Mejoramiento y ampliación del sistema de abastecimiento de agua potable para los centros poblados del distrito de Huáncano – Pisco

Publicación a texto completo no autorizada por el autorAnaliza, evalúa y da solución a los diferentes problemas del sistema de abastecimiento de agua potable de los centros poblados del distrito de Huáncano, en Pisco, provincia de Ica, Perú, con el fin de mejorar el servicio de agua potable, en cuanto al volumen y calidad, para la población en general, que no cuenta con un buen servicio debido ya que no existe un sistema adecuado a pesar de tener agua todo el año y siendo el caudal suficiente para abastecer a toda la población. Estudia los acuíferos como fuentes de alimentación existentes en la zona, así como el tipo de abastecimiento de agua potable para construir el nuevo sistema de abastecimiento de agua potable.Tesi

Plan de gestión logística para disminuir el impacto generado por la Covid-19 en la empresa Agrovision Perú S.A.C. 2020

La presente investigación se orientó a analiza cuales son los efectos del COVID-19 en la gestión de la empresa, para lo cual se realizó un diagnostico en donde se evidencian que existen problemas de gestión logística ya los proveedores actualmente ampliaron los plazos de entrega y disminuyeron su capacidad de atender todos los pedidos realizados. Es por ello que la propuesta se basa en generar acciones en el aprovisionamiento e inventarios, con lo cual se atacara directamente a los efectos del COVID-19 en la gestión de las operaciones de la empresa. Para esta investigación se llega a la conclusión de que se pueden aplicar una serie de herramientas que ayuden a garantizar el control del proceso y así como el control del nivel de calidad de los productos, con ellos se puede hacer frente ante la incertidumbre del entorno.TesisInfraestructura, Tecnología y Medio Ambient

Reinforced column shafts from the monumental architecture of Italica (prov. Baetica). Implementation of new technologies for the reconstruction of an exceptional practice

Esta investigación tiene por objeto presentar los trabajos en curso en torno a un conjunto de fustes procedente de los órdenes arquitectónicos del conocido como Traianeum de Itálica (provincia Baetica, actual Santiponce, Sevilla), complejo de templo central y pórtico perimetral levantado en la ciudad a comienzos del siglo II d. C. En ellos se observan las huellas dejadas por toda una serie de recursos técnicos tales como grapas, espigas metálicas y cavidades para parches marmóreos, asociada con medidas preventivas de refuerzo de piedra eventualmente quebradiza. Para ello, dado su estado fragmentado y fragmentario, se ha recurrido a la aplicación de técnicas fotogramétricas que permitan la obtención de modelos tridimensionales de las piezas, con el fin de reconstruir el funcionamiento y finalidad mecánica de los citados recursos. En último término, se trata de profundizar en aspectos relacionados con una singular capacidad tecnológica selectiva y con la economía y organización de las obras.The pieces under study presented in this paper come from the already well known “Traianeum” of Italica (prov. Baetica, present Santiponce, Seville), a huge complex area, formed by a wide open square with a main central temple, built according to the extension of the city with a new quarter in Hadrian times. Most of them, fragments of column shafts, offer very peculiar technical features: canals for metallic dowels, cavities for marble tasselli and holes for also metallic staples or cramps. All these systems had the aim of reinforce a valuable material with potential structure problems. The ensemble is unique because of the preservation of a sufficient amount of fragments that allows their complete restitution with the help of photogrammetric techniques in order to obtain three-dimensional models of the pieces and to understand the ancient technologic solutions. Even more, the practices make us reflect about technical skills and economy and organization of constructions

Planeamiento financiero y estructura de capital, en empresas constructoras, distrito de San Juan de Lurigancho, 2018

