Cartilage can be thicker in advanced osteoarthritic knees: a tridimensional quantitative analysis of cartilage thickness at posterior aspect of femoral condyles.

To test, through tridimensional analysis, whether (1) cartilage thickness at the posterior aspect of femoral condyles differs in knees with medial femorotibial osteoarthritis (OA) compared to non-OA knees; (2) the location of the thickest cartilage at the posterior aspect of femoral condyles differs between OA and non-OA knees. CT arthrograms of knees without radiographic OA (n = 30) and with severe medial femorotibial OA (n = 30) were selected retrospectively from patients over 50 years of age. The groups did not differ in gender, age and femoral size. CT arthrograms were segmented to measure the mean cartilage thickness, the maximal cartilage thickness and its location in a region of interest at the posterior aspect of condyles. For the medial condyle, mean and maximum cartilage thicknesses were statistically significantly higher in OA knees compared to non-OA knees [1.66 vs 1.46 mm (p = 0.03) and 2.56 vs 2.14 mm (p = 0.003), respectively]. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle for both groups, without significant difference between groups. For the lateral condyle, no statistically significant difference between non-OA and OA knees was found (p ≥ 0.17). Cartilage at the posterior aspect of the medial condyle, but not the lateral condyle, is statistically significantly thicker in advanced medial femorotibial OA knees compared to non-OA knees. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage. Advances in knowledge: This study, through a quantitative tridimensional approach, shows that cartilage at the posterior aspect of the medial condyles is thicker in severe femorotibial osteoarthritic knees compared to non-OA knees. In the posterior aspect of the medial condyle, the thickest cartilage is located in the vicinity of the center of the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage

High pressure mechanical seal

A relatively impervious mechanical seal is formed between the outer surface of a tube and the inside surface of a mechanical fitting of a high pressure fluid or hydraulic system by applying a very thin soft metal layer onto the outer surface of the hard metal tube and/or inner surface of the hard metal fitting. The thickness of such thin metal layer is independent of the size of the tube and/or fittings. Many metals and alloys of those metals exhibit the requisite softness, including silver, gold, tin, platinum, indium, rhodium and cadmium. Suitably, the coating is about 0.0025 millimeters (0.10 mils) in thickness. After compression, the tube and fitting combination exhibits very low leak rates on the order or 10.sup.-8 cubic centimeters per second or less as measured using the Helium leak test

Race Matters: Managing Racial Tension when Teaching Multicultural Competence

In this article, the authors suggest using the Mindful Inquiry (Lee, 2009, 2014) to navigate cultural conversations in the counselor education classroom in tandem with the Multicultural and Social Justice Counseling Competencies (MSJCC; Ratts et al., 2015). The authors highlight the literature about racial tension in and outside the classroom, multicultural counseling and social justice, mindfulness and multiculturalism, and teaching multicultural competence. This article concludes with a case example highlighting how to use the Mindful Inquiry (Lee, 2009, 2014) in the classroom while demonstrating how counselors-in-training develop across the MSJCC (Ratts et al., 2015)

Centrifugal Breakout of Magnetically Confined Line-Driven Stellar Winds

We present 2D MHD simulations of the radiatively driven outflow from a rotating hot star with a dipole magnetic field aligned with the star's rotation axis. We focus primarily on a model with moderately rapid rotation (half the critical value), and also a large magnetic confinement parameter, $\eta_{\ast} \equiv B_{\ast}^2 R_{\ast}^{2} / \dot{M} V_{\infty} = 600$. The magnetic field channels and torques the wind outflow into an equatorial, rigidly rotating disk extending from near the Kepler corotation radius outwards. Even with fine-tuning at lower magnetic confinement, none of the MHD models produce a stable Keplerian disk. Instead, material below the Kepler radius falls back on to the stellar surface, while the strong centrifugal force on material beyond the corotation escape radius stretches the magnetic loops outwards, leading to episodic breakout of mass when the field reconnects. The associated dissipation of magnetic energy heats material to temperatures of nearly $10^{8}$K, high enough to emit hard (several keV) X-rays. Such \emph{centrifugal mass ejection} represents a novel mechanism for driving magnetic reconnection, and seems a very promising basis for modeling X-ray flares recently observed in rotating magnetic Bp stars like $\sigma$ Ori E.Comment: 5 pages, 3 figures, accepted by ApJ

Dynamical Simulations of Magnetically Channeled Line-Driven Stellar Winds: II. The Effects of Field-Aligned Rotation

Building upon our previous MHD simulation study of magnetic channeling in radiatively driven stellar winds, we examine here the additional dynamical effects of stellar {\em rotation} in the (still) 2-D axisymmetric case of an aligned dipole surface field. In addition to the magnetic confinement parameter $\eta_{\ast}$ introduced in Paper I, we characterize the stellar rotation in terms of a parameter $W \equiv V_{\rm{rot}}/V_{\rm{orb}}$ (the ratio of the equatorial surface rotation speed to orbital speed), examining specifically models with moderately strong rotation $W =$ 0.25 and 0.5, and comparing these to analogous non-rotating cases. Defining the associated Alfv\'{e}n radius R_{\rm{A}} \approx \eta_{\ast}^{1/4} \Rstar and Kepler corotation radius R_{\rm{K}} \approx W^{-2/3} \Rstar, we find rotation effects are weak for models with $R_{\rm{A}} < R_{\rm{K}}$, but can be substantial and even dominant for models with R_{\rm{A}} \gtwig R_{\rm{K}}. In particular, by extending our simulations to magnetic confinement parameters (up to $\eta_{\ast} = 1000$) that are well above those ($\eta_{\ast} = 10$) considered in Paper I, we are able to study cases with $R_{\rm{A}} \gg R_{\rm{K}}$; we find that these do indeed show clear formation of the {\em rigid-body} disk predicted in previous analytic models, with however a rather complex, dynamic behavior characterized by both episodes of downward infall and outward breakout that limit the buildup of disk mass. Overall, the results provide an intriguing glimpse into the complex interplay between rotation and magnetic confinement, and form the basis for a full MHD description of the rigid-body disks expected in strongly magnetic Bp stars like $\sigma$ Ori E.Comment: 14 pp, visit this http://shayol.bartol.udel.edu/massivewiki-media/publications/rotation.pdf for full figure version of the paper. MNRAS, in pres

