In vitro evaluation of the influence of bone cortical thickness on the primary stability of conventional- and short-sized implants

The aim of this in vitro study was to evaluate the influence of the cortical thickness on the primary stability of short and conventional-sized implants with two types of prosthetic connection. Seventy-two implants were used. These implants were place

Social support and leisure-time physical activity: longitudinal evidence from the Brazilian Pró-Saúde cohort study

<p>Abstract</p> <p>Background</p> <p>Although social support has been observed to exert a beneficial influence on leisure-time physical activity (LTPA), multidimensional approaches examining social support and prospective evidence of its importance are scarce. The purpose of this study was to investigate how four dimensions of social support affect LTPA engagement, maintenance, type, and time spent by adults during a two-year follow-up.</p> <p>Methods</p> <p>This paper reports on a longitudinal study of 3,253 non-faculty public employees at a university in Rio de Janeiro (the Pró-Saúde study). LTPA was evaluated using a dichotomous question with a two-week reference period, and further questions concerning LTPA type (individual or group) and time spent on the activity. Social support was measured by the Medical Outcomes Study Social Support Scale (MOS-SSS). To assess the association between social support and LTPA, two different statistical models were used: binary and multinomial logistic regression models for dichotomous and polytomous outcomes, respectively. Models were adjusted separately for those who began LTPA in the middle of the follow up (engagement group) and for those who had maintained LTPA since the beginning of the follow up (maintenance group).</p> <p>Results</p> <p>After adjusting for confounders, statistically significant associations (p < 0.05) between dimensions of social support and group LTPA were found in the engagement group. Also, the emotional/information dimension was associated with time spent on LTPA (OR = 2.01; 95% CI 1.2-3.9). In the maintenance group, material support was associated with group LTPA (OR = 1.80; 95% CI; 1.1-3.1) and the positive social interaction dimension was associated with time spent on LTPA (OR = 1.65; 95% CI; 1.1-2.7).</p> <p>Conclusions</p> <p>All dimensions of social support influenced LTPA type or the time spent on the activity. However, our findings suggest that social support is more important in engagement than in maintenance. This finding is important, because it suggests that maintenance of LTPA must be associated with other factors beyond the individual's level of social support, such as a suitable environment and social/health policies directed towards the practice of LTPA.</p

Diferenças de gênero no apoio social e atividade física de lazer

OBJECTIVE To identify gender differences in social support dimensions’ effect on adults’ leisure-time physical activity maintenance, type, and time. METHODS Longitudinal study of 1,278 non-faculty public employees at a university in Rio de Janeiro, RJ, Southeastern Brazil. Physical activity was evaluated using a dichotomous question with a two-week reference period, and further questions concerning leisure-time physical activity type (individual or group) and time spent on the activity. Social support was measured with the Medical Outcomes Study Social Support Scale. For the analysis, logistic regression models were adjusted separately by gender. RESULTS A multinomial logistic regression showed an association between material support and individual activities among women (OR = 2.76; 95%CI 1.2;6.5). Affective support was associated with time spent on leisure-time physical activity only among men (OR = 1.80; 95%CI 1.1;3.2). CONCLUSIONS All dimensions of social support that were examined influenced either the type of, or the time spent on, leisure-time physical activity. In some social support dimensions, the associations detected varied by gender. Future studies should attempt to elucidate the mechanisms involved in these gender differences.OBJETIVO Identificar diferenças de gênero no efeito de dimensões de apoio social na manutenção, tipo e tempo da atividade física de lazer em adultos. MÉTODOS Estudo longitudinal com 1.278 funcionários públicos não docentes de uma universidade do Rio de Janeiro. A atividade física foi avaliada utilizando questão dicotômica, com um período de referência de duas semanas, e outras questões relativas ao tipo de atividade (individual ou grupo) e ao tempo gasto na atividade. O apoio social foi medido pelo Medical Outcomes Study Social Support Scale. Para a análise, os modelos de regressão logística foram ajustados separadamente por gênero. RESULTADOS A regressão logística multinomial mostrou associação entre o apoio material e as atividades individuais (OR = 2,76, IC95% 1,2;6,5) entre as mulheres. O apoio afetivo foi associado com o tempo gasto em atividades físicas de lazer (OR = 1,80, IC95% 1,1;3,2) apenas entre os homens. CONCLUSÕES Todas as dimensões de apoio social examinadas influenciaram o tipo ou o tempo gasto em atividades físicas de lazer. Em algumas dimensões de apoio social, as associações variaram segundo gênero. Estudos futuros devem elucidar os mecanismos envolvidos nessas diferenças entre os gêneros

