Low latitude ionosphere-thermosphere dynamics studies with inosonde chain in Southeast Asia

An ionosonde network consisting of a meridional chain and an equatorial pair was established in the Southeast Asian area. Three of four ionosondes are along the magnetic meridian of 100° E; two are close to the magnetic conjugate points in Northern Thailand and West Sumatra, Indonesia, and the other is near the magnetic equator in the Malay Peninsula, Thailand. The fourth ionosonde is also near the magnetic equator in Vietnam but separated by about 6.3° towards east from the meridional chain. For a preliminary data analysis, nighttime ionospheric height variations at the three stations of the meridional chain were examined. The results demonstrate that the coordination of the network has a great potential for studying ionosphere/thermosphere dynamics. Through the assistance of model calculations, thermospheric neutral winds were inferred and compared with the HWM93 empirical thermospheric wind model. Higher-order wind variations that are not represented in the empirical model were found

Assessment of microalbuminuria for early diagnosis and risk prediction in dengue infections.

BACKGROUND: Dengue is the most important arboviral infection of humans. Following an initial febrile period, a small proportion of infected patients develop a vasculopathy, with children at particular risk for severe vascular leakage and shock. Differentiation between dengue and other common childhood illnesses is difficult during the early febrile phase, and risk prediction for development of shock is poor. The presence of microalbuminuria is recognized as a useful early predictor for subsequent complications in a number of other disorders with vascular involvement. Significant proteinuria occurs in association with dengue shock syndrome and it is possible that early-phase microalbuminuria may be helpful both for diagnosis of dengue and for identification of patients likely to develop severe disease. METHODOLOGY/PRINCIPAL FINDINGS: We measured formal urine albumin to creatinine ratios (UACRs) in daily samples obtained from a large cohort of children with suspected dengue recruited at two outpatient clinics in Ho Chi Minh City, Vietnam. Although UACRs were increased in the 465 confirmed dengue patients, with a significant time trend showing peak values around the critical period for dengue-associated plasma leakage, urine albumin excretion was also increased in the comparison group of 391 patients with other febrile illnesses (OFI). The dengue patients generally had higher UACRs than the OFI patients, but microalbuminuria, using the conventional cutoff of 30 mg albumin/g creatinine discriminated poorly between the two diagnostic groups in the early febrile phase. Secondly UACRs did not prove useful in predicting either development of warning signs for severe dengue or need for hospitalization. CONCLUSION/SIGNIFICANCE: Low-level albuminuria is common, even in relatively mild dengue infections, but is also present in many OFIs. Simple point-of-care UACR tests are unlikely to be useful for early diagnosis or risk prediction in dengue endemic areas

Association of microvascular function and endothelial biomarkers with clinical outcome in dengue: an observational study

Background. The hallmark of severe dengue is increased microvascular permeability, but alterations in the microcirculation and their evolution over the course of dengue are unknown. Methods. We conducted a prospective observational study to evaluate the sublingual microcirculation using side-stream dark-field imaging in patients presenting early (<72 hours after fever onset) and patients hospitalized with warning signs or severe dengue in Vietnam. Clinical findings, microvascular function, global hemodynamics assessed with echocardiography, and serological markers of endothelial activation were determined at 4 time points. Results. A total of 165 patients were enrolled. No difference was found between the microcirculatory parameters comparing dengue with other febrile illnesses. The proportion of perfused vessels (PPV) and the mean flow index (MFI) were lower in patients with dengue with plasma than those without leakage (PPV, 88.1% vs 90.6% [P = .01]; MFI, 2.1 vs 2.4 [P = .007]), most markedly during the critical phase. PPV and MFI were correlated with the endothelial activation markers vascular cell adhesion molecule 1 (P < .001 for both) and angiopoietin 2 (P < .001 for both), negatively correlated. Conclusions. Modest microcirculatory alterations occur in dengue, are associated with plasma leakage, and are correlate with molecules of endothelial activation, angiopoietin 2 and vascular cell adhesion molecule 1

Sun-Earth System Interaction studies over Vietnam: an international cooperative project

International audienceDuring many past decades, scientists from various countries have studied separately the atmospheric motions in the lower atmosphere, in the Earth's magnetic field, in the magnetospheric currents, etc. All of these separate studies lead today to the global study of the Sun and Earth connections, and as a consequence, new scientific programs (IHY- International Heliophysical Year, CAWSES- Climate and Weather in the Sun-Earth System) are defined, in order to assume this new challenge. In the past, many scientists did not have the possibility to collect data at the same time in the various latitude and longitude sectors. Now, with the progress of geophysical sciences in many developing countries, it is possible to have access to worldwide data sets. This paper presents the particularities of geophysical parameters measured by the Vietnamese instrument networks. It introduces a cooperative Vietnamese-IGRGEA (International Geophysical Research Group Europe Africa) project, and presents, for the first time, to the international community, the geophysical context of Vietnam. Concerning the ionosphere: since 1963, during four solar cycles, the ionosonde at Phu Thuy (North Vietnam) was operating. The Phu Thuy data exhibits the common features for the ionospheric parameters, previously observed in other longitude and latitude sectors. The critical frequencies of the E, F1 and F2 ionospheric layers follow the variation of the sunspot cycle. F2 and E critical frequencies also exhibit an annual variation. The first maps of TEC made with data from GPS receivers recently installed in Vietnam illustrate the regional equatorial pattern, i.e. two maxima of electronic density at 15 N and 15 S from the magnetic equator and a trough of density at the magnetic equator. These features illustrate the equatorial fountain effect. Concerning the Earth's magnetic field: a strong amplitude of the equatorial electrojet was first observed by the CHAMP satellite at the height of 400 km in the Vietnamese longitude sector. In this paper we compare the ground magnetic observations of the Indian and Vietnamese magnetometer networks. This comparison highlights the regional structure of the amplitude of the equatorial electrojet, which is stronger in Vietnam than in India. Concerning the monsoon: Vietnam exhibits a strong monsoon and has mainly one rainy season peaking in August, hence associated with the southwest monsoon flow. But some monsoon variability from one place to another is related to the orography. In the mountainous northern regions of Vietnam, there is an "early" monsoon peaking in July. In the coastal regions between 12 N and 19 N the monsoon season is centered on October. Concerning lightning: Vietnam is a country of strong atmospheric storms with some areas of very intense lightning in North Vietnam (22,5 N, 105 E) and in South Vietnam (11 N, 107 E). In North Vietnam strong lightning is associated with the most intense rainy region. Keywords. Ionosphere (Electric fields and currents) - Meteorology and dynamics (Tropical meteorology) - Geomagnetism and paleomagnetism (Time variations, diurnal to secular

Geophysics Integrated Studies in the Sun Earth System: A Cooperative Project of Vietnam, Europe, and Africa

The Hanoi Institute of Geophysics (Vietnam) will participate to international Heliophysical Year. This paper presents Vietnam‘s participation into this International cooperative project : the Vietnamese network of magnetometers, meteorological stations, ionosondes and GPS receivers involved in campaigns of measurements, the research field selected for the training of young Vietnamese scientists, and the Institutes involve in this training. This paper also presents some particularities of geophysical parameters in Vietnam : the strong amplitude of the equatorial electrojet observed by satellite data and confirmed by magnetic observations at the ground level presented for the first time to the international community, the monsoon signature etc. Finally the differences between the Asian sector and the African sector lead to the development of comparative studies between Asia and Africa