Hypertension expérimentale par la désoxycorticostérone

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.Après avoir présenté une revue générale et critique de la littérature sur l’hypertension et les lésions anatomo-pathologiques produites par la désoxycorticostérone, nous rapportons les résultats des expériences qui forment notre contribution personnelle à l'ensemble des travaux cités dans cette thèse. Ces résultats et notre interprétation du mode de l’action hypertensive de la désoxycorticostérone peuvent se résumer ainsi : l’hypertension à la désoxycorticostérone s'établit en trois phases successives d'étiologie et de traduction différentes : Une première phase en rapport avec la dynamique des liquides circulants, qui ne s’accompagne d'aucune lésion du système réno-cardiovasculaire et que nous avons appelée phase mécanique. Une seconde phase où l'on ne peut plus incriminer ce facteur et ou la pression étant déjà élevée, on ne trouve cependant aucune lésion vasculaire, pas plus au niveau du glomériile rénal qu'ailleurs. Pendant cette seconde période, le parenchyme rénal d'apparence morphologiquement nornormale est incapable d' inactiver par rapport aux conditions normales les substances hypertensives du type de I’angiotonine. C’est la période que nous avons appelée enzymatique. Une troisième phase ou les lésions d’angio-néphrosclérose classique accompagnent l'hypertension artérielle, la périartérite noueuse, la myocardite, les hémorragies cérébrales et que nous avons appelée période histologique. Nous expliquons d'autre part pourquoi, à notre point de vue, l'hypertension, la néphrosclérose et l’hyalinose ne sont pas des effets toxiques de la désoxycorticostérone, mais des effets toxiques dus à l'ion sodium, la désoxycorticostérone ne jouant qu'un rôle favorisant dans l'apparition de ces lésions et qui n'est que l'exagération de ses effets physiologiques sur le métabolisme tissulaire des électrolytes. Nous avons renforcé cette hypothèse en montrant qu’en présence de doses considérables de désoxycorticostérone et de sodium, l 'administration d'une substance empêchant l’action du minéralo-corticoïde sur le sodium au niveau de la cellule inhibe les modifications pathologiques normalement ainsi produites. Nous discutons finalement l'intérêt possible de ces résultats dans l'étiologie de l'hypertension essentielle et du traitement des hypertendus

Low-dimensional cohomology of current Lie algebras and analogs of the Riemann tensor for loop manifolds

We obtain formulas for the first and second cohomology groups of a general current Lie algebra with coefficients in the "current" module, and apply them to compute structure functions for manifolds of loops with values in compact Hermitian symmetric spaces.Comment: v8: cosmetic change

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions (GCIs) rich in α-synuclein (α-syn) constitute the disease hallmark, accompanied by neuronal loss and activation of glial cells which indicate neuroinflammation. Recent studies demonstrate that α-syn may be released from degenerating neurons to mediate formation of abnormal inclusion bodies and to induce neuroinflammation which, interestingly, might also favor the formation of intracellular α-syn aggregates as a consequence of cytokine release and the shift to a pro-inflammatory environment. Here, we critically review the relationships between α-syn and astrocytic and microglial activation in MSA to explore the potential of therapeutics which target neuroinflammation.9 page(s

Supersymmetric extensions of Schr\"odinger-invariance

The set of dynamic symmetries of the scalar free Schr\"odinger equation in d space dimensions gives a realization of the Schr\"odinger algebra that may be extended into a representation of the conformal algebra in d+2 dimensions, which yields the set of dynamic symmetries of the same equation where the mass is not viewed as a constant, but as an additional coordinate. An analogous construction also holds for the spin-1/2 L\'evy-Leblond equation. A N=2 supersymmetric extension of these equations leads, respectively, to a `super-Schr\"odinger' model and to the (3|2)-supersymmetric model. Their dynamic supersymmetries form the Lie superalgebras osp(2|2) *_s sh(2|2) and osp(2|4), respectively. The Schr\"odinger algebra and its supersymmetric counterparts are found to be the largest finite-dimensional Lie subalgebras of a family of infinite-dimensional Lie superalgebras that are systematically constructed in a Poisson algebra setting, including the Schr\"odinger-Neveu-Schwarz algebra sns^(N) with N supercharges. Covariant two-point functions of quasiprimary superfields are calculated for several subalgebras of osp(2|4). If one includes both N=2 supercharges and time-inversions, then the sum of the scaling dimensions is restricted to a finite set of possible values.Comment: Latex 2e, 46 pages, with 3 figures include

Supersymmetric extensions of Schr\"odinger-invariance

The set of dynamic symmetries of the scalar free Schr\"odinger equation in d space dimensions gives a realization of the Schr\"odinger algebra that may be extended into a representation of the conformal algebra in d+2 dimensions, which yields the set of dynamic symmetries of the same equation where the mass is not viewed as a constant, but as an additional coordinate. An analogous construction also holds for the spin-1/2 L\'evy-Leblond equation. A N=2 supersymmetric extension of these equations leads, respectively, to a `super-Schr\"odinger' model and to the (3|2)-supersymmetric model. Their dynamic supersymmetries form the Lie superalgebras osp(2|2) *_s sh(2|2) and osp(2|4), respectively. The Schr\"odinger algebra and its supersymmetric counterparts are found to be the largest finite-dimensional Lie subalgebras of a family of infinite-dimensional Lie superalgebras that are systematically constructed in a Poisson algebra setting, including the Schr\"odinger-Neveu-Schwarz algebra sns^(N) with N supercharges. Covariant two-point functions of quasiprimary superfields are calculated for several subalgebras of osp(2|4). If one includes both N=2 supercharges and time-inversions, then the sum of the scaling dimensions is restricted to a finite set of possible values.Comment: Latex 2e, 46 pages, with 3 figures include

