1,384 research outputs found
A First Comparison of the responses of a He4-based fast-neutron detector and a NE-213 liquid-scintillator reference detector
A first comparison has been made between the pulse-shape discrimination
characteristics of a novel He-based pressurized scintillation detector
and a NE-213 liquid-scintillator reference detector using an Am/Be mixed-field
neutron and gamma-ray source and a high-resolution scintillation-pulse
digitizer. In particular, the capabilities of the two fast neutron detectors to
discriminate between neutrons and gamma-rays were investigated. The NE-213
liquid-scintillator reference cell produced a wide range of scintillation-light
yields in response to the gamma-ray field of the source. In stark contrast, due
to the size and pressure of the He gas volume, the He-based
detector registered a maximum scintillation-light yield of 750~keV to
the same gamma-ray field. Pulse-shape discrimination for particles with
scintillation-light yields of more than 750~keV was excellent in the
case of the He-based detector. Above 750~keV its signal was
unambiguously neutron, enabling particle identification based entirely upon the
amount of scintillation light produced.Comment: 23 pages, 7 figures, Nuclear Instruments and Methods in Physics
Research Section A review addresse
On the biological relevance of MHC class II and B7 expression by tumour cells in melanoma metastases
A large number of studies have indicated that specific immune reactivity plays a crucial role in the control of malignant melanoma. In this context, expression of MHC I, MHC II and B7 molecules by melanoma cells is seen as relevant for the immune response against the tumour. For a better understanding of the biological relevance of MHC II and B7 expression by tumour cells in metastatic melanoma, we studied the expression of these molecules in melanoma metastases in relation to the inflammatory response, regression of the tumour and survival from 27 patients treated with biochemotherapy (30 mg m−2 Cisplatin and 250 mg m−2 decarbazine (dimethyl-triazene-imidazole-carboxamide, DTIC) on days 1–3 i.v., and 107 IU IFN-α2b 3 days a week s.c., q. 28d). In 19 out of 27 lesions studied, we found expression of MHC II by the tumour cells, while only in one out of 11 tumour biopsies obtained from untreated metastatic melanoma patients, MHC II expression was detected. Expression of B7.1 and B7.2 by tumour cells was found in nine out of 24 and 19 out of 24 lesions, respectively. In all cases where B7.1 expression was found, expression of B7.2 by the tumour cells was also seen. In general, no or only few inflammatory cells positive for B7 were found. Expression of MHC II by tumour cells was positively correlated with the presence of tumour-infiltrating lymphocytes, regression of the lesion, and with time to progression (TTP) and overall survival (OS) of the patient. However, no significant correlation between B7.1 or B7.2 expression and regression of the tumour, TTP or OS was found. In light of other recent findings, these data altogether do support a role as biomarker for MHC II expression by tumour cells; however, its exact immunological pathomechanism(s) remain to be established
DJ-1 Mutations are Rare in a Swedish Parkinson Cohort
Mutations in the PARK7 gene, DJ-1, have been reported to cause early-onset and familial Parkinson’s disease (PD). The function of DJ-1 and how it contributes to the development of the disease is not clear today, but several studies report that DJ-1 is responsive to oxidative stress and important for the maintenance of mitochondria. We have screened three coding regions of DJ-1 (exon 2, 5 and 7) in a Swedish Parkinson cohort. The Swedish PD material consisted of 67 patients with a self reported positive family history of PD and 77 patients with early-onset of disease (≤50 years old). We detected two patients with the previously reported synonymous mutation, Ala167Ala (c.501A>G, rs71653621), in exon 7. No Ala167Ala carriers were identified among 213 neurologically healthy Swedish controls. Mechanisms by which the synonymous Ala167Ala mutation can have consequences are unknown. It may affect the mRNA stability, secondary structure of mRNA, synthesis, turnover, protein folding and function. We could show a 1.3% decrease in DJ-1 mRNA folding energy in the A<G substituted sequence compared to the wild type sequence in silico, suggesting a possible small effect of Ala167Ala on DJ-1 gene function. This is the first report on an identified DJ-1 mutation in Swedish PD patients. Our results, in combination with those of previous studies, strengthen the hypothesis that alterations in DJ-1 are not a common cause of familial and early-onset PD world-wide
Tagging fast neutrons from an 241Am/9Be source
We report on an investigation of the fast-neutron spectrum emitted by
241Am/9Be. Well-understood shielding, coincidence, and time-of-flight
measurement techniques are employed to produce a continuous, polychromatic,
energy-tagged neutron beam.Comment: 17 pages, 7 figures, submitted to Journal of Applied Radiation and
Isotope
10 Gbit/s error-free DPSK modulation using a push-pull dual-drive silicon modulator
