466 research outputs found
Propagation of Bose-Einstein condensates in a magnetic waveguide
Gaseous Bose-Einstein condensates of 2-3 million atoms were loaded into a
microfabricated magnetic trap using optical tweezers. Subsequently, the
condensates were released into a magnetic waveguide and propagated 12 mm.
Single-mode propagation was observed along homogeneous segments of the
waveguide. Inhomogeneities in the guiding potential arose from geometric
deformations of the microfabricated wires and caused strong transverse
excitations. Such deformations may restrict the waveguide physics that can be
explored with propagating condensates.Comment: 5 pages, 4 figure
Eliminating the mean-field shift in multicomponent Bose-Einstein condensates
We demonstrate that the nonlinear mean-field shift in a multi-component
Bose-Einstein condensate may be eliminated by controlling the two-body
interaction coefficients. This modification is achieved by, e.g., suitably
engineering the environment of the condensate. We consider as an example the
case of a two-component condensate in a tightly confining atom waveguide.
Modification of the atom-atom interactions is then achieved by varying
independently the transverse wave function of the two components. Eliminating
the density dependent phase shift in a high-density atomic beam has important
applications in atom interferometry and precision measurement
Bohr-Sommerfeld Quantization of Periodic Orbits
We show, that the canonical invariant part of corrections to the
Gutzwiller trace formula and the Gutzwiller-Voros spectral determinant can be
computed by the Bohr-Sommerfeld quantization rules, which usually apply for
integrable systems. We argue that the information content of the classical
action and stability can be used more effectively than in the usual treatment.
We demonstrate the improvement of precision on the example of the three disk
scattering system.Comment: revte
A Storage Ring for Neutral Atoms
We have demonstrated a storage ring for ultra-cold neutral atoms. Atoms with
mean velocities of 1 m/s corresponding to kinetic energies of ~100 neV are
confined to a 2 cm diameter ring by magnetic forces produced by two
current-carrying wires. Up to 10^6 atoms are loaded at a time in the ring, and
7 revolutions are clearly observed. Additionally, we have demonstrated multiple
loading of the ring and deterministic manipulation of the longitudinal velocity
distribution of the atoms using applied laser pulses. Applications of this ring
include large area atom interferometers and cw monochromatic atomic beam
generation.Comment: 4 pages, 5 figure
A new cell primo-culture method for freshwater benthic diatom communities
A new cell primo-culture method was developed for the benthic diatom community isolated from biofilm sampled in rivers. The approach comprised three steps: (1) scraping biofilm from river pebbles, (2) diatom isolation
from biofilm, and (3) diatom community culture. With a view to designing a method able to stimulate the growth of diatoms, to limit the development of other microorganisms, and to maintain in culture a community similar to the original natural one, different factors were tested in step 3:
cell culture medium (Chu No 10 vs Freshwater “WC” medium modified), cell culture vessel, and time of culture. The results showed that using Chu No 10 medium in an Erlenmeyer flask for cell culture was the optimal method,
producing enough biomass for ecotoxicological tests as well as minimising development of other microorganisms. After 96 h of culture, communities differed from the original communities sampled in the two rivers studied.
