3,866 research outputs found
Home Based Business Ordinance for the City of Reno
Home based businesses allow for some commercial and business activities to occur within private residences by residents without the need of commercially zoned properties or structures. Home based businesses provide affordable accommodation for less impactful small businesses, but can additionally impact neighbors and communities with negative externalities when not properly regulated. The City of Reno, Nevada currently faces rising land prices and limited availability of commercial properties. Such conditions increase the adoption of home based businesses, and combined with the lack of regulation can create nuisances within communities.
The ordinance proposal analyzes relevant legal cases, case study ordinances, and the contemporary needs of the community to best regulate the operation and growth of home based businesses within the City of Reno through a permitting process and performance standards
Local Guarantees in Graph Cuts and Clustering
Correlation Clustering is an elegant model that captures fundamental graph
cut problems such as Min Cut, Multiway Cut, and Multicut, extensively
studied in combinatorial optimization. Here, we are given a graph with edges
labeled or and the goal is to produce a clustering that agrees with the
labels as much as possible: edges within clusters and edges across
clusters. The classical approach towards Correlation Clustering (and other
graph cut problems) is to optimize a global objective. We depart from this and
study local objectives: minimizing the maximum number of disagreements for
edges incident on a single node, and the analogous max min agreements
objective. This naturally gives rise to a family of basic min-max graph cut
problems. A prototypical representative is Min Max Cut: find an cut
minimizing the largest number of cut edges incident on any node. We present the
following results: an -approximation for the problem of
minimizing the maximum total weight of disagreement edges incident on any node
(thus providing the first known approximation for the above family of min-max
graph cut problems), a remarkably simple -approximation for minimizing
local disagreements in complete graphs (improving upon the previous best known
approximation of ), and a -approximation for
maximizing the minimum total weight of agreement edges incident on any node,
hence improving upon the -approximation that follows from
the study of approximate pure Nash equilibria in cut and party affiliation
games
The environmental impact of climate change adaptation on land use and water quality
Encouraging adaptation is an essential aspect of the policy response to climate change1. Adaptation seeks to reduce the harmful consequences and harness any beneficial opportunities arising from the changing climate. However, given that human activities are the main cause of environmental transformations worldwide2, it follows that adaptation itself also has the potential to generate further pressures, creating new threats for both local and global ecosystems. From this perspective, policies designed to encourage adaptation may conflict with regulation aimed at preserving or enhancing environmental quality. This aspect of adaptation has received relatively little consideration in either policy design or academic debate. To highlight this issue, we analyse the trade-offs between two fundamental ecosystem services that will be impacted by climate change: provisioning services derived from agriculture and regulating services in the form of freshwater quality. Results indicate that climate adaptation in the farming sector will generate fundamental changes in river water quality. In some areas, policies that encourage adaptation are expected to be in conflict with existing regulations aimed at improving freshwater ecosystems. These findings illustrate the importance of anticipating the wider impacts of human adaptation to climate change when designing environmental policies
Protocol for the Smoking, Nicotine and Pregnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy
Background: Smoking in pregnancy remains a public health challenge. Nicotine replacement therapy (NRT) is effective for smoking cessation in non-pregnant people, but because women metabolise nicotine and cotinine much faster in pregnancy, it is unclear whether this will be effective for smoking cessation in pregnancy. The NHS Health Technology Assessment Programme (HTA)-funded smoking, nicotine and pregnancy ( SNAP) trial will investigate whether or not nicotine replacement therapy ( NRT) is effective, cost-effective and safe when used for smoking cessation by pregnant women. Methods/Design: Over two years, in 5 trial centres, 1050 pregnant women who are between 12 and 24 weeks pregnant will be randomised as they attend hospital for ante-natal ultrasound scans. Women will receive either nicotine or placebo transdermal patches with behavioural support. The primary outcome measure is biochemically-validated, self-reported, prolonged and total abstinence from smoking between a quit date ( defined before randomisation and set within two weeks of this) and delivery. At six months after childbirth self-reported maternal smoking status will be ascertained and two years after childbirth, self-reported maternal smoking status and the behaviour, cognitive development and respiratory symptoms of children born in the trial will be compared in both groups. Discussion: This trial is designed to ascertain whether or not standard doses of NRT ( as transdermal patches) are effective and safe when used for smoking cessation during pregnancy
Improving the Longevity and Results of Mastopexy and Breast Reduction Procedures: Reconstructing an Internal Breast Support System with Biocompatible Mesh to Replace the Supporting Function of the Ligamentous Suspension
The original publication is available at http://www.springerlink.com/Publication of this article was funded by the Stellenbosch University Open Access Fund.The reasons for recurrent ptosis in mastopexy
and breast reduction procedures are twofold. First,
available surgical techniques do not reconstruct the normal
breast anatomy responsible for maintaining breast shape.
Second, in many instances the techniques rely on atrophied
tissue to provide long-term support. The discovery in 1997
of the ligamentous suspension (the supporting system of
the breast) gave rise to the concept that reconstruction of
this anatomical structure was needed to ensure a sustained
postoperative result. Applying the latest knowledge
regarding the structural and vascular anatomy of the breast
in the surgical technique and utilizing material other than
atrophied breast tissue enabled us to prevent the recurrence
of breast ptosis.
