Two- and three-pion finite-volume spectra at maximal isospin from lattice QCD

We present the three-pion spectrum with maximal isospin in a finite volume determined from lattice QCD, including excited states in addition to the ground states across various irreducible representations at zero and nonzero total momentum. The required correlation functions, from which the spectrum is extracted, are computed using a newly implemented algorithm which speeds up the computation by more than an order of magnitude. On a subset of the data we extract a nonzero value of the three-pion threshold scattering amplitude using the $1/L$ expansion of the three-particle quantization condition, which consistently describes all states at zero total momentum. The finite-volume spectrum is publicly available to facilitate further explorations within the available three-particle finite-volume approaches.Comment: 10 pages, 5 figures; added discussion of 1/L expansion, matches published versio

Multi-hadron spectroscopy in a large physical volume

We demonstrate the efficacy of the stochastic LapH method to treat all-to-all quark propagation on a $N_f = 2+1$ CLS ensemble with large linear spatial extent $L = 5.5$ fm, allowing us to obtain the benchmark elastic isovector p-wave pion-pion scattering amplitude to good precision already on a relatively small number of gauge configurations. These results hold promise for multi-hadron spectroscopy at close-to-physical pion mass with exponential finite-volume effects under control.Comment: 8 pages, 4 figures. Presented at Lattice 2017, the 35th International Symposium on Lattice Field Theory, Granada, Spain, 18-24 June 201

Chiral perturbation theory for 2+1+1 flavor of Wilson quarks with twisted masses

Wir besprechen die Konstruktion der chiralen Störungstheorie (Chiral Perturbation Theory, ChPT) als effektive Theorie für das Niedrigenergieverhalten der Quantenchromodynamik (QCD). Wir fassen ihre Erweiterung zur Beschreibung von Cutoff-Effekten durch die Formulierung der QCD auf einer diskreten Raumzeit, so genannte Gitter-QCD, mit Wilson-Fermionen zusammen. Insbesondere können auch Wilson-Fermionen mit chiral verdrehtem Massenterm im Rahmen der twisted mass Wilson Chiral Perturbation Theory (tmWChPT) untersucht werden. Wir setzen dann die geeignete effektive Theorie zur Beschreibung aktueller Gitter-QCD-Simulationen mit 2+1+1 dynamischen Quarks mit separat getwisteten Massen im leichten und schweren Sektor auf. Insbesondere behandeln wir die Mesonen, die Charm-Quarks beinhalten, nicht als Pseudo-Goldstone-Bosonen der spontan gebrochenen näherungsweisen chiralen Symmetrie, um für die Phänomenologie nutzbare Formeln zu erhalten, die für schwere D-Mesonen gültig sind. Wir konstruieren den so genannten "charmless Lagrangian" und berechnen exemplarisch Pion- und Kaonmassen sowie -zerfallskonstanten zur Einschleifenordnung. Wir finden von den Kontinuumsresultaten abweichende Ausdrücke. Insbesondere finden wir zusätzliche chirale Logarithmen ohne Pendant in Kontinuums-ChPT, die die Ergebnisse anfällig für verstärkte Finite Volume-Korrekturen machen. Wir schätzen den systematischen Effekt durch Vernachlässigung dieser neuen Terme in der Analyse von Daten der European Twisted Mass Collaboration (ETMC) als vergleichbar groß wie die derzeitigen statistischen Unsicherheiten ein.We briefly review the construction of Chiral Perturbation Theory as an effective theory for the low-energy behavior of Quantum Chromodynamics (QCD). We then summarize its extension to describe cutoff effects induced by formulating QCD on a discrete space-time grid (Lattice QCD) with Wilson fermions. Particularly, Wilson fermions with twisted masses can be studied in the framework of twisted mass Wilson Chiral Perturbation Theory (tmWChPT). We then proceed to setting up the appropriate effective theory to describe recent lattice QCD simulations with 2+1+1 dynamical Wilson quark flavors and twisted masses in the light and heavy sector respectively. We avoid treating the pseudoscalar mesons including charm quark as pseudo Goldstone bosons of a spontaneously broken chiral symmetry to provide accurate formulae for phenomenological applications. After constructing the so-called charmless Lagrangian we exemplarily compute pion masses, kaon masses and decay constants to one loop. We find that the respective expressions differ from continuum ChPT results and that additional chiral logs predispose the results to exhanced finite volume corrections. We estimate the systematic effect of neglecting the novel terms in the analysis of data from the European Twisted Mass Collaboration (ETMC) to be of the same order of magnitude as current statistical uncertainties

The elastic I=3/2I=3/2 pp-wave nucleon-pion scattering amplitude and the Δ(1232)\Delta(1232) resonance from Nf=2+1N_{\mathrm{f}}=2+1 lattice QCD

We present the first direct determination of meson-baryon resonance parameters from a scattering amplitude calculated using lattice QCD. In particular, we calculate the elastic $I=3/2$, $p$-wave nucleon-pion amplitude on a single ensemble of $N_{\mathrm{f}}=2+1$ Wilson-clover fermions with $m_{\pi}=280\mathrm{MeV}$ and $m_{K}=460\mathrm{MeV}$. At these quark masses, the $\Delta(1232)$ resonance pole is found close to the $N-\pi$ threshold and a Breit-Wigner fit to the amplitude gives $g^{\mathrm{BW}}_{\Delta N\pi}=19.0(4.7)$ in agreement with phenomenological determinations.Comment: 7 pages, 2 figures. Agrees with published version, one additional phase shift point and clarification of different coupling convention

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen.

Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast cancer cell lines was studied. Northern blot analysis revealed a decrease in hAR steady state RNA levels in LNCaP cells by 3.3 nht of the synthetic androgen mibolerone. Maximal down-regulation of hAR RNA to 30% of control levels occurred 48 h after hormone addition. T47D breast cancer cells showed a similar effect with mibolerone, while hAR expression in normal skin fibroblasts did not respond to androgen treatment. As shown by nuclease Sl analysis, hAR transcripts initiate at three principal start sites, all of which are equally sensitive to androgen. Steroidal as well as nonsteroidal antiandrogens were capable of partially antagonizing androgen-mediated hAR RNA down-regulation in LNCaP and T47D cells, while not exerting a significant effect when administered alone. While hAR RNA stability was increased by hormone, nuclear run-on analysis revealed a 4-fold reduction of hAR gene transcrip tion 98 h after androgen treatment. Although decreased hAR RNA levels did not coincide with a parallel decrease in AR protein levels, analysis of androgen-inducible reporter constructs demonstrated that prolonged androgen administration to ceils results in a progressively impaired sensitivity of the intracellular androgen response mechanism. These results show that prolonged androgen exposure leads, besides its effect on hAR RNA levels, to functional inactivation of the AR. Thus, in viva, posttranslational control of AR activity appears to be a novel mechanism of negative autoregulation of androgen effects on gene expression

Aerogel keystones: extraction of complete hypervelocity impact events from aerogel collectors

In January 2006, the Stardust mission will return the first samples from a solid solar-system body since Apollo, and the first samples of contemporary interstellar dust ever collected. Although sophisticated laboratory instruments exist for the analysis of Stardust samples, techniques for the recovery of particles and particle residues from aerogel collectors remain primitive. Here we describe our recent progress in developing techniques for extracting small volumes of aerogel, which we have called ``keystones,'' which completely contain particle impacts but minimize the damage to the surrounding aerogel collector. These keystones can be fixed to custom-designed micromachined silicon fixtures (so-called ``microforklifts''). In this configuration the samples are self-supporting, which can be advantageous in situations in which interference from a supporting substrate is undesirable. The keystones may also be extracted and placed onto a substrate without a fixture. We have also demonstrated the capability of homologously crushing these unmounted keystones for analysis techniques which demand flat samples.Comment: 17 pages, 11 figures, submitted to Meteoritics and Planetary Scienc

Patients with Borderline Personality Disorder Not Participating in an RCT: Are They Different?

Background: Despite the notion that randomized controlled trials are regarded as the gold standard in psychotherapy research, questions about their generalizability have been raised. This paper focuses on the differences between participants and eligible nonparticipants of a randomized controlled trial for patients with borderline personality disorder (BPD). Sampling and Methods: One hundred forty-two patients were screened, and 122 were found eligible for study participation. Out of these, 64 patients (52.5%) gave informed consent and were included in the study. Results: The 58 eligible nonparticipants showed a lower level of functioning (global assessment of functioning score), had a history of more outpatient treatment attempts and were living alone more often. Regarding acute symptoms and severity of BPD as indexed by suicide attempts, inpatient treatments, substance abuse and history of trauma, no differences between the groups could be detected. Moreover, participants showed significantly more eating disorders, whereas nonparticipants presented more affective and anxiety disorders. Conclusions: The results indicate that lower psychosocial functioning and comorbid affective and anxiety disorders decrease BPD patients' willingness to participate in an RCT. Copyright (C) 2010 S. Karger AG, Base

The Relationship between Personality Organization and Psychiatric Classification in Chronic Pain Patients

The assessment of PO is a crucial issue for diagnosis and treatment planning in CPPs, since it represents a measure of structural impairment that is to a considerable extent independent of axis I and II diagnoses. Moreover, the STIPO dimensional rating focuses on the most salient dysfunctions at a given time. Copyright (C) 2010 S. Karger AG, BaselBackground: The present study investigated the relationship between psychiatric classification and personality organization (PO) in a secondary/tertiary clinical sample of chronic pain patients (CPPs). Sampling and Methods: Forty-three patients were administered the Structured Clinical Interview for DSM-IV (SCID I+II) and the Structured Interview of Personality Organization (STIPO). The prevalence of axis I and axis II disorders was correlated with the STIPO level of PO. The STIPO dimensional ratings of patients without personality disorder (PD) were compared to those of patients diagnosed with one or more PDs. Results: Axis I comorbidity was high (93%), and 63% of the patients met the criteria for at least one axis II diagnosis. Twenty-five patients (58%) were diagnosed as borderline PO, with high-level impairments in the dimensions `coping/rigidity', `primitive defenses' and `identity'. Higher axis I and axis II comorbidity corresponded with greater severity of PO impairment. No difference was found between the dimensional ratings of patients without PD and those of patients with one or more PDs. Conclusions