185 research outputs found
Extension of holomorphic functions and cohomology classes from non reduced analytic subvarieties
The goal of this survey is to describe some recent results concerning the L 2
extension of holomorphic sections or cohomology classes with values in vector
bundles satisfying weak semi-positivity properties. The results presented here
are generalized versions of the Ohsawa-Takegoshi extension theorem, and borrow
many techniques from the long series of papers by T. Ohsawa. The recent
achievement that we want to point out is that the surjectivity property holds
true for restriction morphisms to non necessarily reduced subvarieties,
provided these are defined as zero varieties of multiplier ideal sheaves. The
new idea involved to approach the existence problem is to make use of L 2
approximation in the Bochner-Kodaira technique. The extension results hold
under curvature conditions that look pretty optimal. However, a major unsolved
problem is to obtain natural (and hopefully best possible) L 2 estimates for
the extension in the case of non reduced subvarieties -- the case when Y has
singularities or several irreducible components is also a substantial issue.Comment: arXiv admin note: text overlap with arXiv:1703.00292,
arXiv:1510.0523
Resistive and magnetized accretion flows with convection
We considered the effects of convection on the radiatively inefficient
accretion flows (RIAF) in the presence of resistivity and toroidal magnetic
field. We discussed the effects of convection on transports of angular momentum
and energy. We established two cases for the resistive and magnetized RIAFs
with convection: assuming the convection parameter as a free parameter and
using mixing-length theory to calculate convection parameter. A self-similar
method was used to solve the integrated equations that govern the behavior of
the presented model. The solutions showed that the accretion and rotational
velocities decrease by adding the convection parameter, while the sound speed
increases. Moreover, by using mixing-length theory to calculate convection
parameter, we found that the convection can be important in RIAFs with magnetic
field and resistivity.Comment: 7 pages, 3 figures, accepted by Ap&S
The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation. Pharmacologically enforced egress of hematopoietic stem cells from BM, or mobilization, has been achieved by directly or indirectly targeting the CXCL12/CXCR4 axis. Shortcomings of the standard mobilizing agent, granulocyte colony-stimulating factor (G-CSF), administered alone or in combination with the only approved CXCR4 antagonist, Plerixafor, continue to fuel the quest for new mobilizing agents. Using Protein Epitope Mimetics technology, a novel peptidic CXCR4 antagonist, POL5551, was developed. In vitro data presented herein indicate high affinity to and specificity for CXCR4. POL5551 exhibited rapid mobilization kinetics and unprecedented efficiency in C57BL/6 mice, exceeding that of Plerixafor and at higher doses also of G-CSF. POL5551-mobilized stem cells demonstrated adequate transplantation properties. In contrast to G-CSF, POL5551 did not induce major morphological changes in the BM of mice. Moreover, we provide evidence of direct POL5551 binding to hematopoietic stem and progenitor cells (HSPCs) in vivo, strengthening the hypothesis that CXCR4 antagonists mediate mobilization by direct targeting of HSPCs. In summary, POL5551 is a potent mobilizing agent for HSPCs in mice with promising therapeutic potential if these data can be orroborated in humans
Postural instability in an immersive Virtual Reality adapts with repetition and includes directional and gender specific effects
The ability to handle sensory conflicts and use the most appropriate sensory information is vital for successful recovery of human postural control after injury. The objective was to determine if virtual reality (VR) could provide a vehicle for sensory training, and determine the temporal and spatial nature of such adaptive changes. Twenty healthy subjects participated in the study (10 females). The subjects watched a 90-second VR simulation of railroad (rollercoaster) motion in mountainous terrain during five repeated simulations, while standing on a force platform that recorded their stability. The immediate response to watching the VR movie was an increased level of postural instability. Repeatedly watching the same VR movie significantly reduced both the anteroposterior (62%, p < 0.001) and lateral (47%, p = 0.001) energy used. However, females adapted more slowly to the VR stimuli as reflected by higher use of total (p = 0.007), low frequency (p = 0.027) and high frequency (p = 0.026) energy. Healthy subjects can significantly adapt to a multidirectional, provocative, visual environment after 4–5 repeated sessions of VR. Consequently, VR technology might be an effective tool for rehabilitation involving visual desensitisation. However, some females may require more training sessions to achieve effects with VR
The effectiveness of the Screening Inventory of Psychosocial Problems (SIPP) in cancer patients treated with radiotherapy: design of a cluster randomised controlled trial
Self-Similar Solutions for Viscous and Resistive ADAF
In this paper, the self-similar solution of resistive advection dominated
accretion flows (ADAF) in the presence of a pure azimuthal magnetic field is
investigated. The mechanism of energy dissipation is assumed to be the
viscosity and the magnetic diffusivity due to turbulence in the accretion flow.
It is assumed that the magnetic diffusivity and the kinematic viscosity are not
constant and vary by position and -prescription is used for them. In
order to solve the integrated equations that govern the behavior of the
accretion flow, a self-similar method is used. The solutions show that the
structure of accretion flow depends on the magnetic field and the magnetic
diffusivity. As, the radial infall velocity and the temperature of the flow
increase, and the rotational velocity decreases. Also, the rotational velocity
for all selected values of magnetic diffusivity and magnetic field is
sub-Keplerian. The solutions show that there is a certain amount of magnetic
field that the rotational velocity of the flow becomes zero. This amount of the
magnetic field depends on the gas properties of the disc, such as adiabatic
index and viscosity, magnetic diffusivity, and advection parameters. The
solutions show the mass accretion rate increases by adding the magnetic
diffusivity and in high magnetic pressure case, the ratio of the mass accretion
rate to the Bondi accretion rate decreases as magnetic field increases. Also,
the study of Lundquist and magnetic Reynolds numbers based on resistivity
indicates that the linear growth of magnetorotational instability (MRI) of the
flow decreases by resistivity. This property is qualitatively consistent with
resistive magnetohydrodynamics (MHD) simulations.Comment: 18 pages, 3 figures, accepted by JA&
Bunnell or cross-lock Bunnell suture for tendon repair? Defining the biomechanical role of suture pretension
Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer
patients with newly diagnosed lung cance
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors
No abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34295/1/2_ftp.pd
Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer
Previous studies suggested that omega-3 fatty acids (FAs) have therapeutic effects against depression, but there is no evidence in the oncological setting. Our preliminary study reported the association between lower omega-3 FA intake and occurrence of depression in lung cancer patients. To explore the association further, the present study examined whether depression was associated with lower levels of omega-3 FAs in serum phospholipids. A total of 717 subjects in the Lung Cancer Database Project were divided into three groups by two cutoff points of the Hospital Anxiety and Depression Scale depression subscale (HADS-D). In all, 81 subjects of the nondepression and minor depression groups (HADS-D<5 and 5⩽HADS-D⩽10, respectively) were selected to match with 81 subjects of the major depression group (HADS-D>10) for age, gender, clinical stage, and performance status. Fatty acids were assayed by gas chromatography and compared among the three matched groups. There were no differences between the major depression group and nondepression group in any FAs. The minor depression group had higher mean levels of docosahexaenoic acid (mean±s.d. (%), nondepression: 7.40±1.54; minor depression: 7.90±1.40; major depression: 7.25±1.52, P=0.017). These results suggested that serum FAs are associated with minor, but not major, depression in lung cancer patients
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