1,558 research outputs found
Synchronization of coupled single-electron circuits based on nanoparticles and tunneling junctions
We explore theoretically the synchronization properties of a device composed of coupled single-electron circuits whose building blocks are nanoparticles interconnected with tunneling junctions. Elementary nanoscillators can be achieved by a single-electron tunneling cell where the relaxation oscillation is induced by the tunneling. We develop a model to describe the synchronization of the nanoscillators and present sample calculations to demonstrate that the idea is feasible and could readily find applications. Instead of considering a particular system, we analyze the general properties of the device making use of an ideal model that emphasizes the essential characteristics of the concept. We define an order parameter for the system as a whole and demonstrate phase synchronization for sufficiently high values of the coupling [email protected] [email protected] [email protected]
Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii
Acinetobacter baumannii is an important human pathogen that can form biofilms and persist under harsh environmental conditions. Biofilm formation and virulence are modulated by blue light, which is thought to be regulated by a BLUF protein, BlsA. To understand the molecular mechanism of light sensing, we have used steady-state and ultrafast vibrational spectroscopy to compare the photoactivation mechanism of BlsA to the BLUF photosensor AppA from Rhodobacter sphaeroides. Although similar photocycles are observed, vibrational data together with homology modeling identify significant differences in the β5 strand in BlsA caused by photoactivation, which are proposed to be directly linked to downstream signaling
Facile one-pot synthesis of amoxicillin-coated gold nanoparticles and their antimicrobial activity
Nanomaterials have been the object of intense study due to promising applications in a number of different disciplines. In particular, medicine and biology have seen the potential of these novel materials with their nanoscale properties for use in diverse areas such as imaging, sensing and drug vectorisation. Gold nanoparticles (GNPs) are considered a very useful platform to create a valid and efficient drug delivery/carrier system due to their facile and well-studied synthesis, easy surface functionalization and biocompatibility. In the present study, stable antibiotic conjugated GNPs were synthesised by a one-step reaction using a poorly water soluble antibiotic, amoxicillin. Amoxicillin, a member of the penicillin family, reduces the chloroauric acid to form nanoparticles and at the same time coats them to afford the functionalised nanomaterial. A range of techniques including UV-vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA) were used to ascertain the gold/drug molar ratio and the optimum temperature for synthesis of uniform monodisperse particles in the ca. 30-40 nm size range. Amoxicillin-conjugated gold showed an enhancement of antibacterial activity against Escherichia coli compared to the antibiotic alone
Yukawa-unified natural supersymmetry
Previous work on t-b-\tau Yukawa-unified supersymmetry, as expected from SUSY
GUT theories based on the gauge group SO(10), tended to have exceedingly large
electroweak fine-tuning (EWFT). Here, we examine supersymmetric models where we
simultaneously require low EWFT ("natural SUSY") and a high degree of Yukawa
coupling unification, along with a light Higgs scalar with m_h\sim125 GeV. As
Yukawa unification requires large tan\beta\sim50, while EWFT requires rather
light third generation squarks and low \mu\sim100-250 GeV, B-physics
constraints from BR(B\to X_s\gamma) and BR(B_s\to \mu+\mu-) can be severe. We
are able to find models with EWFT \Delta\lesssim 50-100 (better than 1-2% EWFT)
and with Yukawa unification as low as R_yuk\sim1.3 (30% unification) if
B-physics constraints are imposed. This may be improved to R_yuk\sim1.2 if
additional small flavor violating terms conspire to improve accord with
B-constraints. We present several Yukawa-unified natural SUSY (YUNS) benchmark
points. LHC searches will be able to access gluinos in the lower 1-2 TeV
portion of their predicted mass range although much of YUNS parameter space may
lie beyond LHC14 reach. If heavy Higgs bosons can be accessed at a high rate,
then the rare H, A\to \mu+\mu- decay might allow a determination of
tan\beta\sim50 as predicted by YUNS models. Finally, the predicted light
higgsinos should be accessible to a linear e+e- collider with \sqrt{s}\sim0.5
TeV.Comment: 18 pages, 7 figures, pdflatex; 3 references adde
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Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa
Background: Transmission of drug susceptible and drug resistant TB occurs in health care facilities, and community and households settings, particularly in highly prevalent TB and HIV areas. There is a paucity of data regarding factors that may affect TB transmission risk in household settings. We evaluated air exchange and the impact of natural ventilation on estimated TB transmission risk in traditional Zulu homes in rural South Africa. Methods: We utilized a carbon dioxide decay technique to measure ventilation in air changes per hour (ACH). We evaluated predominant home types to determine factors affecting ACH and used the Wells-Riley equation to estimate TB transmission risk. Results: Two hundred eighteen ventilation measurements were taken in 24 traditional homes. All had low ventilation at baseline when windows were closed (mean ACH = 3, SD = 3.0), with estimated TB transmission risk of 55.4% over a ten hour period of exposure to an infectious TB patient. There was significant improvement with opening windows and door, reaching a mean ACH of 20 (SD = 13.1, p < 0.0001) resulting in significant decrease in estimated TB transmission risk to 9.6% (p < 0.0001). Multivariate analysis identified factors predicting ACH, including ventilation conditions (windows/doors open) and window to volume ratio. Expanding ventilation increased the odds of achieving ≥12 ACH by 60-fold. Conclusions: There is high estimated risk of TB transmission in traditional homes of infectious TB patients in rural South Africa. Improving natural ventilation may decrease household TB transmission risk and, combined with other strategies, may enhance TB control efforts
