A Kpc-scale Radio Polarization Study of PG BL Lacs with the uGMRT

We present here uGMRT band 4 (~650MHz) polarization images of 8 BL~Lac objects belonging to the Palomar-Green (PG) `blazar' sample. A large fraction of the sources (~63%) reveal core-halo radio structures with most of the polarization detected in the inner core-jet regions. PG1101+385 and PG2254+075 exhibit a `spine-sheath structure' in polarization. The core-halo and `spine-sheath' structures are consistent with the Unified Scheme suggestion that BL~Lacs are the pole-on beamed counterparts of Fanaroff-Riley (FR) type I radio galaxies. PG1418+546 and PG0851+203 (OJ287) show the presence of terminal hotspots similar to FR type II radio galaxies. They were also found to be low-spectrally peaked BL Lacs, supportive of the `blazar envelope' scenario for BL~Lacs and quasars. Fractional polarization ranges from 1-13% in the cores and 2-26% in the inner jets/lobes of the sample BL Lacs. Compared to the varied radio morphology of quasars from the PG `blazar' sample, the BL~Lacs appear to be less diverse. A comparison of the inferred core magnetic (B-) field structures on arcsec- (kpc-) scales w.r.t. the Very Long Baseline Interferometry (VLBI) jet direction does not reveal any preferred orientation, suggesting that if large-scale ordered B-fields exist, they do so on scales smaller than probed by the current observations. However, the presence of polarized emission on arcsec-scales suggests that any mixing of thermal plasma with the synchrotron emitting plasma is insufficient to fully depolarize the emission via the internal depolarization process.Comment: 17 pages; 12 figures; MNRAS accepte

Resilience and well-being among children of migrant parents in South-East Asia

There has been little systematic empirical research on the well-being of children in transnational households in South-East Asia—a major sending region for contract migrants. This study uses survey data collected in 2008 from children aged 9, 10 and 11 and their caregivers in Indonesia, the Philippines, and Vietnam (N=1,498). Results indicate that while children of migrant parents, especially migrant mothers, are less likely to be happy compared to children in non-migrant households, greater resilience in child well-being is associated with longer durations of maternal absence. There is no evidence for a direct parental migration effect on school enjoyment and performance. The analyses highlight the sensitivity of results to the dimension of child well-being measured and who makes the assessment.Publisher PDFPeer reviewe

Pattern & correlates of neurocognitive dysfunction in Asian Indian adults with severe obstructive sleep apnoea

Background & Objectives: No published data are available on neurocognitive dysfunction in Asian Indians with obstructive sleep apnoea (OSA). We therefore, studied the pattern and correlates of neurocognitive dysfunction in Indian adults with severe OSA. Methods: Fifty patients aged 25-65 yr with severe OSA (apnoea-hypopnoea index>30) and 25 age, sex, and education level-matched normal controls were studied. Both groups were administered a standardized battery of neurocognitive tests. Results: Patients with severe OSA had significantly impaired performance on tests of alertness, working memory, response inhibition, problem solving, and executive function. However, the difference in executive function between the groups disappeared after adjusting for delayed information processing. The test scores did not correlate with apnoea-hypopnoea index, arousal index, or Epworth sleepiness score. However, the percentage of time spent at <90 per cent oxygen saturation had a weak correlation with the number of stroop errors (Spearman's rho=0.64; P=0.033), number of trials required (rho=0.05; P=0.02), and perseverative errors on Wisconsin card sorting test (rho=0.36; P=0.02). Interpretation & Conclusions: Our results suggested that delayed information processing rather than impaired abstract thinking was probably the cause of impaired performance on composite tests of neurocognitive function in patients with severe OSA

Attention control in autism: Eye-tracking findings from pre-school children in a low- and middle-income country setting

