Non-invasive Mechanism Classification and Localization in Supraventricular Cardiac Arrhythmias

[EN] In this study, we investigated the most relevant biomarkers for noninvasive classification and mechanism location in atrial tachycardia (AT), flutter (AFL) and fibrillation (AF). Biomarkers were calculated using noninvasive body surface (BSPM) dominant frequency and phase maps. We used 19 simulations of 567 to 64-lead BSPMs, from which were extracted 32 biomarkers. Biomarker ranking was performed with ANOVA, Kendall and Lasso techniques. The best four biomarkers were identified and used to classify the arrhythmias in all combinations, and the best two used for noninvasive driver localization. Arrhythmia classification accuracy was 94.74%. The feature combination which best distinguish AF from non-AF were mean filament displacement and mean OI, while those that best distinguish AFL from AT were mean and SD of SP distribution. There was good agreement across ranking techniques. Mechanism location accuracy was 78.95%, with the most important biomarkers being percentage SPs within each torso division, and SD of filament histogram cluster area. This study highlights that organization related features well identifies AF and spatial SP distribution discriminate AT from AFL and also it¿s localization.VGM is funded by the European Union's Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No. 860974. IS, JAS and JS are supported by grant #2018/25606-2, Sao Paulo Research Foundation (FAPESP).Sandoval, I.; Marques, VG.; Sims, JA.; Rodrigo, M.; Guillem Sánchez, MS.; Salinet, J. (2021). Non-invasive Mechanism Classification and Localization in Supraventricular Cardiac Arrhythmias. 1-4. https://doi.org/10.22489/CinC.2021.2261

A low-mass planet candidate orbiting Proxima Centauri at a distance of 1.5 AU

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Our nearest neighbor, Proxima Centauri, hosts a temperate terrestrial planet. We detected in radial velocities evidence of a possible second planet with minimum mass m c sin i c = 5.8 ± 1.9 M ⊕ and orbital period P c = 5.21 - 0.22 + 0.26 years. The analysis of photometric data and spectro-scopic activity diagnostics does not explain the signal in terms of a stellar activity cycle, but follow-up is required in the coming years for confirming its planetary origin. We show that the existence of the planet can be ascertained, and its true mass can be determined with high accuracy, by combining Gaia astrometry and radial velocities. Proxima c could become a prime target for follow-up and characterization with next-generation direct imaging instrumentation due to the large maximum angular separation of ~1 arc second from the parent star. The candidate planet represents a challenge for the models of super-Earth formation and evolution.Peer reviewedFinal Published versio

AD Leonis: Radial Velocity Signal of Stellar Rotation or Spin–Orbit Resonance?

AD Leonis is a nearby magnetically active M dwarf. We find Doppler variability with a period of 2.23 days, as well as photometric signals: (1) a short-period signal, which is similar to the radial velocity signal, albeit with considerable variability; and (2) a long-term activity cycle of 4070 ± 120 days. We examine the short-term photometric signal in the available All-Sky Automated Survey and Microvariability and Oscillations of STars (MOST) photometry and find that the signal is not consistently present and varies considerably as a function of time. This signal undergoes a phase change of roughly 0.8 rad when considering the first and second halves of the MOST data set, which are separated in median time by 3.38 days. In contrast, the Doppler signal is stable in the combined High-Accuracy Radial velocity Planet Searcher and High Resolution Echelle Spectrometer radial velocities for over 4700 days and does not appear to vary in time in amplitude, phase, period, or as a function of extracted wavelength. We consider a variety of starspot scenarios and find it challenging to simultaneously explain the rapidly varying photometric signal and the stable radial velocity signal as being caused by starspots corotating on the stellar surface. This suggests that the origin of the Doppler periodicity might be the gravitational tug of a planet orbiting the star in spin–orbit resonance. For such a scenario and no spin–orbit misalignment, the measured v sin i indicates an inclination angle of 15°̣5 ± 2°̣5 and a planetary companion mass of 0.237 ± 0.047 M Jup

