Uniform grain-size distribution in the active layer of a shallow, gravel-bedded, braided river (the Urumqi River, China) and implications for paleo-hydrology

The grain-size distribution of ancient alluvial systems is commonly determined from surface samples of vertically exposed sections of gravel deposits. This method relies on the hypothesis that the grain-size distribution obtained from a vertical cross section is equivalent to that of the riverbed. Such an hypothesis implies first that the sediments are uniform in size in the river bed, and second that the sampling method implemented on a vertical section leads to a grain-size distribution equivalent to the bulk one. Here, we report a field test of this hypothesis on granulometric samples collected in an active, gravel-bedded, braided stream: the Urumqi River in China. We compare data from volumetric samples of a trench excavated in an active thread and from surface counts performed on the trench vertical faces. Based on this data set, we show that the grain-size distributions obtained from all the samples are similar and that the deposit is uniform at the scale of the river active layer, a layer extending from the surface to a depth of approximately 10 times the size of the largest clasts. As a consequence, the grid-by-number method implemented vertically leads to a grain-size distribution equivalent to the one obtained by a bulk volumetric sampling. This study thus brings support to the hypothesis that vertical surface counts provide an accurate characterization of the grain-size distribution of paleo-braided rivers.</p

The microRNA-29 family in cartilage homeostasis and osteoarthritis

MicroRNAs have been shown to function in cartilage development and homeostasis, as well as in progression of osteoarthritis. The objective of the current study was to identify microRNAs involved in the onset or early progression of osteoarthritis and characterise their function in chondrocytes. MicroRNA expression in mouse knee joints post-DMM surgery was measured over 7 days. Expression of miR-29b-3p was increased at day 1 and regulated in the opposite direction to its potential targets. In a mouse model of cartilage injury and in end-stage human OA cartilage, the miR-29 family were also regulated. SOX9 repressed expression of miR-29a-3p and miR-29b-3p via the 29a/b1 promoter. TGFβ1 decreased expression of miR-29a, b and c (3p) in primary chondrocytes, whilst IL-1β increased (but LPS decreased) their expression. The miR-29 family negatively regulated Smad, NFκB and canonical WNT signalling pathways. Expression profiles revealed regulation of new WNT-related genes. Amongst these, FZD3, FZD5, DVL3, FRAT2, CK2A2 were validated as direct targets of the miR-29 family. These data identify the miR-29 family as microRNAs acting across development and progression of OA. They are regulated by factors which are important in OA and impact on relevant signalling pathways

Somatosensory Evoked Potentials suppression due to remifentanil during spinal operations; a prospective clinical study

<p>Abstract</p> <p>Background</p> <p>Somatosensory evoked potentials (SSEP) are being used for the investigation and monitoring of the integrity of neural pathways during surgical procedures. Intraoperative neurophysiologic monitoring is affected by the type of anesthetic agents. Remifentanil is supposed to produce minimal or no changes in SSEP amplitude and latency. This study aims to investigate whether high doses of remifentanil influence the SSEP during spinal surgery under total intravenous anesthesia.</p> <p>Methods</p> <p>Ten patients underwent spinal surgery. Anesthesia was induced with propofol (2 mg/Kg), fentanyl (2 mcg/Kg) and a single dose of cis-atracurium (0.15 mg/Kg), followed by infusion of 0.8 mcg/kg/min of remifentanil and propofol (30-50 mcg/kg/min). The depth of anesthesia was monitored by Bispectral Index (BIS) and an adequate level (40-50) of anesthesia was maintained. Somatosensory evoked potentials (SSEPs) were recorded intraoperatively from the tibial nerve (P37) 15 min before initiation of remifentanil infusion. Data were analysed over that period.</p> <p>Results</p> <p>Remifentanil induced prolongation of the tibial SSEP latency which however was not significant (p > 0.05). The suppression of the amplitude was significant (p < 0.001), varying from 20-80% with this decrease being time related.</p> <p>Conclusion</p> <p>Remifentanil in high doses induces significant changes in SSEP components that should be taken under consideration during intraoperative neuromonitoring.</p

The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases

Purpose of review: degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset.Recent findings: the combination of stem cells and miRNA has been successful at regenerating the bone and cartilage in vivo. MiRNAs, including miR-146b known to be involved in chondrogenic differentiation, could provide innovative targets for stem cell-based therapy, for the repair of articular cartilage defects forestalling the onset of OA or in the generation of a stem cell-based therapy for OP.Summary: this review discusses the combination of skeletal stem cells (SSCs) and candidate miRNAs for application in a cell-based therapy approach for skeletal regenerative medicine

