Genetic Algorithm Optimization Model for Determining the Probability of Failure on Demand of the Safety Instrumented System

A more accurate determination for the Probability of Failure on Demand (PFD) of the Safety Instrumented System (SIS) contributes to more SIS realiability, thereby ensuring more safety and lower cost. IEC 61508 and ISA TR.84.02 provide the PFD detemination formulas. However, these formulas suffer from an uncertaity issue due to the inclusion of uncertainty sources, which, including high redundant systems architectures, cannot be assessed, have perfect proof test assumption, and are neglegted in partial stroke testing (PST) of impact on the system PFD. On the other hand, determining the values of PFD variables to achieve the target risk reduction involves daunting efforts and consumes time. This paper proposes a new approach for system PFD determination and PFD variables optimization that contributes to reduce the uncertainty problem. A higher redundant system can be assessed by generalizing the PFD formula into KooN architecture without neglecting the diagnostic coverage factor (DC) and common cause failures (CCF). In order to simulate the proof test effectiveness, the Proof Test Coverage (PTC) factor has been incorporated into the formula. Additionally, the system PFD value has been improved by incorporating PST for the final control element into the formula. The new developed formula is modelled using the Genetic Algorithm (GA) artificial technique. The GA model saves time and effort to examine system PFD and estimate near optimal values for PFD variables. The proposed model has been applicated on SIS design for crude oil test separator using MATLAB. The comparison between the proposed model and PFD formulas provided by IEC 61508 and ISA TR.84.02 showed that the proposed GA model can assess any system structure and simulate industrial reality. Furthermore, the cost and associated implementation testing activities are reduced

FACTS allocation considering loads uncertainty, steady state operation constraints, and dynamic operation constraints

This study proposes an algorithm to allocate different types of flexible AC transmission system (FACTS) in power systems. The main objective of this study is to maximize profit by minimizing the system’s operating cost including FACTS devices (FDs) installation cost. Dynamic and steady state operating restrictions with loads uncertainty are included in the problem formulation. The overall problem is solved using both teaching learning based optimization (TLBO) technique for attaining the optimal allocation of the FDs as main-optimization problem and matpower interior point solver (MIPS) for optimal power flow (OPF) as the sub-optimization problem. The validation of the proposed approach is verified by applying it to test system of 59-bus; Simplified 14-Generator model of the South East Australian power system

Population based optimization algorithms improvement using the predictive particles

A new efficient improvement, called Predictive Particle Modification (PPM), is proposed in this paper. This modification makes the particle look to the near area before moving toward the best solution of the group. This modification can be applied to any population algorithm. The basic philosophy of PPM is explained in detail. To evaluate the performance of PPM, it is applied to Particle Swarm Optimization (PSO) algorithm and Teaching Learning Based Optimization (TLBO) algorithm then tested using 23 standard benchmark functions. The effectiveness of these modifications are compared with the other unmodified population optimization algorithms based on the best solution, average solution, and convergence rate

Generalized optimal placement of PMUs considering power system observability, communication infrastructure, and quality of service requirements

This paper presents a generalized optimal placement of Phasor Measurement Units (PMUs) considering power system observability, reliability, Communication Infrastructure (CI), and latency time associated with this CI. Moreover, the economic study for additional new data transmission paths is considered as well as the availability of predefined locations of some PMUs and the preexisting communication devices (CDs) in some buses. Two cases for the location of the Control Center Base Station (CCBS) are considered; predefined case and free selected case. The PMUs placement and their required communication network topology and channel capacity are co-optimized simultaneously. In this study, two different approaches are applied to optimize the objective function; the first approach is combined from Binary Particle Swarm Optimization-Gravitational Search Algorithm (BPSOGSA) and the Minimum Spanning Tree (MST) algorithm, while the second approach is based only on BPSOGSA. The feasibility of the proposed approaches are examined by applying it to IEEE 14-bus and IEEE 118-bus systems

Location prediction based on a sector snapshot for location-based services

In location-based services (LBSs), the service is provided based on the users' locations through location determination and mobility realization. Most of the current location prediction research is focused on generalized location models, where the geographic extent is divided into regular-shaped cells. These models are not suitable for certain LBSs where the objectives are to compute and present on-road services. Such techniques are the new Markov-based mobility prediction (NMMP) and prediction location model (PLM) that deal with inner cell structure and different levels of prediction, respectively. The NMMP and PLM techniques suffer from complex computation, accuracy rate regression, and insufficient accuracy. In this paper, a novel cell splitting algorithm is proposed. Also, a new prediction technique is introduced. The cell splitting is universal so it can be applied to all types of cells. Meanwhile, this algorithm is implemented to the Micro cell in parallel with the new prediction technique. The prediction technique, compared with two classic prediction techniques and the experimental results, show the effectiveness and robustness of the new splitting algorithm and prediction technique

Blue biotechnology: Computational screening of sarcophyton cembranoid diterpenes for SARS-CoV-2 main protease inhibition

The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication are a promising target; specifically, the main protease (Mpro) that process CoV-encoded polyproteins serves as an Achilles heel for assembly of replication-transcription machinery as well as down-stream viral replication. In the search for potential antiviral drugs that target Mpro, a series of cembranoid diterpenes from the biologically active soft-coral genus Sarcophyton have been examined as SARS-CoV-2 Mpro inhibitors. Over 360 metabolites from the genus were screened using molecular docking calculations. Promising diterpenes were further characterized by molecular dynamics (MD) simulations based on molecular mechanics-generalized Born surface area (MM-GBSA) binding energy calculations. According to in silico calculations, five cembranoid diterpenes manifested adequate binding affinities as Mpro inhibitors with ΔGbinding \u3c -33.0 kcal/mol. Binding energy and structural analyses of the most potent Sarcophyton inhibitor, bislatumlide A (340), was compared to darunavir, an HIV protease inhibitor that has been recently subjected to clinical-trial as an anti-COVID-19 drug. In silico analysis indicates that 340 has a higher binding affinity against Mpro than darunavir with ΔGbinding values of -43.8 and -34.8 kcal/mol, respectively throughout 100 ns MD simulations. Drug-likeness calculations revealed robust bioavailability and protein-protein interactions were identified for 340; biochemical signaling genes included ACE, MAPK14 and ESR1 as identified based on a STRING database. Pathway enrichment analysis combined with reactome mining revealed that 340 has the capability to re-modulate the p38 MAPK pathway hijacked by SARS-CoV-2 and antagonize injurious effects. These findings justify further in vivo and in vitro testing of 340 as an antiviral agent against SARS-CoV-2