Performance of Catalan-Spanish bilinguals on the Bilingual Aphasia Test of Michel Paradis: Influence of age and educational level

El Test de la Afasia para Bilingües (TAB) fue diseñado para valorar las capacidades lingüísticas residuales de individuos bilingües o plurilingües con afasia. En la actualidad, el test está disponible en más de 60 idiomas. Aunque su aparición data de finales de los 80, los estudios destinados a valorar sus propiedades psicométricas son todavía escasos. El objetivo del presente trabajo fue doble: (1) comparar el rendimiento verbal en catalán y en castellano de 56 bilingües sanos con las versiones en catalán (TAB-Cat) y en castellano (TAB-Cast) del test, y (2) determinar si la edad y el nivel educativo influyen en los resultados obtenidos en cada lengua. En general, el rendimiento obtenido en catalán y en castellano fue más similar que diferente. Las diferencias a favor del castellano pueden interpretarse en términos sociolingüísticos. Los análisis de regresión efectuados mostraron que el nivel educativo por sí mismo tuvo una mayor influencia en el rendimiento lingüístico que la edad. Esta influencia también se refleja en la puntuación total de cada versión del TAB. Salvo excepciones, los participantes del estudio alcanzaron el criterio de éxito marcado por el manual para cada subtest. Finalmente, creemos que las versiones en catalán y en castellano del TAB son comparables y adecuadas para su utilización en nuestro entorno. No obstante, es necesario realizar más estudios que permitan profundizar en sus características y propiedades.The Bilingual Aphasia Test (BAT) was designed to assess the residual language capacities of bilingual or multilingual individuals with aphasia. At the present time, the test is available in more than 60 languages. Although its appearance dates from the late 80’s, studies to evaluate its psychometric properties are still scarce. The aim of this study was double: (1) to compare language performance in Catalan and Spanish of 56 healthy bilinguals with the Catalan (BAT-Cat) and Spanish (BAT-Spa) versions of the test, and (2) to determine the influence of age and educational level in each language. In general, language performance in Catalan and Spanish was more similar than different. The differences in favour of Spanish can be interpreted in sociolinguistic terms. In general, the regression analysis performed showed that the educational level itself had a greater influence on language performance than age. Except for some cases, the participants of the study achieved the success criteria set by the test manual for each subtest. Finally, the Catalan and Spanish versions of the BAT are comparable and appropriate for their use in our environment; nevertheless, more studies are needed to deepen in their characteristics and properties

Rendimiento de bilingües catalán-castellano en el test de Afasia para Bilingües de Michel Paradís: influencia de la edad y del nivel educativo

The Bilingual Aphasia Test (BAT) was designed to assess the residual language capacities of bilingual or multilingual individuals with aphasia. At the present time, the test is available in more than 60 languages. Although its appearance dates from the late 80's, studies to evaluate its psychometric properties are still scarce. The aim of this study was double: (1) to compare language performance in Catalan and Spanish of 56 healthy bilinguals with the Catalan (BAT-Cat) and Spanish (BAT-Spa) versions of the test, and (2) to determine the influence of age and educational level in each language. In general, language performance in Catalan and Spanish was more similar than different. The differences in favour of Spanish can be interpreted in sociolinguistic terms. In general, the regression analysis performed showed that the educational level itself had a greater influence on language performance than age. Except for some cases, the participants of the study achieved the success criteria set by the test manual for each subtest. Finally, the Catalan and Spanish versions of the BAT are comparable and appropriate for their use in our environment; nevertheless, more studies are needed to deepen in their characteristics and properties

Rendimiento cognitivo y síntomas afectivos en la fase aguda y tres meses después de un ictus isquémico

After an ictus, decline of cognitive function, mood and behaviour have been described. Our aim is to correlate the volume of the lesion (in sequences DRM and FLAIR) with the raw scores of cognitive and affective tests. Patients (N = 24) with vascular subcortical cerebral lesions were studied, and cognitive and affective behaviour tests were administered twice. The results show a negative correlation be-tween the volume of the lesion in the DRM sequence and the verbal phonetic fluency (r = -0,42) and naming scores (r = -0,64). A negative correlation is also observed with the Naming Boston Test (r = -0,50) in the FLAIR sequence. Correlations between the volume of the lesion in the left hemisphere and the Trail Making Test part B and the naming test, were statistically significant. With relationship to the second evaluation carried out after three months, a certain improvement of the raw scores of the tests was observed.Después de un ictus, se ha descrito deterioro de la cognición, del humor y de la conducta. Nuestro objetivo fue correlacionar el volumen de la lesión (en secuencias DRM y FLAIR) con puntuaciones directas en test cognitivos y afectivos. Se estudian 24 pacientes con lesiones vasculares cerebrales subcorticales, aplicando en dos ocasiones pruebas cognitivas y afectivas. Los resultados muestran una correlación negativa entre el volumen de la lesión en la secuencia DRM y las pruebas de fluencia verbal fonética (r = -0,42) y denominación (r = -0,64). También se observa una correlación negativa con la prueba de denominación de Boston (r = -0,50) en la secuencia FLAIR. Según la lateralización de la lesión, resultan significativas las correlaciones entre el volumen de la misma en el hemisferio izquierdo y el TMT-B, y con el test de denominación. Con relación a la segunda evaluación llevada a cabo tres meses después, se observa una cierta mejoría de las puntuaciones directas