HIDROPONIA COMO ALTERNATIVA DE USO E OCUPAÇÃO DO SOLO EM ÁREAS DEGRADADAS POR PARQUES EÓLICOS: AVALIAÇÃO DE IMPACTOS AO MEIO AMBIENTE

http://dx.doi.org/10.5902/223611707164There are hundreds of years Brazil has been undergoing a process of development, where fromthe time of its discovery the extraction and use of natural resources is being done in anuncontrolled way, degrading vast areas and the soil we inhabit and depend for our food supply.Especially the activity of agriculture emerges as a great responsibility in this scenario, however,closely followed numerous exploratory activities. Faced with this problem, science has beenstudying ways to recover or reuse areas that are or have undergone degradation processesphysical, chemical or biological. In this paper, a proposal is made to use hydroponic techniqueswith lettuce and corn, as an alternative form of land use, as well as the rational use of water,providing conditions for the development of agriculture in these areas. An evaluation mainly as areview of the use of this model as an alternative environmental compensation and reuse ofsewage or effluent from activities of oil exploration, installation of wind farms or mining activity.http://dx.doi.org/10.5902/223611707164Há centenas de anos o Brasil vem passando por um processo de desenvolvimento, onde desde a época de seu descobrimento a extração e uso de seus recursos naturais vem sendo feito de maneira descontrolada, degradando vastas áreas, bem como os solos que habitamos e dependemos para nosso suprimento alimentar. Especialmente a atividade da agricultura desponta como uma grande responsável nesse cenário, porém, acompanhada de perto de inúmeras atividades exploratórias tais como: mineração, exploração de petróleo etc. Diante desta problemática, a ciência vem estudando maneiras de recuperar ou reutilizar áreas que passam ou passaram por processos de degradação física, química ou biológica. Neste trabalho, é feita uma proposta de uso de técnicas de cultivo hidropônico com alface e milho, como forma alternativa de uso do solo, bem como o uso racional de água, dando condições de desenvolvimento da agropecuária nestas áreas. É feita uma avaliação, sobretudo, como uma avaliação de uso desse modelo como uma alternativa de compensação ambiental e reuso de esgotos ou efluentes oriundos de atividades da exploração do petróleo, montagem de usinas eólicas ou mesmo atividade de mineração

Política Nacional de Saúde Integral Lésbicas, Gays, Bissexuais, Travestis e Transexuais

O módulo Política Nacional de Saúde Integral LGBT foi organizado de forma a contribuir com os profissionais de saúde, notadamente os trabalhadores do SUS, para que realizem suas ações de cuidado, promoção e prevenção, com qualidade, de forma equânime, garantindo à população LGBT acesso à saúde integral. O curso é um dos módulos desenvolvidos pela UNA-SUS UERJ que integram o Programa de Valorização da Atenção Básica (PROVAB) e se divide em 03 unidades cujas áreas temáticas são: Gênero e sexualidade; O estudo da Política LGBT e seus marcos; Realizando o acolhimento e o cuidado à População LGBT. Este recurso é referente a 2ª oferta do módulo pela UERJ.Oferta 02Ministério da Saúd

PROSPECÇÃO TECNOLÓGICA DE FITOTERÁPICO (Euphorbia Tirucalli L.) UTILIZADO NO TRATAMENTO DE NEOPLASIAS E OUTRAS DOENÇAS

Atualmente a demanda por medicamentos à base de plantas medicinais é crescente. O uso de fitoterápicos vem aumentando em países em desenvolvimento, bem como em países desenvolvidos, como uma forma adicional para tratar e prevenir doenças. Dentre a diversidade da flora brasileira com potencial terapêutico, pode-se destacar a Euphorbia tirucalli L., sendo uma das plantas medicinais indicada para ser registrada como medicamento fitoterápico no Brasil. Estudos com esse fitoterápico vêm sendo realizado visando sua aplicação no tratamento do câncer, sendo que algumas pesquisas já mostram resultados satisfatórios. O Brasil, seguido da China, apresenta o maior número de patentes depositadas envolvendo essa espécie. Entretanto, considerando a nossa biodiversidade e a herança cultura indígena, no que diz respeito ao uso de plantas medicinais, os resultados ainda não são satisfatórios

