117 research outputs found
Effects and acceptability of implementing improved cookstoves and heaters to reduce household air pollution: a FRESH AIR study
- Author
- J.F.M. van boven
- L.T. van
- Akylbekov A.
- An P.L.
- Anastasaki M.
- Barton A.
- Bertsias A.
- Binh P.D.U.
- Brakema E.A.
- Burges D.
- Buteme S.
- Cartwright L.
- Chartier R.
- Chatzea V.E.
- Chavannes N.H.
- Cragg L.
- Dang T.N.
- Emilov B.
- Ferarrio I.
- FRESH AIR
- Gemert F. van
- Hedrick B.
- Hong L.H.T.C.
- Hopkinson N.
- Jones R.
- Jong C. de
- Kampen S. van
- Katagira W.
- Kirenga B.
- Kjaergaard J.
- Kleij R.M.J.J. van der
- Kocks J.
- Lan L.T.T.
- Linh T.T.D.
- Lionis C.
- Loan K.X.
- Mademilov M.
- McEwen A.
- Musinguzi P.
- Nantanda R.
- Ndeezi G.
- Papadakis S.
- Pinnock H.
- Pooler J.
- Poot C.
- Postma M.J.
- Poulsen A.
- Powell P.
- Quynh N.N.
- Reventlow S.
- Sifaki-Pistolla D.
- Singh S.
- Sooronbaev T.
- Sousa J.C. de
- Stout J.
- Stubbe-Ostergaard M.
- Tabyshova A.
- Tsiligianni I.
- Tuan T.D.
- Tumwine J.
- Vinh N.N.
- Walusimbi S.
- Warren L.
- Williams S.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
The objective was to evaluate the effectiveness and acceptability of locally tailored implementation of improved cookstoves/heaters in low- and middle-income countries. This interventional implementation study among 649 adults and children living in rural communities in Uganda, Vietnam and Kyrgyzstan, was performed after situational analyses and awareness programmes. Outcomes included household air pollution (PM2.5 and CO), self-reported respiratory symptoms (with CCQ and MRC-breathlessness scale), chest infections, school absence and intervention acceptability. Measurements were conducted at baseline, 2 and 6-12 months after implementing improved cookstoves/heaters. Mean PM2.5 values decrease by 31% (to 95.1 µg/m3) in Uganda (95%CI 71.5-126.6), by 32% (to 31.1 µg/m3) in Vietnam (95%CI 24.5-39.5) and by 65% (to 32.4 µg/m3) in Kyrgyzstan (95%CI 25.7-40.8), but all remain above the WHO guidelines. CO-levels remain below the WHO guidelines. After intervention, symptoms and infections diminish significantly in Uganda and Kyrgyzstan, and to a smaller extent in Vietnam. Quantitative assessment indicates high acceptance of the new cookstoves/heaters. In conclusion, locally tailored implementation of improved cookstoves/heaters is acceptable and has considerable effects on respiratory symptoms and indoor pollution, yet mean PM2.5 levels remain above WHO recommendations.European Union’s Horizon 2020 programme under grant agreement no. 680997, TRIAL ID NTR5759, http://www.trialregister.nl/trialreg/admin/rctsearch.asp?Term=23332. The devices, measuring the personal HAP, were funded by Netherlands Enterprise Agency (RVO
Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis
- Author
- A Benetos
- A Smogorzewska
- Alison M. Dunning
- AM Joshua
- AM Valdes
- Amanda Ewart Toland
- BM Unryn
- CB Harley
- CM Raynaud
- EH Blackburn
- EH Blackburn
- ES Epel
- Göran Roos
- H der-Sarkissian
- H. Dean Hosgood
- HD Hosgood 3rd
- HJ Sommerfeld
- Hongxia Ma
- HR Kim
- HX An
- I De Vivo
- IK Moon
- IM Lee
- J Barwell
- J Han
- J Lau
- J Prescott
- J Shen
- J Shen
- J Xing
- JA Van Ziffle
- JP Higgins
- JS Jang
- K Broberg
- K Nordfjall
- KA Pooley
- Karen A. Pooley
- KK Wong
- L Fern
- L Hou
- L Mirabello
- L Mirabello
- L Shao
- LA Panossian
- M Baudis
- M Egger
- M Kammori
- M McGrath
- MA Blasco
- MA Blasco
- Min Shen
- MM Gramatges
- MT Hemann
- N Mantel
- NF Mathon
- PE Slagboom
- Q Lan
- Qingyi Wei
- R Capper
- R DerSimonian
- RA Risques
- RC Allsopp
- RY Zee
- S Brouilette
- SA Stewart
- SE Artandi
- SE Artandi
- Sheng Wei
- SM Gadalla
- SU Wiemann
- T Idei
- T von Zglinicki
- T von Zglinicki
- T von Zglinicki
- U Friedrich
- U Svenson
- Ulrika Svenson
- VG Gorgoulis
- X Liu
- X Wu
- Y Kinouchi
- YL Zheng
- Zhensheng Liu
- Ziyuan Zhou
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
BACKGROUND: Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting. METHODS: A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. Heterogeneity among studies and their publication bias were further assessed by the χ(2)-based Q statistic test and Egger's test, respectively. RESULTS: The results showed that shorter telomeres were significantly associated with cancer risk (OR = 1.35, 95% CI = 1.14-1.60), compared with longer telomeres. In the stratified analysis by tumor type, the association remained significant in subgroups of bladder cancer (OR = 1.84, 95% CI = 1.38-2.44), lung cancer (OR = 2.39, 95% CI = 1.18-4.88), smoking-related cancers (OR = 2.25, 95% CI = 1.83-2.78), cancers in the digestive system (OR = 1.69, 95% CI = 1.53-1.87) and the urogenital system (OR = 1.73, 95% CI = 1.12-2.67). Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis (P = 0.532). CONCLUSIONS: The results of this meta-analysis suggest that the presence of shortened telomeres may be a marker for susceptibility to human cancer, but single larger, well-design prospective studies are warranted to confirm these findings
