407 research outputs found
Is who you ask important? Concordance between survey and registry data on medication use among self- and proxy-respondents in the longitudinal study of aging Danish twins and the Danish 1905-cohort study
This work was supported by the U.S. National Institute of Health (P01AG031719, R01AG026786 and 2P01AG031719), the VELUX Foundation, and the Max Planck Society within the framework of the project “On the edge of societies: New vulnerable populations, emerging challenges for social policies and future demands for social innovation. The experience of the Baltic Sea States (2016–2021).”Background This study investigates the accuracy of the reporting of medication use by proxy- and self-respondents, and it compares the prognostic value of the number of medications from survey and registry data for predicting mortality across self- and proxy-respondents. Methods The study is based on the linkage of the Longitudinal Study of Aging Danish Twins and the Danish 1905–Cohort Study with the Danish National Prescription Registry. We investigated the concordance between survey and registry data, and the prognostic value of medication use when assessed using survey and registry data, to predict mortality for self- and proxy-respondents at intake surveys. Results Among self-respondents, the agreement was moderate (κ = 0.52–0.58) for most therapeutic groups, whereas among proxy-respondents, the agreement was low to moderate (κ = 0.36–0.60). The magnitude of the relative differences was, generally, greater among proxies than among self-respondents. Each additional increase in the total number of medications was associated with 7%–8% mortality increase among self- and 4%–6% mortality increase among proxy-respondents in both the survey and registry data. The predictive value of the total number of medications estimated from either data source was lower among proxies (c-statistic = 0.56–0.58) than among self-respondents (c-statistic = 0.74). Conclusions The concordance between survey and registry data regarding medication use and the predictive value of the number of medications for mortality were lower among proxy- than among self-respondents.Publisher PDFPeer reviewe
From covariant to canonical formulations of discrete gravity
Starting from an action for discretized gravity we derive a canonical
formalism that exactly reproduces the dynamics and (broken) symmetries of the
covariant formalism. For linearized Regge calculus on a flat background --
which exhibits exact gauge symmetries -- we derive local and first class
constraints for arbitrary triangulated Cauchy surfaces. These constraints have
a clear geometric interpretation and are a first step towards obtaining
anomaly--free constraint algebras for canonical lattice gravity. Taking higher
order dynamics into account the symmetries of the action are broken. This
results in consistency conditions on the background gauge parameters arising
from the lowest non--linear equations of motion. In the canonical framework the
constraints to quadratic order turn out to depend on the background gauge
parameters and are therefore pseudo constraints. These considerations are
important for connecting path integral and canonical quantizations of gravity,
in particular if one attempts a perturbative expansion.Comment: 37 pages, 5 figures (minor modifications, matches published version +
updated references
(Broken) Gauge Symmetries and Constraints in Regge Calculus
We will examine the issue of diffeomorphism symmetry in simplicial models of
(quantum) gravity, in particular for Regge calculus. We find that for a
solution with curvature there do not exist exact gauge symmetries on the
discrete level. Furthermore we derive a canonical formulation that exactly
matches the dynamics and hence symmetries of the covariant picture. In this
canonical formulation broken symmetries lead to the replacements of constraints
by so--called pseudo constraints. These considerations should be taken into
account in attempts to connect spin foam models, based on the Regge action,
with canonical loop quantum gravity, which aims at implementing proper
constraints. We will argue that the long standing problem of finding a
consistent constraint algebra for discretized gravity theories is equivalent to
the problem of finding an action with exact diffeomorphism symmetries. Finally
we will analyze different limits in which the pseudo constraints might turn
into proper constraints. This could be helpful to infer alternative
discretization schemes in which the symmetries are not broken.Comment: 32 pages, 15 figure
Nonradiative lifetime extraction using power-dependent relative photoluminescence of III-V semiconductor double-heterostructures
A power-dependent relative photoluminescence measurement method is developed for double-heterostructures composed of III-V semiconductors. Analyzing the data yields insight into the radiative efficiency of the absorbing layer as a function of laser intensity. Four GaAs samples of different thicknesses are characterized, and the measured data are corrected for dependencies of carrier concentration and photon recycling. This correction procedure is described and discussed in detail in order to determine the material's Shockley-Read-Hall lifetime as a function of excitation intensity. The procedure assumes 100% internal radiative efficiency under the highest injection conditions, and we show this leads to less than 0.5% uncertainty. The resulting GaAs material demonstrates a 5.7 ± 0.5 ns nonradiative lifetime across all samples of similar doping (2–3 × 10^(17) cm^(−3)) for an injected excess carrier concentration below 4 × 10^(12) cm^(−3). This increases considerably up to longer than 1 μs under high injection levels due to a trap saturation effect. The method is also shown to give insight into bulk and interface recombination
Interfering Doorway States and Giant Resonances. I: Resonance Spectrum and Multipole Strengths
A phenomenological schematic model of multipole giant resonances (GR) is
considered which treats the external interaction via common decay channels on
the same footing as the coherent part of the internal residual interaction. The
damping due to the coupling to the sea of complicated states is neglected. As a
result, the formation of GR is governed by the interplay and competition of two
kinds of collectivity, the internal and the external one. The mixing of the
doorway components of a GR due to the external interaction influences
significantly their multipole strengths, widths and positions in energy. In
particular, a narrow resonance state with an appreciable multipole strength is
formed when the doorway components strongly overlap.Comment: 20 pages, LaTeX, 3 ps-figures, to appear in PRC (July 1997
Universal Sequencing on an Unreliable Machine
We consider scheduling on an unreliable machine that may experience unexpected changes in processing speed or even full breakdowns. Our objective is to minimize ∑ wjf(Cj) for any nondecreasing, nonnegative, differentiable cost function f(Cj). We aim for a universal solution that performs well without adaptation for all cost functions for any possible machine behavior. We design a deterministic algorithm that finds a universal scheduling sequence with a solution value within 4 times the value of an optimal clairvoyant algorithm that knows the machine behavior in advance. A randomized version of this algorithm attains in expectation a ratio of e. We also show that both performance guarantees are best possible for any unbounded cost function. Our algorithms can be adapted to run in polynomial time with slightly increased cost. When jobs have individual release dates, the situation changes drastically. Even if all weights are equal, there are instances for which any universal solution is a factor of Ω(log n / log log n) worse than an optimal sequence for any unbounded cost function. Motivated by this hardness, we study the special case when the processing time of each job is proportional to its weight. We present a nontrivial algorithm with a small constant performance guarantee
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