1,372 research outputs found
The Optical System for the Large Size Telescope of the Cherenkov Telescope Array
The Large Size Telescope (LST) of the Cherenkov Telescope Array (CTA) is
designed to achieve a threshold energy of 20 GeV. The LST optics is composed of
one parabolic primary mirror 23 m in diameter and 28 m focal length. The
reflector dish is segmented in 198 hexagonal, 1.51 m flat to flat mirrors. The
total effective reflective area, taking into account the shadow of the
mechanical structure, is about 368 m. The mirrors have a sandwich structure
consisting of a glass sheet of 2.7 mm thickness, aluminum honeycomb of 60 mm
thickness, and another glass sheet on the rear, and have a total weight about
47 kg. The mirror surface is produced using a sputtering deposition technique
to apply a 5-layer coating, and the mirrors reach a reflectivity of 94%
at peak. The mirror facets are actively aligned during operations by an active
mirror control system, using actuators, CMOS cameras and a reference laser.
Each mirror facet carries a CMOS camera, which measures the position of the
light spot of the optical axis reference laser on the target of the telescope
camera. The two actuators and the universal joint of each mirror facet are
respectively fixed to three neighboring joints of the dish space frame, via
specially designed interface plate.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
A novel role for microglia in minimizing excitotoxicity
Microglia are the abundant, resident myeloid cells of the central nervous system (CNS) that become rapidly activated in response to injury or inflammation. While most studies of microglia focus on this phenomenon, little is known about the function of 'resting' microglia, which possess fine, branching cellular processes. Biber and colleagues, in a recent paper in Journal of Neuroinflammation, report that ramified microglia can limit excitotoxicity, an important insight for understanding mechanisms that limit neuron death in CNS disease
Sequence learning in Associative Neuronal-Astrocytic Network
The neuronal paradigm of studying the brain has left us with limitations in
both our understanding of how neurons process information to achieve biological
intelligence and how such knowledge may be translated into artificial
intelligence and its most brain-derived branch, neuromorphic computing.
Overturning our fundamental assumptions of how the brain works, the recent
exploration of astrocytes is revealing that these long-neglected brain cells
dynamically regulate learning by interacting with neuronal activity at the
synaptic level. Following recent experimental evidence, we designed an
associative, Hopfield-type, neuronal-astrocytic network and analyzed the
dynamics of the interaction between neurons and astrocytes. We show that
astrocytes were sufficient to trigger transitions between learned memories in
the neuronal component of the network. Further, we mathematically derived the
timing of the transitions that was governed by the dynamics of the
calcium-dependent slow-currents in the astrocytic processes. Overall, we
provide a brain-morphic mechanism for sequence learning that is inspired by,
and aligns with, recent experimental findings. To evaluate our model, we
emulated astrocytic atrophy and showed that memory recall becomes significantly
impaired after a critical point of affected astrocytes was reached. This
brain-inspired and brain-validated approach supports our ongoing efforts to
incorporate non-neuronal computing elements in neuromorphic information
processing.Comment: 8 pages, 5 figure
Experimental study of the sensitivity of a porous silicon ring resonator sensor using continuous in-flow measurements
A highly sensitive photonic sensor based on a porous silicon ring resonator was developed and experimentally characterized. The photonic sensing structure was fabricated by exploiting a porous silicon double layer, where the top layer of a low porosity was used to form photonic elements by e-beam lithography and the bottom layer of a high porosity was used to confine light in the vertical direction. The sensing performance of the ring resonator sensor based on porous silicon was compared for the different resonances within the analyzed wavelength range both for transverse-electric and transverse-magnetic polarizations. We determined that a sensitivity up to 439 nm/RIU for low refractive index changes can be achieved depending on the optical field distribution given by each resonance/polarization
The Fermi Bubble as a Source of Cosmic Rays in the Energy Range > 10E15 eV
The {\it Fermi} Large Area Telescope has recently discovered two giant
gamma-ray bubbles which extend north and south of the Galactic center with
diameters and heights of the order of kpc. We suggest that the
periodic star capture processes by the Galactic supermassive black hole Sgr
A, with a capture rate of
yr and an energy release of erg per capture, can
result in hot plasma injecting into the Galactic halo at a wind velocity of
cm s. The periodic injection of hot plasma can produce a
series of shocks. Energetic protons in the bubble are re-accelerated when they
interact with these shocks. We show that for energy larger than
eV, the acceleration process can be better described by the stochastic
second-order Fermi acceleration.