Thickness of Fluvial Deposits Records Climate Oscillations

Fluvial deposits offer Earth’s best‐preserved geomorphic record of past climate change over geological timescales. However, quantitatively extracting this information remains challenging in part due to the complexity of erosion, sediment transport and deposition processes and how each of them responds to climate. Furthermore, sedimentary basins have the potential to temporarily store sediments, and rivers subsequently rework those sediments. This may introduce time lags into sedimentary signals and obscure any direct correlation with climate forcing. Here, using a numerical model that combines all three processes—and a new analytical solution—we show that the thickness of fluvial deposits at the outlet of a mountain river can be linked to the amplitude and period of rainfall oscillations but is modulated by the mountain uplift rate. For typical uplift rates of a few mm/yr, climate oscillations at Milankovitch periods lead to alluvial sediment thickness of tens of meters as observed in nature. We also explain the time lag of the order of 20%–25% of the forcing period that is commonly observed between the timing of maximum rainfall and erosion. By comparing to field datasets, our predictions for the thickness and time lag of fluvial deposits are broadly consistent with observations despite the simplicity of our modeling approach. These findings provide a new theoretical framework for quantitatively extracting information on past rainfall variations from fluvial deposits.Plain Language Summary: Climate influences the evolution of terrestrial landscapes through the amount of precipitation, which provides water to erode rocks and transport sediment in rivers. At the outlets of mountain ranges, rivers can deposit part of their sediment load; the shape of the deposits is influenced by the amount of flow in the rivers. If the climate changes such that the precipitation rate increases, rivers can cut into their own previous deposits. The remaining deposits are then abandoned above the riverbed. On the contrary, if precipitation decreases, rivers tend to deposit more sediment, leading to increases in the thickness of sediments at the outlets of mountain rivers. Thus, there is a relationship between the amount of precipitations and the thickness of sediments deposited at river outlets. We study this with a computer model that allows us to relate the variations in precipitation rates to variations in thickness of fluvial terrace deposits. This work can be used to better understand how rivers respond to climatic changes, and also to reconstruct climatic variations of the past from observed river deposits.Key Points: We use a numerical model and a new analytical solution to quantify a physical link between fluvial deposits and climate oscillations. Our method provides a theoretical framework for extracting information on past climate variations from fluvial terrace deposits. Our results explain time lag of 20%–25% of forcing period commonly observed between the timing of maximum rainfall and erosion.TOTALMarie Sklodowska‐Curie granthttps://doi.org/10.5281/zenodo.383398

Laboratory alluvial fans in one dimension

International audienceWhen they reach a flat plain, rivers often deposit their sediment load into a cone-shaped structure called alluvial fan. We present a simplified experimental setup that reproduces, in one dimension, basic features of alluvial fans. A mixture of water and glycerol transports and deposits glass beads between two transparent panels separated by a narrow gap. As the beads, which mimic natural sediments, get deposited in this gap, they form an almost one-dimensional fan. At a moderate sediment discharge, the fan grows quasistatically and maintains its slope just above the threshold for sediment transport. The water discharge determines this critical slope. At leading order, the sediment discharge only controls the velocity at which the fan grows. A more detailed analysis reveals a slight curvature of the fan profile, which relates directly to the rate at which sediments are transported

Thickness of Fluvial Deposits Records Climate Oscillations

International audienc

Denudation intensity and control in the Chinese Tian Shan: new constraints from mass balance on catchment-alluvial fan systems

Tectonics and climate are usually seen as the main controlling factors of denudation rates, which seem to rise with the tectonic activity and to decrease when the climate becomes drier. However, the low denudation rates observed in semi-arid to arid contexts are generally measured on orogenic plateaus where the respective influence of the flat relief and the dry climate cannot really be unravelled. The Chinese Tian Shan was chosen as a case study. In the northern piedmont of this mountain range, a series of well-preserved Quaternary alluvial fans offer the opportunity to perform a mass balance study at the scale of several catchment areas and several hundreds of thousands of years. Based on a geometrical reconstruction of these fans, the volumes of sediments exported out of 10 drainage basins during the Middle–Late Pleistocene (from ∼300 to ∼12 kyr) and the Holocene (from ∼12 kyr to present) have been estimated. From these volumes, an average denudation rate of ∼135 m/Myr was determined in the Tian Shan Range for the last 300 kyr. In agreement with other mass balances performed in the same area, the typical denudation intensity of the northern Tian Shan is thus of a few hundred meters per million years at most, regardless of the space and time scales considered. From a comparison with denudation rates in other mountain ranges throughout the world, we suggest that a dry climate can dramatically limit the denudation intensity even in active orogenic systems with a high topographic gradient like the Tian Shan. As a result, the time required to reach equilibrium between denudation and rock uplift in these systems could be extremely long (i.e. of more than several million years)