1,644 research outputs found
Periostin Is Essential for the Integrity and Function of the Periodontal Ligament During Occlusal Loading in Mice
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141255/1/jper1480.pd
Development of a conformational histamine H(3) receptor biosensor for the synchronous screening of agonists and inverse agonists
The histamine H(3) receptor (H(3)R) represents a highly attractive drug target for the treatment of various central nervous system disorders, but the discovery of novel H(3)R targeting compounds relies on the assessment of highly amplified intracellular signaling events that do not only reflect H(3)R modulation and carry the risk of high false-positive and -negative screening rates. To address these limitations, we designed an intramolecular H(3)R biosensor based on the principle of bioluminescence resonance energy transfer (BRET) that reports the receptor's real-time conformational dynamics and provides an advanced tool to screen for both H(3)R agonists and inverse agonists in a live cell screening-compatible assay format. This conformational G-protein-coupled receptor (GPCR) sensor allowed us to characterize the pharmacological properties of known and new H(3) receptor ligands with unprecedented accuracy. Interestingly, we found that one newly developed H(3) receptor ligand possesses even stronger inverse agonistic activity than reference H(3)R inverse agonists including the current gold standard pitolisant. Taken together, we describe here the design and validation of the first screening-compatible H(3)R conformational biosensor that will aid in the discovery of novel H(3)R ligands and can be employed to gain deeper insights into the (in-)activation mechanism of this highly attractive drug target
Analysis of Andean blackberry (Rubus glaucus) production models obtained by means of artificial neural networks exploiting information collected by small-scale growers in Colombia and publicly available meteorological data
The Andean blackberry (Rubus glaucus) is an important source of income in hillside regions of Colombia.
However, growers have little reliable information on the factors that affect the development and yield of
the crop, and therefore there is a dearth of information onhowto effectively manage the crop. Site specific
information recorded by small-scale producers of the Andean blackberry on their production systems and
soils coupled with publicly available meteorological data was used to develop models of such production
systems. Multilayer perceptrons and Self-Organizing Maps were used as computational models in the
identification and visualization of the most important variables for modeling the production of Andean
blackberry. Artificial neural networks were trained with information from 20 sites in Colombia where the
Andean blackberry is cultivated. Multilayer perceptrons predicted with a reasonable degree of accuracy
the production response of the crop. The soil depth, the average temperature, external drainage, and the
accumulated precipitation of the first month before harvest were critical determinants of productivity.
A proxy variable of location was used to describe overall differences in management between farmers
groups. The use of this proxy indicated that, even under essentially similar environmental conditions,
large differences in production could be assigned to management effects. The information obtained can be
used to determine sites that are suitable for Andean blackberry production, and to transfer ofmanagement
practices from sites of high productivity to sites with similar environmental conditions which currently
have lower levels of productivity
Atomic Bose Gas with Negative Scattering Length
We derive the equation of state of a dilute atomic Bose gas with an
interatomic interaction that has a negative scattering length and argue that
two continuous phase transitions, occuring in the gas due to quantum degeneracy
effects, are preempted by a first-order gas-liquid or gas-solid transition
depending on the details of the interaction potential. We also discuss the
consequences of this result for future experiments with magnetically trapped
spin-polarized atomic gasses such as lithium and cesium.Comment: 16 PAGES, REVTEX 3.0, ACCEPTED FOR PUBLICATION IN PHYS. REV.
Phase separation and ferroelectric ordering in charge frustrated LuFe2O4-x
The transmission electron microscopy observations of the charge ordering (CO)
which governs the electronic polarization in LuFe2O4-x clearly show the
presence of a remarkable phase separation at low temperatures. Two CO ground
states are found to adopt the charge modulations of Q1 = (1/3, 1/3, 0) and Q2 =
(1/3 + y, 1/3 + y, 3/2), respectively. Our structural study demonstrates that
the incommensurately Q2-modulated state is chiefly stable in samples with
relatively lower oxygen contents. Data from theoretical simulations of the
diffraction suggest that both Q1- and Q2-modulated phases have ferroelectric
ordering. The effects of oxygen concentration on the phase separation and
electric polarization in this layered system are discussed.Comment: 11 pages, 5 figure
Mass measurements of neutron-deficient Y, Zr, and Nb isotopes and their impact on rp and Îœp nucleosynthesis processes
© 2018 The Authors. Published by Elsevier B.V. This manuscript is made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND 4.0). For further details please see: https://creativecommons.org/licenses/by-nc-nd/4.0/Using isochronous mass spectrometry at the experimental storage ring CSRe in Lanzhou, the masses of 82Zr and 84Nb were measured for the first time with an uncertainty of âŒ10 keV, and the masses of 79Y, 81Zr, and 83Nb were re-determined with a higher precision. The latter are significantly less bound than their literature values. Our new and accurate masses remove the irregularities of the mass surface in this region of the nuclear chart. Our results do not support the predicted island of pronounced low α separation energies for neutron-deficient Mo and Tc isotopes, making the formation of ZrâNb cycle in the rp-process unlikely. The new proton separation energy of 83Nb was determined to be 490(400) keV smaller than that in the Atomic Mass Evaluation 2012. This partly removes the overproduction of the p-nucleus 84Sr relative to the neutron-deficient molybdenum isotopes in the previous Îœp-process simulations.Peer reviewe
A Computational Study of Three Frequent Mutations of EGFR and their Effects on Protein Dimer Formation and Non-Small Cell Lung Cancer Drug Resistance
Measurements of J/psi Decays into 2(pi+pi-)eta and 3(pi+pi-)eta
Based on a sample of 5.8X 10^7 J/psi events taken with the BESII detector,
the branching fractions of J/psi--> 2(pi+pi-)eta and J/psi-->3(pi+pi-)eta are
measured for the first time to be (2.26+-0.08+-0.27)X10^{-3} and
(7.24+-0.96+-1.11)X10^{-4}, respectively.Comment: 11 pages, 6 figure
BESII Detector Simulation
A Monte Carlo program based on Geant3 has been developed for BESII detector
simulation. The organization of the program is outlined, and the digitization
procedure for simulating the response of various sub-detectors is described.
Comparisons with data show that the performance of the program is generally
satisfactory.Comment: 17 pages, 14 figures, uses elsart.cls, to be submitted to NIM
Measurement of branching fractions for the inclusive Cabibbo-favored ~K*0(892) and Cabibbo-suppressed K*0(892) decays of neutral and charged D mesons
The branching fractions for the inclusive Cabibbo-favored ~K*0 and
Cabibbo-suppressed K*0 decays of D mesons are measured based on a data sample
of 33 pb-1 collected at and around the center-of-mass energy of 3.773 GeV with
the BES-II detector at the BEPC collider. The branching fractions for the
decays D+(0) -> ~K*0(892)X and D0 -> K*0(892)X are determined to be BF(D0 ->
\~K*0X) = (8.7 +/- 4.0 +/- 1.2)%, BF(D+ -> ~K*0X) = (23.2 +/- 4.5 +/- 3.0)% and
BF(D0 -> K*0X) = (2.8 +/- 1.2 +/- 0.4)%. An upper limit on the branching
fraction at 90% C.L. for the decay D+ -> K*0(892)X is set to be BF(D+ -> K*0X)
< 6.6%
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