Exploración del T-learning y los Contenidos Digitales en el Contexto Educativo

La televisión digital terrestre (TDT), como tecnología que difunde televisión de mejor calidad y servicios con valor agregado a una amplia población a través del aire y de manera gratuita, ya está en funcionamiento en varios países del mundo, mientras en la mayoría de países latinoamericanos se encuentra en proceso de implementación y en espera del apagón analógico. Por esta razón, es necesario que los diversos sectores de la sociedad, como la academia, se preparen, conozcan, formen e impulsen el desarrollo de aplicaciones y contenidos para la televisión digital (TVD). En este artículo se presenta una contextualización de las aplicaciones para TVD, resaltando el t- learning para procesos de enseñanza/aprendizaje, los escenarios propuestos donde una universidad o institución académica pueden participar.Palabras clave: Televisión digital, gestión de contenidos digitales y aprendizaje virtual

Fiabilidad, validez factorial y datos normativos de la versión española del inventario abreviado de reacciones interpersonales (SIRI) de Grossarth-Maticek y Eysenck

Eysenck and Grossarth-Maticek’s model states that some of their personality types are predisposed to specific illnesses (Types 1 and 5 to cancer, and Type 2 to coronary heart disease), whereas others are preserved (Type 4) or not predisposed (Types 3 and 6). The aim of this study is to provide infor-mation as regards the reliability, factor validity and normative data of the Spanish version of Grossarth-Maticek and Eysenck´s Short Interpersonal Reactions Inventory (SIRI) in a sample of uni-versity students (N=425). The results indicate that 1) internal consistency is adequate (0,88-0,75); 2) factor analysis suggests that this instrument measures four dimensions: Factor 1 compounded by Types 1 and 2 (psychosomatic risk), Factor 2 constituted by Types 3 and 6 (hysteria/psychopathy), Factor 3 configured by Type 5 (rationality) and Factor 4 defined by Type 4 (autonomy); and 3) distribu-tion of personality types is similar to that found in prior studies with samples of young subjects.El modelo de Eysenck y Grossarth-Maticek postula que algunos de sus tipos de personalidad están predispuestos a enfermedades específicas (tipos 1 y 5 al cáncer, y tipo 2 a la enfermedad coronaria), mientras otros están preservados (tipo 4) o no predispuestos (tipos 3 y 6). El objetivo de este estudio ha sido aportar datos sobre la fiabilidad, validez factorial y baremación de la versión española del Inventario abreviado de reacciones interpersonales de Grossarth-Maticek y Eysenck (SIRI) en una muestra de estudiantes universitarios (n = 425). Los resultados indican 1) la aceptable consistencia interna (0,88-0,75); 2) el análisis factorial efectuado sugiere que el instrumento mide cuatro dimensio-nes: un primer factor está formado por los tipos 1 y 2 (riesgo psicosomático), un segundo factor está constituido por los tipos 3 y 6 (histeria/psicopatía), el tercer factor está configurado por el tipo 5 (ra-cionalidad) y el cuarto factor está definido por el tipo 4 (autonomía); y 3) la distribución de los tipos de personalidad es similar a la encontrada en estudios previos con muestras de sujetos jóvenes

APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression

<p>Abstract</p> <p>Background</p> <p>APOBEC3G is an antiretroviral factor that acts by inducing G to A mutations. In this study, we examined the expression of APOBEC3G in uninfected HIV-1 exposed individuals at the time of their partner's diagnosis and one year later. We then compared this expression with that of infected individuals at different disease stages. APOBEC3G mRNA was measured in PBMCs from three groups: healthy controls with no known risk factor to HIV infection (n = 26), exposed uninfected individuals who had unprotected sex with their HIV+ partners for at least 3 months (n = 37), and HIV infected patients at various disease stages (n = 45), including 8 patients with low HIV viral loads < 10,000 copies/mL (LVL) for at least 3 years. Additionally, we obtained sequences from the env, gag, pol, nef, vif and the LTR of the patients' virus.</p> <p>Results</p> <p>Exposed uninfected individuals expressed higher APOBEC3G than healthy controls (3.86 vs. 1.69 relative expression units), and their expression significantly decreased after a year from the HIV diagnosis and subsequent treatment of their partners. Infected individuals showed a positive correlation (Rho = 0.57, p = 0.00006) of APOBEC3G expression with CD4+ T cell count, and a negative correlation with HIV viremia (Rho = -0.54, p = 0.00004). The percentage of G to A mutations had a positive correlation (Rho = 0.43, p = 0.0226) with APOBEC3G expression, and it was higher in LVL individuals than in the other patients (IQR 8.27 to 9.64 vs. 7.06 to 8.1, p = 0.0084). Out of 8 LVLs, 3 had hypermutations, and 4 had premature stop codons only in viral <it>vif</it>.</p> <p>Conclusion</p> <p>The results suggest that exposure to HIV may trigger APOBEC3G expression in PBMCs, in the absence of infection. Additionally, cessation of exposure or advanced disease is associated with decreased APOBEC3G expression.</p

