SNODGRASS Procedure A Versatile Technique for Various Types of Hypospadias Repair

There are about 156 operations described forhypospadias. The sheer number of proceduresindicates that no single procedure is standardfor hypospadias. We report our series of 20patients operated for hypospadias by Snodgrassprocedure. The technical details of the proce-dure and post-operative management protocolis discussed

Degradation of Textile Dye Reactive Navy – Blue Rx (Reactive blue–59) by an Isolated Actinomycete Streptomyces krainskii SUK – 5

The isolated Actinomycete, Streptomyces krainskii, SUK -5 was found to decolorize and degrade textile dye Reactive blue–59.This azo dye was decolorized and degraded completely by Streptomyces krainskii SUK–5 at 24 h in shaking condition in the nutrient medium at pH 8. Induction in the activity of Lignin Peroxidase,and NADH-DCIP Reductase and MR reductase represents their role in degradation .The biodegradation was monitored by TLC, UV vis spectroscopy, FTIR. and GCMS analysis. Microbial and phytotoxicity studies of the product were carried out

A User Oriented Image Retrieval System using Halftoning BBTC

The objective of this paper is to develop a system for content based image retrieval (CBIR) by accomplishing the benefits of low complexity Ordered Dither Block Truncation Coding based on half toning technique for the generation of image content descriptor. In the encoding step ODBTC compresses an image block into corresponding quantizes and bitmap image. Two image features are proposed to index an image namely co-occurrence features and bitmap patterns which are generated using ODBTC encoded data streams without performing the decoding process. The CCF and BPF of an image are simply derived from the two quantizes and bitmap respectively by including visual codebooks. The proposed system based on block truncation coding image retrieval method is not only convenient for an image compression but it also satisfy the demands of users by offering effective descriptor to index images in CBIR system

Characteristics of natural and planted sandalwood-supporting soils in Seoni district, Madhya Pradesh

Two sandalwood-supporting pedons, one planted (P1) and other natural growing, were characterized in Seoni district of Madhya Pradesh. The solum depth of both the pedon was 30 cm underlain by weathered basalt beyond 50 cm. Pedon was dark reddish brown while P2 was characterized by dark reddish brown to dusky red. P2 had sandy clay texture (A1 horizon) and other horizons of both the pedons was associated with clay texture. These soils had more than 35 cmol(p+)kg-1 CEC and dominance of smectite (>20%) followed by vermiculite. There was more than 20 per cent feldspar in Bw horizon of P1 while underlying horizon of P2 had 25 per cent quartz. The nearly neutral soils had more than 1.0 per cent organic carbon barring A2 horizon of P2. These calcareous soils were dominated by exchangeable Ca++ followed by Mg++, Na+, K+ on exchange complex and grouped as Typic Haplustepts and Typic Ustorthents at subgroup level

RIFAMPICIN LOADED SPRAY-DRIED OLIBANUM GUM RESIN PULMOSPHERES FOR LUNG DELIVERY

Pulmospheres of Rifampicin were prepared successfully with cyclodextrin using olibanum gum resin as a rate controlling biodegradable natural polymer by novel spray drying technique. Hydroxypropyl-β-cyclodextrin was used as solubilising agent to enhance the solubility and permeation of poorly soluble rifampicin. The physcochemical characteristics of   rifampicin loaded pulmospheres were evaluated for mean particle size, thermal behaviour and surface morphology. The mean particle size for optimized formulation F1 was found to be 3.5 µm and spray-dried pure rifampicin also showed same value. Scanning Electron Microphotographs of pure drug has shown a typical and regular size indicated crystalline nature, whereas, spray dried pure drug and formulation F1 have shown spherical particles with porous surface indicated the conversion of crystalline drug into amorphous form. Rifampicin loaded spray-dried pulmospheres using olibanum gum resin showed drug release up to 72 hours. The release of rifampicin was greater in simulated physiological fluid of pH 7.4 which was 94 % as compared to simulated lung fluid of pH 5.2 at the end of 72 hours. Rifampicin loaded spray-dried microspheres were proposed for pulmonary drug delivery.   Keywords: Rifampicin, Lung targeting, Olibanum gum resin, Spray-drying, Pulmosphere

