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Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial-mesenchymal transition in mice.
Growing evidence suggests close associations between periodontitis and atherosclerosis. To further understand the pathological relationships of these associations, we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/P.g. LPS) in Apolipoprotein E knock out mice and studied the atherogenesis process in these animals. The mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis, systemic inflammation, and atherosclerosis. Controls did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas, but mice receiving ligature or ligature/P.g. LPS showed severe periodontitis, systemic inflammation, and aortic plaque formation. The aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell markers. The severity of periodontitis was slightly higher in mice receiving ligature/P.g. LPS than ligature alone, and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/P.g. LPS. These observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe periodontitis. In vitro, P.g. LPS enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial cells. Moreover, secretory proteins, such as TNF-α, from macrophages induced endothelial-mesenchymal transitions of the endothelial cells. Taken together, systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via, in part, causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice
Antibody acquisition models: a new tool for serological surveillance of malaria transmission intensity
Serology has become an increasingly important tool for the surveillance of a wide range of infectious diseases. It has been particularly useful to monitor malaria transmission in elimination settings where existing metrics such as parasite prevalence and incidence of clinical cases are less sensitive. Seroconversion rates, based on antibody prevalence to Plasmodium falciparum asexual blood-stage antigens, provide estimates of transmission intensity that correlate with entomological inoculation rates but lack precision in settings where seroprevalence is still high. Here we present a new and widely applicable method, based on cross-sectional data on individual antibody levels. We evaluate its use as a sero-surveillance tool in a Tanzanian setting with declining malaria prevalence. We find that the newly developed mathematical models produce more precise estimates of transmission patterns, are robust in high transmission settings and when sample sizes are small, and provide a powerful tool for serological evaluation of malaria transmission intensity
Individual and organisational factors in the psychosocial work environment are associated with home care staffs’ job strain: A Swedish cross-sectional study
Background
Home care staff (HCS) provide essential service to enable older adults to age in place. However, unreasonable demands in the work environment to deliver a safe, effective service with high quality has a negative impact on the individual employee’s well-being and the care provided to the older adults. The psychosocial work environment is associated with employees´ well-being, although, knowledge regarding which individual and organisational factors that contribute to job strain for HCS is limited. These factors need to be identified to develop targeted interventions and create sustainable work situations for HCS. This study aimed to explore how HCS´s perceived job strain is associated with, and to what extent can be explained by, individual and organisational factors of the psychosocial work environment and psychosomatic health.
Method
An explorative cross-sectional questionnaire survey design was used in a large Swedish county. Five home care agencies with a total of 481 HCS were asked to respond to a questionnaire regarding their perceived level of job strain (Strain in Dementia Care Scale), psychosocial work environment (QPSNordic34+), and psychosomatic health (Satisfaction with Work Questionnaire). Multiple linear regression (MLR) analyses were conducted to explore the association between job strain and individual and organisational factors.
Results
In total, 226 (46%) HCS responded to the questionnaire. Both individual and organisational factors were significant predictors of job strain and explained a variance ranging between 39 to 51% (p = 0.001). The organisational factor job demand and the individual factor feeling worried and restless was most frequently represented in these MRL models. A higher job strain was also associated with adverse outcomes regarding leadership, organisational culture and climate, and control at work.