Covariate effects of resting heart rate variability on affective ratings and startle reflex during cognitive reappraisal of negative emotions

Heart Rate Variability (HRV) has been widely studied in laboratory settings due to its clinical implications, primarily as a potential biomarker of emotion regulation (ER). Studies have reported that individuals with higher resting HRV show more distinct startle reflexes to negative stimuli as compared to those with lower HRV. These responses have been associated with better defense system function when managing the context demands. There is, however, a lack of empirical evidence on the association between resting HRV and eyeblinks during laboratory tasks using instructed ER. This study explored the influence of tonic HRV on voluntary cognitive reappraisal through subjective and startle responses measured during an independent ER task. In total, 122 healthy participants completed a task consisting of attempts to upregulate, downregulate, or react naturally to emotions prompted by unpleasant pictures. Tonic HRV was measured for 5 minutes before the experiment began. Current results did not support the idea that self-reported and eyeblink responses were influenced by resting HRV. These findings suggest that, irrespective of resting HRV, individuals may benefit from strategies such as reappraisal that are useful for managing negative emotions. Experimental studies should further explore the role of individual differences when using ER strategies during laboratory task

Impact of the noise on the emulated grid voltage signal in hardware-in-the-loop used in power converters

This work evaluates the impact of the input voltage noise on a Hardware-In-the-Loop (HIL) system used in the emulation of power converters. A poor signal-to-noise ratio (SNR) can compromise the accuracy and precision of the model, and even make certain techniques for building mathematical models unfeasible. The case study presents the noise effects on a digitally controlled totem-pole converter emulated with a low-cost HIL system using an FPGA. The effects on the model outputs, and the cost and influence of different hardware implementations, are evaluated. The noise of the input signals may limit the benefits of increasing the resolution of the model.This research was funded by the Spanish Ministry of Science and Innovation under Project PID2021-128941OB-I00 TRENTI–Efficient Energy Transformation in Industrial Environment

Evaluación de la actividad de los catalizadores 5% pd/tio2 y 5% pd/tio2 – 5%na en la reacción de hidrodecloración de cloroformo

Se evaluó la actividad de los catalizadores 5%Pd/TiO2 y por primera vez 5%Pd/TiO2-5%Na en la reacción de hidrodecloración de cloroformo en fase líquida a temperatura ambiente y 50°C, utilizando isopropanol c omo solvente y donor de hidrógeno. Se encontró que el catalizador 5%Pd/TiO2-5%Na presentó la mejor actividad tanto a temperatura ambiente como a 50°C, obteniénd ose la mayor conversión a 50°C (32,5%) luego de 5 horas de reacción. La incorporación de los iones sodio en el soporte, favoreció tanto la deshidrogenación del isopropanol, como la captura de los iones cloruro producidos durante la reacción, y por ende la hidrodecloración del cloroformo. Los catalizadores se caracterizaron por AAS, titulación en masa, DRX, BET, quimisorción de hidrógeno, TPR y TGA. El Na y el Pd se depositaron en el soporte prácticamente sin pérdidas; no se observó modificación de la fase cristalina anatasa del TiO2. La modificación del soporte con NaOH, aumentó su punto isoeléctrico, lo que correlaciona con un incremento en su basicidad y parece ser responsable de la mejora en actividad catalítica ABSTRACT The activity of 5%Pd/TiO2 and for the first time 5%Pd/TiO2-5%Na catalysts was evaluated in the liquid phase catalytic hydrodechlorination of chloroform at room temperature and 50°C, using isopropanol as solvent a nd hydrogen donor. 5%Pd/TiO2-5%Na catalyst showed the best catalytic performance at room temperature and 50°C, with the highest conversion at 50°C (32.5%) a fter 5 hours of reaction. The incorporation of sodium ions into the support favored both the dehydrogenation of isopropanol and the capture of chloride ions produced during the reaction, both positive for the hydrodechlorination of chloroform. The catalysts were characterized by AAS, mass titration, XRD, BET, hydrogen chemisorption, TPR and TGA. Na and Pd were loaded on the support practically without loss. and the anatase phase of titanium dioxide did not change with the addition of NaOH increased the catalyst’s isoelectric point, indicating an increase in catalyst basicity. This can explain the improved activity of Na-containing catalysts

Detection and genotyping of HPV DNA in a group of unvaccinated young women from Colombia : baseline measures prior to future monitoring program

