Fiera : feria de fanzines feministas

Identitat gràfica per a una fira de fanzines centrada en abordar temàtiques de gènere, que tindria lloc durant el cap de setmana més proper al vuit de març i que serviria com a plataforma des de la qual lluitar, reivindicar i celebrar.Identidad gráfica para una feria de fanzines centrada en abordar temáticas de género, que tendría lugar durante el fin de semana más próximo al ocho de marzo, y que serviría como plataforma desde la cual luchar, reivindicar y celebrar.Graphic identity for a zine fair focused on gender issues, that takes place during the closest weekend to the eight of March, with the purpose to become a platform to fight, claim and celebrate

Comparación de dos métodos para identificar los factores asociados al inicio del consumo de cannabis en un estudio de cohortes

ResumenObjetivoComparar la utilidad de 2 métodos analíticos multivariados, el análisis como casos y controles (CC) y como casos y controles anidados (CCa) en una cohorte, para identificar los factores asociados al inicio del consumo de cannabis.MétodosEstudio longitudinal con una muestra de 1.056 alumnos de primer curso de Educación Secundaria Obligatoria (ESO), seguidos anualmente hasta cuarto de ESO. En el análisis como CC se consideraron casos los que declararon, en el cuarto año, haber consumido cannabis y controles los que no habían consumido nunca, estimando modelos de regresión logística (RL). En el análisis como CCa, se compararon los casos de cada año de seguimiento con una muestra aleatoria de controles de riesgo en ese mismo año, estimando modelos de RL condicional.ResultadosEn el análisis como CC, se identificaron 6 variables en los chicos y 9 en las chicas en los modelos bivariados, y 3 en los chicos y 4 en las chicas en los multivariados. En el análisis como CCa se obtuvieron 17 variables en los modelos bivariados y 4 en los multivariados, tanto en los chicos como en las chicas. Los estimadores del análisis como CC tenían 1,2 veces más variabilidad.ConclusionesEl análisis como CCa permitió identificar un mayor número de factores asociados al consumo de cannabis y los estimadores fueron más precisos. El CCa puede ser una alternativa más eficiente frente al análisis como CC.AbstractObjectiveTo compare the utility of two multivariate analytic methods, case-control (CC) analysis and nested case-control (NCC) analysis in a cohort, to identify the factors associated with the onset of cannabis use.MethodsA longitudinal cohort study of a sample of secondary school students (n = 1,056) in the first year of secondary school was carried out. Participating students were followed-up annually until the fourth year of secondary school. In the CC analysis, students in the fourth year who reported having consumed cannabis at some time were considered cases and those who had never consumed cannabis were considered controls. Logistic regression (LR) models were estimated. In the NCC analysis, cases in each year of follow-up were compared with a random sample of controls at risk in the same year and conditional LR models were estimated. IResultsIn the CC analysis, 6 variables in boys and 9 variables in girls in bivariate models and 3 variables in boys and 4 variables in girls in multivariate models were identified. In the NCC analysis, 17 variables in univariate models and 4 in multivariate models were obtained in both boys and girls. The estimators of the CC analysis showed an average of 1.2-fold more variability.ConclusionsA higher number of factors associated with cannabis use were identified in the NCC analysis and the estimators were more precise. NCC could be a more efficient option than CC analysis

Design and optimization of a centrifugal pump’s impeller for hydro storage purposes. Overview on hybrid wind-hydro power dimensioning

Pumped Hydroelectric Energy Storage (PHES) is the most used bulk Electric Energy Storage (EES) technology with a global installed capacity of 130 GW. This technology combined with wind power creates a power technology named hybrid wind-hydro. A study case on a hybrid wind-hydro power plant is presented, analyzing in detail 2 different cases in which the plant can operate (with excess wind and with no wind). In the first case, the pump group will play the central role, being able to achieve a head of 200 m for the storage of the excess wind in the upper reservoir. A mathematical model is developed for centrifugal pumps using the pump NK 32-125/142 from Grundfos for such purpose. Lab tests are performed using this same pump to collect data for model validation. The impeller of the Grundfos pump has been optimized based on the mathematical model. Lab tests are conducted also for the new impeller to verify the optimization (despite not being presented in this report). Finally, the optimized impeller is up-scaled to suit the requirements of a 1 MW pump which can be used in the hybrid wind-hydro power plant. This last step will verify that the mathematical model is suitable for pumps of diverse size and application

Air pollution exposure during pregnancy and childhood, APOE ε4 status and Alzheimer polygenic risk score, and brain structural morphology in preadolescents

