648 research outputs found
Towards efficient modelling of optical micromanipulation of complex structures
Computational methods for electromagnetic and light scattering can be used
for the calculation of optical forces and torques. Since typical particles that
are optically trapped or manipulated are on the order of the wavelength in
size, approximate methods such as geometric optics or Rayleigh scattering are
inapplicable, and solution or either the Maxwell equations or the vector
Helmholtz equation must be resorted to. Traditionally, such solutions were only
feasible for the simplest geometries; modern computational power enable the
rapid solution of more general--but still simple--geometries such as
axisymmetric, homogeneous, and isotropic scatterers. However, optically-driven
micromachines necessarily require more complex geometries, and their
computational modelling thus remains in the realm of challenging computational
problems. We review our progress towards efficient computational modelling of
optical tweezers and micromanipulation, including the trapping and manipulation
of complex structures such as optical micromachines. In particular, we consider
the exploitation of symmetry in the modelling of such devices.Comment: 5 pages, 4 figure
Improved optically driven microrotors
Two-photon polymerization of optically curing resins is a powerful method to fabricate micron sized objects which can be used as tools to measure properties at small scales. These microdevices can be driven by means of externally applied focused laser beams (optical tweezers) through angular momentum exchange, giving rise to a net torque. The advantage of the optical drive is that no contact is required, therefore making the microdevices suited to non-invasive biological applications. The fabrication method is versatile and allows building objects of any 3D shape. We discuss the design and modelling of various optically driven rotors. In particular, we consider fabrication of microspheres with an internal shape birefringence in order to obtain rotation in an optical trap. The reason for fabricating this type of object is that they are well-suited for studies of mechanical properties of single biomolecules such as the torsional stiffness of DNA or torque generated by molecular motors. The microspheres fabricated are able to transduce torques of 2000 pNnm with optical powers of 500 mW and could be rotated with frequencies up to 40 Hz in circularly polarized light
Transfer of K-types on local theta lifts of characters and unitary lowest weight modules
In this paper we study representations of the indefinite orthogonal group
O(n,m) which are local theta lifts of one dimensional characters or unitary
lowest weight modules of the double covers of the symplectic groups. We apply
the transfer of K-types on these representations of O(n,m), and we study their
effects on the dual pair correspondences. These results provide examples that
the theta lifting is compatible with the transfer of K-types. Finally we will
use these results to study subquotients of some cohomologically induced
modules
The subconvexity problem for \GL_{2}
Generalizing and unifying prior results, we solve the subconvexity problem
for the -functions of \GL_{1} and \GL_{2} automorphic representations
over a fixed number field, uniformly in all aspects. A novel feature of the
present method is the softness of our arguments; this is largely due to a
consistent use of canonically normalized period relations, such as those
supplied by the work of Waldspurger and Ichino--Ikeda.Comment: Almost final version to appear in Publ. Math IHES. References
updated
Aging Studies for the Large Honeycomb Drift Tube System of the Outer Tracker of HERA-B
The HERA-B Outer Tracker consists of drift tubes folded from polycarbonate
foil and is operated with Ar/CF4/CO2 as drift gas. The detector has to stand
radiation levels which are similar to LHC conditions. The first prototypes
exposed to radiation in HERA-B suffered severe radiation damage due to the
development of self-sustaining currents (Malter effect). In a subsequent
extended R&D program major changes to the original concept for the drift tubes
(surface conductivity, drift gas, production materials) have been developed and
validated for use in harsh radiation environments. In the test program various
aging effects (like Malter currents, gain loss due to anode aging and etching
of the anode gold surface) have been observed and cures by tuning of operation
parameters have been developed.Comment: 14 pages, 6 figures, to be published in the Proceedings of the
International Workshop On Aging Phenomena In Gaseous Detectors, 2-5 Oct 2001,
Hamburg, German
The Outer Tracker Detector of the HERA-B Experiment. Part II: Front-End Electronics
The HERA-B Outer Tracker is a large detector with 112674 drift chamber
channels. It is exposed to a particle flux of up to 2x10^5/cm^2/s thus coping
with conditions similar to those expected for the LHC experiments. The
front-end readout system, based on the ASD-8 chip and a customized TDC chip, is
designed to fulfil the requirements on low noise, high sensitivity, rate
tolerance, and high integration density. The TDC system is based on an ASIC
which digitizes the time in bins of about 0.5 ns within a total of 256 bins.
