Discovery of a wandering radio jet base after a large X-ray flare in the blazar Markarian 421

We investigate the location of the radio jet bases ("radio cores") of blazars in radio images, and their stationarity by means of dense very long baseline interferometry (VLBI) observations. In order to measure the position of a radio core, we conducted 12 epoch astrometric observation of the blazar Markarian 421 with the VLBI Exploration of Radio Astrometry at 22 GHz immediately after a large X-ray flare, which occurred in the middle of 2011 September. For the first time, we find that the radio core is not stationary but rather changes its location toward 0.5 mas downstream. This angular scale corresponds to the de-projected length of a scale of $10^5$ Schwarzschild radii (Rs) at the distance of Markarian~421. This radio-core wandering may be a new type of manifestation associated with the phenomena of large X-ray flares.Comment: 6 pages, 4 figures, 1 table, has been published in ApJ Letter

Rotating and infalling motion around the high-mass young stellar object Cepheus A-HW2 observed with the methanol maser at 6.7 GHz

We have measured the internal proper motions of the 6.7 GHz methanol masers associated with Cepheus A (Cep A) HW2 using Very Long Baseline Interferometery (VLBI) observations. We conducted three epochs of VLBI monitoring observations of the 6.7 GHz methanol masers in Cep A-HW2 with the Japanese VLBI Network (JVN) over the period between 2006-2008. In 2006, we were able to use phase-referencing to measure the absolute coordinates of the maser emission with an accuracy of a few milliarcseconds. We compared the maser distribution with other molecular line observations that trace the rotating disk. We measured the internal proper motions for 29 methanol maser spots, of which 19 were identified at all three epochs and the remaining ten at only two epochs. The magnitude of proper motions ranged from 0.2 to 7.4 km/s, with an average of 3.1 km/s. Although there are large uncertainties in the observed internal proper motions of the methanol maser spots in Cep A, they are well fitted by a disk that includes both rotation and infall velocity components. The derived rotation and infall velocities at the disk radius of 680 au are 0.5 +- 0.7 and 1.8 +- 0.7 km/s, respectively. Assuming that the modeled disk motion accurately represents the accretion disk around the Cep A-HW2 high-mass YSO, we estimated the mass infall rate to be 3 x 10^{-4} n_8 Msun/yr (n_8 is the gas volume density in units of 10^{8} cm^{-3}). The combination of the estimated mass infall rate and the magnitude of the fitted infall velocity suggests that Cep A-HW2 is at an evolutionary phase of active gas accretion from the disk onto the central high-mass YSO. The infall momentum rate is estimated to be 5 x 10^{-4} n_8 Msun/yr km/s, which is larger than the estimated stellar radiation pressure of the HW2 object, supporting the hypothesis that this object is in an active gas accretion phase.Comment: 16 pages, 6 figures, 5 tables, accepted for publication in Astronomy & Astrophysic

An automated archival VLA transients survey

In this paper we present the results of a survey for radio transients using data obtained from the Very Large Array archive. We have reduced, using a pipeline procedure, 5037 observations of the most common pointings - i.e. the calibrator fields. These fields typically contain a relatively bright point source and are used to calibrate `target' observations: they are therefore rarely imaged themselves. The observations used span a time range ~ 1984 - 2008 and consist of eight different pointings, three different frequencies (8.4, 4.8 and 1.4 GHz) and have a total observing time of 435 hours. We have searched for transient and variable radio sources within these observations using components from the prototype LOFAR transient detection system. In this paper we present the methodology for reducing large volumes of Very Large Array data; and we also present a brief overview of the prototype LOFAR transient detection algorithms. No radio transients were detected in this survey, therefore we place an upper limit on the snapshot rate of GHz frequency transients > 8.0 mJy to rho less than or equal to 0.032 deg^-2 that have typical timescales 4.3 to 45.3 days. We compare and contrast our upper limit with the snapshot rates - derived from either detections or non-detections of transient and variable radio sources - reported in the literature. When compared with the current Log N - Log S distribution formed from previous surveys, we show that our upper limit is consistent with the observed population. Current and future radio transient surveys will hopefully further constrain these statistics, and potentially discover dominant transient source populations. In this paper we also briefly explore the current transient commissioning observations with LOFAR, and the impact they will make on the field.Comment: Accepted for publication in MNRA

Possible Detection of Apparent Superluminal inward motion in Markarian 421 after the Giant X-ray flare in February, 2010

We report on the VLBI follow-up observations using the Japanese VLBI Network (JVN) array at 22 GHz for the largest X-ray flare of TeV blazar Mrk 421 that occurred in mid-February, 2010. The total of five epochs of observations were performed at intervals of about 20 days between March 7 and May 31, 2010. No new-born component associated with the flare was seen directly in the total intensity images obtained by our multi-epoch VLBI observations. However, one jet component located at ~1 mas north-west from the core was able to be identified, and its proper motion can be measured as -1.66+/-0.46 mas yr^-1, which corresponds to an apparent velocity of -3.48+/-0.97 c. Here, this negative velocity indicates that the jet component was apparently moving toward the core. As the most plausible explanation, we discuss that the apparent negative velocity was possibly caused by the ejection of a new component, which could not be resolved with our observations. In this case, the obtained Doppler factor of the new component is around 10 to 20, which is consistent with the ones typically estimated by model fittings of spectral energy distribution for this source.Comment: 9 pages, 6 figures, 3 tables, accepted for publication in Ap

Radio and gamma-ray follow-up of the exceptionally high activity state of PKS 1510-089 in 2011