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
- Agnello M.
- Agostinis P.
- Agrewala J. N.
- Agrotis A.
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- Ahmad S. T.
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- Ahumada-Castro U.
- Aits S.
- Aizawa S.
- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
- Aliwaini S.
- Alizadeh J.
- Almacellas E.
- Almasan A.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
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- Alves SC
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- Amargianitakis V
- Amaro R
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- Amerongen MP
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- Cinnella G
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- Harm S
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- Harrison D
- Harrison M
- Hart N
- Hart R
- Hartmann J
- Hashimoto Y
- Hassanin H
- Hatakeyama J
- Hatib F
- Hawkins K
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- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayashi K
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- Hebert P
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- Helmy TA
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- Helyar S
- Hempel D
- Henderson MA
- Hendra H
- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández G
- Hernández-Tejedor A
- Herpain A
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
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- Hidalgo C
- Hikasa Y
- Hillier SD
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- Himpe D
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- Hirata A
- Hirayama T
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- Hodgson LE
- Hodgson LE
- Hofmeijer J
- Hollands S
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- Hopkins PA
- Hoppu S
- Hoppu S
- Horkan CM
- Horstmann C
- Horton A
- Horvat A
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- Houzé S
- Houzé S
- Howes D
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- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
- Hualde JB
- Hualde JB
- Hualde JB
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- Hualde JB
- Hualde JB
- Huang CH
- Huang WC
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- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
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- Ishimatsu S
- Itenov TS
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- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
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- Jian Z
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katabami K
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- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
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- Kellner F
- Kelly JM
- Kenardy J
- Keough E
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- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
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- Kim KS
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- Kim MH
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- Kim W
- Kimmoun A
- King HS
- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
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- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
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- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
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- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
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- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Latini R
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- Latini R
- Latorre J
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- Laureys S
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- Lawrence N
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- Lee EY
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- Legrand M
- Legrand M
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- Leitao AL
- Leite RT
- Leonard H
- Leone M
- Leone M
- Lerma FA
- Lesmes SP
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- Lheureux O
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- Li SH
- Liao X
- Lichtenstein D
- Lim TH
- Limuti R
- Lin KC
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- Lin WC
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- Lischinsky A
- Lissonde F
- Lissonde F
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- Liu CP
- Liu CP
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- Liu D
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- Llorente B
