888 research outputs found
Exploring the Effects of Residence Time on the Utility of Stable Isotopes and S/C Ratios as Proxies for Ocean Connectivity
Various geochemical proxies have been developed to determine if ancient sedimentary strata were deposited in marine or nonmarine environments. A critical parameter for proxy reliability is the residence time of aqueous species in seawater, which is rarely considered for proxies relying on stable isotopes and elemental abundance ratios. Differences in residence time may affect our ability to track geologically short-lived alternations between marine and nonmarine conditions. To test this effect for sulfur and nitrogen isotopes and sulfur/carbon ratios, we investigated a stratigraphic section in the Miocene Oberpullendorf Basin in Austria. Here, previous work revealed typical seawater-like rare earth element and yttrium (REY) systematics transitioning to nonmarine-like systematics. This shift was interpreted as a brief transition from an open marine depositional setting to a restricted embayment with a reduced level of exchange with the open ocean and possibly freshwater influence. Our isotopic results show no discernible response in carbonate-associated sulfate sulfur isotopes and carbon/sulfur abundance ratios during the interval of marine restriction inferred from the REY data, but nitrogen isotopes show a decrease by several permil. This observation is consistent with the much longer residence time of sulfate in seawater compared with REY and nitrate. Hence, this case study illustrates that the residence time is a key factor for the utility of seawater proxies. In some cases, it may make geochemical parameters more sensitive to marine water influx than paleontological observations, as in the Oberpullendorf Basin. Particular care is warranted in deep time, when marine residence times likely differ markedly from the modern
Ab initio simulations of liquid systems: Concentration dependence of the electric conductivity of NaSn alloys
Liquid NaSn alloys in five different compositions (20, 40, 50, 57 and 80%
sodium) are studied using density functional calculations combined with
molecular dynamics(Car-Parrinello method). The frequency-dependent electric
conductivities for the systems are calculated by means of the Kubo-Greenwood
formula.
The extrapolated DC conductivities are in good agreement with the
experimental data and reproduce the strong variation with the concentration.
The maximum of conductivity is obtained, in agreement with experiment, near the
equimolar composition.
The strong variation of conductivity, ranging from almost semiconducting up
to metallic behaviour, can be understood by an analysis of the
densities-of-states.Comment: LaTex 6 pages and 2 figures, to appear in J.Phys. Cond. Ma
The Serum Galactomannan Index Predicts Mortality in Allogeneic Hematopoietic Stem Cell Transplant Recipients with Probable Pulmonary Invasive Aspergillosis
Dynamics of modal power distribution in a multimode semiconductor laser with optical feedback
The dynamics of power distribution between longitudinal modes of a multimode
semiconductor laser subjected to external optical feedback is experimentally
analyzed in the low-frequency fluctuation regime. Power dropouts in the total
light intensity are invariably accompanied by sudden activations of several
longitudinal modes. These activations are seen not to be simultaneous to the
dropouts, but to occur after them. The phenomenon is statistically analysed in
a systematic way, and the corresponding delay is estimated.Comment: 3 pages, 4 figures, revte
Interleukin 23-Helper T Cell 17 Axis as a Treatment Target for Pityriasis Rubra Pilaris.
Treatment of pityriasis rubra pilaris (PRP) is solely based on its resemblance to psoriasis rather than any knowledge of its pathomechanism. Insight into pathogenic mediators of inflammation is essential for targeted and valid treatment options that could replace previous serendipitous therapeutic approaches in refractory PRP.
To determine whether blockade of the interleukin 23-helper T cell 17 (IL-23-TH17) pathway with ustekinumab represents an efficacious and, based on its proinflammatory cytokine profile, targeted treatment option in PRP.
In this case report, a patient with PRP received outpatient treatment at a university hospital department of dermatology with ustekinumab according to the dosing regimen approved for psoriasis. Lesional skin biopsy samples were taken from this patient and 2 others with refractory PRP. Messenger RNA (mRNA) expression of proinflammatory innate and T-cell-derived cytokines were measured and compared with skin samples from patients with psoriasis and healthy donors. From 1 patient, lesional skin samples were taken before ustekinumab treatment and 4 and 28 weeks after treatment initiation. Follow-up was completed after 6 months.
