Game-Theoretic Approach to Tourism Supply Chain Coordination under Demand Uncertainty For Package Holidays

Demand uncertainty is one of the most significant characteristics of the tourism industry. In a typical tourism supply chain (TSC) for package holidays, multiple tour operators reserve rooms from a hotel chain in advance according to their demand predictions. Discrepancies between demand predictions and actual demand lead to shortages or unused room reservations, which inevitably leads to reduced profits for the tour operators concerned. This article examines different TSC coordination strategies to determine how they can be used to help alleviate such negative effects. A game-theoretic approach is used to analyze the different coordination relationships between TSC players. Two coordination programs are discussed. The first is a horizontal coordination program in which tour operators exchange shortages or unused reservations with each other. The second is a vertical coordination program in which tour operators trade shortages or unused reservations with hotel chains. Game models are established and analyzed for the two coordination strategies and uncoordinated conditions, respectively. The analytical results suggest that both coordination strategies can be used to reduce the negative impacts of the demand uncertainty. The results also show that the horizontal coordination is preferred to the vertical coordination when the competition among tour operators is fierce.published_or_final_versio

Strategy choice in tourism supply chains for package holidays: a game-theoretic approach

Enterprises in a tourism supply chain usually adopt and operate two business strategies: maximizing their profits or their revenues. This paper investigates the conditions on which these strategies allow enterprises to achieve the maximum benefits in the context of entire supply chain. Several managerial implications have been derived from this theoretical research. Firstly, theme park operator, tour operators and hotel & accommodation providers obtain larger market shares and profits if they select the revenue maximization (R) strategy. Secondly, the profit maximization (P) strategy is a better strategy for both sectors when all the tour operators and all hotel & accommodation providers choose the same strategy. Finally, if both sectors could freely choose their strategies, there is market equilibrium where P-strategy and R-strategy could coexist.published_or_final_versio

The multi-level and multi-dimensional quantum wavelet packet transforms

© 2018, The Author(s). The classical wavelet packet transform has been widely applied in the information processing field. It implies that the quantum wavelet packet transform (QWPT) can play an important role in quantum information processing. In this paper, we design quantum circuits of a generalized tensor product (GTP) and a perfect shuffle permutation (PSP). Next, we propose multi-level and multi-dimensional (1D, 2D and 3D) QWPTs, including a Haar QWPT (HQWPT), a D4 QWPT (DQWPT) based on the periodization extension and their inverse transforms for the first time, and prove the correctness based on the GTP and PSP. Furthermore, we analyze the quantum costs and the time complexities of our proposed QWPTs and obtain precise results. The time complexities of HQWPTs is at most 6 on 2n elements, which illustrates high-efficiency of the proposed QWPTs. Simulation experiments demonstrate that the proposed QWPTs are correct and effective

Bioreducible Polymer-delivered siRNA Targeting MMP-9: Suppression of Granulation Tissue Formation after Bare Metallic Stent Placement in a Rat Urethral Model

To evaluate the effectiveness of small interfering RNA (siRNA) targeting matrix metalloproteinase 9 (MMP-9) in suppressing granulation tissue formation caused by bare metallic stent placement in a rat urethral model. All experiments were approved by the committee of animal research. In 20 Sprague-Dawley male rats (weight range, 300-350 g), a self-expanding metallic bare stent was inserted in the urethra with fluoroscopic guidance. One group of 10 rats (group A) was treated with MMP-9 siRNA/bioreducible branched polyethylenimine-disulfide cross-linked-indocyanine green (bioreducible BPEI-SS-ICG), while the other group of 10 rats (group B) received control siRNA/bioreducible BPEI-SS-ICG treatment. All rats were sacrificed at 4 weeks. The therapeutic effectiveness of the MMP-9 siRNA/bioreducible BPEI-SS-ICG complex was assessed by comparing the two results of retrograde urethrography, histologic examination, and quantification of MMP-9 by using zymography and Western blot analysis between the two groups. The Mann-Whitney U test was used to evaluate differences. Stent placement was successful in all rats without a single case of migration at follow-up. Retrograde urethrography performed 4 weeks after stent placement demonstrated significantly larger luminal diameters of the urethra within the stents in group A compared with those in group B (P = .011). Histologic analysis revealed that the mean percentage of granulation tissue area (P < .001), mean number of epithelial layers (P < .001), and mean thickness of submucosal fibrosis (P < .001) were significantly decreased in group A compared with group B. Meanwhile, the mean density of inflammatory cell infiltration did not significantly differ between the two groups (P = .184). Quantitative analysis disclosed MMP-9 levels to be lower in group A relative to group B, indicating positive inhibition of MMP-9 by MMP-9 siRNA/bioreducible BPEI-SS-ICG. MMP-9 siRNA/bioreducible BPEI-SS-ICG is effective for inhibiting granulation tissue formation after bare metallic stent placement in a rat urethral model.X1143Ysciescopu

Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study: The Korean Sarcopenic Obesity Study (KSOS)

Objectives: Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. Methods: We observed changes in anthropometric and body composition data during a follow-up period of 27.6±2.8 months in 379 Korean men and women (mean age 51.9±14.6 years) from the Korean Sarcopenic Obesity Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. Results: ALST mass significantly decreased, whereas trunk and total fat mass increased in both men and women despite no significant change in weight and body mass index. In particular, women with visceral obesity at baseline had a greater decrease in ALST mass than those without visceral obesity (P=0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity C-reactive protein and vitamin D levels (P=0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P=0.555). Conclusions: This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into sarcopenic obesity in an aging society

High-efficiency photovoltaic cells with wide optical band gap polymers based on fluorinated phenylene-alkoxybenzothiadiazole

A series of semi-crystalline, wide band gap (WBG) photovoltaic polymers were synthesized with varying number and topology of fluorine substituents. To decrease intramolecular charge transfer and to modulate the resulting band gap of D-A type copolymers, electron-releasing alkoxy substituents were attached to electron-deficient benzothiadiazole (A) and electron-withdrawing fluorine atoms (0-4F) were substituted onto a 1,4-bis(thiophen-2-yl)benzene unit (D). Intra- and/or interchain noncovalent Coulombic interactions were also incorporated into the polymer backbone to promote planarity and crystalline intermolecular packing. The resulting optical band gap and the valence level were tuned to 1.93-2.15 eV and -5.37 to -5.67 eV, respectively, and strong interchain organization was observed by differential scanning calorimetry, high-resolution transmission electron microscopy and grazing incidence X-ray scattering measurements. The number of fluorine atoms and their position significantly influenced the photophysical, morphological and optoelectronic properties of bulk heterojunctions (BHJs) with these polymers. BHJ photovoltaic devices showed a high power conversion efficiency (PCE) of up to 9.8% with an open-circuit voltage of 0.94-1.03 V. To our knowledge, this PCE is one of the highest values for fullerene-based single BHJ devices with WBG polymers having a band gap of over 1.90 eV. A tandem solar cell was also demonstrated successfully to show a PCE of 10.3% by combining a diketopyrrolopyrrole-based low band gap polymer

Simulations of the Microwave Sky

We create realistic, full-sky, half-arcminute resolution simulations of the microwave sky matched to the most recent astrophysical observations. The primary purpose of these simulations is to test the data reduction pipeline for the Atacama Cosmology Telescope (ACT) experiment; however, we have widened the frequency coverage beyond the ACT bands to make these simulations applicable to other microwave background experiments. Some of the novel features of these simulations are that the radio and infrared galaxy populations are correlated with the galaxy cluster populations, the CMB is lensed by the dark matter structure in the simulation via a ray-tracing code, the contribution to the thermal and kinetic Sunyaev-Zel'dovich (SZ) signals from galaxy clusters, groups, and the IGM has been included, and the gas prescription to model the SZ signals matches the most recent X-ray observations. Regarding the contamination of cluster SZ flux by radio galaxies, we find for 148 GHz (90 GHz) only 3% (4%) of halos have their SZ decrements contaminated at a level of 20% or more. We find the contamination levels higher for infrared galaxies. However, at 90 GHz, less than 20% of clusters with M_{200} > 2.5 x 10^{14} Msun and z<1.2 have their SZ decrements filled in at a level of 20% or more. At 148 GHz, less than 20% of clusters with M_{200} > 2.5 x 10^{14} Msun and z<0.8 have their SZ decrements filled in at a level of 50% or larger. Our models also suggest that a population of very high flux infrared galaxies, which are likely lensed sources, contribute most to the SZ contamination of very massive clusters at 90 and 148 GHz. These simulations are publicly available and should serve as a useful tool for microwave surveys to cross-check SZ cluster detection, power spectrum, and cross-correlation analyses.Comment: Sims are now public at http://lambda.gsfc.nasa.gov/toolbox/tb_cmbsim_ov.cfm; Expanded discussion of N-body sim and IGM; Version accepted by Ap

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates for proteasomal degradation. Here we use a segmental labelling approach combined with solution nuclear magnetic resonance (NMR) spectroscopy and biochemical characterization to reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer