Trillingen appelslak (Pomacea canaliculata) : innovatiewijzer 2009

project 325503980

Improvement of the quality of propagation material for organic farming system

The use of organic propagation material is obligatory according to the current EU regulations for organic production. However, frequently difficulties are en-countered regarding the availability, the costs or the quality. In the Netherlands a national research program aims at developing solutions, needed for improving the production of high quality organic propagation material. The main emphasis in the pro-gram is on the model crops cabbage, onion, wheat and potato. Individual projects within the program include epidemiological studies of seed borne dis-eases to develop disease prevention strategies, meth-ods to improve resistance of seeds and seedlings towards pathogens and methods to control silver scurf in seed potatoes, development of multi-spectral analysis and sorting techniques and methods for analysis and improvement of seed vigour. Active involvement of producers and users of the seeds or seed potatoes ensures that the results will be imple-mented in practice. The program also aims at strengthening the international collaboration, amongst others through involvement in international research projects

Optimising Differentiated Tolls on Large Scale Networks, by using an Intellegent Search Algorithm

The design of an optimal road pricing scheme is not a trivial problem. Following the Dutch government’s kilometre charge plans, this paper focuses on the optimisation of link based toll levels differentiated in space and time. The optimal toll level design problem is formulated as a bi-level mathematical program. In the upper level we minimise an object function, e.g. the average travel time in the network, using a fixed number of price categories. At the lower level a dynamic traffic assignment model is used to determine the effects of differentiated road pricing schemes on the traffic system. Focus of the paper is on the upper-level where optimal toll levels are approximated. In the optimisation procedure different variants of a pattern search algorithm are tested in a case study. Inspection of the solution space shows that many local minima exist, so the selection of the initial solution becomes important. In the case study however it appears that in all local minima the value of the objective function is almost the same, indicating the fact that many different toll schemes result in the same average travel time. The case study is also used to test the performance of the different variants of the pattern search algorithm. It appears that it is beneficial to change more variables at a time and to use a memory to remember where improvement of the objective function has been made. First tests on a medium scale network showed that it is possible to apply the framework on this network, though further computational improvements are needed to apply the framework to large scale networks, for example by parallel processing

Energetics and mechanism of drug transport mediated by the lactococcal multidrug transporter LmrP

The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion mediated by LmrP were studied in membrane vesicles of E. coli, LmrP-mediated extrusion of tetraphenyl phosphonium (TPP+) from right-side-out membrane vesicles and uptake of the fluorescent membrane probe 1-[4-(trimethylamino)phenyl]-6-phenylhexa-1,3,5-triene (TMA-DPH) into inside-out membrane vesicles are driven by the membrane potential (Delta psi) and the transmembrane proton gradient (Delta pH), pointing to an electrogenic drug/proton antiport mechanism, Ethidium bromide, a substrate for LmrP, inhibited the LmrP-mediated TPP+ extrusion from right-side-out membrane vesicles, showing that LmrP is capable of transporting structurally unrelated drugs. Kinetic analysis of LmrP-mediated TMA-DPH transport revealed a direct relation between the transport rate and the amount of TMA-DPH associated with the cytoplasmic leaflet of the lipid bilayer. This observation indicates that drugs are extruded from the inner leaflet of the cytoplasmic membrane into the external medium. This is the first report that shows that drug extrusion by a secondary multidrug resistance (MDR) transporter occurs by a ''hydrophobic vacuum cleaner'' mechanism in a similar way as was proposed for the primary lactococcal MDR transporter, LmrA

IHS Roundtable: “The Eyes of Texas" Historians Perspectives on the Origins of the Song

Histor

Numerical characterization of residual stresses in a four-point-bending experiment of textured duplex stainless steel

The resulting shapes in production processes of metal components are strongly influenced by deformation induced residual stresses. Dual-phase steels are commonly used for industrial application of, e.g., forged or deep-drawn structural parts. This is due to their ability to handle high plastic deformations, while retaining desired stiffness for the products. In order to influence the resulting shape as well as component characteristics positively it is important to predict the distribution of phase-specific residual stresses which occur on the microscale of the material. In this contribution a comparative study is presented, where two approaches for the numerical simulation of residual stresses are applied. On the one hand a numerically efficient mean field theory is used to estimate on the grain level the total strain, the plastic strains and the eigenstrains based on macroscopic stress, strain and stiffness data. An alternative ansatz relies on a Taylor approximation for the grain level strains. Both approaches are applied to the corrosion-resistant duplex steel X2CrNiMoN22-5-3 (1.4462), which consists of a ferritic and an austenitic phase with the same volume fraction. Mean field and Taylor approximation strategies are implemented for usage in three dimensional solid finite element analysis and a geometrically exact Euler–Bernoulli beam for the simulation of a four-point-bending test. The predicted residual stresses are compared to experimental data from bending experiments for the phase-specific residual stresses/strains which have been determined by neutron diffraction over the bending height of the specimen

Scaling laws and vortex profiles in 2D decaying turbulence

We use high resolution numerical simulations over several hundred of turnover times to study the influence of small scale dissipation onto vortex statistics in 2D decaying turbulence. A self-similar scaling regime is detected when the scaling laws are expressed in units of mean vorticity and integral scale, as predicted by Carnevale et al., and it is observed that viscous effects spoil this scaling regime. This scaling regime shows some trends toward that of the Kirchhoff model, for which a recent theory predicts a decay exponent $\xi=1$. In terms of scaled variables, the vortices have a similar profile close to a Fermi-Dirac distribution.Comment: 4 Latex pages and 4 figures. Submitted to Phys. Rev. Let

Generalized thermodynamics and Fokker-Planck equations. Applications to stellar dynamics, two-dimensional turbulence and Jupiter's great red spot

We introduce a new set of generalized Fokker-Planck equations that conserve energy and mass and increase a generalized entropy until a maximum entropy state is reached. The concept of generalized entropies is rigorously justified for continuous Hamiltonian systems undergoing violent relaxation. Tsallis entropies are just a special case of this generalized thermodynamics. Application of these results to stellar dynamics, vortex dynamics and Jupiter's great red spot are proposed. Our prime result is a novel relaxation equation that should offer an easily implementable parametrization of geophysical turbulence. This relaxation equation depends on a single key parameter related to the skewness of the fine-grained vorticity distribution. Usual parametrizations (including a single turbulent viscosity) correspond to the infinite temperature limit of our model. They forget a fundamental systematic drift that acts against diffusion as in Brownian theory. Our generalized Fokker-Planck equations may have applications in other fields of physics such as chemotaxis for bacterial populations. We propose the idea of a classification of generalized entropies in classes of equivalence and provide an aesthetic connexion between topics (vortices, stars, bacteries,...) which were previously disconnected.Comment: Submitted to Phys. Rev.