A privacy-aware crowd management system for smart cities and smart buildings

Cities are growing at a dizzying pace and they require improved methods to manage crowded areas. Crowd management stands for the decisions and actions taken to supervise and control densely populated spaces and it involves multiple challenges, from recognition and assessment to application of actions tailored to the current situation. To that end, Wi-Fi-based monitoring systems have emerged as a cost-effective solution for the former one. The key challenge that they impose is the requirement to handle large datasets and provide results in near real-time basis. However, traditional big data and event processing approaches have important shortcomings while dealing with crowd management information. In this paper, we describe a novel system architecture for real-time crowd recognition for smart cities and smart buildings that can be easily replicated. The described system proposes a privacy-aware platform that enables the application of artificial intelligence mechanisms to assess crowds' behavior in buildings employing sensed Wi-Fi traces. Furthermore, the present paper shows the implementation of the system in two buildings, an airport and a market, as well as the results of applying a set of classification algorithms to provide crowd management information.This work was supported in part by the Spanish Government (MINECO) by means of the Project Future Internet Enabled Resilient CitiEs (FIERCE) under Grant RTI2018-093475-A-I00, and in part by the European Union’s Horizon 2020 Programme through the European project Federated CPS Digital Innovation Hubs for the Smart Anything Everywhere Initiative (FED4SAE) under Grant 761708

LA INTEGRACIÓN DEL USO DE LAS TECNOLOGÍAS DE LA INFORMACIÓN Y COMUNICACIÓN Y EL APRENDIZAJE COLABORATIVO, COMO ESTRATEGIA PARA ATENDER EL ÍNDICE REPROBATORIO EN LA ACADEMIA DE COMPUTACIÓN DE LA CARRERA DE INGENIERÍA EN COMUNICACIONES Y ELECTRÓNICA EN LA E

El Propósito de este Trabajo de Investigación, ha sido de identificar las causas por las que los índices de deserción y reprobación se han incrementado en los alumnos de la carrera de Ingeniería en Comunicación y Electrónica que el Instituto Politécnico Nacional brinda a través de su Unidad Académica Culhuacán: Escuela Superior de Ingeniería Mecánica y Eléctrica (ESIME) ubicada en la Ciudad de México. Para tales efectos, se precisaron las causas para posteriormente, emplear el Modelo de Investigación Exploratoria-Descriptiva y con los resultados obtenidos, se recurrió a la Investigación Interpretativa, con la finalidad de emitir una propuesta a través de la cual, se de la atención necesaria y procurar disminuir sus altos índices no aprobatorios. Es necesario destacar, que dentro de las asignaturas reprobadas, sobresalen aquellas que están encaminadas al aspecto sustantivo de la formación de los alumnos, como futuros ingenieros en materia de comunicación y electrónica, por lo que, en espera de que la generación de los aspectos propositivos para su atención, permitan consolidar una alternativa que contribuya de manera favorable. Palabras-clave: Índices de Reprobación Escolar, Tecnologías de la Información y Comunicación, Trabajo Colaborativo, Proceso Educativ

Acceleration of the DNA methylation clock among lynch syndrome‑associated mutation carriers