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- Lobato MS
- Lobo-Civico A
- Loizou C
- Lombardo MD
- Londoño JG
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- Lopez R
- Lopez-Caler C
- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
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- Lotay R
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- Louf-Durier A
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- Louis B
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- Lukaszewicz AC
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- MacPhee I
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- Maekawa K
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- Merino-Vega D
- Messenger D
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Romero I
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- Romeu JD
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- Rossini P
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- Rota L
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- Spadaro S
- Spadaro S
- Spahn DR
- Spatenkova V
- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
- St George’s University of London
- Stamm J
- Stamouli M
- Stanić R
- Starczewska M
- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
- Stiphout C
- Stocchetti N
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- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
- Stümpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
- Sullivan E
- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
- Sylla P
- Sáez VC
- Sánchez B
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- Sánchez MJ
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- Sánchez PC
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- Sánchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
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- Taggu A
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- Takahashi H
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- Tokyo Womens Medical University
- Tomas E
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- Vinsonneau C
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- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
- Vucic M
- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
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- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
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- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
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- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
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- Zogheib E
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- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Quantitative trait loci of stripe rust resistance in wheat
- Author
- A Börner
- AH Carter
- AJ Worland
- AN Mishra
- BL Huynh
- C Uauy
- C. X. Lan
- CW Hiebert
- CX Lan
- D Fu
- DK Santra
- ES Lagudah
- ES McFadden
- F Dedryver
- F Lin
- F Lin
- G. M. Rosewarne
- GM Agenbag
- GM Francki
- GM Rosewarne
- GM Rosewarne
- GM Rosewarne
- HH Flor
- HM William
- HS Bariana
- HS Bariana
- HS Bariana
- HW Ohm
- J Feng
- J. Huerta-Espino
- JA Kolmer
- JE Parlevliet
- JE Plank Van der
- JPE Melichar
- K Suenaga
- LJ Jagger
- M Akbari
- M Lillemo
- MD Vazquez
- MVP Rao
- N Boukhatem
- P Chhuneja
- P Mantovani
- Q Guo
- R Kota
- R Mago
- R. P. Singh
- RA McIntosh
- RP Singh
- RP Singh
- RP Singh
- RS Zwart
- S Mallard
- S. A. Herrera-Foessel
- SA Herrera-Foessel
- SA Herrera-Fossel
- SG Krattinger
- VP Ramburan
- W Farrer
- W Spielmeyer
- XM Chen
- Y Ren
- Y Ren
- YF Hao
- YM Lu
- Z. H. He
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ion formation upon electron collisions with valine embedded in helium nanodroplets
- Author
- A. Mauracher
- A. Mauracher
- A. Mauracher
- A. Mauracher
- A.F. Lago
- A.W. Hauser
- Alexander Kaiser
- B. Bellina
- B.C. Ibǎnescu
- C. Leidlmair
- Diethard K. Böhme
- E. Alizadeh
- F. Bierau
- F. Ferreira da Silva
- F. Ferreira da Silva
- F. Ferreira da Silva
- F. Zappa
- H. Dögg Flosadottir
- H. Schöbel
- H.-W. Jochims
- I. Baccarelli
- J. Postler
- J.-C. Poully
- J.P. Toennies
- K. Martini
- L. An der Lan
- L.F. Gomez
- M. Allan
- M. Goulart
- M. Neustetter
- M. Renzler
- M. Rosenblit
- M. Rosenblit
- M.A. Śmiałek
- Martina Harnisch
- Michael Renzler
- N.B. Brauer
- Nikolaus Weinberger
- O. Echt
- P. Papp
- P. Papp
- Paul Scheier
- R. Janečková
- R. Sliter
- S. Denifl
- S. Denifl
- S. Denifl
- S. Denifl
- S. Maclot
- S. Ralser
- S.E. Huber
- S.F. Yang
- Stefan Denifl
- Stefan Ralser
- T. Schlathölter
- U. Henne
- V. Vorsa
- W. Kong
- W. Wei
- X. Zhang
- Y. Hu
- Y. Ren
- Y. Ren
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
COPD’s early origins in low-and-middle income countries: what are the implications of a false start?