Conclusion
This study indicates that there is an intertwined complexity of individual and organisational factors that are associated with the HCS´s perception of job strain. Implementation of new multidimensional work strategies, such as a reablement approach, could support the development of efficient strategies for HCS and reduce the level of job strain. Policy changes for the provision of home care are also needed to support the development of a sustainable and healthy psychosocial work environment
Charge separation in donor-C60 complexes with real-time Green's functions: The importance of nonlocal correlations
We use the Nonequilibrium Green's Function (NEGF) method to perform real-time
simulations of the ultrafast electron dynamics of photoexcited donor-C60
complexes modeled by a Pariser-Parr-Pople Hamiltonian. The NEGF results are
compared to mean-field Hartree-Fock (HF) calculations to disentangle the role
of correlations. Initial benchmarking against numerically highly accurate
time-dependent Density Matrix Renormalization Group calculations verifies the
accuracy of NEGF. We then find that charge-transfer (CT) excitons partially
decay into charge separated (CS) states if dynamical non-local correlation
corrections are included. This CS process occurs in ~10 fs after
photoexcitation. In contrast, the probability of exciton recombination is
almost 100% in HF simulations. These results are largely unaffected by nuclear
vibrations; the latter become however essential whenever level misalignment
hinders the CT process. The robust nature of our findings indicate that
ultrafast CS driven by correlation-induced decoherence may occur in many
organic nanoscale systems, but it will only be correctly predicted by
theoretical treatments that include time-nonlocal correlations.Comment: 9 pages, 6 figures + supplemental information (4 pages)
Modular termination verification for non-blocking concurrency
© Springer-Verlag Berlin Heidelberg 2016.We present Total-TaDA, a program logic for verifying the total correctness of concurrent programs: that such programs both terminate and produce the correct result. With Total-TaDA, we can specify constraints on a thread’s concurrent environment that are necessary to guarantee termination. This allows us to verify total correctness for nonblocking algorithms, e.g. a counter and a stack. Our specifications can express lock- and wait-freedom. More generally, they can express that one operation cannot impede the progress of another, a new non-blocking property we call non-impedance. Moreover, our approach is modular. We can verify the operations of a module independently, and build up modules on top of each other
Ultrathin Metallic Coatings Can Induce Quantum Levitation between Nanosurfaces
There is an attractive Casimir-Lifshitz force between two silica surfaces in
a liquid (bromobenze or toluene). We demonstrate that adding an ultrathin
(5-50{\AA}) metallic nanocoating to one of the surfaces results in repulsive
Casimir-Lifshitz forces above a critical separation. The onset of such quantum
levitation comes at decreasing separations as the film thickness decreases.
Remarkably the effect of retardation can turn attraction into repulsion. From
that we explain how an ultrathin metallic coating may prevent
nanoelectromechanical systems from crashing together.Comment: 4 pages, 5 figure
The Spin Holonomy Group In General Relativity
It has recently been shown by Goldberg et al that the holonomy group of the
chiral spin-connection is preserved under time evolution in vacuum general
relativity. Here, the underlying reason for the time-independence of the
holonomy group is traced to the self-duality of the curvature 2-form for an
Einstein space. This observation reveals that the holonomy group is
time-independent not only in vacuum, but also in the presence of a cosmological
constant. It also shows that once matter is coupled to gravity, the
"conservation of holonomy" is lost. When the fundamental group of space is
non-trivial, the holonomy group need not be connected. For each homotopy class
of loops, the holonomies comprise a coset of the full holonomy group modulo its
connected component. These cosets are also time-independent. All possible
holonomy groups that can arise are classified, and examples are given of
connections with these holonomy groups. The classification of local and global
solutions with given holonomy groups is discussed.Comment: 21 page
A computational model unifies apparently contradictory findings concerning phantom pain
Amputation often leads to painful phantom sensations, whose pathogenesis is still unclear. Supported by experimental findings, an explanatory model has been proposed that identifies maladaptive reorganization of the primary somatosensory cortex (S1) as a cause of phantom pain. However, it was recently found that BOLD activity during voluntary movements of the phantom positively correlates with phantom pain rating, giving rise to a model of persistent representation. In the present study, we develop a physiologically realistic, computational model to resolve the conflicting findings. Simulations yielded that both the amount of reorganization and the level of cortical activity during phantom movements were enhanced in a scenario with strong phantom pain as compared to a scenario with weak phantom pain. These results suggest that phantom pain, maladaptive reorganization, and persistent representation may all be caused by the same underlying mechanism, which is driven by an abnormally enhanced spontaneous activity of deafferented nociceptive channels
Retardation turns the van der Waals attraction into Casimir repulsion already at 3 nm
Casimir forces between surfaces immersed in bromobenzene have recently been
measured by Munday et al. Attractive Casimir forces were found between gold
surfaces. The forces were repulsive between gold and silica surfaces. We show
the repulsion is due to retardation effects. The van der Waals interaction is
attractive at all separations. The retardation driven repulsion sets in already
at around 3 nm. To our knowledge retardation effects have never been found at
such a small distance before. Retardation effects are usually associated with
large distances
Sign of the Casimir-Polder interaction between atoms and oil-water interfaces: Subtle dependence on dielectric properties
We demonstrate that Casimir-Polder energies between noble gas atoms
(dissolved in water) and oil-water interfaces are highly surface specific. Both
repulsion (e.g. hexane) and attraction (e.g. glycerine and cyclodecane) is
found with different oils. For several intermediate oils (e.g. hexadecane,
decane, and cyclohexane) both attraction and repulsion can be found in the same
system. Near these oil-water interfaces the interaction is repulsive in the
non-retarded limit and turns attractive at larger distances as retardation
becomes important. These highly surface specific interactions may have a role
to play in biological systems where the surface may be more or less accessible
to dissolved atoms.Comment: 5 pages, 6 figure
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