Uso de ácidos orgânicos para reduzir a excreção de Salmonella Typhimurium em suínos

The use of antimicrobials as growth promoters and disease prevention is being constantly reduced in several animal production systems, including in the swine industry. Therefore, this study aimed to evaluate the effectiveness of using acidifiers to control Salmonella Typhimurium in 65-day-old pigs by detecting the pathogen in organs at euthanasia. For this, 24 piglets were divided into two experimental groups consisting of 12 piglets each. An untreated control group (G1) and a treatment group (G2) received a liquid organic acidifier in the drinking water for 10 days (D-5 to D5). Five days after the start of treatment (D0), all piglets were challenged with 106 CFU of Salmonella Typhimurium and assessed for 12 days (D12). Every three days (D3, D6, D9, and D12), three animals from each experimental group were euthanized and then submitted for necropsy. Samples from the intestines (ileum, cecum, mesenteric lymph nodes, and ileocolic lymph nodes), liver, spleen, and lungs were collected to isolate Salmonella. The results show that, numerically, Salmonella isolation in the organs of G2 was lower than in G1 and that the number of positive cecum samples in G1 (66.7%; 8/12) was statistically different from the number of positive models in G2 (16.7%; 2/12), with a reduction of 28.6% of the total cecum positive samples in the treated group compared to the control. Therefore, it was observed that the liquid organic acidifier product could reduce the colonization of organs by Salmonella Typhimurium. O uso de antimicrobianos como promotores de crescimento e prevenção de doenças vem sendo constantemente reduzido em diversos sistemas de produção animal, inclusive na suinocultura. Portanto, o objetivo do presente estudo foi avaliar a eficácia do uso de acidificantes no controle de Salmonella Typhimurium em suínos de 65 dias de idade, detectando o patógeno em órgãos após a eutanásia. Para isso, 24 leitões foram divididos em dois grupos experimentais constituídos por 12 leitões cada. Um grupo controle não tratado (G1) e um grupo de tratamento (G2) que recebeu um acidificante orgânico líquido na água de beber por 10 dias (D-5 a D5). Cinco dias após o início do tratamento (D0), todos os animais foram inoculados oralmente com 106 UFC de Salmonella Typhimurium e avaliados por 12 dias (D12). A cada três dias (D3, D6, D9 e D12), três leitões de cada grupo experimental foram eutanasiados e posteriormente submetidos à necropsia. Amostras de intestino (íleo, ceco, linfonodos mesentéricos e linfonodos ileocólicos), fígado, baço e pulmões foram coletadas para o isolamento de Salmonella. Os resultados mostram que, numericamente, o isolamento de Salmonella nos órgãos do G2 foi inferior ao G1, e que o número de amostras positivas de ceco no G1 (66,7%; 8/12) foi estatisticamente diferente do número de amostras positivas no G2 (16,7%; 2/12), com redução de 28,6% do total de amostras positivas de ceco no grupo tratado em relação ao controle. Portanto, observou se que o ácido orgânico líquido foi capaz de reduzir a colonização de órgãos por Salmonella Typhimurium

