Veneziano ghost, modified gluon propagator, and gauge copies in QCD

In this short note, we come back to the recent proposal put forward by Kharzeev and Levin [Phys. Rev. Lett. 114, 242001 (2015)], in which they phenomenologically couple the nonperturbative Veneziano ghost to the perturbative gluon, leading to a modified gluon propagator (the "glost") of the Gribov type, with complex poles. As such, a possible link was made between the QCD topological theta-vacuum (Veneziano ghost) and color confinement (no physically observable gluons). We discuss some subtleties concerning gauge (Becchi-Rouet-Stora-Tuytin) invariance of this proposal, related to the choice of Feynman gauge. We draw particular attention to the incompatibility in the longitudinal sector with available nonperturbative results for the linear covariant gauge. We furthermore provide an example in the Landau gauge of a similar phenomenological vertex that also describes the necessary Veneziano ghost but does not affect the Landau gauge gluon propagator

Spontaneous breaking of the BRST symmetry in the presence of the Gribov horizon : renormalizability

An all orders algebraic proof of the multiplicative renormalizability of the novel formulation of the Gribov-Zwanziger action proposed in Phys. Rev. D 86, 045005 (2012) [arXiv:1205.3934], and allowing for an exact but spontaneously broken BRST symmetry, is provided.Comment: 15 page

SU(2) x U(1) Yang-Mills theories in 3d with Higgs field and Gribov ambiguity

We study the structure of the gauge propagators of a 3d version of the electroweak interaction in terms of the Higgs vacuum expectation value., of the non-Abelian gauge coupling g, and of the Abelian gauge coupling g', when nonperturbative effects related to the non-Abelian gauge fixing are introduced by means of an adapted path integral measure. In the perturbative regime of small nonAbelian coupling g and sufficiently large, nu the well-known standard Z and W propagators are recovered, together with a massless photon. In general, depending on the relative magnitudes of g, g' and., we uncover a quite different propagator structure. In a later stage of research, the results here derived can be used to study the associated phase diagram in more depth

Glueball masses from an infrared moment problem

We set up an infrared-based moment problem to obtain estimates of the masses of the scalar, pseudoscalar, and tensor glueballs in Euclidean Yang-Mills theories using the refined Gribov-Zwanziger (RGZ) version of the Landau gauge, which takes into account nonperturbative physics related to gauge copies. Employing lattice input for the mass scales of the RGZ gluon propagator, the lowest order moment problem approximation gives the values m(0++) approximate to 1.96 GeV, m(2++) approximate to 2.04 GeV, and m(0-+) approximate to 2.19 GeV in the SU(3) case, all within a 20% range of the corresponding lattice values. We also recover the mass hierarchy m(0++) < m(2++) < m(0-+)

Nonperturbative aspects of Euclidean Yang-Mills theories in linear covariant gauges : Nielsen identities and a BRST-invariant two-point correlation function

In order to construct a gauge-invariant two-point function in a Yang-Mills theory, we propose the use of the all-order gauge-invariant transverse configurations A(h). Such configurations can be obtained through the minimization of the functional A(min)(2) along the gauge orbit within the BRST-invariant formulation of the Gribov-Zwanziger framework recently put forward in [1,2] for the class of the linear covariant gauges. This correlator turns out to provide a characterization of nonperturbative aspects of the theory in a BRST-invariant and gauge-parameter-independent way. In particular, it turns out that the poles of are the same as those of the transverse part of the gluon propagator, which are also formally shown to be independent of the gauge parameter alpha entering the gauge condition through the Nielsen identities. The latter follow from the new exact BRST-invariant formulation introduced before. Moreover, the correlator enables us to attach a BRST-invariant meaning to the possible positivity violation of the corresponding temporal Schwinger correlator, giving thus for the first time a consistent, gauge parameter independent, setup to adopt the positivity violation of as a signature for gluon confinement. Finally, in the context of gauge theories supplemented with a fundamental Higgs field, we use to probe the pole structure of the massive gauge boson in a gauge-invariant fashion

Semiclassical analysis of the phases of 4d SU(2) Higgs gauge systems with cutoff at the Gribov horizon

We present an analytical study of continuum 4d SU(2) gauge-Higgs models with a single Higgs field with fixed length in either the fundamental or adjoint representation. We aim at analytically probing the renowned predictions of Fradkin and Shenker on the phase diagram in terms of confinement versus Higgs behavior, obtained for the lattice version of the model. We work in the Landau version of the ' t Hooft R xi gauges in which case we can access potential nonperturbative physics related to the existence of the Gribov copies. In the fundamental case, we clearly show that in the perturbative regime of small gauge coupling constant g and large Higgs vacuum expectation value (vev) nu, there is a Higgs phase with Yukawa gauge boson propagators without Gribov effects. For a small value of the Higgs vev nu and/or large g, we enter a region with Gribov-type propagators that have no physical particle interpretation: the gauge bosons are as such confined. The transition between both behaviors is found to be continuous. In the adjoint case, we find evidence of a more drastic transition between the different behaviors for the propagator of the off- diagonal gauge bosons, whereas the "photon,'' i.e. the diagonal component of the gauge field, displays a propagator of the Gribov-type. In the limit of infinite Higgs condensate, we show that a massless photon is recovered. We compare our findings with those of Fradkin and Shenker as well as with more recent numerical lattice simulations of the fundamental Higgs model. We also carefully discuss in which region of the parameter space (nu, g) our approximations are trustworthy

