473 research outputs found
A randomised controlled trial testing a web-based, computer-tailored self-management intervention for people with or at risk for chronic obstructive pulmonary disease: a study protocol
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125231.pdf (publisher's version ) (Open Access)BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality. Effective self-management support interventions are needed to improve the health and functional status of people with COPD or at risk for COPD. Computer-tailored technology could be an effective way to provide this support. METHODS/DESIGN: This paper presents the protocol of a randomised controlled trial testing the effectiveness of a web-based, computer-tailored self-management intervention to change health behaviours of people with or at risk for COPD. An intervention group will be compared to a usual care control group, in which the intervention group will receive a web-based, computer-tailored self-management intervention. Participants will be recruited from an online panel and through general practices. Outcomes will be measured at baseline and at 6 months. The primary outcomes will be smoking behaviour, measuring the 7-day point prevalence abstinence and physical activity, measured in minutes. Secondary outcomes will include dyspnoea score, quality of life, stages of change, intention to change behaviour and alternative smoking behaviour measures, including current smoking behaviour, 24-hour point prevalence abstinence, prolonged abstinence, continued abstinence and number of quit attempts. DISCUSSION: To the best of our knowledge, this will be the first randomised controlled trial to test the effectiveness of a web-based, computer-tailored self-management intervention for people with or at risk for COPD. The results will be important to explore the possible benefits of computer-tailored interventions for the self-management of people with or at risk for COPD and potentially other chronic health conditions. DUTCH TRIAL REGISTER: NTR3421
PCN103 Reanalysis of Cost-Effectiveness of Abiraterone Acetate as Second Line Treatment for Metastatic Castration-Resistant Prostate Cancer in Japan Using a Japanese Claim Data Set
Multi-wavelength analysis of 18um-selected galaxies in the AKARI/IRC monitor field towards the North Ecliptic Pole
We present an initial analysis of AKARI 18um-selected galaxies using all 9
photometric bands at 2-24um available in the InfraRed Camera (IRC), in order to
demonstrate new capabilities of AKARI cosmological surveys. We detected 72
sources at 18um in an area of 50.2 arcmin^2 in the AKARI/IRC monitor field
towards the North Ecliptic Pole (NEP). From this sample, 25 galaxies with
probable redshifts z>~ 0.5 are selected with a single colour cut (N2-N3>0.1)
for a detailed SED analysis with ground-based BVRi'z'JK data. Using an SED
radiative transfer model of starbursts covering the wavelength range UV --
submm, we derive photometric redshifts from the optical-MIR SEDs of
18um-selected galaxies. From the best-fit SED models, we show that the IRC
all-band photometry is capable of tracing the steep rise in flux at the blue
side of the PAH 6.2um emission feature. This indicates that the IRC all-band
photometry is useful to constrain the redshift of infrared galaxies,
specifically for dusty galaxies with a less prominent 4000A break. Also, we
find that the flux dip between the PAH 7.7 and 11.2um emission feature is
recognizable in the observed SEDs of galaxies at z~1. By using such a colour
anomaly due to the PAH and silicate absorption features, unique samples of
ULIRGs at z~1, `silicate-break' galaxies, can be constructed from large
cosmological surveys of AKARI towards the NEP, i.e. the NEP-Deep and NEP-Wide
survey. This pilot study suggests the possibility of detecting many interesting
galaxy properties in the NEP-Deep and Wide surveys, such as a systematic
difference in SEDs between high- and low-z ULIRGs, and a large variation of the
PAH inter-band strength ratio in galaxies at high redshifts. [abridged]Comment: Accepted for publication in PASJ, AKARI special issu
A monitoring and feedback tool embedded in a counselling protocol to increase physical activity of patients with COPD or type 2 diabetes in primary care: study protocol of a three-arm cluster randomised controlled trial
BACKGROUND: Physical activity is important for a healthy lifestyle. Although physical activity can delay complications and decrease the burden of the disease, the level of activity of patients with chronic obstructive pulmonary disease (COPD) or type 2 Diabetes Mellitus (DM2) is often far from optimal. To stimulate physical activity, a monitoring and feedback tool, consisting of an accelerometer linked to a smart phone and webserver (It’s LiFe! tool), and a counselling protocol for practice nurses in primary care was developed (the Self-management Support Program). The main objective of this study is to measure the longitudinal effects of this counselling protocol and the added value of using the tool. METHODS/DESIGN: This three-armed cluster randomised controlled trial with 120 participants with COPD and 120 participants with DM2 (aged 40–70), compares the counselling protocol with and without the use of the tool (group 1 and 2) with usual care (group 3). Recruitment takes place at GP practices in the southern regions of the Netherlands. Randomisation takes place at the practice level. The intended sample (three arms of 8 practices) powers the study to detect a 10-minute difference of moderate and intense physical activity per day between groups 1 and 3. Participants in the intervention groups have to visit the practice nurse 3–4 times for physical activity counselling, in a 4-6-month period. Specific activity goals tailored to the individual patient's preferences and needs will be set. In addition, participants in group 1 will be instructed to use the tool in daily life. The primary outcome, physical activity, will be measured in all groups with a physical activity monitor (PAM). Secondary outcomes are quality of life, general - and exercise - self-efficacy, and health status. Follow-up will take place after 6 and 9 months. Separately, a process evaluation will be conducted to explore reasons for trial non-participation, and the intervention’s acceptability for participating patients and nurses. DISCUSSION: Results of this study will give insight into the effects of the It’s LiFe! monitoring and feedback tool combined with care from a practice nurse for people with COPD or DM2 on physical activity. TRIAL REGISTRATION: ClinicalTrials.gov: NCT0186797
High-precision CTE measurement of hybrid C/SiC composite for cryogenic space telescopes
This paper presents highly precise measurements of thermal expansion of a
"hybrid" carbon-fiber reinforced silicon carbide composite,
HB-Cesic\textregistered - a trademark of ECM, in the temperature region of
\sim310-10K. Whilst C/SiC composites have been considered to be promising for
the mirrors and other structures of space-borne cryogenic telescopes, the
anisotropic thermal expansion has been a potential disadvantage of this
material. HB-Cesic\textregistered is a newly developed composite using a
mixture of different types of chopped, short carbon-fiber, in which one of the
important aims of the development was to reduce the anisotropy. The
measurements indicate that the anisotropy was much reduced down to 4% as a
result of hybridization. The thermal expansion data obtained are presented as
functions of temperature using eighth-order polynomials separately for the
horizontal (XY-) and vertical (Z-) directions of the fabrication process. The
average CTEs and their dispersion (1{\sigma}) in the range 293-10K derived from
the data for the XY- and Z-directions were 0.8050.003\times10
K and 0.837\pm0.001\times10 K, respectively. The absolute
accuracy and the reproducibility of the present measurements are suggested to
be better than 0.01\times10 K and 0.001\times(10)^{-6} K^{-1},
respectively. The residual anisotropy of the thermal expansion was consistent
with our previous speculation regarding carbon-fiber, in which the residual
anisotropy tended to lie mainly in the horizontal plane.Comment: Accepted by Cryogeincs. 12 pages, 3 figures, 1 tabll
A monitoring and feedback tool embedded in a counselling protocol to increase physical activity of patients with COPD or type 2 diabetes in primary care: study protocol of a three-arm cluster randomised controlled trial
Appartient à l’ensemble documentaire : HNormand1Contient une table des matièresAvec mode text
Clonal interference and Muller's ratchet in spatial habitats
Competition between independently arising beneficial mutations is enhanced in
spatial populations due to the linear rather than exponential growth of clones.
Recent theoretical studies have pointed out that the resulting fitness dynamics
is analogous to a surface growth process, where new layers nucleate and spread
stochastically, leading to the build up of scale-invariant roughness. This
scenario differs qualitatively from the standard view of adaptation in that the
speed of adaptation becomes independent of population size while the fitness
variance does not. Here we exploit recent progress in the understanding of
surface growth processes to obtain precise predictions for the universal,
non-Gaussian shape of the fitness distribution for one-dimensional habitats,
which are verified by simulations. When the mutations are deleterious rather
than beneficial the problem becomes a spatial version of Muller's ratchet. In
contrast to the case of well-mixed populations, the rate of fitness decline
remains finite even in the limit of an infinite habitat, provided the ratio
between the deleterious mutation rate and the square of the
(negative) selection coefficient is sufficiently large. Using again an analogy
to surface growth models we show that the transition between the stationary and
the moving state of the ratchet is governed by directed percolation
MLN51 Stimulates the RNA-Helicase Activity of eIF4AIII
The core of the exon-junction complex consists of Y14, Magoh, MLN51 and eIF4AIII, a DEAD-box RNA helicase. MLN51 stimulates the ATPase activity of eIF4AIII, whilst the Y14-Magoh complex inhibits it. We show that the MLN51-dependent stimulation increases both the affinity of eIF4AIII for ATP and the rate of enzyme turnover; the K (M) is decreased by an order of magnitude and k (cat) increases 30 fold. Y14-Magoh do inhibit the MLN51-stimulated ATPase activity, but not back to background levels. The ATP-bound form of the eIF4AIII-MLN51 complex has a 100-fold higher affinity for RNA than the unbound form and ATP hydrolysis reduces this affinity. MLN51 stimulates the RNA-helicase activity of eIF4AIII, suggesting that this activity may be functionally important
Modular Lie algebras and the Gelfand-Kirillov conjecture
Let g be a finite dimensional simple Lie algebra over an algebraically closed
field of characteristic zero. We show that if the Gelfand-Kirillov conjecture
holds for g, then g has type A_n, C_n or G_2.Comment: 20 page
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