Stop the Top Background of the Stop Search
The main background for the supersymmetric stop direct production search
comes from Standard Model ttbar events. For the single-lepton search channel,
we introduce a few kinematic variables to further suppress this background by
focusing on its dileptonic and semileptonic topologies. All are defined to have
end points in the background, but not signal distributions. They can
substantially improve the stop signal significance and mass reach when combined
with traditional kinematic variables such as the total missing transverse
energy. Among them, our variable M^W_T2 has the best overall performance
because it uses all available kinematic information, including the on-shell
mass of both W's. We see 20%-30% improvement on the discovery significance and
estimate that the 8 TeV LHC run with 20 fb-1 of data would be able to reach an
exclusion limit of 650-700 GeV for direct stop production, as long as the stop
decays dominantly to the top quark and a light stable neutralino. Most of the
mass range required for the supersymmetric solution of the naturalness problem
in the standard scenario can be covered.Comment: 16 pages, 5 figure
Independent movement of cusps during occlusal loading
An integrated experimental and theoretical approach is proposed for the evaluation of stress within a natural tooth during bruxing. A physical model was developed that used strain gauges bonded to the buccal and lingual heights of contour of extracted, intact maxillary premolar teeth for the validation of a two-dimensional finite element model of a natural, intact maxillary premolar tooth. Results from the finite element model were in good agreement with the experimental results. The tooth exhibits "cuspal independence", which describes the relative independence of the loaded cusp from the remaining cusp that is not loaded. In other words, the control cusp does not demonstrate significant strain when the adjacent cusp is loaded. The overall stiffness of the tooth does not appear to be significantly affected by separation of the enamel of the two cusps and appears to be primarily a function of the dentin.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29249/1/0000306.pd
Fitting Neutrino Physics with a U(1)_R Lepton Number
We study neutrino physics in the context of a supersymmetric model where a
continuous R-symmetry is identified with the total Lepton Number and one
sneutrino can thus play the role of the down type Higgs. We show that
R-breaking effects communicated to the visible sector by Anomaly Mediation can
reproduce neutrino masses and mixing solely via radiative contributions,
without requiring any additional degree of freedom. In particular, a relatively
large reactor angle (as recently observed by the Daya Bay collaboration) can be
accommodated in ample regions of the parameter space. On the contrary, if the
R-breaking is communicated to the visible sector by gravitational effects at
the Planck scale, additional particles are necessary to accommodate neutrino
data.Comment: 19 pages, 3 figures; v2: references added, constraints updated,
overall conclusions unchange
BLUF Domain Function Does Not Require a Metastable Radical Intermediate State
BLUF
(blue light using flavin) domain proteins are an important
family of blue light-sensing proteins which control a wide variety
of functions in cells. The primary light-activated step in the BLUF
domain is not yet established. A number of experimental and theoretical
studies points to a role for photoinduced electron transfer (PET)
between a highly conserved tyrosine and the flavin chromophore to
form a radical intermediate state. Here we investigate the role of
PET in three different BLUF proteins, using ultrafast broadband transient
infrared spectroscopy. We characterize and identify infrared active
marker modes for excited and ground state species and use them to
record photochemical dynamics in the proteins. We also generate mutants
which unambiguously show PET and, through isotope labeling of the
protein and the chromophore, are able to assign modes characteristic
of both flavin and protein radical states. We find that these radical
intermediates are not observed in two of the three BLUF domains studied,
casting doubt on the importance of the formation of a population of
radical intermediates in the BLUF photocycle. Further, unnatural amino
acid mutagenesis is used to replace the conserved tyrosine with fluorotyrosines,
thus modifying the driving force for the proposed electron transfer
reaction; the rate changes observed are also not consistent with a
PET mechanism. Thus, while intermediates of PET reactions can be observed
in BLUF proteins they are not correlated with photoactivity, suggesting
that radical intermediates are not central to their operation. Alternative
nonradical pathways including a keto–enol tautomerization induced
by electronic excitation of the flavin ring are considered
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