The Rigidly Rotating Magnetosphere of Sigma Ori E

We attempt to characterize the observed variability of the magnetic helium-strong star sigma Ori E in terms of a recently developed rigidly rotating magnetosphere model. This model predicts the accumulation of circumstellar plasma in two co-rotating clouds, situated in magnetohydrostatic equilibrium at the intersection between magnetic and rotational equators. We find that the model can reproduce well the periodic modulations observed in the star's light curve, H alpha emission-line profile, and longitudinal field strength, confirming that it furnishes an essentially correct, quantitative description of the star's magnetically controlled circumstellar environment.Comment: 4 pages, 3 figures, accepted by Ap

Analyzing Femorotibial Cartilage Thickness Using Anatomically Standardized Maps: Reproducibility and Reference Data.

Alterations in cartilage thickness (CTh) are a hallmark of knee osteoarthritis, which remain difficult to characterize at high resolution, even with modern magnetic resonance imaging (MRI), due to a paucity of standardization tools. This study aimed to assess a computational anatomy method producing standardized two-dimensional femorotibial CTh maps. The method was assessed with twenty knees, processed following three common experimental scenarios. Cartilage thickness maps were obtained for the femorotibial cartilages by reconstructing bone and cartilage mesh models in tree-dimension, calculating three-dimensional CTh maps, and anatomically standardizing the maps. The intra-operator accuracy (median (interquartile range, IQR) of -0.006 (0.045) mm), precision (0.152 (0.070) mm), entropy (7.02 (0.71) and agreement (0.975 (0.020))) results suggested that the method is adequate to capture the spatial variations in CTh and compare knees at varying osteoarthritis stages. The lower inter-operator precision (0.496 (0.132) mm) and agreement (0.808 (0.108)) indicate a possible loss of sensitivity to detect differences in a setting with multiple operators. The results confirmed the promising potential of anatomically standardized maps, with the lower inter-operator reproducibility stressing the need to coordinate operators. This study also provided essential reference data and indications for future research using CTh maps

Induced osteogenic differentiation of human smooth muscle cells as a model of vascular calcification

Vascular calcification is a severe pathological event in the manifestation of atherosclerosis. Pathogenic triggers mediating osteogenic differentiation of arterial smooth muscle cells (SMC) in humans remain insufficiently understood and are to a large extent investigated in animal models or cells derived thereof. Here, we describe an in vitro model based on SMC derived from healthy and diseased humans that allows to comprehensively investigate vascular calcification mechanisms. Comparing the impact of the commonly used SMC culture media VascuLife, DMEM, and M199, cells were characterised by immunofluorescence, flow cytometry, qPCR, and regarding their contractility and proliferative capacity. Irrespective of the arterial origin, the clinical background and the expansion medium used, all cells expressed typical molecular SMC marker while contractility varied between donors. Interestingly, the ability to induce an osteogenic differentiation strongly depended on the culture medium, with only SMC cultured in DMEM depositing calcified matrix upon osteogenic stimulation, which correlated with increased alkaline phosphatase activity, increased inorganic phosphate level and upregulation of osteogenic gene markers. Our optimized model is suitable for donor-oriented as well as broader screening of potential pathogenic mediators triggering vascular calcification. Translational studies aiming to identify and to evaluate therapeutic targets in a personalized fashion would be feasible

Soft coronal X-rays from \beta{} Pictoris

A type stars are expected to be X-ray dark, yet weak emission has been detected from several objects in this class. We present new Chandra/HRC-I observations of the A5 V star \beta{} Pictoris. It is clearly detected with a flux of 9+-2 10^{-4} counts/s. In comparison with previous data this constrains the emission mechanism and we find that the most likely explanation is an optically thin, collisionally dominated, thermal emission component with a temperature around 1.1 MK. We interpret this component as a very cool and dim corona, with \log L_X/L_{bol}=-8.2 (0.2-2.0 keV). Thus, it seems that \beta{} Pictoris shares more characteristics with cool stars than previously thought.Comment: accepted by ApJ, 5 pages, 2 figure

High pressure mechanical seal

A relatively impervious mechanical seal is formed between the outer surface of a tube and the inside surface of a mechanical fitting of a high pressure fluid or hydraulic system by applying a very thin soft metal layer onto the outer surface of the hard metal tube and/or inner surface of the hard metal fitting, prior to swaging the fitting onto the tube. The thickness of such thin metal layer is independent of the size of the tube and/or fittings. Many metals and alloys of those metals exhibit the requisite softness, including silver, gold, nickel, tin, platinum, indium, rhodium and cadmium. Suitably, the coating is about 0.0025 millimeters (0.10 mils) in thickness. After swaging, the tube and fitting combination exhibits very low leak rates on the order or 10.sup.-8 cubic centimeters per second or less as meaured using the Helium leak test