- Author
- J.F.M. van boven
- L.T. van
- Akmatalieva M.
- Akylbekov A.
- An P.L.
- Anastasaki M.
- Barton A.
- Bertsias A.
- Binh P.D.U.
- Brakema E.A.
- Burges D.
- Cartwright L.
- Chatzea V.E.
- Chavannes N.H.
- Cragg L.
- Dang T.N.
- Dautov I.
- Emilov B.
- Ferarrio I.
- FRESH AIR Collaborators
- Gemert F.A. van
- Hedrick B.
- Hong L.H.T.C.
- Hopkinson N.
- Isaeva E.
- Jones R.
- Jong C. de
- Kampen S. van
- Katagira W.
- Kirenga B.
- Kjaergaard J.
- Kleij R.M.J.J. van der
- Kocks J.
- Lan L.T.T.
- Linh T.T.D.
- Lionis C.
- Loan K.X.
- Mademilov M.
- McEwen A.
- Musinguzi P.
- Nantanda R.
- Ndeezi G.
- Papadakis S.
- Pinnock H.
- Pooler J.
- Poot C.
- Postma M.J.
- Poulsen A.
- Powell P.
- Puhan M.
- Quynh N.N.
- Reventlow S.
- Salvi S.
- Sifaki-Pistolla D.
- Singh S.
- Sooronbaev T.
- Sousa J.C. de
- Stout J.
- Stubbe-Ostergaard M.
- Tabyshova A.
- Tsiligianni I.
- Tuan T.D.
- Tumwine J.
- Vinh N.N.
- Walusimbi S.
- Warren L.
- Williams S.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
[Excerpt] The Global Initiative for chronic Obstructive Lung disease (GOLD)guideline of 2018 describes COPD as‘the result of a complexinterplay of long-term cumulative exposure to noxious gases andparticles, combined with a variety of host factors includinggenetics, airway hyper-responsiveness and poor lung growthduring childhood’.1Tobacco smoking is traditionally viewed as themain contributing factor to the development of COPD. However,COPD also occurs among non-smokers, especially in low-incomeand middle-income countries (LMICs).2,3Notably, more than 90%of COPD-related deaths occur in LMICs.4For these countries, otherrisk factors, such as ambient, occupational and household airpollution play a significant role in the development of COPD.1,2,5–7Does COPD in these settings have a different pathophysiologicaltrajectory compared to COPD in high-income countries, and if so:what does this imply?In normal lung development, airway branching is completed bythe 17th week of gestation, after which airways increase in volumeuntil young adulthood. Alveoli are present at birth and developfurther during childhood. Lung volume and airflow continue toincrease as the thorax grows, influenced by age, sex, and ethnicity,reaching a peak at young adulthood. Lung function then remainsconstant for about 10 years (the plateau phase), after which itgradually declines.8In the‘classic’COPD patient, the decline inlung function is more rapid than in healthy individuals. However,in a considerable proportion of COPD patients, lung function doesnot decline rapidly, but reaches a lower plateau phase in earlyadulthood instead. For these patients, a completely differentpathophysiological trajectory seems to lead to the diagnosis ofCOPD: the decline in lung function follows a normal pattern, yetthey seem to have a‘false start’by attaining a lower maximumlung function. [...