Alterations in the development of attention control and learning have been associated with autism and can be measured using the ‘antisaccade task’, which assesses a child’s ability to make an oculomotor response away from a distracting stimulus, and learn to instead anticipate a later reward. We aimed to assess these cognitive processes using portable eye-tracking in an understudied population of pre-school children with and without a diagnosis of autism spectrum disorder in community settings in New Delhi, India. The eye-tracking antisaccade task was presented to children in three groups (n = 104) (children with a clinical diagnosis of autism spectrum disorder or intellectual disability and children meeting developmental milestones). In accordance with findings from high-income, laboratory-based environments, children learnt to anticipate looks towards a reward, as well as inhibit eye-movements towards a distractor stimulus. We also provide novel evidence that while differences in inhibition responses might be applicable to multiple developmental conditions, a reduced learning to anticipate looks towards a target in this age group may be specific to autism. This eye-tracking task may, therefore, have the potential to identify and assess autism specific traits across development, and be used in longitudinal research studies such as investigating response to intervention in low-resource settings

Automated Determination of Stellar Parameters from Simulated Dispersed Images for DIVA

We have assessed how well stellar parameters (T_eff, logg and [Fe/H]) can be retrieved from low-resolution dispersed images to be obtained by the DIVA satellite. Although DIVA is primarily an all-sky astrometric mission, it will also obtain spectrophotometric information for about 13 million stars (operational limiting magnitude V ~ 13.5 mag). Constructional studies foresee a grating system yielding a dispersion of ~200nm/mm on the focal plane (first spectral order). For astrometric reasons there will be no cross dispersion which results in the overlapping of the first to third diffraction orders. The one-dimensional, position related intensity function is called a DISPI (DISPersed Intensity). We simulated DISPIS from synthetic spectra (...) for a limited range of metallicites i.e. our results are for [Fe/H] in the range -0.3 to 1 dex. We show that there is no need to deconvolve these low resolution signals in order to obtain basic stellar parameters. Using neural network methods and by including simulated data of DIVA's UV telescope, we can determine T_eff to an average accuracy of about 2% for DISPIS from stars with 2000 K < T_eff < 20000 K and visual magnitudes of V=13 mag (end of mission data). logg can be determined for all temperatures with an accuracy better than 0.25 dex for magnitudes brighter than V=12 mag. For low temperature stars with 2000 K < T_eff < 5000 K and for metallicities in the range -0.3 to +1 dex a determination of [Fe/H] is possible (to better than 0.2 dex) for these magnitudes. Additionally we examined the effects of extinction E(B-V) on DISPIS and found that it can be determined to better than 0.07 mag for magnitudes brighter than V=14 mag if the UV information is included.Comment: 12 pages, 8 figures, Accepted for publication in A&

Prevention, Detection, and Management of Heart Failure in Patients Treated for Breast Cancer

Purpose of Review: Long-term survival has increased significantly in breast cancer patients, and cardiovascular side effects are surpassing cancer-related mortality. We summarize risk factors, prevention strategies, detection, and management of cardiotoxicity, with focus on left ventricular dysfunction and heart failure, during breast cancer treatment. Recent Findings: Baseline treatment of cardiovascular risk factors is recommended. Anthracycline and trastuzumab treatment constitute a substantial risk of developing cardiotoxicity. There is growing evidence that this can be treated with beta blockers and angiotensin antagonists. Early detection of cardiotoxicity with cardiac imaging and circulating cardiovascular biomarkers is currently evaluated in clinical trials. Chest wall irradiation accelerates atherosclerotic processes and induces fibrosis. Immune checkpoint inhibitors require consideration for surveillance due to a small risk of severe myocarditis. Cyclin-dependent kinases4/6 inhibitors, cyclophosphamide, taxanes, tyrosine kinase inhibitors, and endocrine therapy have a lower-risk profile for cardiotoxicity. Summary: Preventive and management strategies to counteract cancer treatment–related left ventricular dysfunction or heart failure in breast cancer patients should include a comprehensive cardiovascular risk assessment and individual clinical evaluation. This should include both patient and treatment-related factors. Further clinical trials especially on early detection, cardioprevention, and management are urgently needed. © 2020, The Author(s).Peer reviewe

Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.

Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; &lt;4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here, we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the local field potential and the related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in the perilesional cortex. Sensorimotor LFOs were also diminished in a human subject with chronic disability after stroke in contrast to two non-stroke subjects who demonstrated robust LFOs. Therapeutic delivery of electrical stimulation time-locked to the expected onset of LFOs was found to significantly improve skilled reaching in stroke animals. Together, our results suggest that restoration or modulation of cortical oscillatory dynamics is important for the recovery of upper-limb function and that they may serve as a novel target for clinical neuromodulation

Renal cell carcinoma with a tumor thrombus in the ureter: a case report

<p>Abstract</p> <p>Background</p> <p>Renal cell carcinoma (RCCs) is the most common malignancy of the kidney. When RCC progresses, it is known to form tumor thrombus in the renal vein and/or inferior vena cava. However, RCC does not normally form tumor thrombus in the ureter or renal pelvis.</p> <p>Case presentation</p> <p>A 43-year-old man presented to our department for the treatment of a renal tumor with asymptomatic gross hematuria. In a dynamic CT study, contrast enhancement revealed a tumor suspected to be RCC, but atypical finding as a tumor thrombus that filled the renal pelvis and the whole ureter was also observed. Nephroureterectomy was performed, and the tumor was diagnosed histopathologically as RCC.</p> <p>Conclusion</p> <p>We report here a very rare case of RCC with a tumor thrombus in the whole ureter.</p

A prospective study of risk factor profile &amp; incidence of deep venous thrombosis among medically-ill hospitalized patients at a tertiary care hospital in Northern India

Background &amp; Objective: Hospitalization for medical-illness is associated with an increased risk of deep venous thrombosis (DVT). However, there are no published data from India addressing at this issue. We sought to study the risk factor profile and the incidence of DVT among hospitalized medically-ill patients, a tertiary care hospital in northern India. Methods: All adults admitted to the medical wards and intensive care unit with level 1 or 2 mobility over a period of two years (July 2006 to July 2008) at the All India Institute of Medical Sciences hospital, New Delhi, were prospectively studied. Patients having DVT at admission or an anticipated hospital stay less than 48 h were excluded. The presence of clinical risk factors for DVT was recorded and laboratory evaluation was done for hypercoagulable state. A routine surveillance venous compression Doppler ultrasonography was performed 12 ± 8 days after hospital admission. Results: Of the 163 patients, 77 (47%) had more than one risk factor for DVT. Five (3%) patients developed DVT; none of them had symptomatic DVT. None of these patients received anticoagulation prior to the development of DVT. The mean age of those who developed DVT was 40 ± 13 (25-50) yr; two of five were male. The incidence rate of DVT was 2.7 per 1000 person-days of hospital stay [95% confidence interval (CI): 0.87 to 6.27]. None of the factors was found to be significantly associated with the risk of DVT. Interpretation &amp; Conclusion: In our setting, although many hospitalized medically-ill patients had risk factors for DVT, the absolute risk of DVT was low compared to the western population but clearly elevated compared to non hospitalized patients. Large studies from India are required to confirm our findings

The role of endogenous and exogenous mechanisms in the formation of R&D networks

We develop an agent-based model of strategic link formation in Research and Development (R&D)networks. Empirical evidence has shown that the growth of these networks is driven by mechanisms whichare both endogenous to the system (that is, depending on existing alliances patterns) and exogenous (that is, driven by an exploratory search for newcomer firms). Extant research to date has not investigated both mechanisms simultaneously in a comparative manner. To overcome this limitation, we develop a general modeling framework to shed light on the relative importance of these two mechanisms. We test our model against a comprehensive dataset, listing cross-country and cross-sectoral R&D alliances from 1984 to 2009. Our results show that by fitting only three macroscopic properties of the network topology, this framework is able to reproduce a number of micro-level measures, including the distributions of degree, local clustering, path length and component size, and the emergence of network clusters. Furthermore, by estimating the link probabilities towards newcomers and established firms from the data, we find that endogenous mechanisms are predominant over the exogenous ones in the network formation, thus quantifying the importance of existing structures in selecting partner firms