Spin coherence time measurements for a polarized deuteron beam

The measurement of a non-zero electric dipole moment (EDM) of a fundamental particle would probe new physics beyond the standard model. It has been proposed to search for the EDM of charged particles using a storage ring. The polarization of the charged particle beam is initially aligned along the velocity and the EDM signal would be a rotation of this polarization into the vertical direction as a consequence of the radial electric field always present in the particle frame. This experiment requires ring conditions that can ensure a longitudinal, and stable, polarization (spin coherence time, SCT) up to 1000 s. A study is beginning at the COoler SYnchrotron (COSY) located at the Forschungszentrum-J¨ulich to examine the effects of emittance and momentum spread on the SCT of a polarized deuteron beam at 0.97 GeV/c. A special DAQ has been developed in order to provide the first direct measurement of a rapidly rotating horizontal polarization as a function of time. The preliminary tests presented here will show how the horizontal emittance affects the spin coherence time and how the SCT can be increased using sextupole magnets. The longest horizontal polarization lifetime recorded is τ (1/e) = 316±40 s

On the complexity of earthquake sequences: a historical seismology perspective based on the L'Aquila seismicity (Abruzzo, Central Italy), 1315-1915

Most damaging earthquakes come as complex sequences characterized by strong aftershocks, sometimes by foreshocks and often by multiple mainshocks. Complex earthquake sequences have enormous seismic hazard, engineering and societal implications as their impact on buildings and infrastructures may be much more severe at the end of the sequence than just after the mainshock. In this paper we examine whether historical sources can help characterizing the rare earthquake sequences of pre-instrumental times in full, including fore-, main- and aftershocks. Thanks to the its huge documentary heritage, Italy relies on one of the richest parametric earthquake catalogues worldwide. Unfortunately most current methods for assessing seismic hazard require that earthquake catalogues be declustered by removing all shocks that bear some dependency with those identified as mainshocks. We maintain that this requirement has led most modern historical seismologists to focus mainly on mainshocks rather than also on the fore- and aftershocks. To shed light onto major earthquake sequences of the past, rather than onto individual mainshocks, we investigated 10 damaging earthquake sequences ($M_w$ 수식 이미지 4.7-7.0) that hit the L'Aquila area and central Abruzzo from the 14th to the 20th century. We find that most of the results of historical research are important for modern seismology, yet their rendering by the current parametric catalogues causes most information to be lost or not easily transferred to the potential users. For this reason we advocate a change in current strategies and the creation of a more flexible standard for storing and using all the information made available by historical seismology

How to Reach a Thousand-Second in-Plane Polarization Lifetime with 0.97-GeV/c Deuterons in a Storage Ring

We observe a deuteron beam polarization lifetime near 1000 s in the horizontal plane of a magnetic storage ring (COSY). This long spin coherence time is maintained through a combination of beam bunching, electron cooling, sextupole field corrections, and the suppression of collective effects through beam current limits. This record lifetime is required for a storage ring search for an intrinsic electric dipole moment on the deuteron at a statistical sensitivity level approaching 10-29 e cm

The Controversy of Myopia as a Risk Factor for Glaucoma: a Mathematical Approach

poster abstractPurpose: to quantify how individual variations in anatomical parameters often associated with myopia (e.g. longer ocular axial length (OAL), reduced scleral thickness (ST), lamina cribrosa diameter (LCD) and thickness (LCT)) affect retinal blood flow (RBF) and its sensitivity to ocular perfusion pressure (OPP). Methods: A mathematical model is used to calculate RBF through central retinal artery (CRA), arterioles, capillaries, venules, and central retinal vein (CRV). The flow is time-dependent, driven by systemic pressure and regulated by variable resistances to account for nonlinear effects due to (1) autoregulation (AR), and (2) lamina cribrosa effect on CRA and CRV. The latter is a nonlinear function of intraocular pressure (IOP), cerebrospinal fluid pressure (CSF) and OAL, ST, LCD, and LCT. RBF is computed as the solution of a system of five non-linear ordinary differential equations. The system is solved for different OPP values, obtained by varying independently IOP and mean arterial pressure (MAP), with and without AR. Results: Four representative eyes are compared: Eye 1 (OAL=24mm, ST=1mm, LCD=3mm, LCT=0.4mm), Eye 2 (OAL=28mm, ST=1mm, LCD=3mm, LCT=0.4mm), Eye 3 (OAL=24mm, ST=0.7mm, LCD=2mm, LCT=0.2mm), Eye 4 (OAL=28mm, ST=0.7mm, LCD=2mm, LCT=0.2mm). The model predicts that the cardiac cycle RBF average (RBFav) for eyes with smaller LCD and LCT is notably less than in normal eyes when IOP is elevated and without AR (c). Without AR and reduced MAP, the four eyes show similar RBFav reductions (d). With AR, anatomical changes do not induce notable changes in RBFav, (a) and (b). Conclusions: Reduced LCD and LCT, often associated with myopia, seem to affect RBFav more than elevated OAL. RBFav reductions magnify when AR is impaired, and this might reduce IOP safe levels for eyes with reduced LCD and LCT. These findings suggest that a combination of anatomical and vascular factors might cause certain myopic eyes to be at higher risk for glaucomatous damage than others

