13 research outputs found
Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review
Objectives: To systematically review and discuss the current evidence from placebo-controlled
clinical trials that investigated the use of alternative medicines and herbal remedies in the
management of erectile dysfunction (ED).
Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-
based systematic review using specific keyword combinations was conducted on the PubMed
and Scopus databases. Randomised controlled trials investigating herbal medicine in at least
one group and using the International Index of Erectile Function (IIEF) as an outcome in
patients primarily diagnosed with ED were included for review.
Results: Following the literature search, screening and eligibility analysis, a total of 42 articles
were included. The 42 articles were categorised as single herb extractions (n = 14), combination
herbal formula (n = 5), combination of herbal formula and non-herbal nutraceuticals (n = 7),
non-herbal nutraceuticals (n = 5), acupuncture and moxibustion (n = 2), diet and nutrition
(n = 3), exercise (n = 5), and topical treatments (n = 1). Based on the results, Korean ginseng,
Pygnogenol and Prelox, Tribulus terrestris, Lepidium meyenii, L-arginine, acupuncture and lifestyle
interventions were the more predominantly investigated treatments interventions for ED.
Conclusions: Panax ginseng, Pygnogenol, Prelox and Tribulus terrestris have promising evidence
as herbal products, alongside L-arginine as a nutritional supplement, for ED based on
IIEF outcomes, and warrant further clinical investigation. The mechanisms of action remain
unclear, but each of these appears to in part increase nitric oxide synthesis. Importantly,
improved diet and exercise should be considered, particularly in patients with obesity or
diabetes mellitus
How safe is intravenous sedation with midazolam and fentanyl for pediatric gastrointestinal endoscopy?
Keratomykose durch Cylindrocarpon lichenicola. Keratomycosis due to Cylindrocarpon lichenicola
Clinical and pathological responses of water buffalo (Bubalus bubalis) to experimental infection with bovine ephemeral fever virus—Chinese strain
Purification and characterization of a 315 kDa keratinolytic subtilisin-like serine protease from Microsporum canis
Arsenic-containing soil from geogenic source in Hong Kong: Leaching characteristics and stabilization/solidification
Production, partial optimization and characterization of keratinase enzyme by Arthrobacter sp. NFH5 isolated from soil samples
Abstract The study was conducted to select the best promising keratinolytic bacterial strain. A good keratinase positive bacterium isolated from the soil samples of Hazaribagh tannery industrial zone, Dhaka was identified as Arthrobacter genus depending on the conventional techniques and confirmed as Arthrobacter sp. by sequencing 16S rRNA gene. The medium components and culture conditions were optimized to enhance keratinase production through shake flask culture. Keratin and feather powder (10 g/l or 1%) were good substrates for the highest keratinase production along with yeast extract (0.2 g/l or 0.02%) as an organic nitrogen source and potassium nitrate (1 g or 0.1%) as an inorganic nitrogen source. Maximum yield of keratinase was found after 24 h of incubation at 37 °C with an initial pH of 7.0 and inoculums volume 5% under 150 rpm when keratin, yeast extract and potassium nitrate were used as nutrient sources. Keratinase production was more than 5.0-fold increased when all optimized parameters were applied simultaneously. The optimum reaction temperature and pH were determined to be 40 °C and 8.0 respectively for crude keratinase activity. Therefore, Arthrobacter sp. NFH5 might be used for large scale production of keratinase for industrial purposes in less time