975 research outputs found

    Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings

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    Cataloged from PDF version of article.Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon alpha (IFN alpha) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity

    Electromigration-Induced Propagation of Nonlinear Surface Waves

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    Due to the effects of surface electromigration, waves can propagate over the free surface of a current-carrying metallic or semiconducting film of thickness h_0. In this paper, waves of finite amplitude, and slow modulations of these waves, are studied. Periodic wave trains of finite amplitude are found, as well as their dispersion relation. If the film material is isotropic, a wave train with wavelength lambda is unstable if lambda/h_0 < 3.9027..., and is otherwise marginally stable. The equation of motion for slow modulations of a finite amplitude, periodic wave train is shown to be the nonlinear Schrodinger equation. As a result, envelope solitons can travel over the film's surface.Comment: 13 pages, 2 figures. To appear in Phys. Rev.

    Experimental observation of speckle instability in nonlinear disordered media

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    Temporal fluctuations of the speckle pattern formed upon backscattering of a laser beam from an interface between gold and nonlinear polymer film have been observed as a function of optical power. The instability can be explained by coupling of laser light to surface plasmons and other guided modes, which experience multiple scattering while propagating in the film along the interface. The speckle pattern produced in this process is extremely sensitive to fluctuations of the scattering potential near the interface.Comment: 4 pages, 5 figure
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