Impacts of permafrost degradation on infrastructure

The warming and thawing of ice-rich permafrost pose considerable threat to the integrity of polar and high-altitude infrastructure, in turn jeopardizing sustainable development. In this Review, we explore the extent and costs of observed and predicted infrastructure damage associated with permafrost degradation, and the methods available to mitigate such adverse consequences. Permafrost change imposes various threats to infrastructure, namely through warming, active layer thickening and thaw-related hazards such as thermokarst and mass wasting.These impacts, often linked to anthropogenic warming, are exacerbated through increased human activity. Observed infrastructure damage is substantial, with up to 80% of buildings in some Russian cities and -30% of some road surfaces in the Qinghai-Tibet Plateau reporting damage. Under anthropogenic warming, infrastructure damage is projected to continue, with 30-50% of critical circumpolar infrastructure thought to be at high risk by 2050. Accordingly, permafrost degradation-related infrastructure costs could rise to tens of billions of US dollars by the second half of the century. Several mitigation techniques exist to alleviate these impacts, including convection embankments, thermosyphons and piling foundations, with proven success at preserving and cooling permafrost and stabilizing infrastructure. To be effective, however, better understanding is needed on the regions at high risk.Peer reviewe

Long-term increases in soil carbon due to ecosystem fertilization by atmospheric nitrogen deposition demonstrated by regional-scale modelling and observations

Fertilization of nitrogen (N)-limited ecosystems by anthropogenic atmospheric nitrogen deposition (Ndep) may promote CO2 removal from the atmosphere, thereby buffering human effects on global radiative forcing. We used the biogeochemical ecosystem model N14CP, which considers interactions among C (carbon), N and P (phosphorus), driven by a new reconstruction of historical Ndep, to assess the responses of soil organic carbon (SOC) stocks in British semi-natural landscapes to anthropogenic change. We calculate that increased net primary production due to Ndep has enhanced detrital inputs of C to soils, causing an average increase of 1.2 kgCm−2 (c. 10%) in soil SOC over the period 1750–2010. The simulation results are consistent with observed changes in topsoil SOC concentration in the late 20th Century, derived from sample-resample measurements at nearly 2000 field sites. More than half (57%) of the additional topsoil SOC is predicted to have a short turnover time (c. 20 years), and will therefore be sensitive to future changes in Ndep. The results are the first to validate model predictions of Ndep effects against observations of SOC at a regional field scale. They demonstrate the importance of long-term macronutrient interactions and the transitory nature of soil responses in the terrestrial C cycle

Estimating the number of people who inject drugs in Australia

Abstract Background Injecting drug use is associated with considerable morbidity and mortality. Estimates of the size of the population of people who inject drugs are critical to inform service planning and estimate disease burden due to injecting drug use. We aimed to estimate the size of the population of people who inject drugs in Australia. Methods We applied a multiplier method which used benchmark data (number of people in opioid substitution therapy (OST) on a snapshot day in 2014) and multiplied it by a factor derived from the prevalence of current OST among people who inject drugs participating in the Australian Needle and Syringe Program Survey in 2014. Estimates of the total population of people who inject drugs were calculated in each state and territory and summed to produce a national estimate. We used the sex and age group distribution seen in datasets relating to people who inject drugs to derive sex- and age-stratified estimates, and calculated prevalence per 1000 population. Results Between 68,000 and 118,000 people aged 15–64 years inject drugs in Australia. The population prevalence of injecting drug use was 6.0 (lower and upper uncertainty intervals of 4.3 and 7.6) per 1000 people aged 15–64 years. Injecting drug use was more common among men than women, and most common among those aged 35–44 years. Comparison of expected drug-related deaths based on these estimates to actual deaths suggest that these figures may be underestimates. Conclusions These are the first indirect prevalence estimates of injecting drug use in Australia in over a decade. This work has identified that there are limited data available to inform estimates of this population. These estimates can be used as a basis for further work estimating injecting drug use in Australia

Scale dependence of the primordial spectrum from combining the three-year WMAP, Galaxy Clustering, Supernovae, and Lyman-alpha forests

We probe the scale dependence of the primordial spectrum in the light of the three-year WMAP (WMAP3) alone and WMAP3 in combination with the other cosmological observations such as galaxy clustering and Type Ia Supernova (SNIa). We pay particular attention to the combination with the Lyman $\alpha$ (Ly$\alpha$) forest. Different from the first-year WMAP (WMAP1), WMAP3's preference on the running of the scalar spectral index on the large scales is now fairly independent of the low CMB multipoles $\ell$. A combination with the galaxy power spectrum from the Sloan Digital Sky Survey (SDSS) prefers a negative running to larger than 2$\sigma$, regardless the presence of low $\ell$ CMB ($2\le \ell \le 23$) or not. On the other hand if we focus on the Power Law $\Lambda$CDM cosmology with only six parameters (matter density $\Omega_m h^2$, baryon density $\Omega_b h^2$, Hubble Constant $H_0$, optical depth $\tau$, the spectral index, $n_s$, and the amplitude, $A_s$, of the scalar perturbation spectrum) when we drop the low $\ell$ CMB contributions WMAP3 is consistent with the Harrison-Zel'dovich-Peebles scale-invariant spectrum ($n_s=1$ and no tensor contributions) at $\sim 1\sigma$. When assuming a simple power law primordial spectral index or a constant running, in case one drops the low $\ell$ contributions ($2\le \ell \le 23$) WMAP3 is consistent with the other observations better, such as the inferred value of $\sigma_8$. We also find, using a spectral shape with a minimal extension of the running spectral index model, LUQAS$+$ CROFT Ly$\alpha$ and SDSS Ly$\alpha$ exhibit somewhat different preference on the spectral shape.Comment: 16 pages, 13 figures Revtex

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Sodium icarbonate induces crystalline wax generation, activates host-resistance, and increases imazalil level in rind wounds of oranges, improving the control of green mold during shborage

Imazalil (IMZ) was quantified in the flavedo and albedo (Citrus fruits outer and inner tissue of the exocarp) of wounded and unwounded Valencia L. Olinda oranges following a 2 min immersion at 25 °C in 50, 100, or 250 μg mL−1 of the fungicide mixture with or without 3% sodium bicarbonate (SBC). The addition of SBC significantly reduced the decay incidence throughout 30 d of storage at 10 °C with 95% RH and 6 d of simulated marketing period at 25 °C and 75% RH. In unwounded oranges, IMZ uptake was not changed by the coapplication of SBC, and the fungicide was predominantly recovered in the flavedo. To the contrary, in the albedo of wounded fruit, the residue level increased by about 6-fold when the fungicide was applied with SBC. When SBC was coapplied to wounded fruit, the phytoalexin scoparone was induced in the albedo and the accumulation was not affected by IMZ. When fruit was treated with SBC, scanning electron microscopy observations evidenced a production of crystalline wax patches with branched stripes and the magnitude was positively correlated to the salt concentration in the mixture. The generation as fast as 24 h post-treatment, and the different morphology of the new wax suggests a displacement of intracuticular waxes which can affect the fungicide sorption and diffusion coefficient into the rind

Correspondences regarding UBC Library as the Canadian depository library for Japanese Government Publications (1957-1958)

Eight letters among the University of British Columbia, the Canadian Embassy, the National Library of Canada, the Canadian Library Association and the National Diet Library of Japan are listed. All are about designating the University of British Columbia as the Canadian depository library for Japanese Government Publications.Library, UBCNon UBCUnreviewedOthe