226 research outputs found

    PDB49 UNDERSTANDING AND ASSESSING THE IMPACT OF GROWTH HORMONE DEFICIENCY IN ADULTS

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    Zonal pressure gradient along the equatorial Atlantic

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    For three consecutive periods during the summer of 1974, ships of many nations made observations along the Atlantic equator as part of the GATE program [GARP (Global Atmospheric Research Program) Atlantic Tropical Experiment]. Combining these observations, it is found that the zonal pressure gradient over the central Atlantic at the surface and at 50 dbar, relative to 500 dbar, increased from 3.2 to 7.3 and 2.2 to 5.3 × 10-5 dynes/g respectively between June/July and August and then held close to the high values in September...

    A novel decision model to predict the impact of weight management interventions: the Core Obesity Model

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    Aims: Models are needed to quantify the economic implications of obesity in relation to health outcomes and health-related quality of life. This report presents the structure of the Core Obesity Model (COM) and compare its predictions with the UK clinical practice data. Materials and methods: The COM is a Markov, closed-cohort model, which expands on earlier obesity models by including prediabetes as a risk factor for type 2 diabetes (T2D), and sleep apnea and cancer as health outcomes. Selected outcomes predicted by the COM were compared with observed event rates from the Clinical Practice Research Datalink-Hospital Episode Statistics (CPRD-HES) study. The importance of baseline prediabetes prevalence, a factor not taken into account in previous economic models of obesity, was tested in a scenario analysis using data from the 2011 Health Survey of England. Results: Cardiovascular (CV) event rates predicted by the COM were well matched with those in the CPRD-HES study (7.8–8.5 per 1000 patient-years across BMI groups) in both base case and scenario analyses (8.0–9.4 and 8.6–9.9, respectively). Rates of T2D were underpredicted in the base case (1.0–7.6 vs. 2.1–22.7) but increased to match those observed in CPRD-HES for some BMI groups when a prospectively collected prediabetes prevalence was used (2.7–13.1). Mortality rates in the CPRD-HES were consistently higher than the COM predictions, especially in higher BMI groups. Conclusions: The COM predicts the occurrence of CV events and T2D with a good degree of accuracy, particularly when prediabetes is included in the model, indicating the importance of considering this risk factor in economic models of obesity

    THE MOTIVATION RESEARCH PRODUCTION OF NURSES ON THE PELOTAS CITY-RS THE PERIOD OF 1986-1996

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    Estudo sobre os motivos de produção de pesquisa dos enfermeiros de um município do Estado do Rio Grande do Sul no período de 1986-1996. Utilizou-se como metodologia um questionário. Os dados obtidos demonstraram uma íntima relação com a literatura revista.Study about of nurses’ research production motives in Pelotas city-RS in the period 1986-1996. The methodoloy used was questionary. The results give evidence of a close relation with the reviewd literature

    Climate fluctuations and the spring invasion of the North Sea by Calanus finmarchicus

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    The population of Calanus finmarchicus in the North Sea is replenished each spring by invasion from an overwintering stock located beyond the shelf edge. A combincation of field observations, statistical analysis of Continuous Plankton Recorder (CPR) data, and particle tracking model simulations, was used to investigate the processes involved in the cross-shelf invasion. The results showed that the main source of overwintering animals entering the North Sea in the spring is at depths of greater than 600m in the Faroe Shetland Channel, where concentrations of up to 620m -3 are found in association with the overflow of Norwegian Sea Deep Water (NSDW) across the Iceland Scotland Ridge. The input of this water mass to the Faroe Shetland Channel, and hence the supply of overwintering C. finmarchicus, has declined since the late 1960s due to changes in convective processes in the Greenland Sea. Beginning in February, animals start to emerge from the overwintering state and migrate to the surface waters, where their transport into the North Sea is mainly determined by the incidence of north-westerly winds that have declined since the 1960s. Together, these two factors explain a high proportion of the 30-year trends in spring abundance in the North Sea as measured by the CPR survey. Both the regional winds and the NSDW overflow are connected to the North Atlantic Oscillation Index (NAO), which is an atmospheric climate index, but with different time scales of response. Thus, interannual fluctuations in the NAO can cause immediate changes in the incidence of north-westerly winds without leading to corresponding changes in C. finmarchicus abundance in the North Sea, because the NSDW overflow responds over longer (decadal) time scales

