Turn-key module for neutron scattering with sub-micro-eV resolution

We report the development of a compact turn-key module that boosts the resolution in quasi-elastic neutron scattering by several orders of magnitude down to the low sub-micro-eV range. It is based on a pair of neutron resonance spin flippers that generate a well defined temporal intensity modulation, also known as MIEZE (Modulation of IntEnsity by Zero Effort). The module may be used under versatile conditions, in particular in applied magnetic fields and for depolarising and incoherently scattering samples. We demonstrate the power of MIEZE in studies of the helimagnetic order in MnSi under applied magnetic fields

Qualitätsentwicklung und Qualitässicherung in Schule und Schulsystem durch Evaluation

Der Beitrag ordnet den Evaluationsbegriff in die schulpädagogische Diskussion ein, gibt Auskunft über die Verbreitung von Evaluationskonzepten in der Bundesrepublik und im europäischen Ausland, fragt nach dem Sinn von Evaluation in der Schule, kennzeichnet Evaluation als Verfahren und schließt mit einem kritischen Resümée

Inhibition of caspase-2 translation by the mrna binding protein hur : a novel path of therapy resistance in colon carcinoma cells?

An increased expression and cytoplasmic abundance of the ubiquitous RNA binding protein human antigen R (HuR) is critically implicated in the dysregulated control of post-transcriptional gene expression during colorectal cancer development and is frequently associated with a high grade of malignancy and therapy resistance. Regardless of the fact that HuR elicits a broad cell survival program by increasing the stability of mRNAs coding for prominent anti-apoptotic factors, recent data suggest that HuR is critically involved in the regulation of translation, particularly, in the internal ribosome entry site (IRES) controlled translation of cell death regulatory proteins. Accordingly, data from human colon carcinoma cells revealed that HuR maintains constitutively reduced protein and activity levels of caspase-2 through negative interference with IRES-mediated translation. This review covers recent advances in the understanding of mechanisms underlying HuR’s modulatory activity on IRES-triggered translation. With respect to the unique regulatory features of caspase-2 and its multiple roles (e.g., in DNA-damage-induced apoptosis, cell cycle regulation and maintenance of genomic stability), the pathophysiological consequences of negative caspase-2 regulation by HuR and its impact on therapy resistance of colorectal cancers will be discussed in detail. The negative HuR-caspase-2 axis may offer a novel target for tumor sensitizing therapies