Genome of Mycoplasma haemofelis, unraveling its strategies for survival and persistence

Mycoplasma haemofelis is a mycoplasmal pathogen (hemoplasma) that attaches to the host's erythrocytes. Distributed worldwide, it has a significant impact on the health of cats causing acute disease and, despite treatment, establishing chronic infection. It might also have a role as a zoonotic agent, especially in immunocompromised patients. Whole genome sequencing and analyses of M. haemofelis strain Ohio2 was undertaken as a step toward understanding its survival and persistence. Metabolic pathways are reduced, relying on the host to supply many of the nutrients and metabolites needed for survival. M. haemofelis must import glucose for ATP generation and ribose derivates for RNA/DNA synthesis. Hypoxanthine, adenine, guanine, uracil and CMP are scavenged from the environment to support purine and pyrimidine synthesis. In addition, nicotinamide, amino acids and any vitamins needed for growth, must be acquired from its environment. The core proteome of M. haemofelis contains an abundance of paralogous gene families, corresponding to 70.6% of all the CDSs. This "paralog pool" is a rich source of different antigenic epitopes that can be varied to elude the host's immune system and establish chronic infection. M. haemofelis also appears to be capable of phase variation, which is particularly relevant to the cyclic bacteremia and persistence, characteristics of the infection in the cat. The data generated herein should be of great use for understanding the mechanisms of M. haemofelis infection. Further, it will provide new insights into its pathogenicity and clues needed to formulate media to support the in vitro cultivation of M. haemofelis

Inclusion of sweet sorghum flour in bread formulations

Sweet sorghum (Sorghum bicolor L. Moench) has been studied as an additional source of raw material for production or partial replacement of foods due to its high fiber concentration. Its consumption is associated with the prevention of some diseases and nutritional benefits. The aim of this study was to evaluate the partial replacement of wheat flour by sweet sorghum flour in bread formulations in order to characterize the nutritional and physical profile of the flour. Four bread formulations were prepared and evaluated for sensory and textural profile. The composition of sweet sorghum flour showed high fiber content and relative protein value, and moisture showed average value, in accordance with limits established by legislation. The addition of 3% sweet sorghum flour to bread was shown to be technically feasible, with great acceptance by consumers, being a nutritious and tasty option.Key words: Functional food, fiber, baking, texture

A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita

© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops. Pasteuria penetrans is a hyperparasitic bacterium capable of suppressing the nematode reproduction, and represents a typical coevolved pathogen-hyperparasite system. Attachment of Pasteuria endospores to the cuticle of second-stage nematode juveniles is the first and pivotal step in the bacterial infection. RNA-Seq was used to understand the early transcriptional response of the root-knot nematode at 8 h post Pasteuria endospore attachment. Results: A total of 52,485 transcripts were assembled from the high quality (HQ) reads, out of which 582 transcripts were found differentially expressed in the Pasteuria endospore encumbered J2 s, of which 229 were up-regulated and 353 were down-regulated. Pasteuria infection caused a suppression of the protein synthesis machinery of the nematode. Several of the differentially expressed transcripts were putatively involved in nematode innate immunity, signaling, stress responses, endospore attachment process and post-attachment behavioral modification of the juveniles. The expression profiles of fifteen selected transcripts were validated to be true by the qRT PCR. RNAi based silencing of transcripts coding for fructose bisphosphate aldolase and glucosyl transferase caused a reduction in endospore attachment as compared to the controls, whereas, silencing of aspartic protease and ubiquitin coding transcripts resulted in higher incidence of endospore attachment on the nematode cuticle. Conclusions: Here we provide evidence of an early transcriptional response by the nematode upon infection by Pasteuria prior to root invasion. We found that adhesion of Pasteuria endospores to the cuticle induced a down-regulated protein response in the nematode. In addition, we show that fructose bisphosphate aldolase, glucosyl transferase, aspartic protease and ubiquitin coding transcripts are involved in modulating the endospore attachment on the nematode cuticle. Our results add new and significant information to the existing knowledge on early molecular interaction between M. incognita and P. penetrans.Peer reviewedFinal Published versio

A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NF-κB

The development of forward genetic screens in human haploid cells has the potential to transform our understanding of the genetic basis of cellular processes unique to man. So far, this approach has been limited mostly to the identification of genes that mediate cell death in response to a lethal agent, likely due to the ease with which this phenotype can be observed. Here, we perform the first reporter screen in the near-haploid KBM7 cell line to identify constitutive inhibitors of NF-κB. CYLD was the only currently known negative regulator of NF-κB to be identified, thus uniquely distinguishing this gene. Also identified were three genes with no previous known connection to NF-κB. Our results demonstrate that reporter screens in haploid human cells can be applied to investigate the many complex signaling pathways that converge upon transcription factors