18 research outputs found
Sustained CD28 Expression Delays Multiple Features of Replicative Senescence in Human CD8 T Lymphocytes
- Author
- A Hakansson
- BH Lemster
- CE Rudd
- CH June
- CL Verweij
- D Schmidt
- DJ Lenschow
- DM Sze
- DN Posnett
- H Vaziri
- HF Valenzuela
- JD Fraser
- JD Powell
- Jennifer E. Wu
- JJ Goronzy
- K Steiner
- KA Frauwirth
- L Rink
- M Dagarag
- M Saurwein-Teissl
- MS Topp
- NL Perillo
- R Pacheco
- R Simone
- RB Effros
- RB Effros
- RB Effros
- RB Effros
- Rita B. Effros
- SF Stone
- SN Saldanha
- SR Fauce
- SR Hadrup
- ST Parish
- ST Parish
- Stanley T. Parish
- T Lindstein
- T Tsukishiro
- V Appay
- W Cao
- Y Liu
- Y Shimizu
- Publication venue
- Springer US
- Publication date
- 01/11/2010
- Field of study
CD28 costimulatory signal transduction in T lymphocytes is essential for optimal telomerase activity, stabilization of cytokine mRNAs, and glucose metabolism. During aging and chronic infection with HIV-1, there are increased proportions of CD8 T lymphocytes that lack CD28 expression and show additional features of replicative senescence. Moreover, the abundance of these cells correlates with decreased vaccine responsiveness, early mortality in the very old, and accelerated HIV disease progression. Here, we show that sustained expression of CD28, via gene transduction, retards the process of replicative senescence, as evidenced by enhanced telomerase activity, increased overall proliferative potential, and reduced secretion of pro-inflammatory cytokines. Nevertheless, the transduced cultures eventually do reach senescence, which is associated with increased CTLA-4 gene expression and a loss of CD28 cell surface expression. These findings further elucidate the central role of CD28 in the replicative senescence program, and may ultimately lead to novel therapies for diseases associated with replicative senescence
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
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- Passali D
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- Patel NA
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- Patel ZM
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- Peng Y
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- Perkasa MF
- Perloff JR
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- Pfaar O
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- Ramakrishnan V
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- Sedaghat AR
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- Seiberling K
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- Servat JJ
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- Snidvongs K
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- Tan NC
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- Tanaka S
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- Tarrant BJ
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- Thamboo A
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- Tharakan A
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- Tosun F
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- Tran Khai Hoan N
- Tripathi A
- Trompette A
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- Turan A
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- Tyler MA
- Tyler MA
- Tyler MA
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- Tzelnick S
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- Ueda D
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- Unlu HH
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- Vaezi MF
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- Vaira LA
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- Valdes CJ
- Valentine R
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- Valera FCP
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- Workman AD
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- Workman AD
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- Wormald PJ
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- Wright ED
- Wu AW
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- Xian M
- Xu J
- Xu JJ
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- Yamada T
- Yamasaki A
- Yan C
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- Yan CH
- Yan CH
- Yan CH
- Yan CH
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- Yan M
- Yancey KL
- Yancey KL
- Yang C
- Yang C
- Yaniv D
- Yaniv D
- Yao Y
- Yarmohammadi H
- Yatsunenko T
- Yayik AM
- Yel L
- Yelverton JC
- Yilmaz S
- Yip J
- Yip J
- Yohai RA
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- Yoon H
- Yoon HY
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- Young Jang T
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- Yu XM
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- Zainine R
- Zajac AE
- Zalmanovici Trestioreanu A
- Zalmanovici Trestioreanu A
- Zariwala MA
- Zeiger J
- Zeng M
- Zeng M
- Zhai GT
- Zhang L
- Zhang ML
- Zhang N
- Zhang N
- Zhang N
- Zhang Q
- Zhang S
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao CY
- Zhao K
- Zhao K
- Zhao L
- Zhao YC
- Zhao YC
- Zheng C
- Zheng Z
- Zhou B
- Zia S
- Ziegler CGK
- Zielinska‐Blizniewska H
- Zou L
- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Čulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS
Magnet-assist endoscopic augmentation of the lower esophageal sphincter for treatment of gastroesophageal reflux disease: cadaveric and survival studies in a porcine model (with video)
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sprouting Ability and Seasonal Changes of Sugar Concentrations in Rhizomes of Calystegia sepium and Roots of Convolvulus arvensis
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD
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- A Chaouat
- A Engler
- A Ludwig
- Alen Faiz
- Benjamin Marsland
- C Raherison
- C Rius
- Caroline Leuenberger
- CF Clarenbach
- Claudio Schuoler
- Célia Mignan
- D Jung
- DE Newby
- DP Bartel
- FD Urnov
- Giovanni G. Camici
- GO Osoata
- H Dweep
- Hannah Bye
- HF Hakansson
- Isabelle Opitz
- J Zhang
- JH Noh
- K Ito
- K Steiling
- KF Chung
- Lars C. Huber
- M Berge van den
- M Brock
- Malcolm Kohler
- Matthias Brock
- ME Ezzie
- N Ismail
- Pieter S. Hiemstra
- PJ Barnes
- PJ Barnes
- PJ Barnes
- RC Friedman
- S Chung
- Sven Hillinger
- T Min
- Thomas Rechsteiner
- TS Lapperre
- Wim Timens
- WQ Gan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Electroweak parameters of the z0 resonance and the standard model
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- Zeng M
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- Zevgolatakos E
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- Zukanovich-Funchal R
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- Zuniga J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1992
- Field of study
Contains fulltext :
124399.pdf (publisher's version ) (Open Access
A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis
- Author
- A Chabes
- A Prudova
- AE Beaudin
- AE Beaudin
- AE Beaudin
- B Schwahn
- BC Blount
- BJ Brewer
- BL Tsang
- C Solis
- CF Woeller
- DD Anderson
- DT Gillespie
- EP Chiang
- EP Quinlivan
- GL Neil
- H Ghandour
- H Niida
- HF Nijhout
- I Sagi
- JG Hilton
- JH Gillespie
- JT Fox
- K Herbig
- KA Becker
- L Marchetti
- L Martiniova
- M Scotti
- M Zhao
- MC Anguera
- MC Reed
- MC Reed
- MC Reed
- MS Field
- MS Field
- MT Greenwood
- MV Martinov
- P Hakansson
- PF Morrison
- PJ Bagley
- PJ Goss
- PJ Stover
- PJ Stover
- PM Ueland
- PP Poon
- R Gostner
- RC Jackson
- RC Young
- RL Seither
- S Gon
- SC Liew
- SR Davis
- V Schirch
- WB Strong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Leptin and Reproduction in the Male
- Author
- A Ewart-Toland
- A Garg
- A Strobel
- AM Isidori
- CC Cheung
- CC Cheung
- CS Mantzoros
- CT Montague
- DA Schreihofer
- DJ Burks
- DL Coleman
- DL Coleman
- EE Otukonyong
- F Andreelli
- FF Chehab
- FX Hausberger
- GA Bray
- GC Kennedy
- GH Lee
- GR Hervey
- H Chen
- HF Urbanski
- IS Farooqi
- J Lado-Abeal
- J Lado-Abeal
- J Lado-Abeal
- J Lado-Abeal
- J Qiu
- JA Germak
- JC Bruning
- JC Erickson
- JC Erickson
- JE Schneider
- JE Schneider
- JK Elmquist
- JL Cameron
- JL Halaas
- JW Kolaczynski
- K Clement
- K Mounzih
- L Herberg
- LA Tartaglia
- M Caprio
- M Ferin
- M Ozata
- M Rosenbaum
- M Tena-Sempere
- M Tena-Sempere
- M Wabitsch
- M Wauters
- M-L Hakansson
- MA Pelleymounter
- MD Chen
- MM Gruaz
- MR Palmert
- MS Hickey
- MW Schwartz
- N Lima
- PD Finn
- PL Zamorano
- RE Frisch
- RS Ahima
- RS Swerdloff
- RS Swerdloff
- RV Considine
- RV Garcia Mayor
- S Kamohara
- S Nagatami
- S Nagatani
- S Westman
- SC Chua
- SP Kalra
- TM Plant
- V Pineiro
- VC Pardini
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2003
- Field of study
Introduction
- Author
- AP Craig-Holmes
- AP Craig-Holmes
- AV Mikelsaar
- B Marcais
- BC Ballif
- BJ Lorber
- BS Emanuel
- C Conference
- C Macilwain
- CC Lin
- CG Palmer
- E Ginelli
- E Meyer
- E Pennisi
- EB Hook
- EC Moores
- F Sergovich
- FE Arrighi
- G Gimelli
- GG Miklos
- GK Livingston
- GS Sekhon
- H Gürtler
- HA Lubs
- HA Lubs
- HF Willard
- HJ Muller
- HJ Muller
- HL Cooper
- J Nielsen
- JJ Yunis
- JL Hammerton
- JM Geraedts
- JM Geraedts
- JR Gosden
- JR Lobitz
- JR Lupski
- K Stergianou
- KH Ramesh
- KW Jones
- KW Jones
- KW Jones
- L Hakansson
- London
- M Hauge
- M Mikkelsen
- MV Zaragoza
- P Conference
- P Genest
- P Genest
- P Pearson
- PA Jacobs
- PA Jacobs
- PA Jacobs
- PE Warburton
- PH Fitzgerald
- PN Howard-Peebles
- R Mazzarella
- RC Juberg
- RE Magenis
- RE Magenis
- RP Donahue
- RV Samonte
- RW Redline
- S Luke
- S Olson
- S Walzer
- SA Farrel
- SB Olson
- SB Olson
- U Friedrich
- WH Mckenzie
- Y Ji
- Y Lau
- YF Lau
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2004
- Field of study
Oral exposure of deltamethrin and/or lipopolysaccharide (LPS) induced activation of the pulmonary immune system in Swiss albino mice
- Author
- A Anadon
- A Bhatia
- A Tewari
- A Tewari
- A Wu
- AA Chougule
- AK Singh
- Anita Tewari
- AR Khalatbary
- B Moldoveanu
- Baljit Singh
- BD Banerjee
- BJ Proskocil
- BK Das
- C Lu
- CJ Burns
- D Bagchi
- DB Barr
- F Cantalamessa
- GS Berkowitz
- H Bouwman
- H Rehman
- HF Hakansson
- HT Khashan
- I Chargui
- J Thorn
- Jasbir Bedi
- Jatinder Paul Singh Gill
- JE Casida
- KB Kim
- KE Stebbins
- KK Grewal
- L Imamura
- LO Ruzo
- LP Sheets
- M Ermert
- M Liu
- MAT Santos
- MK Morgan
- Q Li
- RA Goldsby
- RM Whyatt
- RS Sethi
- S Erdogan
- S Kumar
- S Manna
- S Parvez
- S Tos-Luty
- SJ Skerrett
- SK Tayebati
- SS Oda
- TE Krysinska
- TM Al-Shaikh
- TP Swarnam
- V Liebers
- Y Imai
- Y Kitamura
- Y Shukla
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study