[EN] We experimentally demonstrate a high-speed differential phase shift keying (DPSK) modulation using a silicon push-pull operated dual-drive Mach Zehnder modulator (MZM) based on carrier depletion. 5 Gbit/s and 10 Gbit/s error-free modulation is demonstrated by demodulating the generated DPSK modulated signal using a demodulation circuit based on a polarization delay interferometer through the use of a differential group delay (DGD). Furthermore, the potential for higher DPSK modulation speeds up to 20 Gbit/s is also demonstrated. The obtained results validate the potential to achieve higher order modulation formats, such as quadrature phase shift keying (QPSK), by arranging the MZM in a nested configuration. (C) 2013 Elsevier B.V. All rights reserved.Financial supports from HELIOS (Photonics Electronics Functional Integration on CMOS) FP7-224312 and Generalitat Valenciana under PROMETEO-2010-087 R&D Excellency Program (NANOMET) are acknowledged. M. Aamer and P. Sanchis thank Dr. Javier Herrera for his useful help. D.J. Thomson, F.Y. Gardes and G.T. Reed are supported by funding received from the UK EPSRC funding body under the grant “UK Silicon Photonics”.Aamer, M.; Thomson, DJ.; Gutiérrez Campo, AM.; Brimont, ACJ.; Gardes, FY.; Reed, GT.; Fedeli, JM.... (2013). 10 Gbit/s error-free DPSK modulation using a push-pull dual-drive silicon modulator. Optics Communications. 304:107-110. https://doi.org/10.1016/j.optcom.2013.04.051S10711030
The molybdenum isotopic composition of the modern ocean
Natural variations in the isotopic composition of molybdenum (Mo) are showing increasing potential as a tool in geochemistry. Although the ocean is an important reservoir of Mo, data on the isotopic composition of Mo in seawater are scarce. We have recently developed a new method for the precise determination of Mo isotope ratios on the basis of preconcentration using a chelating resin and measurement by multiple-collector inductively coupled plasma mass spectrometry (MC-ICP-MS), which allows us to measure every stable Mo isotope. In this study, 172 seawater samples obtained from 9 stations in the Pacific, Atlantic, and Southern Oceans were analyzed, giving global coverage and the first full depth-profiles. The average isotope composition in δA/95Mo (relative to a Johnson Matthey Mo standard solution) was as follows: δ92/95Mo = –2.54 ± 0.16‰ (2SD), δ94/95Mo = –0.73 ± 0.19‰, δ96/95Mo = 0.85 ± 0.07‰, δ97/95Mo = 1.68 ± 0.08‰, δ98/95Mo = 2.48 ± 0.10‰, and δ100/95Mo = 4.07 ± 0.18‰. The δ values showed an excellent linear correlation with atomic mass of AMo (R2 = 0.999). Three-isotope plots for the Mo isotopes were fitted with straight lines whose slopes agreed with theoretical values for mass-dependent isotope fractionation. These results demonstrate that Mo isotopes are both uniformly distributed and follow a mass-dependent fractionation law in the modern oxic ocean. A common Mo standard is urgently required for the precise comparison of Mo isotopic compositions measured in different laboratories. On the other hand, our results strongly support the possibility of seawater as an international reference material for Mo isotopic composition
A Search for Very High-Energy Gamma Rays from the Missing Link Binary Pulsar J1023+0038 with VERITAS
The binary millisecond radio pulsar PSR J1023+0038 exhibits many
characteristics similar to the gamma-ray binary system PSR B1259--63/LS 2883,
making it an ideal candidate for the study of high-energy non-thermal emission.
It has been the subject of multi-wavelength campaigns following the
disappearance of the pulsed radio emission in 2013 June, which revealed the
appearance of an accretion disk around the neutron star. We present the results
of very high-energy gamma-ray observations carried out by VERITAS before and
after this change of state. Searches for steady and pulsed emission of both
data sets yield no significant gamma-ray signal above 100 GeV, and upper limits
are given for both a steady and pulsed gamma-ray flux. These upper limits are
used to constrain the magnetic field strength in the shock region of the PSR
J1023+0038 system. Assuming that very high-energy gamma rays are produced via
an inverse-Compton mechanism in the shock region, we constrain the shock
magnetic field to be greater than 2 G before the disappearance of the
radio pulsar and greater than 10 G afterwards.Comment: 7 pages, 3 figures, accepted for publication in Ap
Very-High-Energy -Ray Observations of the Blazar 1ES 2344+514 with VERITAS
We present very-high-energy -ray observations of the BL Lac object
1ES 2344+514 taken by the Very Energetic Radiation Imaging Telescope Array
System (VERITAS) between 2007 and 2015. 1ES 2344+514 is detected with a
statistical significance above background of in hours
(livetime) of observations, making this the most comprehensive very-high-energy
study of 1ES 2344+514 to date. Using these observations the temporal properties
of 1ES 2344+514 are studied on short and long times scales. We fit a constant
flux model to nightly- and seasonally-binned light curves and apply a
fractional variability test, to determine the stability of the source on
different timescales. We reject the constant-flux model for the 2007-2008 and
2014-2015 nightly-binned light curves and for the long-term seasonally-binned
light curve at the level. The spectra of the time-averaged emission
before and after correction for attenuation by the extragalactic background
light are obtained. The observed time-averaged spectrum above 200 GeV is
satisfactorily fitted () by a power-law function with
index and extends to at least 8
TeV. The extragalactic-background-light-deabsorbed spectrum is adequately fit
() by a power-law function with index while an F-test indicates that the power-law with
exponential cutoff function provides a marginally-better fit ( =
) at the 2.1 level. The source location is found to be
consistent with the published radio location and its spatial extent is
consistent with a point source.Comment: 7 pages, 2 figures. Published in Monthly Notices of the Royal
Astronomical Societ
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