Q2Q1In 2012, Colombia launched human papillomavirus (HPV) vaccination program for girls ages 9 to 12, and in 2013, the target age was expanded to 9 to 17 years. Monitoring the changes of HPV infection prevalence among young women has been proposed as an endpoint for early assessment of HPV vaccination programs. However, the data on HPV prevalence in young ages are very limited. The purpose of this study was to determine the prevalence of HPV infection and the distribution of genotypes in a group of nonvaccinated women ages 18 to 25 years old in three Colombian cities as baseline for the monitoring of the HPV national vaccination program. A total of 1,782 sexually active women were included. Cervical smear samples were collected to perform the Pap smear and HPV DNA detection using a Linear Array HPV assay. Of the 1,782 specimens analyzed, 60.3% were positive for any HPV type; 42.2% were positive for highrisk HPV (HR-HVP) types, and 44.4% for low-risk HPV (LR-HPV) types. Multiple and single infections were identified in 37.1% and 23.2% of samples, respectively. HR-HPV types -16, -52, and -51 were the most predominant with proportions of 11.3%, 7.92%, and 7.9%, correspondingly. The prevalence for HR-HPV 16/18 was 14.4%. HR-HPV prevalence in women with abnormal cytology (75.16%) was higher than in women with normal cytology (38.6%). In conclusion, a high prevalence of HR-HPV was observed among younger women. This HPV typespecific prevalence baseline may be used to monitor postvaccination longitudinal changes and to determine its impact on HPV-related disease incidence in Colombia population.https://orcid.org/0000-0002-0610-6477https://orcid.org/0000-0001-7187-9946https://orcid.org/0000-0002-3373-1809https://orcid.org/0000-0001-6295-7316Revista Internacional - Indexad

In Situ Characterization of Human Lymphoid Tissue Immune Cells by Multispectral Confocal Imaging and Quantitative Image Analysis; Implications for HIV Reservoir Characterization

CD4 T cells are key mediators of adaptive immune responses during infection and vaccination. Within secondary lymphoid organs, helper CD4 T cells, particularly those residing in germinal centers known as follicular helper T cells (Tfh), provide critical help to B-cells to promote their survival, isotype switching and selection of high affinity memory B-cells. On the other hand, the important role of Tfh cells for the maintenance of HIV reservoir is well documented. Thus, interrogating and better understanding the tissue specific micro-environment and immune subsets that contribute to optimal Tfh cell differentiation and function is important for designing successful prevention and cure strategies. Here, we describe the development and optimization of eight multispectral confocal microscopy immunofluorescence panels designed for in depth characterization and immune-profiling of relevant immune cells in formalin-fixed paraffin-embedded human lymphoid tissue samples. We provide a comprehensive library of antibodies to use for the characterization of CD4+ T-cells -including Tfh and regulatory T-cells- as well as CD8 T-cells, B-cells, macrophages and dendritic cells and discuss how the resulting multispectral confocal datasets can be quantitatively dissected using the HistoCytometry pipeline to collect information about relative frequencies and immune cell spatial distributions. Cells harboring actively transcribed virus are analyzed using an in-situ hybridization assay for the characterization of HIV mRNA positive cells in combination with additional protein markers (multispectral RNAscope). The application of this methodology to lymphoid tissues offers a means to interrogate multiple relevant immune cell targets simultaneously at increased resolution in a reproducible manner to guide CD4 T-cell studies in infection and vaccination

La función tutorial en la virtualidad como un aspecto relevante en la capacitación docente

El papel del tutor virtual es indispensable para desarrollar y potenciar los aprendizajes en la educación a distancia. De hecho, este nuevo rol docente en entornos virtuales de aprendizaje es tratado con especial atención en las capacitaciones ofrecidas en nuestra unidad académica. Una de ellas es una propuesta de Curso de Posgrado denominada “Herramientas para la Gestión de Aulas Virtuales” (HGAV), aprobada por resolución en el año 2015, y replicada en varias cohortes sucesivas y que continúa desarrollándose actualmente. En el presente trabajo, se realiza un análisis de las intervenciones realizadas por los participantes de este curso dictado en sendas cohortes, 2021 y 2022, mediante un foro de trabajo relativo a los nuevos roles en la virtualidad, con el fin de poder relevar las concepciones respecto a la función tutorial en el marco de propuestas pedagógicas a distancia, sus implicancias y los aspectos más importantes involucrados en dicha tarea. La metodología utilizada comprende el análisis de las palabras que integran los foros en base a dos estrategias, una estrategia de Procesamiento de Lenguaje Natural (PLN) y una estrategia de codificación utilizando la herramienta Atlas.ti Las conclusiones son alentadoras, pero también implican nuevos desafíos referidos a la capacitación en las competencias docentes requeridas para una mayor eficacia en el rol tutorial, que los docentes señalaron en cada edición.Red de Universidades con Carreras en Informátic

Simulador hemodinámico cardiaco “HEMOSIM-1”

Es de gran utilidad para los expertos en el área médica simular comportamientos de un determinado sistema del cuerpo humano. Es así como HEMOSIM 1 pretende ser un módulo de Vigilancia. control y diagnóstico de un paciente que presente diversos desórdenes hemodínámícos.Sistemas de estas características facilitan y hacen más técnico el manejo de los pacientes llamados críticos. Gravemente enfermos. que ingresan a la UCI. así como el manejo de pacientes de alto riesgo anestésico que son llevados a cirugía.Hemosím 1 busca registrar los cambios hemodíriárnícos, representarIos gráficamente permitiendo el seguimiento del paciente y simulando respuestas a dosis variables de drogas en pacientes críticamente enfermos