The research leading to these results has received funding from "la Caixa" Foundation (Ref: CAIXA2017/1) for library preparation, sequencing, and employment of research personnel, from The Fundacion Progreso y Salud, Junta de Andalucia, Spain and from DPI2017-84439-R of MINECO, Madrid and FEDER for sequencing and employment of research personnel. Finally, grant ref. A-BIO-470-UGR20 from University of Granada and FEDER has funded article processing charges (APC) and sample processing expenses.Background: DNA methylation (DNAm) age metrics have been widely accepted as an epigenetic biomarker for biological aging and disease. The purpose of this study is to assess whether or not individuals carrying Lynch Syndromeassociated mutations are affected in their rate of biological aging, as measured by the epigenetic clock. Methods: Genome-wide bisulfite DNA sequencing data were generated using DNA from CD4 + T-cells obtained from peripheral blood using 27 patient samples from Lynch syndrome families. Horvath’s DNAm age model based on penalized linear regression was applied to estimate DNAm age from patient samples with distinct clinical and genetic characteristics to investigate cancer mutation-related aging effects. Results: Both Lynch mutation carriers and controls exhibited high variability in their estimated DNAm age, but regression analysis showed steeper slope for the Lynch mutation carriers. Remarkably, six Lynch Syndrome-associated mutation carriers showed a strong correlation to the control group, and two sisters carrying Lynch Syndrome-associated mutations, with no significant difference in lifestyle and similar chronological age, were assigned very different DNAm age. Conclusions: Future studies will be required to explore, in larger patient populations, whether specific epigenetic age acceleration is predictive of time-to-cancer development, treatment response, and survival. Epigenetic clock DNAm metrics may be affected by the presence of cancer mutations in the germline, and thus show promise of potential clinical utility for stratified surveillance strategies based on the relative risk for imminent emergence of tumor lesions in otherwise healthy Lynch Syndrome-associated mutation carriers.La Caixa Foundation CAIXA2017/1Junta de AndaluciaSpanish Government DPI2017-84439-REuropean CommissionUniversity of Granada A-BIO-470-UGR2

Tracking bluefin tuna cohorts from east Atlantic Spanish fisheries since the 1980s

Relative abundance and mean size at age analyses were performed for the catches of three Atlantic Spanish fisheries, in search of an exceptionally abundant cohort in the recent history of the eastern Atlantic and Mediterranean bluefin tuna stock. Length distributions of baitboat fisheries, both in the Bay of Biscay and areas close to the Strait of Gibraltar as well as trap catches from the Spanish Atlantic coast were converted to age distributions using age length keys from calcified structures. Results do validate indirectly the ageing method. The 1994 cohort was clearly tracked for juveniles and young adults, 3 to 7 years old, in baitboat catches, and also for older specimens, 9 to 11 years old, in the trap fisheries. Based on these results, it is suggested that the juvenile and young adults fisheries in the western part of the Iberian Peninsula are interconnected between one another and with the Balearic Islands area of the western Mediterranean, as it is the nearest spawning ground described and because it is also supported by tagging and other studies.Afin de trouver une cohorte exceptionnellement abondante dans la récente histoire du stock de ton rouge de l’Atlantique Est et de la Méditerranée, on a procédé à une analyse de l’abondance relative et de la taille moyenne par âge des captures réalisées par trois pêcheries espagnoles de l’Atlantique. Les distributions par tailles de deux pêcheries de canneurs dans le Golfe de Gascogne et dans les eaux proches du Détroit de Gibraltar, ainsi que les prises des madragues de la côte atlantique espagnole, ont été converties en âges à l’aide des clefs taille-âge obtenues à partir de la lecture de structures calcifiées. Les résultats valident indirectement la méthode de détermination de l’âge. La cohorte de 1994 affiche une forte indication présente chez les juvéniles et les jeunes adultes, de 3 à 7 ans, capturés dans les pêcheries de canneurs ainsi que chez les spécimens d’âge plus avancé, de 9 à 11 ans, pêchés à la madrague. Ces résultats suggèrent que les pêcheries de juvéniles et de jeunes adultes de la partie occidentale de la péninsule ibérique sont interconnectées entre elles ainsi qu’avec la zone des îles Baléares, en Méditerranée occidentale, étant donné qu’il s’agit de la zone de frai la plus proche et qu’il existe des indices de cette relation d’après les études de marquage et d’autres études.Para encontrar una cohorte excepcionalmente abundante en la historia reciente del stock de atún rojo del Atlántico este y Mediterráneo, se realizó un análisis de la abundancia relativa y la talla media por edad de las capturas de tres pesquerías atlánticas españolas. Las distribuciones de tallas de dos pesquerías de cebo vivo, en el Golfo de Vizcaya y en aguas próximas al Estrecho de Gibraltar, así como las capturas de las almadrabas de la costa atlántica española, fueron convertidas a edades mediante el uso de claves talla edad, obtenidas a partir de la lectura de piezas esqueléticas. Los resultados validan indirectamente el método de determinación de la edad. La cohorte de 1994 presenta una fuerte señal que pudo ser encontrada en los juveniles y adultos jóvenes, 3 a 7 años, capturados en las pesquerías de cebo vivo y también en especimenes mayores, 9 a 11 años, pescados con las almadrabas. Con esto resultados se sugiere que las pesquerías de juveniles y adultos jóvenes de la parte occidental de la península Ibérica están interconectadas entre ellas y con el área de las Islas Baleares, en el Mediterráneo occidental, puesto que es la zona de puesta más próxima y porque también hay evidencias de esta relación mediante el marcado y otros estudios

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true