Sistema Dragados–Plastbau

Not Available.El sistema Dragados-Plastbau forma parte de una familia de sistemas, nacido en los Estados Unidos y hoy aplicado muy crecientemente en Inglaterra, Francia, Alemania, Australia, Italia y Suiza. Pero si bien tiene en común con ellos la integración del poliestireno expandido en el panel, es ciertamente innovadora en conseguir con unas sencillas máquinas una variedad de paneles con diferentes espesores, que se pueden trasladar sin ningún problema, montar con facilidad y producir un semiprefabricado que facilita una solución ágil para cualquier proyecto, incluso aunque se haya pensado para otro tipo de proceso o para obra tradicional

Expression of spidroin proteins in the silk glands of golden orb-weaver spiders.

The expression of spidroins in the major ampullate, minor ampullate, flagelliform, and tubuliform silk glands of Trichonephila clavipes spiders was analyzed using proteomics analysis techniques. Spidroin peptides were identified and assigned to different gene products based on sequence concurrence when compared with the whole genome of the spider. It was found that only a relatively low proportion of the spidroin genes are expressed as proteins in any of the studied glands. In addition, the expression of spidroin genes in different glands presents a wide range of patterns, with some spidroins being found in a single gland exclusively, while others appear in the content of several glands. The combination of precise genomics, proteomics, microstructural, and mechanical data provides new insights both on the design principles of these materials and how these principles might be translated for the production of high-performance bioinspired artificial fibers.Ministerio de Innovación, Cultura y Deportes(Spain), Grant/Award Numbers: PGC2018‐097019‐B‐I00, PID2020‐116403RB‐I00;Instituto de Salud Carlos III,Grant/Award Number: CB16/11/00277;Comunidad de Madrid, Grant/Award Numbers:NEUROCENTRO‐B2017/BMD‐3760,Tec4Bio‐CM/P2018/NMT‐4443 Spiders were reared by Oscar Campos (Reptilmadrid S.L., Spain). The artwork was made by Carmen Calvo. This study was funded by Comunidad de Madrid (Spain) through grants NEUROCENTRO‐ B2017/BMD‐3760 and Tec4Bio‐CM/P2018/NMT‐4443. This study was also supported by Spanish Ministerio de Innovación, Cultura y Deportes (PGC2018‐097019‐B‐I00 and PID2020‐116403RB‐I00), and Instituto de Salud Carlos III (CIBER de Enfermedades Cardiovasculares (CB16/11/00277); Plataforma de Recursos Biomoleculares PRB3 (ProteoRed; PT17/0019/0003)). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV‐2015‐0505).S

Chronic renal dysfunction in maintenance heart transplant patients: the ICEBERG study

[Abstract] Chronic renal dysfunction (CRD) is a major complication after heart transplantation. We sought to describe the renal function over time, to assess the risk factors associated with CRD development, and to evaluate the clinical attitudes on diagnosis and treatment of CRD. A retrospective, cross-sectional, multicenter study was conducted in 13 outpatient clinics in Spain. A total of 244 heart recipients who survived more than 2 years after transplantation were included. Post-transplantation follow-up was 7.7 years (range: 2-22 years). CRD was diagnosed in 32.4% of patients at a mean of 3.3 years after transplantation. Serum creatinine increased 0.1 ± 0.2 mg/dL per year in CRD group compared with 0.0 ± 0.2 mg/dL per year in non-CRD group (P = .003) and glomerular filtration rate decreased −1.5 ± 4.3 mL/min/1.73 m2 per year in CRD group versus −0.1 ± 4.8 mL/min/1.73 m2 per year in non-CRD group (P = .027). After CRD diagnosis, major changes in immunosuppression based on calcineurin inhibitors reduction were instituted in 46.8% of patients. Multivariate model identified recipient age (P < .0001), female sex (P = .0398), and time since transplant (P < .0001) as predictors of CRD. In conclusion, the prevalence of CRD in long-term heart recipient survivors was quite high. CRD was associated with nonmodifiable factors (age, gender, and time since transplant)

Nutritional and socio-economic factors associated with Plasmodium falciparum infection in children from Equatorial Guinea: results from a nationally representative survey