Apolipoprotein E; Genetic modifiers; NeurodevelopmentApolipoproteïna E; Modificadors genètics; NeurodesenvolupamentApolipoproteína E; Modificadores genéticos; NeurodesarrolloBackground Air pollution exposure is associated with impaired neurodevelopment, altered structural brain morphology in children, and neurodegenerative disorders. Differential susceptibility to air pollution may be influenced by genetic features. Objectives To evaluate whether the apolipoprotein E (APOE) genotype or the polygenic risk score (PRS) for Alzheimer's Disease (AD) modify the association between air pollution exposure during pregnancy and childhood and structural brain morphology in preadolescents. Methods We included 1186 children from the Generation R Study. Concentrations of fourteen air pollutants were calculated at participants’ home addresses during pregnancy and childhood using land-use-regression models. Structural brain images were collected at age 9–12 years to assess cortical and subcortical brain volumes. APOE status and PRS for AD were examined as genetic modifiers. Linear regression models were used to conduct single-pollutant and multi-pollutant (using the Deletion/Substitution/Addition algorithm) analyses with a two-way interaction between air pollution and each genetic modifier. Results Higher pregnancy coarse particulate matter (PMcoarse) and childhood polycyclic aromatic hydrocarbons exposure was differentially associated with larger cerebral white matter volume in APOE ε4 carriers compared to non-carriers (29,485 mm3 (95% CI 6,189; 52,781) and 18,663 mm3 (469; 36,856), respectively). Higher pregnancy PMcoarse exposure was differentially associated with larger cortical grey matter volume in children with higher compared to lower PRS for AD (19436 mm3 (825, 38,046)). Discussion APOE status and PRS for AD possibly modify the association between air pollution exposure and brain structural morphology in preadolescents. Higher air pollution exposure is associated with larger cortical volumes in APOE ε4 carriers and children with a high PRS for AD. This is in line with typical brain development, suggesting an antagonistic pleiotropic effect of these genetic features (i.e., protective effect in early-life, but neurodegenerative effect in adulthood). However, we cannot discard chance findings. Future studies should evaluate trajectorial brain development using a longitudinal design.The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam, and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. We gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam; the Erasmus University Rotterdam; the Netherlands Organization for Health Research and Development (ZonMw); the Netherlands Organization for Scientific Research (NWO); and the Ministry of Health, Welfare and Sport. A.N. was supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (024.001.003, Consortium on Individual Development), a grant of the Canadian Institutes of Health Research team, and by the Research Foundation Flanders (FWO). S.A. was supported by the Programa Talen_UAB-Banc de Santander. The geocodification of the addresses of the study participants and the air pollution estimations were done within the framework of a project funded by the Health Effects Institute (HEI) (Assistance Award No. R-82811201). We received funding from the Spanish Institute of Health Carlos III (CPII18/00018), the EU Commission (733,206, 824,989), and the Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (EST-18 RF-25). We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program”

Sleep problems at ages 8–9 and ADHD symptoms at ages 10–11:evidence in three cohorts from INMA study

Sleep problems and attention deficit hyperactivity disorder (ADHD) are interrelated during childhood and preadolescence. The objective of this work is assessing if sleep problems at ages 8–9 represent an alarm sign for presenting ADHD problems at ages 10–11 in three cohorts from INMA Study. Participants were 1244 children from Gipuzkoa, Sabadell, and Valencia cohorts. Sleep problems were assessed (ages 8–9) with the sleep items of the Child’s Behaviour Checklist (CBCL), and ADHD problems were collected through the Conner’s Parent Rating Scales-Revised: Short Form (CPRS-R:S) (age 10–11). Minimally and fully adjusted negative binomial models were fitted for each CPRS-R:S scale. Linearity of the relationship was assessed with generalized additive models (cubic smoothing splines with 2, 3, and 4 knots). For sensitivity analyses, children with previous symptoms, those born preterm and small for gestational age, and cases with extreme values, were excluded. Sleep problems presented IRR (95% CI) of 1.14 (1.10–1.19), 1.20 (1.14–1.26), 1.18 (1.11–1.25), and 1.18 (1.13–1.23) for opposition, inattention, hyperactivity, and ADHD scales, respectively. Fully adjusted models slightly decreased the IRR, but the association remained similar and significant. Sensitivity analyses showed similar results to fully adjusted models with only hyperactivity shown a slight decrease on significance (p = 0.051) when ADHD cases at age 9 were excluded. Conclusion: Sleep problems are an alarm sign for later neurodevelopment problems such as ADHD. Healthcare systems could take advantage implementing policies to pay special attention on the sleep habits and sleep hygiene. This could contribute to add evidence to public health programmes such as the Healthy Child Programme.</p

Методичні підходи до оцінки ефективності функціонування ринку праці в аграрному секторі економіки

Ціль статті - визначити методичні підходи до оцінки ефективності функціонування ринку праці в аграрному секторі економіки на сучасному етапі