A theoretical approach for the electrochemical characterization of ciliary epithelium

The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion. Modulation of ionic secretion is a fundamental target for drug therapy in glaucoma, and therefore it is important to identify the main factors contributing to it. Since several ion transporters have been hypothesized as relevant players in CE physiology, we propose a theoretical approach to complement experimental methods in characterizing their role in the electrochemical and fluid-dynamical conditions of CE. As a first step, we compare two model configurations that differ by (i) types of transporters included for ion exchange across the epithelial membrane, and by (ii) presence or absence of the intracellular production of carbonic acid mediated by the carbonic anhydrase enzyme. The proposed model configurations do not include neurohumoral mechanisms such as P2Y receptor dependent, cAMP or calcium dependent pathways, which occur in the ciliary epithelium bilayer and influence the activity of ion transporters, pumps and channels present in the cell membrane. Results suggest that one of the two configurations predicts sodium and potassium intracellular concentrations and transmembrane potential much more accurately than the other. Because of its quantitative prediction power, the proposed theoretical approach may help relate phenomena at the cellular scale, that cannot be accessed clinically, with phenomena occuring at the scale of the whole eye, for which clinical assessment is feasible

Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions

This work aims at investigating the interactions between the flow of fluids in the eyes and the brain and their potential implications in structural and functional changes in the eyes of astronauts, a condition also known as spaceflight associated neuro-ocular syndrome (SANS). To this end, we propose a reduced (0-dimensional) mathematical model of fluid flow in the eyes and brain, which is embedded into a simplified whole-body circulation model. In particular, the model accounts for: (i) the flows of blood and aqueous humor in the eyes; (ii) the flows of blood, cerebrospinal fluid and interstitial fluid in the brain; and (iii) their interactions. The model is used to simulate variations in intraocular pressure, intracranial pressure and blood flow due to microgravity conditions, which are thought to be critical factors in SANS. Specifically, the model predicts that both intracranial and intraocular pressures increase in microgravity, even though their respective trends may be different. In such conditions, ocular blood flow is predicted to decrease in the choroid and ciliary body circulations, whereas retinal circulation is found to be less susceptible to microgravity-induced alterations, owing to a purely mechanical component in perfusion control associated with the venous segments. These findings indicate that the particular anatomical architecture of venous drainage in the retina may be one of the reasons why most of the SANS alterations are not observed in the retina but, rather, in other vascular beds, particularly the choroid. Thus, clinical assessment of ocular venous function may be considered as a determinant SANS factor, for which astronauts could be screened on earth and in-flight

Electro-fluid dynamics of aqueous humor production: simulations and new directions.

Purpose: to theoretically investigate the role of bicarbonate ion (HCO− 3 ) on the nonpigmented transepithelial potential di erence Vm, the sodium potassium pump (Na/K) and the active secretion of aqueous humor. Methods: a three-dimensional mathematical model is proposed to isolate the roles of HCO− 3 and Na+, which are di icult to investigate experimentally. The model combines the velocity-extended Poisson-Nernst-Planck equations to describe ion electrodi usion and the Stokes equations to describe aqueous humor flow into the basolateral space adjacent to the nonpigmented ephitelial cells. Results: Computations show that Vm is close to baseline experimental measurements (on monkeys) in the range [−2.7, −2.3]mV only if HCO− 3 is included in the simulation. The model is also capable of reproducing the flow of Na+ exiting the cell and the flow of K+ entering the cell, in accordance with the physiology of the Na/K pump. The simulated Na/K ratio is 1.53, which is in very good agreement with the theoretical value of 1.5. Conclusion: Model simulations suggest that HCO− 3 inhibition may prevent physiologically correct baseline values of the nonpigmented transepithelial potential di erence and Na/K ATPase function. This may provide useful indication in the design of medications that decrease the active secretion of aqueous humor, and supports the advantage of using mathematical models as a noninvasive complement of animal models