homophobic violence, which is aimed at “curing” lesbians of their homosexuality. The aim of this research report is to examine how activist methods, such as art exhibitions and public performances, are challenging homophobic violence. The report explores the effectiveness of activist artworks (which include public performances and works by South African artists Zanele Mutholi and Gabrielle Le Roux) in raising awareness and educating South Africans about homophobic violence, which is a daily reality for many members of the South African LGBTQ community. For the purpose of this report, the Queer and Trans Art-iculations exhibition, which was held at the Wits Art Museum (WAM) in 2014, is compared to the annual Johannesburg Pride parade of 2012. These events are analysed in terms of their effectiveness in creating awareness about homophobic violence and how they can improve on being more informative and effective in the future. The importance of this research is to add to the existing body of work around art activism as it explores the ways in which activist artists attempt to make social and political change regarding the South African LGBTQ community.MT201

Postgraduate research supervision:An 'agreed' conceptual view of good practice through derived metaphors

The paper explores the role of the postgraduate supervisor through advising, mentoring, and monitoring for the varied and complex process towards successful doctoral thesis completion. There is a scarcity of research into this important area, and we therefore undertake a comprehensive literature review to determine the current state of knowledge and international approaches. This involved an initial analysis of policy documents from European and Australian universities to provide insights into institutional norms. Primary data collection was then collected through surveys and personal interviews with a range of experienced academics involved in postgraduate supervision. We identify three metaphors related to a 'machine', 'coach' and 'journey' as critical perspectives towards professional student engagement. Our findings are believed to be of benefit to academics and doctoral candidates involved in challenging and original research

Localisation of Putative Mechanoelectrical Transducer Channels in Cochlear Hair Cells by Immunoelectron Microscopy

Displacement of the apical stereociliary bundle of cochlear hair cells mechanically gates transducer channels. Knowing the position of the channels with regard to the apical structures of the hair cell could indicate how this mechanism operates. At present, there is conflicting evidence regarding their precise location; the channels have been suggested to be located either towards the base of the stereocilia or at the tips where they could be operated by extracellular links running from the top of shorter stereocilia to the sides of adjacent taller ones. The channels have been shown to be reversibly blocked by amiloride. This has prompted us to use a polyclonal antibody raised against another amiloride-sensitive channel to search for them using immunolabelling. The location of the primary antibody has been revealed using pre-embedding labelling with a colloidal gold-conjugated secondary antibody followed by scanning transmission electron microscopy of semi-thin sections. In this way, more complete information on the relationship of the labelling to the three-dimensional organisation of the stereociliary bundle has been obtained in comparison with previous immunofluorescence and transmission electron microscopic results. Labelling occurs in discrete areas towards the tips of the stereocilia, one of the possible sites for the transducer channels, predominantly between the membranes of shorter and taller stereocilia

An experimental strategy for fractionating 33 and 34 factorial experiments

In the design of statistical experiments, situations may arise when resource constraints hinder the use of factorial designs for process improvement. This paper explores how 9, 18 and 27-run orthogonal arrays compare against each other and against a proposed experimental plan referred to as a 'Segmented Fractional Plan' when used to fractionate 33 and 34 factorial experiments. Based on the analysis of 8 responses from 6 factorial experiments, it was observed that to identify the process setting that produces the desired product quality, with a reduced number of experimental runs, the segmented fractional plan can perform as well or better than some orthogonal arrays thus, providing an option for fractionating 33 and 34 factorial experiments

\u27Academic Capitalism\u27: Universities\u27 Consultancy Agendas

Recent debate in Higher Education (HE) has attempted to identify the legitimate components at the core of academic scholarship. Teaching and research, are recognized activities of modern academia; although their nexus is at times questioned. This paper seeks to understand the role of a rising academic activity, academic consultancy, and to portray its impact onto HE. A two-stage research design including a web-based survey and semi-structured interviews was implemented to gather the experiences and perceptions of academics in information technology/information systems/information management (IT/IS/IM) in the United Kingdom (UK). The findings reveal that the majority of consultancy activities undertaken by the study participants are of small scale, of technical nature and in areas strongly related to the research interest of the academics in questions. Although a shared understanding of what consultancy is can be found among academics, the perception of how consultancy impacts teaching practices and research differs significantly within research-led or teaching-led universities. Such findings are significant as they portray entrepreneurship as a contributing factor that may help universities to shape their policy, culture and structure

Reliability and Validity of Ultrasound Cross Sectional Area Measurements for Long-Duration Spaceflight

