2,016 research outputs found
Deep ACS Imaging in the Globular Cluster NGC 6397: The Cluster Color Magnitude Diagram and Luminosity Function
We present the CMD from deep HST imaging in the globular cluster NGC 6397.
The ACS was used for 126 orbits to image a single field in two colors (F814W,
F606W) 5 arcmin SE of the cluster center. The field observed overlaps that of
archival WFPC2 data from 1994 and 1997 which were used to proper motion (PM)
clean the data. Applying the PM corrections produces a remarkably clean CMD
which reveals a number of features never seen before in a globular cluster CMD.
In our field, the main sequence stars appeared to terminate close to the
location in the CMD of the hydrogen-burning limit predicted by two independent
sets of stellar evolution models. The faintest observed main sequence stars are
about a magnitude fainter than the least luminous metal-poor field halo stars
known, suggesting that the lowest luminosity halo stars still await discovery.
At the bright end the data extend beyond the main sequence turnoff to well up
the giant branch. A populous white dwarf cooling sequence is also seen in the
cluster CMD. The most dramatic features of the cooling sequence are its turn to
the blue at faint magnitudes as well as an apparent truncation near F814W = 28.
The cluster luminosity and mass functions were derived, stretching from the
turn off down to the hydrogen-burning limit. It was well modeled with either a
very flat power-law or a lognormal function. In order to interpret these fits
more fully we compared them with similar functions in the cluster core and with
a full N-body model of NGC 6397 finding satisfactory agreement between the
model predictions and the data. This exercise demonstrates the important role
and the effect that dynamics has played in altering the cluster IMF.Comment: 43 pages including 4 tables and 12 diagrams. Figures 2 and 3 have
been bitmapped. Accepted for publication in the Astronomical Journa
The White Dwarf Cooling Sequence of NGC6397
We present the results of a deep Hubble Space Telescope (HST) exposure of the
nearby globular cluster NGC6397, focussing attention on the cluster's white
dwarf cooling sequence. This sequence is shown to extend over 5 magnitudes in
depth, with an apparent cutoff at magnitude F814W=27.6. We demonstrate, using
both artificial star tests and the detectability of background galaxies at
fainter magnitudes, that the cutoff is real and represents the truncation of
the white dwarf luminosity function in this cluster. We perform a detailed
comparison between cooling models and the observed distribution of white dwarfs
in colour and magnitude, taking into account uncertainties in distance,
extinction, white dwarf mass, progenitor lifetimes, binarity and cooling model
uncertainties. After marginalising over these variables, we obtain values for
the cluster distance modulus and age of \mu_0 = 12.02 \pm 0.06 and T_c = 11.47
\pm 0.47Gyr (95% confidence limits). Our inferred distance and white dwarf
initial-final mass relations are in good agreement with other independent
determinations, and the cluster age is consistent with, but more precise than,
prior determinations made using the main sequence turnoff method. In
particular, within the context of the currently accepted \Lambda CDM
cosmological model, this age places the formation of NGC6397 at a redshift z=3,
at a time when the cosmological star formation rate was approaching its peak.Comment: 56 pages, 30 figure
Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases
Engineering polyketide synthases (PKS) to produce new metabolites requires an understanding of catalytic points of failure during substrate processing. Growing evidence indicates the thioesterase (TE) domain as a significant bottleneck within engineered PKS systems. We created a series of hybrid PKS modules bearing exchanged TE domains from heterologous pathways and challenged them with both native and nonânative polyketide substrates. Reactions pairing wildtype PKS modules with nonânative substrates primarily resulted in poor conversions to anticipated macrolactones. Likewise, product formation with native substrates and hybrid PKS modules bearing nonâcognate TE domains was severely reduced. In contrast, nonânative substrates were converted by most hybrid modules containing a substrate compatible TE, directly implicating this domain as the major catalytic gatekeeper and highlighting its value as a target for protein engineering to improve analog production in PKS pathways.Improved catalysis with engineered polyketide synthases: Pairing wildâtype polyketide synthases with nonânative substrates largely failed to produce the anticipated products. A series of hybrid modules bearing heterologous thioesterase domains were generated and employed to alleviate the observed catalytic bottleneck, resulting in the efficient processing of nonânative substrates and an unexpected path to product diversity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156208/3/anie202004991-sup-0001-misc_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156208/2/anie202004991_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156208/1/anie202004991.pd
Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases
Engineering polyketide synthases (PKS) to produce new metabolites requires an understanding of catalytic points of failure during substrate processing. Growing evidence indicates the thioesterase (TE) domain as a significant bottleneck within engineered PKS systems. We created a series of hybrid PKS modules bearing exchanged TE domains from heterologous pathways and challenged them with both native and nonânative polyketide substrates. Reactions pairing wildtype PKS modules with nonânative substrates primarily resulted in poor conversions to anticipated macrolactones. Likewise, product formation with native substrates and hybrid PKS modules bearing nonâcognate TE domains was severely reduced. In contrast, nonânative substrates were converted by most hybrid modules containing a substrate compatible TE, directly implicating this domain as the major catalytic gatekeeper and highlighting its value as a target for protein engineering to improve analog production in PKS pathways.Improved catalysis with engineered polyketide synthases: Pairing wildâtype polyketide synthases with nonânative substrates largely failed to produce the anticipated products. A series of hybrid modules bearing heterologous thioesterase domains were generated and employed to alleviate the observed catalytic bottleneck, resulting in the efficient processing of nonânative substrates and an unexpected path to product diversity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156161/2/ange202004991-sup-0001-misc_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156161/1/ange202004991.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156161/3/ange202004991_am.pd
Deep ACS Imaging in the Globular Cluster NGC6397: Dynamical Models
We present N-body models to complement deep imaging of the metal-poor
core-collapsed cluster NGC6397 obtained with the Hubble Space Telescope. All
simulations include stellar and binary evolution in-step with the stellar
dynamics and account for the tidal field of the Galaxy. We focus on the results
of a simulation that began with 100000 objects (stars and binaries), 5%
primordial binaries and Population II metallicity. After 16 Gyr of evolution
the model cluster has about 20% of the stars remaining and has reached
core-collapse. We compare the color-magnitude diagrams of the model at this age
for the central region and an outer region corresponding to the observed field
of NGC6397 (about 2-3 half-light radii from the cluster centre). This
demonstrates that the white dwarf population in the outer region has suffered
little modification from dynamical processes - contamination of the luminosity
function by binaries and white dwarfs with non-standard evolution histories is
minimal and should not significantly affect measurement of the cluster age. We
also show that the binary fraction of main-sequence stars observed in the
NGC6397 field can be taken as representative of the primordial binary fraction
of the cluster. For the mass function of the main-sequence stars we find that
although this has been altered significantly by dynamics over the cluster
lifetime, especially in the central and outer regions, that the position of the
observed field is close to optimal for recovering the initial mass function of
the cluster stars (below the current turn-off mass). More generally we look at
how the mass function changes with radius in a dynamically evolved stellar
cluster and suggest where the best radial position to observe the initial mass
function is for clusters of any age.Comment: 34 pages, 11 figures, submitted to AJ, companion paper to 0708.403
How a Diverse Research Ecosystem Has Generated New Rehabilitation Technologies: Review of NIDILRRâs Rehabilitation Engineering Research Centers
Over 50 million United States citizens (1 in 6 people in the US) have a developmental, acquired, or degenerative disability. The average US citizen can expect to live 20% of his or her life with a disability. Rehabilitation technologies play a major role in improving the quality of life for people with a disability, yet widespread and highly challenging needs remain. Within the US, a major effort aimed at the creation and evaluation of rehabilitation technology has been the Rehabilitation Engineering Research Centers (RERCs) sponsored by the National Institute on Disability, Independent Living, and Rehabilitation Research. As envisioned at their conception by a panel of the National Academy of Science in 1970, these centers were intended to take a âtotal approach to rehabilitationâ, combining medicine, engineering, and related science, to improve the quality of life of individuals with a disability. Here, we review the scope, achievements, and ongoing projects of an unbiased sample of 19 currently active or recently terminated RERCs. Specifically, for each center, we briefly explain the needs it targets, summarize key historical advances, identify emerging innovations, and consider future directions. Our assessment from this review is that the RERC program indeed involves a multidisciplinary approach, with 36 professional fields involved, although 70% of research and development staff are in engineering fields, 23% in clinical fields, and only 7% in basic science fields; significantly, 11% of the professional staff have a disability related to their research. We observe that the RERC program has substantially diversified the scope of its work since the 1970âs, addressing more types of disabilities using more technologies, and, in particular, often now focusing on information technologies. RERC work also now often views users as integrated into an interdependent society through technologies that both people with and without disabilities co-use (such as the internet, wireless communication, and architecture). In addition, RERC research has evolved to view users as able at improving outcomes through learning, exercise, and plasticity (rather than being static), which can be optimally timed. We provide examples of rehabilitation technology innovation produced by the RERCs that illustrate this increasingly diversifying scope and evolving perspective. We conclude by discussing growth opportunities and possible future directions of the RERC program