We investigate the radio and gamma-ray variability of the flat spectrum radio quasar PKS 1510-089 in the time range between 2010 November and 2012 January. In this period the source showed an intense activity, with two major gamma-ray flares detected in 2011 July and October. During the latter episode both the gamma-ray and the radio flux density reached their historical peak. Multiwavelength analysis shows a rotation of about 380 deg of the optical polarization angle close in time with the rapid and strong gamma-ray flare in 2011 July. An enhancement of the optical emission and an increase of the fractional polarization both in the optical and in radio bands is observed about three weeks later, close in time with another gamma-ray outburst. On the other hand, after 2011 September a huge radio outburst has been detected, first in the millimeter regime followed with some time delay at centimeter down to decimeter wavelengths. This radio flare is characterized by a rising and a decaying stage, in agreement with the formation of a shock and its evolution, as a consequence of expansion and radiative cooling. If the gamma-ray flare observed in 2011 October is related to this radio outburst, then this strongly indicates that the region responsible for the gamma-ray variability is not within the broad line, but a few parsecs downstream along the jet.Comment: 14 pages, 12 figures, accepted for publication in MNRA

Quadricuspid aortic valve not discovered by transthoracic echocardiography

BACKGROUND: Quadricuspid aortic valve is a rare congenital heart defect. Several different anatomical variations of a quadricuspid aortic valve has been described and aortic regurgitation is the predominant valvular dysfunction associated with quadricuspid aortic valve. CASE PRESENTATION: A 68-year-old woman presented with almost a years history of increasing dyspnoea on exertion. The patient have had two previous transthoracic echocardiographic exams in the last six years and they had only documented moderate aortic regurgitation. Transoesophageal echocardiography displayed a rare case of quadricuspid aortic valve with three cusps of equal size and one larger cusp. The malformation was associated with severe aortic regurgitation. CONCLUSION: Liberal use of transoesophageal echocardiography is often warranted if optimal display of valvular morphology is desired

Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data

OBJECTIVE: To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups of patients. DESIGN: Prospectively designed meta-analysis of individual patient data from prospective diagnostic accuracy studies. DATA SOURCES: Medline, Embase, and Web of Science for published studies. Unpublished studies were identified via direct contact with participating investigators. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Prospective diagnostic accuracy studies that compared coronary CTA with coronary angiography as the reference standard, using at least a 50% diameter reduction as a cutoff value for obstructive CAD. All patients needed to have a clinical indication for coronary angiography due to suspected CAD, and both tests had to be performed in all patients. Results had to be provided using 2×2 or 3×2 cross tabulations for the comparison of CTA with coronary angiography. Primary outcomes were the positive and negative predictive values of CTA as a function of clinical pretest probability of obstructive CAD, analysed by a generalised linear mixed model; calculations were performed including and excluding non-diagnostic CTA results. The no-treat/treat threshold model was used to determine the range of appropriate pretest probabilities for CTA. The threshold model was based on obtained post-test probabilities of less than 15% in case of negative CTA and above 50% in case of positive CTA. Sex, angina pectoris type, age, and number of computed tomography detector rows were used as clinical variables to analyse the diagnostic performance in relevant subgroups. RESULTS: Individual patient data from 5332 patients from 65 prospective diagnostic accuracy studies were retrieved. For a pretest probability range of 7-67%, the treat threshold of more than 50% and the no-treat threshold of less than 15% post-test probability were obtained using CTA. At a pretest probability of 7%, the positive predictive value of CTA was 50.9% (95% confidence interval 43.3% to 57.7%) and the negative predictive value of CTA was 97.8% (96.4% to 98.7%); corresponding values at a pretest probability of 67% were 82.7% (78.3% to 86.2%) and 85.0% (80.2% to 88.9%), respectively. The overall sensitivity of CTA was 95.2% (92.6% to 96.9%) and the specificity was 79.2% (74.9% to 82.9%). CTA using more than 64 detector rows was associated with a higher empirical sensitivity than CTA using up to 64 rows (93.4% v 86.5%, P=0.002) and specificity (84.4% v 72.6%, P<0.001). The area under the receiver-operating-characteristic curve for CTA was 0.897 (0.889 to 0.906), and the diagnostic performance of CTA was slightly lower in women than in with men (area under the curve 0.874 (0.858 to 0.890) v 0.907 (0.897 to 0.916), P<0.001). The diagnostic performance of CTA was slightly lower in patients older than 75 (0.864 (0.834 to 0.894), P=0.018 v all other age groups) and was not significantly influenced by angina pectoris type (typical angina 0.895 (0.873 to 0.917), atypical angina 0.898 (0.884 to 0.913), non-anginal chest pain 0.884 (0.870 to 0.899), other chest discomfort 0.915 (0.897 to 0.934)). CONCLUSIONS: In a no-treat/treat threshold model, the diagnosis of obstructive CAD using coronary CTA in patients with stable chest pain was most accurate when the clinical pretest probability was between 7% and 67%. Performance of CTA was not influenced by the angina pectoris type and was slightly higher in men and lower in older patients. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42012002780

Upregulation of AEBP1 in endothelial cells promotes tumor angiogenesis in colorectal cancer

血管新生は大腸がんの重要な治療標的である．本論文では，大腸がんの腫瘍血管関連遺伝子を探索し，AEBP1（Adipocyte enhancer binding protein 1）の血管内皮細胞における高発現を同定し，AEBP1が腫瘍血管新生促進に働くことを明らかにした