<p>Abstract</p> <p>Background</p> <p>Malaria has traditionally been a major endemic disease in Equatorial Guinea. Although parasitaemia prevalence on the insular region has been substantially reduced by vector control in the past few years, the prevalence in the mainland remains over 50% in children younger than five years. The aim of this study is to investigate the risk factors for parasitaemia and treatment seeking behaviour for febrile illness at country level, in order to provide evidence that will reinforce the EG National Malaria Control Programme.</p> <p>Methods</p> <p>The study was a cross-sectional survey of children 0 to 5 years old, using a multistaged, stratified, cluster-selected sample at the national level. It included a socio-demographic, health and dietary questionnaires, anthropometric measurements, and thick and thin blood smears to determine the <it>Plasmodium </it>infection. A multivariate logistic regression model was used to determine risk factors for parasitaemia, taking into account the cluster design.</p> <p>Results</p> <p>The overall prevalence of parasitemia was 50.9%; it was higher in rural (58.8%) compared to urban areas (44.0%, p = 0.06). Age was positively associated with parasitemia (p < 0.0001). In rural areas, risk factors included longer distance to health facilities (p = 0.01) and a low proportion of households with access to protected water in the community (p = 0.02). Having had an episode of cough in the 15 days prior to the survey was inversely related to parasitemia (p = 0.04). In urban areas, the risk factors were stunting (p = 0.005), not having taken colostrum (p = 0.01), and that someone in the household slept under a bed net (p = 0.002); maternal antimalarial medication intake during pregnancy (p = 0.003) and the household socio-economic status (p = 0.0002) were negatively associated with parasitemia. Only 55% of children with fever were taken outside their homes for care, and treatment seeking behaviour differed substantially between rural and urban populations.</p> <p>Conclusion</p> <p>Results suggest that a national programme to fight malaria in Equatorial Guinea should take into account the differences between rural and urban communities in relation to risk factors for parasitaemia and treatment seeking behaviour, integrate nutrition programmes, incorporate campaigns on the importance of early treatment, and target appropriately for bed nets to reach the under-fives.</p

Sistema Dragados–Plastbau

Not Available.<br><br>El sistema Dragados-Plastbau forma parte de una familia de sistemas, nacido en los Estados Unidos y hoy aplicado muy crecientemente en Inglaterra, Francia, Alemania, Australia, Italia y Suiza. Pero si bien tiene en común con ellos la integración del poliestireno expandido en el panel, es ciertamente innovadora en conseguir con unas sencillas máquinas una variedad de paneles con diferentes espesores, que se pueden trasladar sin ningún problema, montar con facilidad y producir un semiprefabricado que facilita una solución ágil para cualquier proyecto, incluso aunque se haya pensado para otro tipo de proceso o para obra tradicional

Combination of Candida biomarkers in patients receiving empirical antifungal therapy in a Spanish tertiary hospital: a potential role in reducing the duration of treatment

Objectives: Initiation of empirical antifungal therapy for invasive candidiasis (IC) is usually based on clinical suspicion. Serological biomarkers have not yet been studied as a means of ruling out IC. We evaluated the potential role of two combined biomarkers in stopping unnecessary antifungals in patients at risk of IC in the ICU and in other wards.Methods: This was a prospective observational study including adults starting empirical antifungal treatment for suspected IC, at Gregorio Maranon Hospital, Madrid (Spain). Patients were stratified according to admission department (ICU or other wards) and final diagnosis (no IC or proven or probable IC). Type of candidiasis (candidaemia or deep-seated candidiasis) was also considered. The Candida albicans germ tube antibody (CAGTA) test and the beta-D-glucan (BDG) test were performed on serum samples collected by venepuncture on days 0, 3 and 5 after starting empirical antifungal therapy.Results: Sixty-three ICU patients and 37 non-ICU patients were included. High-risk gastrointestinal surgery and sepsis in non-surgical patients were the main indications for empirical treatment (30% each). Patients had no IC (58%), proven IC (30%) or probable IC (12%). Overall, sensitivity and negative predictive value of the combination of both the CAGTA test and the BDG test were 97% for the entire population. The best performance was observed in ICU patients (sensitivity and negative predictive value of 100%). Among patients without IC, all biomarkers were negative in 31 patients.Conclusions: Serial determination of CAGTA/BDG during empirical antifungal therapy has a high sensitivity and negative predictive value. If properly confirmed, this strategy could be used to discontinue antifungal treatment in at least 31% of patients as a complementary tool in antifungal stewardship programmes

Optimizacion de la produccion de biotensioactivos por Pseudomonas aeruginosa 44T1

En este trabajo se describen los resultados experimentales destinados a la optimización de la producción de biotensioactivos por Pseudomonas aeruginosa 44T1 en un medio mineral con glucosa como fuente de carbono. Se han ensayado diversos componentes del medio de cultivo y condiciones de incubación, siendo la relación C/N, la concentración de hierro así como la temperatura de incubación, los parámetros fundamentales que han incrementado los valores de CMC-1 como medida de la acumulación de tensioactivos

Mine waste pollutes Mediterranean

1 página.-- Correspondencia.Peer reviewe