Comparison of long-term field-measured and RUSLE-based modelled soil loss in Switzerland

Long-term field measurements to asses model-based soil erosion predictions by water are rare. We have compared field measurements based on erosion assessment surveys from a 10-year monitoring process with spatial-explicit model predictions with the Revised Universal Soil Loss Equation (RUSLE). Robust input data were available for both the mapped and the modelled parameters for 203 arable fields covering an area of 258 ha in the Swiss Midlands. The 1639 mapped erosion forms were digitized and converted to raster format with a 2 m resolution. A digital terrain model using 2 m resolution and a multiple flow direction algorithm for the calculation of the topographic factors and the support practice factor was available for modelling with the RUSLE. The other input data for the RUSLE were determined for each field. The comparison of mapped and modelled soil loss values revealed a substantially higher estimation of soil loss values from modelling by a factor of 8, with a mean mapped soil loss of 0.77 t/ha/yr vs. modelled soil loss of 6.20 t/ha/yr. However, high mapped soil losses of >4 t/ha/yr were reproduced quite reliably by the model, while the model predicted drastically higher erosion values for mapped losses of <4 t/ha/yr. Our study shows the value of long-term field data based on erosion assessment surveys for model evaluation. RUSLE-type model results should be compared with erosion assessment surveys at the field to landscape scale in order to improve the calibration of the model. Further factors related to land management like headlands, traffic lanes and potato furrows need to be included before they may be used for policy advice

Drug Hypersensitivity Syndrome toCarbamazepine and Human Herpes Virus 6 Infection: Case Reportand Literature Review

Abstract.: We describe a patient with a drug-induced hypersensitivity syndrome to carbamazepine and a concomitant active infection with human herpes virus 6 (HHV-6). The potential role of HHV-6 regarding the drug-induced hypersensitivity syndrome is discussed and the main clinical features of this potentially fatal adverse drug reaction are highlighte

A soil moisture and temperature network for SMOS validation in Western Denmark

The Soil Moisture and Ocean Salinity Mission (SMOS) acquires surface soil moisture data of global coverage every three days. Product validation for a range of climate and environmental conditions across continents is a crucial step. For this purpose, a soil moisture and soil temperature sensor network was established in the Skjern River Catchment, Denmark. The objectives of this article are to describe a method to implement a network suited for SMOS validation, and to present sample data collected by the network to verify the approach. The design phase included (1) selection of a single SMOS pixel (44 × 44 km), which is representative of the land surface conditions of the catchment and with minimal impact from open water (2) arrangement of three network clusters along the precipitation gradient, and (3) distribution of the stations according to respective fractions of classes representing the prevailing environmental conditions. Overall, measured moisture and temperature patterns could be related to the respective land cover and soil conditions. Texture-dependency of the 0–5 cm soil moisture measurements was demonstrated. Regional differences in 0–5 cm soil moisture, temperature and precipitation between the north-east and south-west were found to be small. A first comparison between the 0–5 cm network averages and the SMOS soil moisture (level 2) product is in range with worldwide validation results, showing comparable trends for SMOS retrieved soil moisture (&lt;i&gt;R&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; of 0.49) as well as initial soil moisture and temperature from ECMWF used in the retrieval algorithm (&lt;i&gt;R&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; of 0.67 and 0.97, respectively). While retrieved/initial SMOS soil moisture indicate significant under-/overestimation of the network data (biases of −0.092/0.057 m&lt;sup&gt;3&lt;/sup&gt; m&lt;sup&gt;−3&lt;/sup&gt;), the initial temperature is in good agreement (bias of −0.2 °C). Based on these findings, the network performs according to expectations and proves to be well-suited for its purpose. The discrepancies between network and SMOS soil moisture will be subject of subsequent studies

Exchange-coupling constants, spin density map, and Q dependence of the inelastic neutron scattering intensity in single-molecule magnets

