Improved Holographic QCD

We provide a review to holographic models based on Einstein-dilaton gravity with a potential in 5 dimensions. Such theories, for a judicious choice of potential are very close to the physics of large-N YM theory both at zero and finite temperature. The zero temperature glueball spectra as well as their finite temperature thermodynamic functions compare well with lattice data. The model can be used to calculate transport coefficients, like bulk viscosity, the drag force and jet quenching parameters, relevant for the physics of the Quark-Gluon Plasma.Comment: LatEX, 65 pages, 28 figures, 9 Tables. Based on lectures given at several Schools. To appear in the proceedinds of the 5th Aegean School (Milos, Greece

The Bethe-Ansatz for N=4 Super Yang-Mills

We derive the one loop mixing matrix for anomalous dimensions in N=4 Super Yang-Mills. We show that this matrix can be identified with the Hamiltonian of an integrable SO(6) spin chain with vector sites. We then use the Bethe ansatz to find a recipe for computing anomalous dimensions for a wide range of operators. We give exact results for BMN operators with two impurities and results up to and including first order 1/J corrections for BMN operators with many impurities. We then use a result of Reshetikhin's to find the exact one-loop anomalous dimension for an SO(6) singlet in the limit of large bare dimension. We also show that this last anomalous dimension is proportional to the square root of the string level in the weak coupling limit.Comment: 35 pages, 3 figures, LaTeX; v2 references added, typos corrected, \Lambda fixed; v3 expanded discussion of higher loops in conclusion, matches published versio

Orbiting Membranes in M-theory on AdS_7 x S^4 Background

We study classical solutions describing rotating and boosted membranes on AdS_7 x S^4 background in M-theory. We find the dependence of the energy on the spin and R-charge of these solutions. In the flat space limit we get E ~ S^{2/3}, while for AdS at leading order E-S grows as S^{1/3}. The membranes on AdS_4 x S^7 background have briefly been studied as well.Comment: 13 pages, latex, v2: a note and refs. added, some typos correcte

String interactions and discrete symmetries of the pp-wave background

Free string theory on the plane-wave background displays a discrete Z2 symmetry exchanging the two transverse SO(4) rotation groups. This symmetry should be respected also at the interacting level. We show that the zero mode structure proposed in hep-th/0208148 can be completed to a full kinematical vertex, contrary to claims appeared in the previous literature. We also comment on the relation with recent works on the string-bit formalism and on the comparison with the field theory side of the correspondence.Comment: Proceeding of the 35th Symposium Ahrenshoop Aug 2002 and the Leuven RTN-workshop Sept 200

Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis

Cataloged from PDF version of article.Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development. Most tumor cells are believed to bypass the senescence barrier (become "immortal") by inactivating growth control genes such as TP53 and CDKN2A. They also reactivate telomerase reverse transcriptase. Senescence-to-immortality transition is accompanied by major phenotypic and biochemical changes mediated by genome-wide transcriptional modifications. This appears to happen during hepatocellular carcinoma (HCC) development in patients with liver cirrhosis, however, the accompanying transcriptional changes are virtually unknown. We investigated genome-wide transcriptional changes related to the senescence-to-immortality switch during hepatocellular carcinogenesis. Initially, we performed transcriptome analysis of senescent and immortal clones of Huh7 HCC cell line, and identified genes with significant differential expression to establish a senescence-related gene list. Through the analysis of senescence-related gene expression in different liver tissues we showed that cirrhosis and HCC display expression patterns compatible with senescent and immortal phenotypes, respectively; dysplasia being a transitional state. Gene set enrichment analysis revealed that cirrhosis/senescence-associated genes were preferentially expressed in non-tumor tissues, less malignant tumors, and differentiated or senescent cells. In contrast, HCC/immortality genes were up-regulated in tumor tissues, or more malignant tumors and progenitor cells. In HCC tumors and immortal cells genes involved in DNA repair, cell cycle, telomere extension and branched chain amino acid metabolism were up-regulated, whereas genes involved in cell signaling, as well as in drug, lipid, retinoid and glycolytic metabolism were down-regulated. Based on these distinctive gene expression features we developed a 15-gene hepatocellular immortality signature test that discriminated HCC from cirrhosis with high accuracy. Our findings demonstrate that senescence bypass plays a central role in hepatocellular carcinogenesis engendering systematic changes in the transcription of genes regulating DNA repair, proliferation, differentiation and metabolism