Interference effects in the photorecombination of argonlike Sc3+ ions: Storage-ring experiment and theory
Absolute total electron-ion recombination rate coefficients of argonlike
Sc3+(3s2 3p6) ions have been measured for relative energies between electrons
and ions ranging from 0 to 45 eV. This energy range comprises all dielectronic
recombination resonances attached to 3p -> 3d and 3p -> 4s excitations. A broad
resonance with an experimental width of 0.89 +- 0.07 eV due to the 3p5 3d2 2F
intermediate state is found at 12.31 +- 0.03 eV with a small experimental
evidence for an asymmetric line shape. From R-Matrix and perturbative
calculations we infer that the asymmetric line shape may not only be due to
quantum mechanical interference between direct and resonant recombination
channels as predicted by Gorczyca et al. [Phys. Rev. A 56, 4742 (1997)], but
may partly also be due to the interaction with an adjacent overlapping DR
resonance of the same symmetry. The overall agreement between theory and
experiment is poor. Differences between our experimental and our theoretical
resonance positions are as large as 1.4 eV. This illustrates the difficulty to
accurately describe the structure of an atomic system with an open 3d-shell
with state-of-the-art theoretical methods. Furthermore, we find that a
relativistic theoretical treatment of the system under study is mandatory since
the existence of experimentally observed strong 3p5 3d2 2D and 3p5 3d 4s 2D
resonances can only be explained when calculations beyond LS-coupling are
carried out.Comment: 11 pages, 7 figures, 3 tables, Phys. Rev. A (in print), see also:
http://www.strz.uni-giessen.de/~k
A Deep, Wide-Field, and Panchromatic View of 47 Tuc and the SMC with HST: Observations and Data Analysis Methods
In HST Cycle 17, we imaged the well known globular star cluster 47 Tucanae
for 121 orbits using ACS and both the UVIS and IR channels of WFC3 (GO-11677,
PI - H. Richer). This unique data set was obtained to address many scientific
questions that demand a very deep, panchromatic, and panoramic view of the
cluster's stellar populations. In total, the program obtained over 0.75 Ms of
imaging exposure time with the three HST cameras, over a time span of 9 months
in 2010. The primary ACS field was imaged in the two broadband filters F606W
and F814W filters, at 13 orientations, for all 121 orbits. The parallel WFC3
imaging provides a panchromatic (0.4 - 1.7 micron) and contiguous imaging swath
over a 250 degree azimuthal range at impact radii of 6.5 -- 17.9 pc in 47 Tuc.
This imaging totals over 60 arcmin^2 in area and utilizes the F390W and F606W
broadband filters on WFC3/UVIS and the F110W and F160W broadband filters on
WFC3/IR.
In this paper, we describe the observational design of the new survey and one
of the methods used to analyze all of the imaging data. This analysis combines
over 700 full-frame images taken with the three HST cameras into a handful of
ultra-deep, well-sampled combined images in each of the six filters. The
results reveal unprecedented color-magnitude diagrams (CMDs) of the cluster
extending to >30th magnitude in the optical, 29th magnitude in the UV, and 27th
magnitude in the IR. The data set provides a characterization of the complete
stellar populations of 47 Tuc, extending from the faintest hydrogen burning
dwarfs through the main-sequence and giant branches, down to very cool white
dwarf remnants in the cluster. The imaging also provides the deepest probe of
the stellar populations of the background Small Magellanic Cloud (SMC) galaxy,
resolving low mass main-sequence dwarfs with M < 0.2 Msun.Comment: Accepted for Publication in the Astronomical Journal. 23 pages, 13
figures, and 4 tables. Companion paper by K. Woodley is astro-ph/037477
Association of Mild to Moderate Chronic Kidney Disease With Venous Thromboembolism Pooled Analysis of Five Prospective General Population Cohorts
BACKGROUND: Recent findings suggest that chronic kidney disease (CKD) may be associated with increased risk of venous thromboembolism (VTE). Given the high prevalence of mild-to-moderate CKD in the general population, in depth analysis of this association is warranted. METHODS AND RESULTS: We pooled individual participant data from five community-based cohorts from Europe (HUNT2, PREVEND and TromsĂž study) and United States (ARIC and CHS study) to assess the association of estimated glomerular filtration rate (eGFR), albuminuria and CKD with objectively verified VTE. To estimate adjusted hazard ratios (HRs) for VTE, categorical and continuous spline models were fit using Cox regression with shared-frailty or random-effect meta-analysis. A total of 1,178 VTE events occurred over 599,453 person-years follow-up. Relative to eGFR 100 mL/min/1.73m(2), HRs for VTE were 1.29 (95%CI, 1.04-1.59) for eGFR 75, 1.31 (1.00-1.71) for 60, 1.82 (1.27-2.60) for 45 and 1.95 (1.26-3.01) for 30 mL/min/1.73m(2). Compared with albumin-creatinine ratio (ACR) of 5.0 mg/g, the HRs for VTE were 1.34 (1.04-1.72) for 30 mg/g, 1.60 (1.08-2.36) for 300 mg/g and 1.92 (1.19-3.09) for 1000 mg/g. There was no interaction between clinical categories of eGFR and ACR (P=0.20). The adjusted HR for CKD defined as eGFR <60 mL/min/1.73m(2) or albuminuria â„30 mg/g (vs. no CKD) was 1.54 (95%CI, 1.15-2.06). Associations were consistent in subgroups according to age, gender, and comorbidities as well as for unprovoked versus provoked VTE. CONCLUSIONS: Both eGFR and ACR are independently associated with increased risk of VTE in the general population, even across the normal eGFR and ACR ranges
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