Subcutaneous ustekinumab, 45 mg, at weeks 0 and 4 and quarterly thereafter.
The primary outcome was to determine the changes in expression of proinflammatory innate and T-cell-derived cytokines during ustekinumab therapy. The secondary objective was to evaluate the clinical and histopathologic phenotype in relation to the mRNA expression profile of proinflammatory cytokines.
In lesional PRP skin samples from a single patient, upregulated expression levels were found for most proinflammatory innate cytokines, including tumor necrosis factor (TNF), IL-6, IL-12, IL-23, and IL-1β. Among adaptive T-cell cytokines, an increase of TH1 cytokines and, in particular, TH17 cytokines IL-17A, IL-17F, and IL-22 was seen in PRP. The patient with PRP who received ustekinumab showed regression of skin lesions after 2 weeks and almost complete resolution after 1 month. Clinical and histopathologic improvement paralleled the expression levels of TH17 cytokines but not of interferon-γ and TNF, which lagged behind the amelioration.
In this case report, a role of the IL-23-TH17-axis in PRP was identified, suggesting a shared pathogenic inflammatory pathway with psoriasis, despite evident clinical and histopathologic differences. In addition, this report provides a rationale for targeting the IL-23-TH17-pathway as a treatment option for refractory PRP
Ab initio simulations of liquid NaSn alloys: Zintl anions and network formation
Using the Car-Parrinello technique, ab initio molecular dynamics simulations
are performed for liquid NaSn alloys in five different compositions (20, 40,
50, 57 and 80 % sodium). The obtained structure factors agree well with the
data from neutron scattering experiments. The measured prepeak in the structure
factor is reproduced qualitatively for most compositions. The calculated and
measured positions of all peaks show the same trend as function of the
composition.\\ The dynamic simulations also yield information about the
formation and stability of Sn clusters (Zintl anions) in the liquid. In our
simulations of compositions with 50 and 57 % sodium we observe the formation of
networks of tin atoms. Thus, isolated tin clusters are not stable in such
liquids. For the composition with 20 % tin only isolated atoms or dimers of tin
appear, ``octet compounds'' of one Sn atom surrounded by 4 Na atoms are not
observed.Comment: 12 pages, Latex, 3 Figures on reques
Recommended from our members
Strontium-90 Liquid Concentration Solubility Correlation in the Hanford Tank Waste Operations Simulator
A new correlation was developed to estimate the concentration of strontium-90 in a waste solution based on total organic carbon. This correlation replaces the strontium-90 wash factors, and when applied in the Hanford Tank Waste Operations Simulator, significantly reduced the estimated quantity of strontium-90 in the delivered low-activity waste feed. This is thought to be a more realistic estimate of strontium-90 than using the wash-factor method
Boxy/peanut/X bulges, barlenses and the thick part of galactic bars: What are they and how did they form?
Bars have a complex three-dimensional shape. In particular their inner part
is vertically much thicker than the parts further out. Viewed edge-on, the
thick part of the bar is what is commonly known as a boxy-, peanut- or X- bulge
and viewed face-on it is referred to as a barlens. These components are due to
disc and bar instabilities and are composed of disc material. I review here
their formation, evolution and dynamics, using simulations, orbital structure
theory and comparisons to observations.Comment: 21 pages, 7 figures, invited review to appear in "Galactic Bulges",
E. Laurikainen, R. Peletier, D. Gadotti, (eds.), Springe
The regeneration of stellar bars by tidal interactions. Numerical simulations of fly-by encounters
We study the regeneration of stellar bars triggered by a tidal interaction,
using numerical simulations of either purely stellar or stellar+gas disc
galaxies. We find that interactions which are sufficiently strong to regenerate
the bar in the purely stellar models do not lead to a regeneration in the
dissipative models, owing to the induced gas inflow in those models. In models
in which the bar can be regenerated, we find a tight correlation between the
strength and the pattern speed of the induced bar. This relation can be
explained by a significant radial redistribution of angular momentum in the
disc due to the interaction, similar to the processes and correlations found
for isolated barred spirals. We furthermore show that the regenerated bars show
the same dynamical properties as their isolated counterparts.Comment: 18 pages, 26 figures, accepted for publication in MNRA
- …