Species tolerant of eutrophic or saprobic conditions were favoured during culture. This method of diatom community culture affords the opportunity to assess, in vitro, the effects of different chemicals or effluents (water samples andindustrial effluents) on diatom communities, as well as on diatom cells, from a wide range of perspectives
Spatial Transferability of an Agent‑Based Model to Simulate Taenia solium control interventions
Background
Models can be used to study and predict the impact of interventions aimed at controlling the spread of infectious agents, such as Taenia solium, a zoonotic parasite whose larval stage causes epilepsy and economic loss in many rural areas of the developing nations. To enhance the credibility of model estimates, calibration against observed data is necessary. However, this process may lead to a paradoxical dependence of model parameters on location-specific data, thus limiting the model’s geographic transferability. Methods
In this study, we adopted a non-local model calibration approach to assess whether it can improve the spatial transferability of CystiAgent, our agent-based model of local-scale T. solium transmission. The calibration dataset for CystiAgent consisted of cross-sectional data on human taeniasis, pig cysticercosis and pig serology collected in eight villages in Northwest Peru. After calibration, the model was transferred to a second group of 21 destination villages in the same area without recalibrating its parameters. Model outputs were compared to pig serology data collected over a period of 2 years in the destination villages during a trial of T. solium control interventions, based on mass and spatially targeted human and pig treatments. Results
Considering the uncertainties associated with empirical data, the model produced simulated pre-intervention pig seroprevalences that were successfully validated against data collected in 81% of destination villages. Furthermore, the model outputs were able to reproduce validated pig seroincidence values in 76% of destination villages when compared to the data obtained after the interventions. The results demonstrate that the CystiAgent model, when calibrated using a non-local approach, can be successfully transferred without requiring additional calibration. Conclusions
This feature allows the model to simulate both baseline pre-intervention transmission conditions and the outcomes of control interventions across villages that form geographically homogeneous regions, providing a basis for developing large-scale models representing T. solium transmission at a regional level
Mach's Principle and the Origin of Inertia
The current status of Mach's principle is discussed within the context of
general relativity. The inertial properties of a particle are determined by its
mass and spin, since these characterize the irreducible unitary representations
of the inhomogeneous Lorentz group. The origin of the inertia of mass and
intrinsic spin are discussed and the inertia of intrinsic spin is studied via
the coupling of intrinsic spin with rotation. The implications of spin-rotation
coupling and the possibility of history dependence and nonlocality in
relativistic physics are briefly mentioned.Comment: 14 pages. Dedicated to Carl Brans in honor of his 80th birthday. To
appear in the Brans Festschrift; v2: typo corrected, published in: At the
Frontier of Spacetime, edited by T. Asselmeyer-Maluga (Springer, 2016),
Chapter 10, pp. 177-18
Physics with Coherent Matter Waves
This review discusses progress in the new field of coherent matter waves, in
particular with respect to Bose-Einstein condensates. We give a short
introduction to Bose-Einstein condensation and the theoretical description of
the condensate wavefunction. We concentrate on the coherence properties of this
new type of matter wave as a basis for fundamental physics and applications.
The main part of this review treats various measurements and concepts in the
physics with coherent matter waves. In particular we present phase manipulation
methods, atom lasers, nonlinear atom optics, optical elements, interferometry
and physics in optical lattices. We give an overview of the state of the art in
the respective fields and discuss achievements and challenges for the future
Selective nanomanipulation using optical forces
We present a detailed theoretical study of the recent proposal for selective
nanomanipulation of nanometric particles above a substrate using near-field
optical forces [Chaumet {\it et al.} Phys. Rev. Lett. {\bf 88}, 123601 (2002)].
Evanescent light scattering at the apex of an apertureless near-field probe is
used to create an optical trap. The position of the trap is controlled on a
nanometric scale via the probe and small objects can be selectively trapped and
manipulated. We discuss the influence of the geometry of the particles and the
probe on the efficiency of the trap. We also consider the influence of multiple
scattering among the particles on the substrate and its effect on the
robustness of the trap.Comment: 12 pages, 17 figure
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders
Background
Cerebral palsy (CP) is an heterogeneous group of neurological disorders of movement and/or posture, with an estimated incidence of 1 in 1000 live births. Non-progressive forms of symmetrical, spastic CP have been identified, which show a Mendelian autosomal recessive pattern of inheritance. We recently described the mapping of a recessive spastic CP locus to a 5 cM chromosomal region located at 2q24-31.1, in rare consanguineous families.
Methods
Here we present data that refine this locus to a 0.5 cM region, flanked by the microsatellite markers D2S2345 and D2S326. The minimal region contains the candidate gene GAD1, which encodes a glutamate decarboxylase isoform (GAD67), involved in conversion of the amino acid and excitatory neurotransmitter glutamate to the inhibitory neurotransmitter Îł-aminobutyric acid (GABA).
Results
A novel amino acid mis-sense mutation in GAD67 was detected, which segregated with CP in affected individuals.
Conclusions
This result is interesting because auto-antibodies to GAD67 and the more widely studied GAD65 homologue encoded by the GAD2 gene, are described in patients with Stiff-Person Syndrome (SPS), epilepsy, cerebellar ataxia and Batten disease. Further investigation seems merited of the possibility that variation in the GAD1 sequence, potentially affecting glutamate/GABA ratios, may underlie this form of spastic CP, given the presence of anti-GAD antibodies in SPS and the recognised excitotoxicity of glutamate in various contexts
- …