The Q dependence of the inelastic neutron scattering (INS) intensity of transitions within the ground-state spin multiplet of single-molecule magnets (SMMs) is considered. For these transitions, the Q dependence is related to the spin density map in the ground state, which in turn is governed by the Heisenberg exchange interactions in the cluster. This provides the possibility to infer the exchange-coupling constants from the Q dependence of the INS transitions within the spin ground state. The potential of this strategy is explored for the M = +-10 -> +- 9 transition within the S = 10 multiplet of the molecule Mn12 as an example. The Q dependence is calculated for powder as well as single-crystal Mn12 samples for various exchange-coupling situations discussed in the literature. The results are compared to literature data on a powder sample of Mn12 and to measurements on an oriented array of about 500 single-crystals of Mn12. The calculated Q dependence exhibits significant variation with the exchange-coupling constants, in particular for a single-crystal sample, but the experimental findings did not permit an unambiguous determination. However, although challenging, suitable experiments are within the reach of today's instruments.Comment: 11 pages, 6 figures, REVTEX4, to appear in PR

High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - a prospective cohort study

Poor adherence to antiretroviral drugs and viral resistance are the main drivers of treatment failure in HIV-infected patients. In sub-Saharan Africa, avoidance of treatment failure on second-line protease inhibitor therapy is critical as treatment options are limited.; In the prospective observational study of the Kilombero & Ulanga Antiretroviral Cohort in rural Tanzania, we assessed virologic failure (viral load ≥1,000 copies/mL) and drug resistance mutations in bio-banked plasma samples 6-12 months after initiation of a protease inhibitor-based treatment regimen. Additionally, viral load was measured before start of protease inhibitor, a second time between 1-5 years after start, and at suspected treatment failure in patients with available bio-banked samples. We performed resistance testing if viral load was ≥1000 copies/ml. Risk factors for virologic failure were analyzed using logistic regression.; In total, 252 patients were included; of those 56% were female and 21% children. Virologic failure occurred 6-12 months after the start of a protease inhibitor in 26/199 (13.1%) of adults and 7/53 of children (13.2%). The prevalence of virologic failure did not change over time. Nucleoside reverse transcriptase inhibitors drug resistance mutation testing performed at 6-12 months showed a positive signal in only 9/16 adults. No cases of resistance mutations for protease inhibitors were seen at this time. In samples taken between 1-5 years protease inhibitor resistance was demonstrated in 2/7 adults. In adult samples before protease inhibitor start, resistance to nucleoside reverse transcriptase inhibitors was detected in 30/41, and to non-nucleoside reverse-transcriptase inhibitors in 35/41 patients. In 15/16 pediatric samples, resistance to both drug classes but not for protease inhibitors was present.; Our study confirms high early failure rates in adults and children treated with protease inhibitors, even in the absence of protease inhibitors resistance mutations, suggesting an urgent need for adherence support in this setting

Heterogeneous dermatitis complaints after change in drinking water treatment: a case report

BACKGROUND: The disinfectant monochloramine minimizes the formation of potentially hazardous and regulated byproducts, and many drinking water utilities are shifting to its use. CASE PRESENTATION: After a drinking water utility serving 2.4 million people switched to monochloramine for residual disinfection, a small number of residents complained of dermatitis reactions. We interviewed 17 people about their symptoms. Skin appearance, symptoms, and exposures were heterogeneous. Five respondents had history of hives or rash that preceded the switch to monochloramine. CONCLUSION: The complaints described were heterogeneous, and many of the respondents had underlying or preexisting conditions that would offer plausible alternative explanations for their symptoms. We did not recommend further study of these complaints

Crater formation by fast ions: comparison of experiment with Molecular Dynamics simulations