Methods A surgical technique was developed to replace
the supportive function of a failed ligamentous suspension
in 112 patients with ptotic breasts. This was done by reconstructing an internal breast-supporting system (IBSS)
with biocompatible mesh.
Results Satisfactory breast shape, nipple projection, and
upper breast fullness was obtained with this technique in
mastopexy patients with moderate-sized ptotic breasts. In
patients with larger breasts good results were obtained with
a simultaneous breast reduction. The longest follow-up is
6 years 3 months.
Conclusions With this technique recurrent breast ptosis can
be prevented in mastopexy and breast reduction procedures.
The results are such that it eliminates the need for silicone
prostheses to obtain satisfactory upper-breast fullness. The
surgical technique is especially indicated in patients with skin
of poor quality or patients with high expectations.Stellenbosch University Open Access FundPublishers' Versio
Early and efficient detection of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures.
Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not yet widely available in resource-limited settings. In a developing-country setting, we prospectively evaluated two methods for culturing and detecting M. tuberculosis in sputum. Sputum samples were cultured in liquid assay (micro broth culture) in microplate wells and growth was detected by microscopic observation, or in Löwenstein-Jensen (LJ) solid media where growth was detected by visual inspection for colonies. Sputum samples were collected from 321 tuberculosis (TB) suspects attending Bugando Medical Centre, in Mwanza, Tanzania, and were cultured in parallel. Pulmonary tuberculosis cases were diagnosed using the American Thoracic Society diagnostic standards. There were a total of 200 (62.3%) pulmonary tuberculosis cases. Liquid assay with microscopic detection detected a significantly higher proportion of cases than LJ solid culture: 89.0% (95% confidence interval [CI], 84.7% to 93.3%) versus 77.0% (95% CI, 71.2% to 82.8%) (p = 0.0007). The median turn around time to diagnose tuberculosis was significantly shorter for micro broth culture than for the LJ solid culture, 9 days (interquartile range [IQR] 7-13), versus 21 days (IQR 14-28) (p<0.0001). The cost for micro broth culture (labor inclusive) in our study was US 11.35 per sample for the LJ solid culture. The liquid assay (micro broth culture) is an early, feasible, and inexpensive method for detection of pulmonary tuberculosis in resource limited settings
Rationality and the experimental study of reasoning
A survey of the results obtained during the past three decades in some of the most widely used tasks and paradigms in the experimental study of reasoning is presented. It is shown that, at first sight, human performance suffers from serious shortcomings. However, after the problems of communication between experimenter and subject are taken into account, which leads to clarify the subject's representation of the tasks, one observes a better performance, although still far from perfect. Current theories of reasoning, of which the two most prominent are very briefly outlined, agree in identifying the load in working memory as the main source of limitation in performance. Finally, a recent view on human rationality prompted by the foregoing results is described
Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications
Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid. The model presented in this article focuses mainly on the description of mechanical interactions of the growing tumour with the host tissue, their influence on tumour growth, and the attachment/detachment mechanisms between cells and ECM. Starting from some recent experimental evidences, we propose to describe the interaction forces involving the extracellular matrix via some concepts coming from viscoplasticity. We then apply the model to the description of the growth of tumour cords and the formation of fibrosis
Topologically Protected Quantum State Transfer in a Chiral Spin Liquid
Topology plays a central role in ensuring the robustness of a wide variety of
physical phenomena. Notable examples range from the robust current carrying
edge states associated with the quantum Hall and the quantum spin Hall effects
to proposals involving topologically protected quantum memory and quantum logic
operations. Here, we propose and analyze a topologically protected channel for
the transfer of quantum states between remote quantum nodes. In our approach,
state transfer is mediated by the edge mode of a chiral spin liquid. We
demonstrate that the proposed method is intrinsically robust to realistic
imperfections associated with disorder and decoherence. Possible experimental
implementations and applications to the detection and characterization of spin
liquid phases are discussed.Comment: 14 pages, 7 figure
Quantum flutter of supersonic particles in one-dimensional quantum liquids
The non-equilibrium dynamics of strongly correlated many-body systems
exhibits some of the most puzzling phenomena and challenging problems in
condensed matter physics. Here we report on essentially exact results on the
time evolution of an impurity injected at a finite velocity into a
one-dimensional quantum liquid. We provide the first quantitative study of the
formation of the correlation hole around a particle in a strongly coupled
many-body quantum system, and find that the resulting correlated state does not
come to a complete stop but reaches a steady state which propagates at a finite
velocity. We also uncover a novel physical phenomenon when the impurity is
injected at supersonic velocities: the correlation hole undergoes long-lived
coherent oscillations around the impurity, an effect we call quantum flutter.
We provide a detailed understanding and an intuitive physical picture of these
intriguing discoveries, and propose an experimental setup where this physics
can be realized and probed directly.Comment: 13 pages, 9 figure
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