Conformal Dimensions of Two-Derivative BMN Operators

We compute the anomalous dimensions of BMN operators with two covariant derivative impurities at the planar level up to first order in the effective coupling lambda'. The result equals those for two scalar impurities as well as for mixed scalar and vector impurities given in the literature. Though the results are the same, the computation is very different from the scalar case. This is basically due to the existence of a non-vanishing overlap between the derivative impurity and the ``background'' field Z. We present details of these differences and their consequences.Comment: 27 pages, v2: references added, minor change

Holonomy from wrapped branes

Compactifications of M-theory on manifolds with reduced holonomy arise as the local eleven-dimensional description of D6-branes wrapped on supersymmetric cycles in manifolds of lower dimension with a different holonomy group. Whenever the isometry group SU(2) is present, eight-dimensional gauged supergravity is a natural arena for such investigations. In this paper we use this approach and review the eleven dimensional description of D6-branes wrapped on coassociative 4-cycles, on deformed 3-cycles inside Calabi-Yau threefolds and on Kahler 4-cycles.Comment: 1+8 pages, Latex. Proceedings of the Leuven workshop, 2002. v2: Corrected typos in equations (4)-(8

Chiral primary cubic interactions from pp-wave supergravity

We explicitly construct cubic interaction light-cone Hamiltonian for the chiral primary system involving the metric fields and the self-dual four-form fields in the IIB pp-wave supergravity. The background fields representing pp-waves exhibit SO(4)*SO(4)*Z_2 invariance. It turns out that the interaction Hamiltonian is precisely the same as that for the dilaton-axion system, except for the fact that the chiral primary system fields have the opposite parity to that of the dilaton-axion fields under the Z_2 transformation that exchanges two SO(4)'s.Comment: 14 pages, A few comments are adde

Let's Twist Again: General Metrics of G(2) Holonomy from Gauged Supergravity

We construct all complete metrics of cohomogeneity one G(2) holonomy with S^3 x S^3 principal orbits from gauged supergravity. Our approach rests on a generalization of the twisting procedure used in this framework. It corresponds to a non-trivial embedding of the special Lagrangian three-cycle wrapped by the D6-branes in the lower dimensional supergravity. There are constraints that neatly reduce the general ansatz to a six functions one. Within this approach, the Hitchin system and the flop transformation are nicely realized in eight dimensional gauged supergravity.Comment: 31 pages, latex; v2: minor changes, references adde

Spacetime singularity resolution by M-theory fivebranes: calibrated geometry, Anti-de Sitter solutions and special holonomy metrics

The supergravity description of various configurations of supersymmetric M-fivebranes wrapped on calibrated cycles of special holonomy manifolds is studied. The description is provided by solutions of eleven-dimensional supergravity which interpolate smoothly between a special holonomy manifold and an event horizon with Anti-de Sitter geometry. For known examples of Anti-de Sitter solutions, the associated special holonomy metric is derived. One explicit Anti-de Sitter solution of M-theory is so treated for fivebranes wrapping each of the following cycles: K\"{a}hler cycles in Calabi-Yau two-, three- and four-folds; special lagrangian cycles in three- and four-folds; associative three- and co-associative four-cycles in $G_2$ manifolds; complex lagrangian four-cycles in $Sp(2)$ manifolds; and Cayley four-cycles in $Spin(7)$ manifolds. In each case, the associated special holonomy metric is singular, and is a hyperbolic analogue of a known metric. The analogous known metrics are respectively: Eguchi-Hanson, the resolved conifold and the four-fold resolved conifold; the deformed conifold, and the Stenzel four-fold metric; the Bryant-Salamon-Gibbons-Page-Pope $G_2$ metrics on an $\mathbb{R}^4$ bundle over $S^3$, and an $\mathbb{R}^3$ bundle over $S^4$ or $\mathbb{CP}^2$; the Calabi hyper-K\"{a}hler metric on $T^*\mathbb{CP}^2$; and the Bryant-Salamon-Gibbons-Page-Pope $Spin(7)$ metric on an $\mathbb{R}^4$ bundle over $S^4$. By the AdS/CFT correspondence, a conformal field theory is associated to each of the new singular special holonomy metrics, and defines the quantum gravitational physics of the resolution of their singularities.Comment: 1+52 page