When Silence is Not Golden: Why Acknowledgement Matters Even When Being Excluded

Following ostracism, individuals are highly sensitive to social cues. Here we investigate whether and when minimal acknowledgment can improve need satisfaction following an ostracism experience. In four studies, participants were either ostracized during Cyberball (Studies 1 and 2) or through a novel apartment-application paradigm (Studies 3 and 4). To signal acknowledgement following ostracism, participants were either thrown a ball a few times at the end of the Cyberball game, or received a message that was either friendly, neutral, or hostile in the apartment-application paradigm. Both forms of acknowledgment increased need satisfaction, even when the acknowledgment was hostile (Study 4), emphasizing the beneficial effect of any kind of acknowledgment following ostracism. Reinclusion buffered threat immediately, whereas acknowledgment without reinclusion primarily aided recovery. Our results suggest that minimal acknowledgment such as a few ball throws or even an unfriendly message can reduce the sting of ostracism

Cell migration and chimerism after whole‐organ transplantation: The basis of graft acceptance

Improvements in the prevention or control of rejection of the kidney and liver have been largely interchangeable (1, 2) and then applicable, with very little modification, to thoracic and other organs. However, the mechanism by which anti rejection treatment permits any of these grafts to be “accepted” has been an immunological enigma (3, 4). We have proposed recently that the exchange of migratory leukocytes between the transplant and the recipient with consequent long-term cellular chimerism in both is the basis for acceptance of all whole-organ allografts and xenografts (5). Although such chimerism was demonstrated only a few months ago, the observations have increased our insight into transplantation immunology and have encouraged the development of alternative therapeutic strategies (6)

Unsteady flow phenomena in human undulatory swimming: a numerical approach

The undulatory underwater sequence is one of the most important phases in competitive swimming. An understanding of the recurrent vortex dynamics around the human body and their generation could therefore be used to improve swimming techniques. In order to produce a dynamic model, we applied human joint kinematics to three-dimensional (3D) body scans of a female swimmer. The flow around this dynamic model was then calculated using computational fluid dynamics with the aid of moving 3D meshes. Evaluation of the numerical results delivered by the various motion cycles identified characteristic vortex structures for each of the cycles, which exhibited increasing intensity and drag influence. At maximum thrust, drag forces appear to be 12 times higher than those of a passive gliding swimmer. As far as we know, this is the first disclosure of vortex rings merging into vortex tubes in the wake after vortex recapturing. All unsteady structures were visualized using a modified Q-criterion also incorporated into our methods. At the very least, our approach is likely to be suited to further studies examining swimmers engaging in undulatory swimming during training or competition

Baboon-to-human liver transplantation

Our ability to control both the cellular and humoral components of xenograft rejection in laboratory experiments, together with an organ shortage that has placed limits on clinical transplantation services, prompted us to undertake a liver transplantation from a baboon to a 35-year-old man with B virus-associated chronic active hepatitis and human immunodeficiency virus infection. Liver replacement was performed according to conventional surgical techniques. Immunosuppression was with the FK 506-prednisone-prostaglandin regimen used routinely for hepatic allotransplantation, to which a daily non-myelotoxic dose of cyclophosphamide was added. During 70 days of survival, there was little evidence of hepatic rejection by biochemical monitoring or histopathological examination. Products of hepatic synthesis, including clotting factors, became those of the baboon liver with no obvious adverse effects. Death followed a cerebral and subarachnoid haemorrhage that was caused by an angioinvasive aspergillus infection. However, the underlying cause of death was widespread biliary sludge that formed in the biliary tree despite a seemingly satisfactory choledochojejunostomy. During life and in necropsy samples, there was evidence of the chimerism that we believe is integral to the acceptance of both xenografts and allografts. Our experience has shown the feasibility of controlling the rejection of the baboon liver xenograft in a human recipient. The biliary stasis that was the beginning of lethal infectious complications may be correctable by modifications of surgical technique. In further trials, the error of over-immunosuppression should be avoidable. © 1993

Upgrade of the Cold Electronics of the ATLAS HEC Calorimeter for sLHC

The signal amplification and summation electronics of the ATLAS Hadronic End-cap Calorimeter (HEC) is operated at the circumference of the HEC calorimeters inside the cryostats in liquid argon. The present electronics is designed to operate at irradiation levels expected for the LHC. For operation at the sLHC the irradiation levels are expected to be a factor 10 higher, therefore a new electronic system might be needed. The technological possibilities are investigated. From irradiation tests of the present HEC electronics it is known that it will operate up to a dose of 55 kGy of ionizing radiation and up to a neutron fluence of 3 * 10**14 n/cm**2, where it shows some degradation of performance. This matches well the requirements of up to 1.5 * 10**13 n/cm**2 for 10 years of LHC operation, including safety factors. For a subsequent sLHC running phase with 10 times higher expected irradiation levels, a more radiation hard HEC electronics will be needed. Therefore generic studies of different technologies have been carried out at the transistor level to understand the radiation hardness up to integrated neutron fluxes of ~2*10**16 n/cm**2 and the behaviour during operation at cryogenic temperatures. The S-parameter technique has been used to monitor the performance e.g. of gain and linearity during irradiation at room temperature. In addition, DC measurements before and after irradiation have been compared. Results of these tests and of accompanying noise tests are reported. In addition, results of S-parameter measurements will be reported operating the transistors in liquid nitrogen. Conclusions are drawn and the potential is assessed on the viability of using the tested technologies for carrying out the design of new HEC cold electronics for the sLHC

Us and the virus: understanding the COVID-19 pandemic through a social psychological lens

From a social psychological perspective, the COVID-19 pandemic and its associated protective measures affected individuals’ social relations and their basic psychological needs. We aim to identify sources of need frustration (stressors) and possibilities to bolster need satisfaction (buffers). Particularly, we highlight emerging empirical research in areas in which social psychological theorizing can contribute to our understanding of the pandemic’s social consequences: Loneliness, social networks, role conflicts, social identity, compliance, trust, reactance, and conspiracy beliefs. We highlight directions for future social psychological research as the pandemic continues

Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation

Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n=2) or modest (n=2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance). © 1993 Williams and wilkins

Who gets ostracized? A personality perspective on risk and protective factors of ostracism

Ostracism, excluding and ignoring others, results from a variety of factors. Here, we investigate the effect of personality on the likelihood of becoming a target of ostracism. Theorizing that individuals low in conscientiousness or agreeableness are at risk of getting ostracized, we tested our hypotheses within five pre-registered studies: Four experiments investigating participants' willingness to ostracize targets characterized by different personality traits and a reverse correlation face modelling study where we determined and subsequently validated the stereotypical face of an ostracized person. A survey study within a representative German data panel further corroborated our findings. In line with our hypotheses, persons low in conscientiousness or agreeableness provoke more ostracism intentions (Studies 1, 2, and 4), are more likely to be actually ostracized by others (Study 3), represent the stereotype of an "ostracizable" person (Study 5), and report experiencing more ostracism (Study 6). Effects remained stable even after controlling for likeability of the target (Study 2 and 4). Moreover, being described as negative on one personality dimension could not be compensated by being described as positive on the other (Study 4). In exploratory analyses, we further investigated the effects of openness to experience, neuroticism and extraversion. In sum, we find evidence that personality affects the likelihood of becoming a target of ostracism, and that especially low agreeableness and conscientiousness represent risk factors