    A quasi-synoptic survey of the thermocline circulation and water mass distribution within the Canary Basin

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    Shipboard hydrographic measurements and moored current meters are used to infer both the large-scale and mesoscale water mass distribution and features of the general circulation in the Canary Basin. We found a convoluted current system dominated by the time-dependent meandering of the eastward flowing Azores Current and the formation of mesoscale eddies. At middepths, several distinctly different water masses are identified: Subpolar Mode and Labrador Sea Water are centered in the northwest, Subantarctic Intermediate Water is centered in the southeast, and the saltier, warmer Mediterranean tongue lies between them. Mesoscale structures of these water masses suggest the presence of middepth meanders and detached eddies which may be caused by fluctuations of the Azores Current

    Cooling and ventilating the abyssal ocean

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    The abyssal ocean is filled with cold, dense waters that sink along the Antarctic continental slope and overflow sills that lie south of the Nordic Seas. Recent integrations of chlorofluorocarbon‐11 (CFC) measurements are similar in Antarctic Bottom Water (AABW) and in lower North Atlantic Deep Water (NADW), but Antarctic inputs are ≈ 2°C colder than their northern counterparts. This indicates comparable ventilation rates from both polar regions, and accounts for the Southern Ocean dominance over abyssal cooling. The decadal CFC‐based estimates of recent ventilation are consistent with other hydrographic observations and with longer‐term radiocarbon data, but not with hypotheses of a 20th‐century slowdown in the rate of AABW formation. Significant variability is not precluded by the available ocean measurements, however, and interannual to decadal changes are increasingly evident at high latitudes

    Dispersion of carbon nanotubes in polyamide 6 for microinjection moulding

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    The focus of this study was to investigate the dispersion state of pure and functionalized carbon nanotubes in polyamide 6, on composites prepared by twin-screw extrusion and then processed by microinjection moulding. Nanocomposites were prepared with different carbonvnanotube compositions, with and without functionalization. The nanotubes were functionalized by the 1,3-dipolar cycloaddition reaction. The dispersion of the carbon nanotube agglomerates was quantified using optical microscopy and image analysis. The effect of functionalization on the polyamide 6/carbon nanotube interface, the nanocomposite morphology and the mechanical and electrical properties were studied. It was observed that the microinjected composites with functionalized carbon nanotubes presented improved dispersion, with smaller carbon nanotube agglomerate area ratio compared to the composites with pure nanotubes. The functionalized nanotubes showed better adhesion to polyamide 6 compared to pure nanotubes, as observed by scanning electron microscopy. The incorporation of carbon nanotubes considerably improved the mechanical properties. The effect of high polymer shear rate on carbon nanotube alignment during microinjection moulding was assessed by comparing the electrical resistivity of the composite after extrusion and after microinjection moulding, through the thickness and along the flow direction. The experiments showed that the mould design and processing conditions significantly affected electrical resistivity.Fundação para a Ciência e Tecnologia (project PEst-C/CTM/LA0025/2013

    From pole to pole : 33 years of physical oceanography onboard R/V Polarstern

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    Measuring temperature and salinity profiles in the world's oceans is crucial to understanding ocean dynamics and its influence on the heat budget, the water cycle, the marine environment and on our climate. Since 1983 the German research vessel and icebreaker Polarstern has been the platform of numerous CTD (conductivity, temperature, depth instrument) deployments in the Arctic and the Antarctic. We report on a unique data collection spanning 33 years of polar CTD data. In total 131 data sets (1 data set per cruise leg) containing data from 10 063 CTD casts are now freely available at doi: 10.1594/PANGAEA.860066. During this long period five CTD types with different characteristics and accuracies have been used. Therefore the instruments and processing procedures (sensor calibration, data validation, etc.) are described in detail. This compilation is special not only with regard to the quantity but also the quality of the data -the latter indicated for each data set using defined quality codes. The complete data collection includes a number of repeated sections for which the quality code can be used to investigate and evaluate long-term changes. Beginning with 2010, the salinity measurements presented here are of the highest quality possible in this field owing to the introduction of the OPTIMARE Precision Salinometer.Peer reviewe
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