El presente trabajo de investigación, tiene como objetivo determinar la relación entre planeamiento financiero y estructura de capital en las empresas constructoras en el distrito de San Juan de Lurigancho, 2018. La importancia del estudio radica que las empresas constructoras que licitan con el estado no tienen un buen planeamiento financiero razón por la cual las empresas presentan un alto endeudamiento por ende no podrán tener una estructura de capital óptima La investigación se realizó con la Teoría de Lawrence y Gitman para la variable 1: Planeamiento Financiero y para la variable 2: Estructura de Capital, Perez y Carballa de igual forma se trabajó con diferentes autores que nos hablan sobre las 2 variables a estudiar. El tipo de investigación es aplicada, con diseño no experimental y nivel correlacional-descriptivo, de igual forma se encuestaron a 33 trabajadores de áreas específicas. Dicho instrumento, fue validado por expertos en la materia, para medir la confiabilidad se aplicó el método dos mitades En esta investigación se llegó a la conclusión que el planeamiento financiero se relaciona en un 95% con la estructura de capital en las empresas del distrito de San Juan de Lurigancho, 2017

EVALUATION OF LATERAL CONDENSATION ENDODONTIC TECHNIQUE WITH 7/D11 SPREADER, FINGER SPREADERS AND AN ULTRASONIC ACTIVATED TIP

The aim of this study was to compare the apical sealing ability,evaluating dye penetration in root canals filled with lateral condensationtechnique with the use of a 7/D11 spreader, a finger-spreader and anultrasonic activated tip. 90 distal roots of mandibular first molars wererandomly divided into three groups, each with 30 roots. Additionally wereused 4 roots as positive control and 4 as negative control. The preparedcanals were obturated with lateral condensation technique with sealer andgutta-percha cones condensed with 7/D11 in group 1, finger-spreader ingroup 2 and a tip activated by ultrasound in group 3. The samples wereimmersed in India ink and subsequently submitted to a demineralization andclearing process. The extent of dye penetration was measured using astereomicroscope with software Motic Images Advanced 3.0. The lowestmean leakage values were observed for 7/D11 group and the highest wereobserved for the ultrasound group. The difference between 7/D11 by oneside and finger spreader and ultrasound on the other was statisticallysignificant (p <0.05). Between ultrasonic tip and finger spreader groups thedifference was not significant.Under the conditions of this study it can be concluded that the use of the7/D11 instrument during condensation of gutta-percha showed better sealingability by allowing less leakage of the dye between the interphaseguttapercha-dentin than finger spreader and the ultrasonic tip

TRACKING LEAD (Pb) IN THE ENVIRONMENT OF JAKARA, KANO STATE, NIGERIA

Lead is considered a toxic substance that is already available in environment and has health impacts. The objective of the present study is to track the availability of lead in the environment of Jakara, Kano State, Nigeria. Lead was tracked in water, soil, and vegetables including lettuce, spinach, and onion. Study methodology involved taking random samples from water, soil, and vegetables at Jakara. Samples were prepared and assayed by atomic absorption spectrometry. Study findings showed that the mean concentration of lead in water was 0.115±0.023 mg/l, while it was in soil 2.46 ±0.95 μg/g. The mean concentration of lead in both lettuce and spinach was the same (22.95+ 3.28 mg/kg), and in onion was 19.67 ±3.28 mg/kg . Conclusions: the present study showed that there is a lead contamination of Jakara region by heavy metal (lead). This contamination is evident in water, soil, and vegetables

Human pluripotent stem cell-derived astrocytes from alzheimer´s disease patients for disease modeling

Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effective therapies. Glial cells have a key role in AD pathology, but this cannot be properly modeled using available animal models, so we hypothesized that cells derived from Alzheimer's patients can serve as a better platform for studying the disease. In this sense, human pluripotent stem cells (hPSC) allow the generation of different types of neural cells, which can be used for disease modeling, identification of new targets and drugs development. Methods: We have a collection of hiPSCs derived from patients with sporadic forms of AD stratified based on APOE genotype. We have differentiated these cells towards neural lineage to obtain astrocytes to assess intrinsic differences between those derived from AD patients or healthy controls. Results: We have implemented a serum-free approach and generated neural precursors and astrocytes from all the lines tested. Cells are different at the phenotypic level, suggesting intrinsic differences in neural cells derived from AD patients. Conclusions: Human pluripotent stem cell-derived methodology can be used to elucidate the pathogenic pathways associated with neurodegeneration and to identify new therapeutic targets susceptible to modulation, contributing to the development of new effective drugs against AD.Supported by Instituto de Salud Carlos III of Spain PI18/01557, PI21/00915 (to AG), PI18/01556 (to JV), and CIBERNED (CB06/05/1116 to AG and CB06/05/0094 to JV); by Junta de Andalucia UMA18-FEDERJA-211 (to AG), PY18-RT-2233 (to AG) and US-1262734 (to JV), Consejeria de Salud PI-0276-2018 (to JAGL) and Programa Operativo de Empleo Juvenil SNGJ4-11 to LCP. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Distribution of eosinophils in the gastrointestinal tract of children with no organic disease