The chip also comprises a pipeline to store data from 128 events which is
required for a deadtime-free trigger and data acquisition system. We report on
the development, installation, and commissioning of the front-end electronics,
including the grounding and noise suppression schemes, and discuss its
performance in the HERA-B experiment
Adjuvant statin therapy for oesophageal adenocarcinoma: the STAT‐ROC feasibility study
Background Statins inhibit proliferative signalling in oesophageal adenocarcinoma (OAC) and their use is associated with better survival in observational studies. The present study was undertaken to examine the feasibility of assessing adjuvant statin therapy in patients with operable OAC in a phase III RCT. Methods For this multicentre, double‐blind, parallel‐group, randomized, placebo‐controlled feasibility trial, adults with OAC (including Siewert I–II lesions) who had undergone oesophagectomy were centrally allocated (1 : 1) to simvastatin 40 mg or matching placebo by block randomization, stratified by centre. Participants, clinicians and investigators were blinded to treatment allocation. Patients received treatment for up to 1 year. Feasibility outcomes were recruitment, retention, drug absorption, adherence, safety, quality of life, generalizability and survival. Results A total of 120 patients were assessed for eligibility at four centres, of whom 32 (26·7 per cent) were randomized, 16 in each group. Seven patients withdrew. Participants allocated to simvastatin had lower low‐density lipoprotein cholesterol levels by 3 months (adjusted mean difference −0·83 (95 per cent c.i. −1·4 to −0·22) mmol/l; P = 0·009). Median adherence to medication was greater than 90 per cent between 3 and 12 months' follow‐up. Adverse events were similar between the groups. Quality‐of‐life data were complete for 98·3 per cent of questionnaire items. Cardiovascular disease, diabetes and aspirin use were more prevalent in the non‐randomized group, whereas tumour site, stage and grade were similar between groups. Survival estimates were imprecise. Conclusion This RCT supports the conduct and informs the design considerations for a future phase III trial of adjuvant statin therapy in patients with OAC. Registration number: ISRCTN98060456 (www.isrctn/com)
Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden.
Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate infection-associated morbidity. Murine resistin-like molecules (RELM) exhibit pleiotropic functions following helminth infection including modulating the host immune response; however, the relevance of human RELM proteins in helminth infection is unknown. To examine the function of human resistin (hResistin), we utilized transgenic mice expressing the human resistin gene (hRetnTg+). Following infection with the helminth Nippostrongylus brasiliensis (Nb), hResistin expression was significantly upregulated in infected tissue. Compared to control hRetnTg- mice, hRetnTg+ mice suffered from exacerbated Nb-induced inflammation characterized by weight loss and increased infiltration of inflammatory monocytes in the lung, along with elevated Nb egg burdens and delayed parasite expulsion. Genome-wide transcriptional profiling of the infected tissue revealed that hResistin promoted expression of proinflammatory cytokines and genes downstream of toll-like receptor signaling. Moreover, hResistin preferentially bound lung monocytes, and exogenous treatment of mice with recombinant hResistin promoted monocyte recruitment and proinflammatory cytokine expression. In human studies, increased serum resistin was associated with higher parasite load in individuals infected with soil-transmitted helminths or filarial nematode Wuchereria bancrofti, and was positively correlated with proinflammatory cytokines. Together, these studies identify human resistin as a detrimental factor induced by multiple helminth infections, where it promotes proinflammatory cytokines and impedes parasite clearance. Targeting the resistin/proinflammatory cytokine immune axis may provide new diagnostic or treatment strategies for helminth infection and associated immune-mediated pathology
Inclusive Production Cross Sections from 920 GeV Fixed Target Proton-Nucleus Collisions
Inclusive differential cross sections and
for the production of \kzeros, \lambdazero, and
\antilambda particles are measured at HERA in proton-induced reactions on C,
Al, Ti, and W targets. The incident beam energy is 920 GeV, corresponding to
GeV in the proton-nucleon system. The ratios of differential
cross sections \rklpa and \rllpa are measured to be and , respectively, for \xf . No significant dependence upon the
target material is observed. Within errors, the slopes of the transverse
momentum distributions also show no significant
dependence upon the target material. The dependence of the extrapolated total
cross sections on the atomic mass of the target material is
discussed, and the deduced cross sections per nucleon are
compared with results obtained at other energies.Comment: 17 pages, 7 figures, 5 table
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