1,393 research outputs found
Value and limitation of thallium-201 scintigraphy in myocardial infarction patients after thrombolytic therapy
W/Z Bremsstrahlung as the Dominant Annihilation Channel for Dark Matter, Revisited
We revisit the calculation of electroweak bremsstrahlung contributions to
dark matter annihilation. Dark matter annihilation to leptons is necessarily
accompanied by electroweak radiative corrections, in which a or boson
is also radiated. Significantly, while many dark matter models feature a
helicity suppressed annihilation rate to fermions, bremsstrahlung process can
remove this helicity suppression such that the branching ratios Br(), Br(), and Br() dominate over
Br() and Br(). We find this is most significant in
the limit where the dark matter mass is nearly degenerate with the mass of the
boson which mediates the annihilation process. Electroweak bremsstrahlung has
important phenomenological consequences both for the magnitude of the total
dark matter annihilation cross section and for the character of the
astrophysical signals for indirect detection. Given that the and gauge
bosons decay dominantly via hadronic channels, it is impossible to produce
final state leptons without accompanying protons, antiprotons, and gamma rays.Comment: 8 pages, 6 figures; replaced to match published versio
Finite Radiative Electroweak Symmetry Breaking from the Bulk
A new physical origin for electroweak symmetry breaking is proposed,
involving compact spatial dimensions of scale 1/R \approx 1 TeV. The higher
dimensional theory is supersymmetric, and hence requires the top-quark Yukawa
coupling to be localized on some ``Yukawa brane'' in the bulk. The short
distance divergence in the Higgs-boson mass is regulated because supersymmetry
is unbroken in the vicinity of this Yukawa brane. A finite, negative Higgs
mass-squared is generated radiatively by the top-quark supermultiplet
propagating a distance of order R from the Yukawa brane to probe supersymmetry
breaking. The physics of electroweak symmetry breaking is therefore closely
related to this top propagation across the bulk, and is dominated by the mass
scale 1/R, with exponential insensitivity to higher energy scales. The masses
of the superpartners and the Kaluza-Klein resonances are also set by the mass
scale 1/R, which is naturally larger than the W boson mass by a loop factor.
Explicit models are constructed which are highly constrained and predictive.
The finite radiative correction to the Higgs mass is computed, and the Higgs
sector briefly explored. The superpartner and Kaluza-Klein resonance spectra
are calculated, and the problem of flavor violation from squark and slepton
exchange is solved. Important collider signatures include highly ionizing
charged tracks from stable top squarks, and events with two Higgs bosons and
missing transverse energy.Comment: 40 pages, latex, version to appear in Nucl. Phys.
Decisional Informatics for Psychosocial Rehabilitation: A Feasibility Pilot on Tailored and Fluid Treatment Algorithms for Serious Mental Illness
This study introduces a computerized clinical decision-support tool, the Fluid Outpatient Rehabilitation Treatment (FORT), that incorporates individual and ever-evolving patient needs to guide clinicians in developing and updating treatment decisions in real-time. In this proof-of-concept feasibility pilot, FORT was compared against traditional treatment planning using similar behavioral therapies in 52 adults with severe mental illness attending community-based day treatment. At posttreatment and follow-up, group differences and moderate-to-large effect sizes favoring FORT were detected in social function, work readiness, self-esteem, working memory, processing speed, and mental flexibility. Of participants who identified obtaining a General Education Diploma as their goal, 73% in FORT passed the examination compared with 18% in traditional treatment planning. FORT was also associated with higher agency cost-effectiveness and a better average benefit-cost ratio, even when considering diagnosis, baseline symptoms, and education. Although the comparison groups were not completely equivalent, the findings suggest computerized decision support systems that collaborate with human decision-makers to personalize psychiatric rehabilitation and address critical decisions may have a role in improving treatment effectiveness and efficiency
Size constancy in bat biosonar?
Perception and encoding of object size is an important feature of sensory systems. In the visual system object size is encoded by the visual angle (visual aperture) on the retina, but the aperture depends on the distance of the object. As object distance is not unambiguously encoded in the visual system, higher computational mechanisms are needed. This phenomenon is termed "size constancy". It is assumed to reflect an automatic re-scaling of visual aperture with perceived object distance. Recently, it was found that in echolocating bats, the 'sonar aperture', i.e., the range of angles from which sound is reflected from an object back to the bat, is unambiguously perceived and neurally encoded. Moreover, it is well known that object distance is accurately perceived and explicitly encoded in bat sonar. Here, we addressed size constancy in bat biosonar, recruiting virtual-object techniques. Bats of the species Phyllostomus discolor learned to discriminate two simple virtual objects that only differed in sonar aperture. Upon successful discrimination, test trials were randomly interspersed using virtual objects that differed in both aperture and distance. It was tested whether the bats spontaneously assigned absolute width information to these objects by combining distance and aperture. The results showed that while the isolated perceptual cues encoding object width, aperture, and distance were all perceptually well resolved by the bats, the animals did not assign absolute width information to the test objects. This lack of sonar size constancy may result from the bats relying on different modalities to extract size information at different distances. Alternatively, it is conceivable that familiarity with a behaviorally relevant, conspicuous object is required for sonar size constancy, as it has been argued for visual size constancy. Based on the current data, it appears that size constancy is not necessarily an essential feature of sonar perception in bats
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3D simulations of axially confined heavy ion beams in round and square pipes
We have been using the 3d PIC code WARP6 to model the behavior of beams in a heavy ion induction accelerator; such linacs are candidates for an ICF driver. Improvements have been added to the code to model an axially confined beam using comoving axial electric fields to simulate the confining ears'' applied to the accelerating pulses in a real system. We have also added a facility for modeling a beam in a round pipe, applying a capacity matrix to each axial Fourier mode in turn. These additions are described along with results, such as the effect of pipe shape on the beam quality degradation from quadrupole misalignments. 4 refs., 6 figs., 1 tab
A Complete Theory of Grand Unification in Five Dimensions
A fully realistic unified theory is constructed, with SU(5) gauge symmetry
and supersymmetry both broken by boundary conditions in a fifth dimension.