Inhibition of protein ubiquitination by paraquat and 1-methyl-4-phenylpyridinium impairs ubiquitin-dependent protein degradation pathways
- Author
- A Anandhan
- A Chorfa
- A Chorfa
- A Garcia-Garcia
- A Jong de
- A Lau
- A Yamamuro
- AB Manning-Bog
- AB Manning-Bog
- AM Choi
- AM Cuervo
- AN Carvalho
- Annadurai Anandhan
- Annemieke de Jong
- B Caneda-Ferron
- B Fauvet
- Betzabet Quintanilla-Vega
- Bo Yarabe
- BP Monia
- BY Zeng
- C Cook
- C Dixon
- C Klein
- C Liu
- C Marques
- C Oh
- CL Simms
- CM Tanner
- CR Berkers
- CS Cho
- D Ebrahimi-Fakhari
- D Lan
- D Martins-Branco
- D Petroi
- D Scholz
- D Yao
- DC Rubinsztein
- DJ Klionsky
- DM Sampathu
- DW Miller
- E Gomez-Tortosa
- E Kuusisto
- E Kuusisto
- Erin Bradley
- F Buttgereit
- F Fornai
- F Kamel
- F Liu
- F Meier
- F Shang
- F Shang
- F Shang
- F Sun
- F Sun
- F Yang
- FK Lee
- FM Cunha da
- G Asher
- G Srivastava
- GK Tofaris
- GK Tofaris
- H Jang
- H Rodriguez-Rocha
- H Rodriguez-Rocha
- H Sawada
- HA Lashuel
- Huib Ovaa
- I Ahmed
- Iryna Bohovych
- J Bove
- J Choi
- J Fang
- J Gal
- J Hanna
- J Jahngen-Hodge
- J Klucken
- J Lim
- J Ling
- J Long
- J Navarro-Yepes
- J Trinh
- J Wills
- JB Martins
- JF Linares
- JG Lee
- JH Kordower
- JH Stack
- JL Webb
- JM Gorell
- JR Babu
- JT Lee
- Juliana Navarro-Yepes
- JX Song
- K Okada
- K Prasad
- K Tanaka
- K Tanji
- K Wakabayashi
- K Zatloukal
- KK Chung
- KS McNaught
- KS McNaught
- KS McNaught
- L Wang
- L Yang
- LG Friedman
- LJ Corcoran
- M Caballero
- M Haj-Yahya
- M Kastle
- M Komatsu
- M Mark van der
- M Obin
- M Shamoto-Nagai
- M Tanaka
- M Zhu
- MF Notter
- MG Spillantini
- MJ Clague
- ML Seibenhener
- MW Wooten
- N Chondrogianni
- N Kadoguchi
- N Myeku
- N Myeku
- N Wei
- NF Bence
- NF Bence
- Oleh Khalimonchuk
- P Corish
- P Goel
- PH Weinreb
- Q Ding
- Q Ding
- Q Ding
- Q Xu
- R Betarbet
- R Endo
- R Shringarpure
- RA Dunlop
- RL Levine
- Rodrigo Franco
- RS Sohal
- S Giordano
- S Kageyama
- S Kuzuhara
- S Lei
- S Luo
- S Mitra
- S Odagiri
- S Shaid
- S Waelter
- S Zucchelli
- SA Mulherkar
- SB Janen
- SM Goldman
- SR Subramaniam
- T Bartels
- T Hara
- T Ishii
- T Ravid
- TA Yacoubian
- U Dettmer
- U Nagaoka
- UB Pandey
- V Khurana
- V Rogov
- VI Korolchuk
- VI Korolchuk
- W Seufert
- W Xie
- W Yang
- WM Caudle
- X Li
- X Li
- X Shan
- X Shan
- X Zhang
- XF Wang
- XM Cotto-Rios
- Y Bang
- Y Chang
- Y Huang
- Y Saito
- Y Watanabe
- Y Watanabe
- Y Yang
- YH Seo
- YM Kim
- You Zhou
- ZI Alam
- Publication venue
- DigitalCommons@University of Nebraska - Lincoln
- Publication date
- 01/01/2016
- Field of study
Intracytoplasmic inclusions of protein aggregates in dopaminergic cells (Lewy bodies) are the pathological hallmark of Parkinson’s disease (PD). Ubiquitin (Ub), alpha [α]-synuclein, p62/sequestosome 1 and oxidized proteins are major components of Lewy bodies. However, the mechanisms involved in the impairment of misfolded/oxidized protein degradation pathways in PD are still unclear. PD is linked to mitochondrial dysfunction and environmental pesticide exposure. In this work, we evaluated the effect of the pesticide paraquat (PQ) and the mitochondrial toxin 1-methyl-4-phenylpyridinium (MPP+) on Ub-dependent protein degradation pathways. No increase in the accumulation of Ub-bound proteins or aggregates was observed in dopaminergic cells (SK-N-SH) treated with PQ or MPP+, or in mice chronically exposed to PQ. PQ decreased Ub protein content, but not its mRNA transcription. Protein synthesis inhibition with cycloheximide depleted Ub levels and potentiated PQ–induced