The Aging Heart: Mitophagy at the Center of Rejuvenation.

Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular levels in various tissues, including the heart. It is known that there is an age-related decline in cellular quality control pathways such as autophagy and mitophagy, which leads to accumulation of potentially harmful cellular components in cardiac myocytes. There is evidence that diminished autophagy and mitophagy accelerate the aging process, while enhancement preserves cardiac homeostasis and extends life span. Here, we review the current knowledge of autophagy and mitophagy in aging and discuss how age-associated alterations in these processes contribute to cardiac aging and age-related cardiovascular diseases

Modeling the Black Hole Excision Problem

We analyze the excision strategy for simulating black holes. The problem is modeled by the propagation of quasi-linear waves in a 1-dimensional spatial region with timelike outer boundary, spacelike inner boundary and a horizon in between. Proofs of well-posed evolution and boundary algorithms for a second differential order treatment of the system are given for the separate pieces underlying the finite difference problem. These are implemented in a numerical code which gives accurate long term simulations of the quasi-linear excision problem. Excitation of long wavelength exponential modes, which are latent in the problem, are suppressed using conservation laws for the discretized system. The techniques are designed to apply directly to recent codes for the Einstein equations based upon the harmonic formulation.Comment: 21 pages, 14 postscript figures, minor contents updat

Would You Choose to be Happy? Tradeoffs Between Happiness and the Other Dimensions of Life in a Large Population Survey

A large literature documents the correlates and causes of subjective well-being, or happiness. But few studies have investigated whether people choose happiness. Is happiness all that people want from life, or are they willing to sacrifice it for other attributes, such as income and health? Tackling this question has largely been the preserve of philosophers. In this article, we find out just how much happiness matters to ordinary citizens. Our sample consists of nearly 13,000 members of the UK and US general populations. We ask them to choose between, and make judgments over, lives that are high (or low) in different types of happiness and low (or high) in income, physical health, family, career success, or education. We find that people by and large choose the life that is highest in happiness but health is by far the most important other concern, with considerable numbers of people choosing to be healthy rather than happy. We discuss some possible reasons for this preference

The young stellar population of NGC 4214 as observed with HST. I. Data and methods

We present the data and methods that we have used to perform a detailed UV-optical study of the nearby dwarf starburst galaxy NGC 4214 using multifilter HST/WFPC2+STIS photometry. We explain the process followed to obtain high-quality photometry and astrometry of the stellar and cluster populations of this galaxy. We describe the procedure used to transform magnitudes and colors into physical parameters using spectral energy distributions. The data show the existence of both young and old stellar populations that can be resolved at the distance of NGC 4214 (2.94 Mpc) and we perform a general description of those populations.Comment: 33 pages, 9 figures, and 8 table

Gaia FGK Benchmark Stars: Effective temperatures and surface gravities

Large Galactic stellar surveys and new generations of stellar atmosphere models and spectral line formation computations need to be subjected to careful calibration and validation and to benchmark tests. We focus on cool stars and aim at establishing a sample of 34 Gaia FGK Benchmark Stars with a range of different metallicities. The goal was to determine the effective temperature and the surface gravity independently from spectroscopy and atmospheric models as far as possible. Fundamental determinations of Teff and logg were obtained in a systematic way from a compilation of angular diameter measurements and bolometric fluxes, and from a homogeneous mass determination based on stellar evolution models. The derived parameters were compared to recent spectroscopic and photometric determinations and to gravity estimates based on seismic data. Most of the adopted diameter measurements have formal uncertainties around 1%, which translate into uncertainties in effective temperature of 0.5%. The measurements of bolometric flux seem to be accurate to 5% or better, which contributes about 1% or less to the uncertainties in effective temperature. The comparisons of parameter determinations with the literature show in general good agreements with a few exceptions, most notably for the coolest stars and for metal-poor stars. The sample consists of 29 FGK-type stars and 5 M giants. Among the FGK stars, 21 have reliable parameters suitable for testing, validation, or calibration purposes. For four stars, future adjustments of the fundamental Teff are required, and for five stars the logg determination needs to be improved. Future extensions of the sample of Gaia FGK Benchmark Stars are required to fill gaps in parameter space, and we include a list of suggested candidates.Comment: Accepted by A&A; 34 pages (printer format), 14 tables, 13 figures; language correcte

Spectral methods for the wave equation in second-order form

Current spectral simulations of Einstein's equations require writing the equations in first-order form, potentially introducing instabilities and inefficiencies. We present a new penalty method for pseudo-spectral evolutions of second order in space wave equations. The penalties are constructed as functions of Legendre polynomials and are added to the equations of motion everywhere, not only on the boundaries. Using energy methods, we prove semi-discrete stability of the new method for the scalar wave equation in flat space and show how it can be applied to the scalar wave on a curved background. Numerical results demonstrating stability and convergence for multi-domain second-order scalar wave evolutions are also presented. This work provides a foundation for treating Einstein's equations directly in second-order form by spectral methods.Comment: 16 pages, 5 figure

The resultant on compact Riemann surfaces

We introduce a notion of resultant of two meromorphic functions on a compact Riemann surface and demonstrate its usefulness in several respects. For example, we exhibit several integral formulas for the resultant, relate it to potential theory and give explicit formulas for the algebraic dependence between two meromorphic functions on a compact Riemann surface. As a particular application, the exponential transform of a quadrature domain in the complex plane is expressed in terms of the resultant of two meromorphic functions on the Schottky double of the domain.Comment: 44 page

Scaling Limits for Internal Aggregation Models with Multiple Sources

We study the scaling limits of three different aggregation models on Z^d: internal DLA, in which particles perform random walks until reaching an unoccupied site; the rotor-router model, in which particles perform deterministic analogues of random walks; and the divisible sandpile, in which each site distributes its excess mass equally among its neighbors. As the lattice spacing tends to zero, all three models are found to have the same scaling limit, which we describe as the solution to a certain PDE free boundary problem in R^d. In particular, internal DLA has a deterministic scaling limit. We find that the scaling limits are quadrature domains, which have arisen independently in many fields such as potential theory and fluid dynamics. Our results apply both to the case of multiple point sources and to the Diaconis-Fulton smash sum of domains.Comment: 74 pages, 4 figures, to appear in J. d'Analyse Math. Main changes in v2: added "least action principle" (Lemma 3.2); small corrections in section 4, and corrected the proof of Lemma 5.3 (Lemma 5.4 in the new version); expanded section 6.