Despite the local explicit breaking of SU(5) at a boundary of the dimension,
the large size of the extra dimension allows precise predictions for gauge
coupling unification, alpha_s(M_Z) = 0.118 \pm 0.003, and for Yukawa coupling
unification, m_b(M_Z) = 3.3 \pm 0.2 GeV. A complete understanding of the MSSM
Higgs sector is given; with explanations for why the Higgs triplets are heavy,
why the Higgs doublets are protected from a large tree-level mass, and why the
mu and B parameters are naturally generated to be of order the SUSY breaking
scale. All sources of d=4,5 proton decay are forbidden, while a new origin for
d=6 proton decay is found to be important. Several aspects of flavor follow
from an essentially unique choice of matter location in the fifth dimension:
only the third generation has an SU(5) mass relation, and the lighter two
generations have small mixings with the heaviest generation. The entire
superpartner spectrum is predicted in terms of only two free parameters. The
squark and slepton masses are determined by their location in the fifth
dimension, allowing a significant experimental test of the detailed structure
of the extra dimension. Lepton flavor violation is found to be generically
large in higher dimensional unified theories with high mediation scales of SUSY
breaking. In our theory this forces a common location for all three neutrinos,
predicting large neutrino mixing angles. Rates for mu -> e gamma, mu -> e e e,
mu -> e conversion and tau -> mu gamma are larger in our theory than in
conventional 4D supersymmetric GUTs. Proposed experiments probing mu -> e
transitions will probe the entire interesting parameter space of our theory.Comment: 51 pages, late
Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions
Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions. We provide striking in vivo evidence of the cooperation between DNA polymerase η, which is mutated in the variant form of the cancer predisposition disorder xeroderma pigmentosum (XP-V), and DNA polymerase ζ by generating POLη−/−/POLζ−/− cells from the chicken DT40 cell line. POLζ−/− cells are hypersensitive to a very wide range of DNA damaging agents, whereas XP-V cells exhibit moderate sensitivity to ultraviolet light (UV) only in the presence of caffeine treatment and exhibit no significant sensitivity to any other damaging agents. It is therefore widely believed that Polη plays a very specific role in cellular tolerance to UV-induced DNA damage. The evidence we present challenges this assumption. The phenotypic analysis of POLη−/−/POLζ−/− cells shows that, unexpectedly, the loss of Polη significantly rescued all mutant phenotypes of POLζ−/− cells and results in the restoration of the DNA damage tolerance by a backup pathway including HR. Taken together, Polη contributes to a much wide range of TLS events than had been predicted by the phenotype of XP-V cells
Changes in Plasma von Willebrand Factor and Cellular Fibronectin in MRI-Defined Traumatic Microvascular Injury
The neuropathology of traumatic brain injury (TB) is diverse, including primary injury to neurons, axons, glial cells, vascular structures, and secondary processes, such as edema and inflammation that vary between individual patients. Traumatic microvascular injury is an important endophenotype of TBI-related injury. We studied patients who sustained a TBI requiring ER evaluation and had an MRI performed within 48 h of injury. We classified patients into 3 groups based on their MRI findings: (1) those that had evidence of traumatic microvascular injury on susceptibility or diffusion weighted MRI sequences without frank hemorrhage [Traumatic Vascular Injury (TVI) group; 20 subjects]. (2) those who had evidence of intraparenchymal, subdural, epidural, or subarachnoid hemorrhage [Traumatic Hemorrhage (TH) group; 26 subjects], and (3) those who had no traumatic injuries detected by MRI [MRI-negative group; 30 subjects]. We then measured plasma protein biomarkers of vascular injury [von Willebrand Factor (vWF) or cellular fibronectin (cFn)] and axonal injury (phosphorylated neurofilament heavy chain; pNF-H). We found that the TVI group was characterized by decreased expression of plasma vWF (p < 0.05 compared to MRI-negative group; p < 0.00001 compared to TH group) ≤48 h after injury. cFN was no different between groups ≤48 h after injury, but was increased in the TVI group compared to the MRI-negative (p < 0.00001) and TH (p < 0.00001) groups when measured >48 h from injury. pNF-H was increased in both the TH and TVI groups compared to the MRI-negative group ≤48 h from injury. When we used the MRI grouping and molecular biomarkers in a model to predict Glasgow Outcome Scale-Extended (GOS-E) score at 30–90 days, we found that inclusion of the imaging data and biomarkers substantially improved the ability to predict a good outcome over clinical information alone. These data indicate that there is a distinct, vascular-predominant endophenotype in a subset of patients who sustain a TBI and that these injuries are characterized by a specific biomarker profile. Further work to will be needed to determine whether these biomarkers can be useful as predictive and pharmacodynamic biomarkers for vascular-directed therapies after TBI
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