A preliminary study on perioperative hemostatic effect of spray dried powder of <i>Chromolaena odorata</i> leaf extract

547-555Accidents or surgery often cause internal haemorrhage in liver and arteries which may lead to patient morbidity and mortality. The current hemostatic agents used for treatment like collagen, oxidized cellulose, and chitosan suffer from side effects which include infection, inflammation and even sepsis. In the present study, we studied the spray dried powder (SDP) of the aqueous extract of the leaves of Chromolaena odorata (L.) R.M.King & H.Rob., commonly known as Siam weed or Common floss flower and also Christmas bush, for its hemostatic efficacy in two experimental models of surgery. Firstly, the SDP was screened through standard pharmacognostical parameters, and a part of the liver was lacerated in rats and femoral artery was transected in rabbits to assess the blood loss in pre-weighed gauze with and without treatment. In the liver laceration model, an effective blood loss reduction of 54.30 % was observed with oral administration of SDP 7 days prior to surgery. Similarly, application of SDP at the site of artery transection caused 70.36% reduction in blood loss as compared to the control rabbit artery. The results suggest that oral delivery and/or application of SDP of C. odorata by formulating it in a suitable drug delivery tool could minimize perioperative bleeding in hepatic and arterial tissue and improve recovery

Оптимизация преподавания темы "Диагностика и лечение атеросклероза" на факультете повышения квалификации врачей

ФАКУЛЬТЕТЫ ПОВЫШЕНИЯ КВАЛИФИКАЦИИПОВЫШЕНИЕ КВАЛИФИКАЦИИОБРАЗОВАНИЕ МЕДИЦИНСКОЕ, ПОВЫШЕНИЕ КВАЛИФИКАЦИИПРЕПОДАВАНИЕМЕТОДИКА ПРЕПОДАВАНИЯОБРАЗОВАТЕЛЬНЫЕ ТЕХНОЛОГИ

Exploring the therapeutic mechanisms of Cassia glauca in diabetes mellitus through network pharmacology, molecular docking and molecular dynamics

Cassia glauca is reported as anti-diabetic medicinal plant and is also used as an ethnomedicine. However, its mode of action as an anti-diabetic agent has not been clearly elucidated. Hence, the present study investigated the probable mechanism of action of C. glauca to manage diabetes mellitus via network pharmacology and molecular docking and simulations studies. The reported bioactives from C. glauca were retrieved from an open-source database, i.e. ChEBI, and their targets were predicted using SwissTargetPrediction. The proteins involved in the pathogenesis of diabetes were identified from the therapeutic target database. The targets involved in diabetes were enriched in STRING, and the pathways involved in diabetes were identified concerning the KEGG. Cytoscape was used to construct the network among bioactives, proteins, and probably regulated pathways, which were analyzed based on edge count. Similarly, molecular docking was performed using the Glide module of the Schrodinger suite against majorly targeted proteins with their respective ligands. Additionally, the drug-likeness score and ADMET profile of the individual bioactives were predicted using MolSoft and admetSAR2.0 respectively. The stability of these complexes were further studied via molecular dynamics simulations and binding energy calculations. Twenty-three bio-actives were retrieved from the ChEBI database in which cassiarin B was predicted to modulate the highest number of proteins involved in diabetes mellitus. Similarly, GO analysis identified the PI3K-Akt signaling pathway to be primarily regulated by modulating the highest number of gene. Likewise, aldose reductase (AKR1B1) was majorly targeted via the bioactives of C. glauca. Similarly, docking study revealed methyl-3,5-di-O-caffeoylquinate (docking score −9.209) to possess the highest binding affinity with AKR1B1. Additionally, drug-likeness prediction identified cassiaoccidentalin B to possess the highest drug-likeness score, i.e. 0.84. The molecular dynamics simulations and the MMGBSA indicate high stability and greater binding energy for the methyl-3,5-di-O-caffeoylquinate (ΔGbind = −40.33 ± 6.69 kcal mol−1) with AKR1B1, thus complementing results from other experiments. The study identified cassiarin B, cassiaoccidentalin B, and cinnamtannin A2 as lead hits for the anti-diabetic activity of C. glauca. Further, the PI3K-Akt and AKR1B1 were traced as majorly modulated pathway and target, respectively