Background This study aimed to assess the eosinophil (eos) density of the mucosa of the gastrointestinal (GI) tract in children undergoing endoscopic procedures following an extensive workup, without diagnosis of an organic disease. Methods Biopsies from GI endoscopies performed at 3 major children’s hospitals (Athens, Madrid and Rome), between January 2012 and June 2018, were evaluated by a single pathologist in each center. Peak eos counts were expressed /high power field and /mm2. Other histological abnormalities were also reported. Results A total of 111 children (median age 11 years; 48 boys) underwent upper endoscopy (333 biopsies), while 44 (median age 12; 25 boys) underwent ileocolonoscopy (262 biopsies). The median (interquartile range) eos/mm2 were as follows: esophagus 0 (0-0); stomach 0 (0-3); duodenum 22 (13-29); ileum 29 (19-46); cecum 39 (25-71); ascending colon 24 (20-41); transverse colon 27 (21-57); descending colon 21 (13-27); sigmoid colon 22 (13-30); and rectum 10 (6-22). Geographical variations in GI tissue eos counts were found amongst the participating centers, but the causative factors need further evaluation. Functional GI disorders according to the Rome IV criteria were diagnosed in 73 children (37 boys, median age 13 years). No differences were found between children with or without functional GI disorder diagnosis, with regard to eos density in the GI tract. Conclusion The reported peak counts of GI tissue eos in children with no organic diseases provide normative values that may be useful in the evaluation of children with GI symptoms suggestive of eosinophilic GI disorders

Joyero engastador

Se presenta el diseño didáctico de la especialidad en joyería así como los bloques modulares, módulos instruccionales, objetivos, requisitos, operaciones y contenidos.The didactic design of the specialty in jewelry is presented as well as the modular blocks, instructional modules, objectives, requirements, operations and contents.Armado por moldeo -- Cadenerìa manual -- Engaste al grano -- Proceso de la cera perdida -- Armado especial -- Gestion empresarialna182 página

Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy

Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less is known about their involvement in tauopathies. Here, we aimed to analyze astroglial reactivity to hyperphosphorylated-tau (ptau) in the hippocampus of two transgenic mouse models of tauopathy, ThyTau22 and P301S (2- to 12/18-months). Methods: Proteinopathy was assessed by western-blotting and immunohistochemistry (AT8). Neuroinflammation was analyzed by qPCR and bright-field immunohistochemistry, glial-ptau relationship by confocal and transmission electron microscopy. Results: P301S mice exhibited an intense reactive astrogliosis, increasing progressively with aging accordingly to a strong ptau accumulation, whereas ThyTau22 model showed slighter astrocytosis related to lesser proteinopathy. P301S astrogliosis correlated with an acute DAM-like microglial activation, not observed in ThyTau22 hippocampus. In both models, reactive astrocytes contained ptau, especially around vessels. Conclusions: Our results support that astrocytes respond to ptau in the absence of Abeta. This reactivity correlates with tau pathology and depends on microglial DAM-like activation. In addition, reactive astrocytes may play a role in the elimination/spreading of ptau species through the brain. Deciphering the mechanisms underlying these processes might allow the development of strategies to slow down the progression of AD and other tauopathies.Supported by Instituto de Salud Carlos III of Spain, co-financed by FEDER funds from European Union, through grants PI18/01557 (to AG),PI18/01556 (to JV), and Junta de Andalucia through Consejería de Economía y Conocimiento grants UMA18-FEDERJA-211 (AG), P18-RT-2233 (AG) and US-1262734 (JV) co-financed by Programa Operativo FEDER 2014-2020. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech