5,017 research outputs found

    An investigation of hydraulic-line resonance and its attenuation

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    An investigation of fluid resonance in high-pressure hydraulic lines has been made with two types of fluid dampers (or filters) installed in the line. One type involved the use of one or more closed-end tubes branching at right angles from a main line, and the other type was a fluid muffler installed in-line. These devices were evaluated in forced vibration tests with oscillatory disturbances over a 1000-Hz range applied to one end of the line and with oscillatory pressures measured at various stations along the main pipe. Limited applications of acoustic-wave theory to the branched systems are also included. Results show varying attenuations of pressure perturbations, depending on the number and location of branches and the type of muffler. Up to three branches were used in the branch-resonator study, and the largest frequency range with maximum attenuation was obtained for a three-branch configuration. The widest frequency ranges with significant attenuations were obtained with two types of fluid mufflers

    E2F Activation of S Phase Promoters via Association with HCF-1 and the MLL Family of Histone H3K4 Methyltransferases

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    E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle progression, particularly the S phase. E2F proteins repress transcription in association with retinoblastoma pocket proteins, but less is known about how they activate transcription. Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells. Human HCF-1-E2F interactions are versatile: their associations and binding to E2F-responsive promoters are cell-cycle selective, and HCF-1 displays coactivator properties when bound to the E2F1 activator and corepressor properties when bound to the E2F4 repressor. During the G1-to-S phase transition, HCF-1 recruits the mixed-lineage leukemia (MLL) and Set-1 histone H3 lysine 4 methyltransferases to E2F-responsive promoters and induces histone methylation and transcriptional activation. These results suggest that HCF-1 induces cell-cycle-specific transcriptional activation by E2F proteins to promote cell proliferation

    Prediction of asynchronous cell survival with the cell cycle extended GLOBLE model

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    Experience with a Low Emittance Optics in LEP

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    Since start-up in 1998, LEP has operated with a low emittance lattice with a phase advance of 102 deg in the horizontal and 90 deg in the vertical planes. This optics provides a horizontal detuning with amplitude which is small enough to avoid a reduced dynamic aperture in the horizontal plane, a problem experienced in other low emittance lattices. The optics is designed to operate at the highest LEP energies up to and above 100 GeV, as well as at 45.6 GeV (still required to provide Z0s for the calibration of the experiments detectors). The experience gained with this low emittance lattice after one year of operation is presented and its future potential is discussed

    DEVELOPMENT OF STANDARDS FOR PLACEMENT OF STEEL GUARDRAIL POSTS IN ROCK

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    A steel post W-beam guardrail system was developed for installation in rock-soil foundations. The guardrail system was constructed with a 2.66-mm (12-gauge) thick W-beam rail, 53.34 m in length. The W-beam guardrail was supported by twenty-seven W152x13.4 by 1,346-mm long steel posts, spaced at 1,905 mm on center. The posts were installed in drilled holes in concrete, constructed by drilling three 203-mm diameter holes on 165- mm centers to a depth of 610 mm. The drilled holes were backfilled with compacted ASTM C33 coarse aggregate, size no. 57. One full-scale vehicle crash test, using a 3⁄4-ton pickup truck, was performed on the W-beam guardrail system. The test was conducted and reported in accordance with the requirements specified in the National Cooperative Highway Research Program (NCHRP) Report No. 350, Recommended Procedures for the Safety Performance Evaluation of Highway Features. The safety performance of the W-beam guardrail system with post placed in rock was determined to be acceptable according to the Test Level 3 (TL-3) evaluation criteria specified in NCHRP Report No. 350. Further, guardrail post placement recommendations were also developed for situations where rock is located below the surface. These recommendations were developed through an analysis of bogie testing of posts

    A solution of the coincidence problem based on the recent galactic core black hole mass density increase

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    A mechanism capable to provide a natural solution to two major cosmological problems, i.e. the cosmic acceleration and the coincidence problem, is proposed. A specific brane-bulk energy exchange mechanism produces a total dark pressure, arising when adding all normal to the brane negative pressures in the interior of galactic core black holes. This astrophysically produced negative dark pressure explains cosmic acceleration and why the dark energy today is of the same order to the matter density for a wide range of the involved parameters. An exciting result of the analysis is that the recent rise of the galactic core black hole mass density causes the recent passage from cosmic deceleration to acceleration. Finally, it is worth mentioning that this work corrects a wide spread fallacy among brane cosmologists, i.e. that escaping gravitons result to positive dark pressure.Comment: 14 pages, 3 figure

    Introducing Originality and Innovation in Engineering Teaching: The Hydraulic Design of Culverts

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    Recently the teaching of engineering design has become a presentation of standards and codes rather than the learning of sound design practices. Too many students request formulae and equations to solve a design exercise and they fail to develop any design originality. The present student attitude leads to young graduate engineers without critical ability and innovative flair. The writer has developed an innovative hydraulic design exercise based upon culvert design. Each design exercise could lead to more than one correct design per student in the class. Students have to learn basic design calculations based upon lecture material, notes, field visits and laboratory experiment. The practical component (laboratory, field visit) contributes significantly to their understanding of the complete system, including some basic safety and professional issues

    An Intersectional Approach to Equity, Inequity, and Archaeology

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    The year 2020 was an awakening for some. For others, it reiterated the persistent social injustice in the United States. Compelled by these events, 30 diverse individuals came together from January to May 2021 for a semester-long seminar exploring inequity in archaeological practice. The seminar's discussions spotlighted the inequity and social injustices that are deeply embedded within the discipline. However, inequity in archaeology is often ignored or treated narrowly as discrete, if loosely bound, problems. A broad approach to inequity in archaeology revealed injustice to be intersectional, with compounding effects. Through the overarching themes of individual, community, theory, and practice, we (a subset of the seminar's participants) explore inequity and its role in various facets of archaeology, including North-South relations, publication, resource distribution, class differences, accessibility, inclusive theories, service to nonarchaeological communities, fieldwork, mentorship, and more. We focus on creating a roadmap for understanding the intersectionality of issues of inequity and suggesting avenues for continued education and direct engagement. We argue that community-building - by providing mutual support and building alliances - provides a pathway for realizing greater equity in our discipline.Fil: Rivera Prince, Jordi A.. University of Florida; Estados UnidosFil: Blackwood, Emily M.. University of Maine; Estados UnidosFil: Brough, Jason A.. University of Maine; Estados UnidosFil: Landázuri, Heather A.. University of Maine; Estados UnidosFil: Leclerc, Elizabeth L.. University of Maine; Estados UnidosFil: Barnes, Monica. American Museum of Natural History; Estados UnidosFil: Brasil, Kareen Kristina. Columbia University; Estados UnidosFil: Gutierrez, Maria Amelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano. Universidad Nacional del Centro de la Provincia de Buenos Aires. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano; ArgentinaFil: Herr, Sarah. Desert Archaeology, Inc.; MéxicoFil: Maasch, Kirk A.. University of Maine; Estados UnidosFil: Sandweiss, Daniel H.. University of Maine; Estados Unido
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