cell death. Inhibition of proteasomal activity by PQ was found to be a late event in cell death progression, and had no effect on either the toxicity of MPP+ or PQ, or the accumulation of oxidized sulfenylated, sulfonylated (DJ-1/PARK7 and peroxiredoxins) and carbonylated proteins induced by PQ. PQ- and MPP+-induced Ub protein depletion prompted the dimerization/inactivation of the Ub-binding protein p62 that regulates the clearance of ubiquitinated proteins by autophagic. We confirmed that PQ and MPP+ impaired autophagy flux, and that the blockage of autophagy by the overexpression of a dominant-negative form of the autophagy protein 5 (dnAtg5) stimulated their toxicity, but there was no additional effect upon inhibition of the proteasome. PQ induced an increase in the accumulation of α-synuclein in dopaminergic cells and membrane associated foci in yeast cells. Our results demonstrate that inhibition of protein ubiquitination by PQ and MPP+ is involved in the dysfunction of Ub-dependent protein degradation pathways
Perspectives on the use of transcriptomics to advance biofuels
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- Ezeji T Blaschek HP
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- Fischer CR Klein-Marcuschamer D, Stephanopoulos
- Fitzgerald D Stratford M, Gasson M, et al.
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- Lütke-Eversloh T Bahl H
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- Macdonald J Master ER
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
As a field within the energy research sector, bioenergy is continuously expanding. Although much has been achieved and the yields of both ethanol and butanol have been improved, many avenues of research to further increase these yields still remain. This review covers current research related with transcriptomics and the application of this high-throughput analytical tool to engineer both microbes and plants with the penultimate goal being better biofuel production and yields. The initial focus is given to the responses of fermentative microbes during the fermentative production of acids, such as butyric acid, and solvents, including ethanol and butanol. As plants offer the greatest natural renewable source of fermentable sugars within the form of lignocellulose, the second focus area is the transcriptional responses of microbes when exposed to plant hydrolysates and lignin-related compounds. This is of particular importance as the acid/base hydrolysis methods commonly employed to make the plant-based cellulose available for enzymatic hydrolysis to sugars also generates significant amounts of lignin-derivatives that are inhibitory to fermentative bacteria and microbes. The article then transitions to transcriptional analyses of lignin-degrading organisms, such as Phanerochaete chrysosporium, as an alternative to acid/base hydrolysis. The final portion of this article will discuss recent transcriptome analyses of plants and, in particular, the genes involved in lignin production. The rationale behind these studies is to eventually reduce the lignin content present within these plants and, consequently, the amount of inhibitors generated during the acid/base hydrolysis of the lignocelluloses. All four of these topics represent key areas where transcriptomic research is currently being conducted to identify microbial genes and their responses to products and inhibitors as well as those related with lignin degradation/formation.clos
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