Limb muscle atrophy and the accompanying decline in function can adversely affect the performance of astronauts during mission-related activities and upon re-ambulation in a gravitational environment. Previous characterization of space flight-induced muscle atrophy has been performed using pre and post flight magnetic resonance imaging (MRI). In addition to being costly and time consuming, MRI is an impractical methodology for assessing in-flight changes in muscle size. Given the mobility of ultrasound (US) equipment, it may be more feasible to evaluate changes in muscle size using this technique. PURPOSE: To examine the reliability and validity of using a customized template to acquire panoramic ultrasound (US) images for determining quadriceps and gastrocnemius anatomical cross sectional area (CSA). METHODS: Vastus lateralis (VL), rectus femoris (RF), medial gastrocnemius (MG), and lateral gastrocnemius (LG) CSA were assessed in 10 healthy individuals (36+/-2 yrs) using US and MRI. Panoramic US images were acquired by 2 sonographers using a customized template placed on the thigh and calf and analyzed by the same 2 sonographers (CX50 Philips). MRI images of the leg were acquired while subjects were supine in a 1.5T scanner (Signa Horizon LX, General Electric) and were analyzed by 3 trained investigators. The average of the 2 US and 3 MRI values were used for validity analysis. RESULTS: High inter-experimenter reliability was found for both the US template and MRI analysis as coefficients of variation across muscles ranged from 2.4 to 4.1% and 2.8 to 3.8%, respectively. Significant correlations were found between US and MRI CSA measures (VL, r = 0.85; RF, r = 0.60; MG, r = 0.86; LG, r = 0.73; p < 0.05). Furthermore, the standard error of measurement between US and MRI ranged from 0.91 to 2.09 sq cm with high limits of agreement analyzed by Bland-Altman plots. However, there were significant differences between absolute values of MRI and US for all muscles. CONCLUSION: The present results indicate that utilizing a customized US template provides reliable measures of leg muscle CSA, and thus could be used to characterize changes in muscle CSA both in flight and on the ground

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells

Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present report describes functional and structural analyses of hair cells from Pcdh15av3J (av3J), Pcdh15av6J (av6J) and Cdh23v2J (v2J) mice. The av3J and v2J mice carry point mutations that are predicted to introduce premature stop codons in the transcripts for Pcdh15 and Cdh23, respectively, and av6J mice have an in-frame deletion predicted to remove most of the 9th cadherin ectodomain from PCDH15. Severe disruption of hair-bundle morphology is observed throughout the early-postnatal cochlea in av3J/av3J and v2J/v2J mice. In contrast, only mild-to-moderate bundle disruption is evident in the av6J/av6J mice. Hair cells from av3J/av3J mice are unaffected by aminoglycosides and fail to load with [3H]-gentamicin or FM1-43, compounds that permeate the hair cell's mechanotransducer channels. In contrast, hair cells from av6J/av6J mice load with both FM1-43 and [3H]-gentamicin, and are aminoglycoside sensitive. Transducer currents can be recorded from hair cells of all three mutants but are reduced in amplitude in all mutants and have abnormal directional sensitivity in the av3J/av3J and v2J/v2J mutants. Scanning electron microscopy of early postnatal cochlear hair cells reveals tip-link like links in av6J/av6J mice, substantially reduced numbers of links in the av3J/av3J mice and virtually none in the v2J/v2J mice. Analysis of mature vestibular hair bundles reveals an absence of tip links in the av3J/av3J and v2J/v2J mice and a reduction in av6J/av6J mice. These results therefore provide genetic evidence consistent with PCDH15 and CDH23 being part of the tip-link complex and necessary for normal mechanotransduction

Decreasing rates of disorganised attachment in infants and young children, who are at risk of developing, or who already have disorganised attachment. A systematic review and meta-analysis of early parenting interventions

BACKGROUND: Disorganised attachment patterns in infants have been linked to later psychopathology. Services have variable practices for identifying and providing interventions for families of children with disorganised attachment patterns, which is the attachment pattern leading to most future psychopathology. Several recent government reports have highlighted the need for better parenting interventions in at risk groups. OBJECTIVES: The objective of this review and meta-analysis was to evaluate the clinical effectiveness of available parenting interventions for families of children at high risk of developing, or already showing, a disorganised pattern of attachment. METHODS: Population: Studies were included if they involved parents or caregivers of young children with a mean age under 13 years who had a disorganised classification of attachment or were identified as at high risk of developing such problems. Included interventions were aimed at parents or caregivers (e.g. foster carers) seeking to improve attachment. Comparators included an alternative intervention, an attention control, treatment as usual or no intervention. The primary outcome was a disorganised pattern in childhood measured using a validated attachment instrument. Studies that did not use a true Randomised Controlled Trial (RCT) design were excluded from the review. Both published and unpublished papers were included, there were no restrictions on years since publication and foreign language papers were included where translation services could be accessed within necessary timescales. RESULTS: A comprehensive search of relevant databases yielded 15,298 papers. This paper reports a systematic review as part of an NIHR HTA study identifying studies pre-2012, updated to include all papers to October 2016. Two independent reviewers undertook two stage screening and data extraction of the included studies at all stages. A Cochrane quality assessment was carried out to assess the risk of bias. In total, fourteen studies were included in the review. In a meta-analysis of these fourteen studies the interventions saw less disorganised attachment at outcome compared to the control (OR = 0.50, (0.32, 0.77), p = 0.008). The majority of the interventions targeted maternal sensitivity. We carried out exploratory analyses to examine factors that may influence treatment outcome but these should be treated with caution given that we were limited by small numbers of studies. CONCLUSIONS: Parenting interventions that target parental sensitivity show promise in reducing disorganised attachment. This is limited by few high quality studies and the fact that most studies are with mothers. More high quality randomised controlled trials are required to elucidate this further