Supersymmetric extensions of Schr\"odinger-invariance

The set of dynamic symmetries of the scalar free Schr\"odinger equation in d space dimensions gives a realization of the Schr\"odinger algebra that may be extended into a representation of the conformal algebra in d+2 dimensions, which yields the set of dynamic symmetries of the same equation where the mass is not viewed as a constant, but as an additional coordinate. An analogous construction also holds for the spin-1/2 L\'evy-Leblond equation. A N=2 supersymmetric extension of these equations leads, respectively, to a `super-Schr\"odinger' model and to the (3|2)-supersymmetric model. Their dynamic supersymmetries form the Lie superalgebras osp(2|2) *_s sh(2|2) and osp(2|4), respectively. The Schr\"odinger algebra and its supersymmetric counterparts are found to be the largest finite-dimensional Lie subalgebras of a family of infinite-dimensional Lie superalgebras that are systematically constructed in a Poisson algebra setting, including the Schr\"odinger-Neveu-Schwarz algebra sns^(N) with N supercharges. Covariant two-point functions of quasiprimary superfields are calculated for several subalgebras of osp(2|4). If one includes both N=2 supercharges and time-inversions, then the sum of the scaling dimensions is restricted to a finite set of possible values.Comment: Latex 2e, 46 pages, with 3 figures include

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study

The kynurenine pathway (KP) is dysregulated in neuroinflammatory diseases including Alzheimer\u27s disease (AD), however has not been investigated in preclinical AD characterized by high neocortical amyloid-β load (NAL), prior to cognitive impairment. Serum KP metabolites were measured in the cognitively normal KARVIAH cohort. Participants, aged 65-90 y, were categorised into NAL+ (n = 35) and NAL- (n = 65) using a standard uptake value ratio cut-off = 1.35. Employing linear models adjusting for age and APOEϵ4, higher kynurenine and anthranilic acid (AA) in NAL+ versus NAL- participants were observed in females (kynurenine, p = 0.004; AA, p = 0.001) but not males (NALxGender, p = 0.001, 0.038, respectively). To evaluate the predictive potential of kynurenine or/and AA for NAL+ in females, logistic regressions with NAL+/- as outcome were carried out. After age and APOEϵ4 adjustment, kynurenine and AA were individually and jointly significant predictors (p = 0.007, 0.005, 0.0004, respectively). Areas under the receiver operating characteristic curves were 0.794 using age and APOEϵ4 as predictors, and 0.844, 0.866 and 0.871 when kynurenine, AA and both were added. Findings from the current study exhibit increased KP activation in NAL+ females and highlight the predictive potential of KP metabolites, AA and kynurenine, for NAL+. Additionally, the current study also provides insight into he influence of gender in AD pathogenesi

Canonical Structure of Classical Field Theory in the Polymomentum Phase Space

Canonical structure of the space-time symmetric analogue of the Hamiltonian formalism in field theory based on the De Donder-Weyl (DW) theory is studied. In $n$ space-time dimensions the set of $n$ polymomenta is associated to the space-time derivatives of field variables. The polysymplectic $(n+1)$-form generalizes the simplectic form and gives rise to a map between horizontal forms playing the role of dynamical variables and vertical multivectors generalizing Hamiltonian vector fields. Graded Poisson bracket is defined on forms and leads to the structure of a Z-graded Lie algebra on the subspace of the so-called Hamiltonian forms for which the map above exists. A generalized Poisson structure arises in the form of what we call a ``higher-order'' and a right Gerstenhaber algebra. Field euations and the equations of motion of forms are formulated in terms of the graded Poisson bracket with the DW Hamiltonian $n$-form H\vol (\vol is the space-time volume form and $H$ is the DW Hamiltonian function). A few applications to scalar fields, electrodynamics and the Nambu-Goto string, and a relation to the standard Hamiltonian formalism in field theory are briefly discussed. This is a detailed and improved account of our earlier concise communications (hep-th/9312162, hep-th/9410238, and hep-th/9511039).Comment: 45 pages, LaTeX2e, to appear in Reports on Mathematical Physics v. 41 No. 1 (1998

Schr\"odinger Manifolds

This article propounds, in the wake of influential work of Fefferman and Graham about Poincar\'e extensions of conformal structures, a definition of a (Poincar\'e-)Schr\"odinger manifold whose boundary is endowed with a conformal Bargmann structure above a non-relativistic Newton-Cartan spacetime. Examples of such manifolds are worked out in terms of homogeneous spaces of the Schr\"odinger group in any spatial dimension, and their global topology is carefully analyzed. These archetypes of Schr\"odinger manifolds carry a Lorentz structure together with a preferred null Killing vector field; they are shown to admit the Schr\"odinger group as their maximal group of isometries. The relationship to similar objects arising in the non-relativisitc AdS/CFT correspondence is discussed and clarified.Comment: 42 pages, 1 figure, published version: J. Phys. A: Math. Theor. 45 (2012) 395203 (24pp