The burden of Noncommunicable Diseases in Portuguese Language Countries

Funding Information: Agreement letter SCON2022-00453 Pan American Health Organization (PAHO)/Ministério da Saúde (MS), Conselho Nacional de Desenvolvi-mento Científico e Tecnológico (CNPq). Publisher Copyright: © 2023, Associacao Brasileira de Pos - Graduacao em Saude Coletiva. All rights reserved.The present study analyzed trends in premature mortality from Noncommunicable diseases (NCDs) between 1990 and 2019, the projections up to 2030, and the risk factors (RFs) attributable to these diseases in the Community of Portuguese Language Countries (CPLP). Esti-mates from the Global Burden of Disease (GBD) study and the analysis of the burden of premature mortality due to NCDs were used for nine CPLP countries, applying age-standardized rates, us-ing RStudio. Portugal, Brazil, Equatorial Guin-ea, Angola, and Guinea Bissau showed declining premature mortality rates caused by NCDs, while East Timor, Cape Verde, São Tomé and Príncipe, and Mozambique showed an increase in rates. Projections indicate that none of the countries is expected to achieve the goals of reducing premature mortality due to NCDs by one third by 2030. The attributable burden of disease showed that the most important RFs in 2019 were: high sys-tolic blood pressure (SBP), tobacco, dietary risks, high body mass index (BMI), and air pollution. It can therefore be concluded that there are pro-found differences in the burden of NCDs among the countries, with better results in Portugal and Brazil, and that no CPLP country is likely to reach the NCD reduction target by 2030.publishersversionpublishe

SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo

SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the inflammatory status. In vitro we used a murine macrophage cell line to assess the physical interaction between SOCS3 and STAT3 by coimmunoprecipitation. 30 ug of LPS from Escherichia coli were injected in the gingival tissues on the palatal aspect of first molars of the animals 3x/week for up to 4 weeks. Control animals were injected with the vehicle (PBS). The rats were sacrificed at 7, 15, and 30 days. Inflammation and gene expression were assessed by stereometric analysis, immunohistochemistry, RT-qPCR, and western blot. LPS injections increased inflammation, paralleled by an upregulation of SOCS3, of the proinflammatory cytokines IL-1β, IL-6, and TNF-α and increased phosphorylation of STAT3 and p38 MAPK. SOCS3 expression accompanied the severity of inflammation and the expression of proinflammatory cytokines, as well as the activation status of STAT3 and p38 MAPK. LPS stimulation in a macrophage cell line in vitro induced transient STAT3 activation, which was inversely correlated with a dynamic physical interaction with SOCS3, suggesting that this may be a mechanism for SOCS3 regulatory function

Polypodium leucotomos targets multiple aspects of oral carcinogenesis and it is a potential antitumor phytotherapy against tongue cancer growth

Introduction: Oral cancer refers to malignant tumors, of which 90% are squamous cell carcinomas (OSCCs). These malignancies exhibit rapid progression, poor prognosis, and often mutilating therapeutical approaches. The determination of a prophylactic and/or therapeutic antitumor role of the polyphenolic extract Polypodium leucotomos(PL) would be relevant in developing new tools for prevention and treatment.Methods: We aimed to determine the antitumor effect of PL by treating OSCC cell lines with PL metabolites and evaluating its action during OSCC progression in vivo.Results: PL treatment successfully impaired cell cycling and proliferation, migration, and invasion, enhanced apoptosis, and modulated macrophage polarization associated with the tumoral immune-inflammatory response of tongue cancer cell lines (TSCC). PL treatment significantly decreased the expression of MMP1 (p &lt; 0.01) and MMP2 (p &lt; 0.001), and increased the expression of TIMP1 (p &lt; 0.001) and TIMP2 (p &lt; 0.0001) in these cells. The mesenchymal-epithelial transition phenotype was promoted in cells treated with PL, through upregulation of E-CAD (p &lt; 0.001) and reduction of N-CAD (p &lt; 0.05). PL restrained OSCC progression in vivo by inhibiting tumor volume growth and decreasing the number of severe dysplasia lesions and squamous cell carcinomas. Ki-67 was significantly higher expressed in tongue tissues of animals not treated with PL(p &lt; 0.05), and a notable reduction in Bcl2 (p &lt; 0.05) and Pcna (p &lt; 0.05) cell proliferation-associated genes was found in dysplastic lesions and TSCCs of PL-treated mice. Finally, N-cad(Cdh2), Vim, and Twist were significantly reduced in tongue tissues treated with PL.Conclusion: PL significantly decreased OSCC carcinogenic processes in vitro and inhibited tumor progression in vivo. PL also appears to contribute to the modulation of immune-inflammatory oral tumor-associated responses. Taken together, these results suggest that PL plays an important antitumor role in processes associated with oral carcinogenesis and may be a potential phytotherapeutic target for the prevention and/or adjuvant treatment of TSCC