Imaging findings in 14 dogs and 3 cats with lobar emphysema

Abstract Background Lobar emphysema in dogs and cats is caused by bronchial collapse during expiration and subsequent air trapping. Congenital causes such as bronchial cartilage defects or acquired causes such as compressive neoplastic lesions have been reported. Morbidity results from hyperinflation of the affected lung lobe and compression of adjacent thoracic structures. Objective To describe patient characteristics and imaging findings in dogs and cats with lobar emphysema. Animals Fourteen dogs and 3 cats with lobar emphysema diagnosed by imaging findings were retrospectively identified from veterinary referral hospital populations over a 10‐year period. Methods Cases that included thoracic radiography, thoracic computed tomography (CT), or both were included. All images were reviewed by a European College of Veterinary Diagnostic Imaging diplomate. Relevant case information included signalment, clinical findings, treatment, and histopathology where available. Results Ten of 17 (59%) patients were presented for evaluation of dyspnea and 6 (35%) for coughing. Eleven (65%) patients were <3 years of age. The right middle lung lobe was affected in 12 cases (71%) and multiple lobes were affected in 7 cases (41%). Congenital lobar emphysema was suspected in 14 cases (82%). Conclusion and Clinical Importance Lung lobe hyperinflation, atelectasis of nonaffected lung lobes, mediastinal shift, and thoracic wall and diaphragmatic wall deformation were common findings. Lobar or multilobar emphysema should be considered in patients with dyspnea or coughing, particularly younger patients. Although radiography is useful, CT provides better detail. In older patients, acquired causes of bronchial compression should be considered

An interdisciplinary vision of "Cova Beneito"

Aquest freball ofereix una visió interdisciplimiria i global dels nivells del paleolític mijà i superior de la cova Beneito (Muro del Comtat, Alacant). L'estudi sedimentològic, palinològic i faunístic de la seua dilatada estratigrafia aporta dades imprescindibles per al reconeixement de l'lnterestadial II-III, per a la consolidació de la climatoestratigrafia del Pleistocé Superior i, a més, una comprensió millor de la relació home-medi. El desenvolupamenr cultural ofereix altenatives interessants per a la seqüència mediterrànea i aporta la novetat de I'Aurinyacià evolucionat final a l'ambit valencià. S'hi dedica una apartat a l'estudi d'una tomba ritual secundària solutriogravetiana.The present work attempts to offer an interdisciplinary and global vision on the levels of the Middle and Upper Paleolithic period in "Cova Beneito" (Muro-Alicante-Spain). The sedimentological, palynological and faunistic study of its vast stratigraphy bring forward essential facts for the identification of the midlast glacial stage and for strengthening of the climatostratigraphy of the Upper Pleistocene, as well as for a better reconstruction of the retationship between man and environment. The cultural development supplies interesting alternatives to the Mediterranean sequence, and brings out the novelty of the Evolued Aurignacian in the Valencian area. There is a special section on the study of a secondary Solutrean-Gravettian ritual burial.El presente trabajo ofrece una visión interdisciplinar y global de los niveles del Paleolítico Medio y Superior de Cova Beneito (Muro- Alicante). El estudio sedimentológico, palinológico y faunístico de su dilatada estratigrafía aportan datos imprescindibles para el reconocimiento del Interestadial II-III y el afianzamiento de la climatoestratigrafía del Pleistoceno Superior, así como para una mejor comprensidn de la relación hombre-medio. El desarrollo cultural ofrece alternativas interesantes a tu secuencia mediterránea, aportando la novedad del Auriñaciense evolucionado final al ámbito valenciano. Se dedica un apartado al estudio de un enterramiento ritual secundario Solútreogravetiense

Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12

The use of gene therapy to enhance antitumor immunity has emerged as a promising procedure to fight cancer. In this study we have tested the ability of an adenovirus carrying interleukin 12 (IL-12) gene (AdCMVIL-12) to eliminate tumoral lesions in 3 animal models of orthotopic hepatocellular carcinoma (HCC). Intratumoral injection of AdCMVIL-12 in animals with a single big tumor nodule implanted in the liver resulted in significant inhibition of tumor growth in a dose-dependent manner. Fifty percent of animals that received a dose of 5 x 10(9) plaque-forming units, showed complete regression of the tumor 2 weeks after treatment. In animals with 2 independent tumor nodules in the left liver lobe, injection in only one of them of 5 x 10(9) pfu AdCMVIL-12 induced, 15 days after therapy, complete regression of 50% of treated tumors and also of 50% of untreated lesions, with 60% long-term survival. Rats that were tumor free after therapy with AdCMVIL-12 showed protection against tumor rechallenge. A group of rats received the carcinogen diethylnitrosamine and developed multiple hepatic dysplasic nodules of 1 to 5 mm in diameter. These animals were treated by intrahepatic artery injection of either AdCMVIL-12 (5 x 10(9) pfu) or control vector. In this model AdCMVIL-12 induced complete tumor regression in 20% of treated rats and inhibited tumor growth in 60% of cases with an increase in rat survival. Activation of natural killer (NK) cells and inhibition of angiogenesis were found to be antitumor mechanisms set in motion by AdCMVIL-12. Our data indicate that experimental HCC can be efficiently treated by intratumoral or intravascular injection of adenovirus expressing IL-12