An incident fast ion in the electronic stopping regime produces a track of excitations which can lead to particle ejection and cratering. Molecular Dynamics simulations of the evolution of the deposited energy were used to study the resulting crater morphology as a function of the excitation density in a cylindrical track for large angle of incidence with respect to the surface normal. Surprisingly, the overall behavior is shown to be similar to that seen in the experimental data for crater formation in polymers. However, the simulations give greater insight into the cratering process. The threshold for crater formation occurs when the excitation density approaches the cohesive energy density, and a crater rim is formed at about six times that energy density. The crater length scales roughly as the square root of the electronic stopping power, and the crater width and depth seem to saturate for the largest energy densities considered here. The number of ejected particles, the sputtering yield, is shown to be much smaller than simple estimates based on crater size unless the full crater morphology is considered. Therefore, crater size can not easily be used to estimate the sputtering yield.Comment: LaTeX, 7 pages, 5 EPS figures. For related figures/movies, see: http://dirac.ms.virginia.edu/~emb3t/craters/craters.html New version uploaded 5/16/01, with minor text changes + new figure

Transcutaneous flow related variables measured in vivo: the effects of gender

BACKGOUND: The identification of potential sources of error is a crucial step for any new assessment technique. This is the case for transcutaneous variables, such as flow and arterial gases, which have been applied as functional indicators of various aspects of human health. Regarding gender, a particular subject-related determinant, it is often claimed that women present higher transcutaneous oxygen pressure (tcpO(2)) values than men. However, the statistical significance of this finding is still uncertain. METHODS: The haemodynamical-vascular response to a local reactive hyperaemia procedure (the tourniquet cuff manoeuvre) was studied in two previously selected group of volunteers (n = 16; 8 women and 8 men). The effect of gender was assessed under standardised experimental conditions, using the transcutaneous flow-related variables tcpO(2)-tcpCO(2) and Laser-doppler Flowmetry (LDF). RESULTS: Regarding tcpO(2), statistically significant differences between genders were not found, although higher values were consistently found for the gases in the female group. Regarding LDF, high statistically significant differences (p < 0.005) were found, with the men's group presenting the highest values and variability. Other derived parameters used to characterise the vascular response following the cuff-deflation (t-peak) were similar in both groups. CONCLUSIONS: The relative influence of gender was not clearly demonstrated using these experimental conditions. However the gender-related LDF differences suggest that further investigation should be done on this issue. Perhaps in the presence of certain pathological disparities involving peripheral vascular regulation, other relationships may be found between these variables

Joint Sentinel-1 and SMAP data assimilation to improve soil moisture estimates

SMAP (Soil Moisture Active and Passive) radiometer observations at similar to 40 km resolution are routinely assimilated into the NASA Catchment Land Surface Model to generate the 9 km SMAP Level-4 Soil Moisture product. This study demonstrates that adding high-resolution radar observations from Sentinel-1 to the SMAP assimilation can increase the spatiotemporal accuracy of soil moisture estimates. Radar observations were assimilated either separately from or simultaneously with radiometer observations. Assimilation impact was assessed by comparing 3-hourly, 9 km surface and root-zone soil moisture simulations with in situ measurements from 9 km SMAP core validation sites and sparse networks, from May 2015 to December 2016. The Sentinel-1 assimilation consistently improved surface soil moisture, whereas root-zone impacts were mostly neutral. Relatively larger improvements were obtained from SMAP assimilation. The joint assimilation of SMAP and Sentinel-1 observations performed best, demonstrating the complementary value of radar and radiometer observations

The contribution of the environment (especially diet) to breast cancer risk

Environmental factors play an important role in breast carcinogenesis. Opportunities for prevention are limited, however, because most of the known or suspected risk factors are not targets for modification. Dietary factors have generally not emerged as crucial contributors to mammary tumor causation. We still appear to be missing a critical piece of the breast cancer puzzle because we can only explain a moderate proportion of international and national variation in breast cancer rates. Research needs to pursue new avenues, focusing on exposure windows that have not yet been sufficiently explored, such as events between conception and adolescence, and on modifiable risk factors that show large variation within or between populations