We propose that hadronic cosmic rays (CRs) within the ``knee'' of the
observed CR spectrum are produced by Galactic supernova remnants distributed in
the Galactic disk. Re-acceleration of these particles in the Fermi Bubble
produces CRs beyond the knee. With a mean CR diffusion coefficient in this
energy range in the bubble cm s, we can
reproduce the spectral index of the spectrum beyond the knee and within. The
conversion efficiency from shock energy of the bubble into CR energy is about
10\%. This model provides a natural explanation of the observed CR flux,
spectral indices, and matching of spectra at the knee.Comment: 43 pages, 8 figues, to be published in the Astrophysical Journal;
version 2, 45 pages, 8 figures, added references and corrected typo
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic machinery. Besides in vitro environmental exposures, the possible impact on the reprogramming of methylation profiles at imprinted genes at a much earlier time point, such as during spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to determine associations between preconceptional obesity and DNA methylation profiles in the offspring, particularly at the differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene
The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NFκB Feedback
Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease
The RINGO2 and DIPOL optical polarization catalogue of blazars
We present ∼2000 polarimetric and ∼3000 photometric observations of 15 γ-ray bright blazars over a period of 936 days (2008-10-11 to 2012-10-26) using data from the Tuorla blazar monitoring program (KVA DIPOL) and Liverpool Telescope (LT) RINGO2 polarimeters (supplemented with data from SkyCamZ (LT) and Fermi-LAT γ-ray data). In 11 out of 15 sources we identify a total of 19 electric vector position angle (EVPA) rotations and 95 flaring episodes. We group the sources into subclasses based on their broad-band spectral characteristics and compare their observed optical and γ-ray properties. We find that (1) the optical magnitude and γ-ray flux are positively correlated, (2) EVPA rotations can occur in any blazar subclass, four sources show rotations that go in one direction and immediately rotate back, (3) we see no difference in the γ-ray flaring rates in the sample; flares can occur during and outside of rotations with no preference for this behaviour, (4) the average degree of polarization (DoP), optical magnitude and γ-ray flux are lower during an EVPA rotation compared with during non-rotation and the distribution of the DoP during EVPA rotations is not drawn from the same parent sample as the distribution outside rotations, (5) the number of observed flaring events and optical polarization rotations are correlated, however we find no strong evidence for a temporal association between individual flares and rotations and (6) the maximum observed DoP increases from ∼10 per cent to ∼30 per cent to ∼40 per cent for subclasses with synchrotron peaks at high, intermediate and low frequencies, respectively
The Cherenkov Telescope Array Large Size Telescope
The two arrays of the Very High Energy gamma-ray observatory Cherenkov
Telescope Array (CTA) will include four Large Size Telescopes (LSTs) each with
a 23 m diameter dish and 28 m focal distance. These telescopes will enable CTA
to achieve a low-energy threshold of 20 GeV, which is critical for important
studies in astrophysics, astroparticle physics and cosmology. This work
presents the key specifications and performance of the current LST design in
the light of the CTA scientific objectives.Comment: 4 pages, 5 figures, In Proceedings of the 33rd International Cosmic
Ray Conference (ICRC2013), Rio de Janeiro (Brazil). All CTA contributions at
arXiv:1307.223
Optical spectroscopy of Blazars for the Cherenkov Telescope Array
Context. Blazars are the most numerous class of High Energy (HE; E about 50
MeV - few 100 GeV) and Very High Energy (VHE; E about 100 GeV - 10 TeV)
gamma-ray emitters. As of today, a measured spectroscopic redshift is available
for only about 50% of gamma-ray BL Lacs, mainly due to the difficulty of
measuring reliable redshifts from their nearly featureless, continuum-dominated
optical spectra. The knowledge of the redshift is fundamental for understanding
the emission from blazars, for population studies and also for indirect studies
of the extragalactic background light and searches for Lorentz invariance
violation and axion-like particles using blazars. Aims. This paper is the first
of a series of papers which aim to measure the redshift of a sample of blazars
likely to be detected with the upcoming Cherenkov Telescope Array (CTA), a
ground based gamma-ray observatory. Methods. Monte Carlo simulations were
performed to select those hard spectrum gamma-ray blazars detected with the
Fermi-LAT telescope still lacking redshift measurements but likely to be
detected by CTA in 30 hours of observing time or less. Optical observing
campaigns involving deep imaging and spectroscopic observations were organised
to efficiently constrain their redshifts. We performed deep medium to high
resolution spectroscopy of nineteen blazar optical counterparts using the ESI
spectrograph at Keck, the RSS spectrograph at the SALT telescope, and the
EFOSC2 spectrograph at the ESO NTT. We searched systematically for spectral
features and, when possible, we estimated the contribution of the host galaxy
to the total flux. Results. We measured eleven firm spectroscopic redshifts
with values ranging from 0.1116 to 0.482. one tentative redshift, three
redshift lower limits including one at z > 0.449 and another at z > 0.868.
There were four objects found to have featureless spectra.Comment: Accepted by Astronomy & Astrophysic
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