PUDENDAL NERVE BLOCK AND OBSTETRIC SIMULATION

A primeira descrição do bloqueio do nervo pudendo foi em 1908. Esta é uma técnica indicada para analgesia nas fases mais adiantadas do trabalho de parto. O uso de técnicas analgésicas eficazes desde os estadios mais precoces do trabalho de parto, como as técnicas do neuro-eixo, deixaram o bloqueio do pudendo para segundo plano. No entanto, é de fácil execução, habitualmente pelo obstetra, e com baixo risco de hemorragia ou infeção. O bloqueio do pudendo é um procedimento com poucas oportunidades de treino na prática clínica, pelo que o retomar da prática na sua execução através do uso de simuladores obstétricos torna-se pertinente. Ainda, a sua utilização em cenários simulados permite a familiarização de equipas multidisciplinares na sua aplicação em diversos contextos, emergentes ou não emergentes. Os principais objetivos deste trabalho são (1) efetuar uma revisão sobre o bloqueio do nervo pudendo na analgesia de parto, focando as principais vantagens e limitações, (2) repensar a sua utilização na ausência ou contraindicação de outras técnicas analgésicas, (3) reavivar a técnica de execução através da simulação aplicada à Obstetrícia

Twists and turns in the salicylate catabolism of aspergillus terreus, revealing new roles of the 3-hydroxyanthranilate pathway

This work was financially supported by Fundacao para a Ciencia e a Tecnologia (FCT), project MOSTMICRO ITQB with reference no. UIDB/04612/2020 and UIDP/04612/2020, and by project "PinusResina" no. PDR2020-101-031905, funded by PDR2020 through Portugal2020. This research was carried out through a partnership with the RESOLUTION LAB, an infrastructure at NOVA School of Science and Technology. The authors acknowledge and thank the support given by the Portuguese Foundation for Science and Technology (FCT) to CENSE through the strategic project UIDB/04085/2020. T.M. and C.M. are grateful to FCT for the working contract financed by national funds under Norma Transitoria D.L. no. 57/2016 and the fellowship SFRH/BD/118377/2016, respectively.In fungi, salicylate catabolism was believed to proceed only through the catechol branch of the 3-oxoadipate pathway, as shown, e.g., in Aspergillus nidulans. However, the observation of a transient accumulation of gentisate upon the cultivation of Aspergillus terreus in salicylate medium questions this concept. To address this, we have run a comparative analysis of the transcriptome of these two species after growth in salicylate using acetate as a control condition. The results revealed the high complexity of the salicylate metabolism in A. terreus with the concomitant positive regulation of several pathways for the catabolism of aromatic compounds. This included the unexpected joint action of two pathways—3-hydroxyanthranilate and nicotinate—possibly crucial for the catabolism of aromatics in this fungus. Importantly, the 3-hydroxyanthranilate catabolic pathway in fungi is described here for the first time, whereas new genes participating in the nicotinate metabolism are also proposed. The transcriptome analysis showed also for the two species an intimate relationship between salicylate catabolism and secondary metabolism. This study emphasizes that the central pathways for the catabolism of aromatic hydrocarbons in fungi hold many mysteries yet to be discovered. IMPORTANCE Aspergilli are versatile cell factories used in industry for the production of organic acids, enzymes, and pharmaceutical drugs. To date, bio-based production of organic acids relies on food substrates. These processes are currently being challenged to switch to renewable nonfood raw materials—a reality that should inspire the use of lignin-derived aromatic monomers. In this context, aspergilli emerge at the forefront of future bio-based approaches due to their industrial relevance and recognized prolific catabolism of aromatic compounds. Notwithstanding considerable advances in the field, there are still important knowledge gaps in the central catabolism of aromatic hydrocarbons in fungi. Here, we disclose a novel central pathway, 3-hydroxyanthranilate, defying previously established ideas on the central metabolism of the aromatic amino acid tryptophan in Ascomycota. We also observe that the catabolism of the aromatic salicylate greatly activated the secondary metabolism, furthering the significance of using lignin-derived aromatic hydrocarbons as a distinctive biomass source.publishersversionpublishe

Methodology to Calculate the Costs of a Floating Offshore Renewable Energy Farm

This paper establishes a general methodology to calculate the life-cycle cost of floating offshore renewable energy devices, applying it to wave energy and wind energy devices. It is accounts for the contributions of the six main phases of their life-cycle: concept definition, design and development, manufacturing, installation, exploitation and dismantling, the costs of which have been defined. Moreover, the energy produced is also taken into account to calculate the Levelized Cost of Energy of a floating offshore renewable energy farm. The methodology proposed has been applied to two renewable energy devices: a floating offshore wave energy device and a floating offshore wind energy device. Two locations have been considered: Aguçadoura and São Pedro de Moel, both in Portugal. Results indicate that the most important cost in terms of the life-cycle of a floating offshore renewable energy farm is the exploitation cost, followed by the manufacturing and the installation cost. In addition, the best area in terms of costs is the same independently of the type of floating offshore renewable energy considered: Aguçadoura. However, the results in terms of Levelized Cost of Energy are different: Aguçadoura is better when considering wave energy technology and the São Pedro de Moel region is the best option when considering floating wind energy technology. The method proposed aims to give a direct approach to calculate the main life-cycle cost of a floating offshore renewable energy farm. It helps to assess its feasibility and evaluating the relevant characteristics that influence it the most

Lesões em atletas barreristas e ranqueados na Federação Catarinense de atletismo (FCA) de 2015 pertencentes à AMREC e AMUREL

Trabalho de Conclusão de Curso, apresentado para obtenção do grau de Bacharel no curso de Educação Física da Universidade do Extremo Sul Catarinense, UNESC.Por estar evoluindo cada vez mais, o atletismo está exigindo dos atletas uma melhor performance, o que proporciona o surgimento de lesões. Por esta razão, as distensões, contusões e luxações aparecem de forma predominante no esporte. O objetivo desta pesquisa é identificar as prevalências de lesão em atletas barreiristas, no ranking de 2015 da AMREC e AMUREL. Nesta pesquisa descritiva, o instrumento de coleta foi um questionário adaptado. Participaram da pesquisa 21 atletas especialistas nas provas de 100m, 110m e 400m com barreiras, os quais se encontravam no local de treinos durante a pesquisa. Os resultados mostraram que 75% dos atletas foram acometidos por lesões, sendo que a distensão muscular apresentou prevalência; já no mecanismo, foi a corrida de velocidade; enquanto a região mais afetada foi a posterior da coxa. A variável dor também foi referida pelos atletas, após a lesão. Diante disso, identificou-se que ocorreu um alto índice de acometimento de lesão em atletas jovens, tendo como fatores de risco o desequilíbrio de força, alongamento e aquecimento, além do trabalho excessivo e extenuante que o atletismo proporciona

Tumor de Buschke-Lowenstein

Introduction: Giant condyloma acuminatum belongs to a spectrum of diseases with malignant degeneration. Clinically, it presents as exophytic, fungating masses, sometimes with a cauliflower-like morphology. Case presentation: We present a case of a 32-year-old female patient with a 180x95x80mm exophytic mass of the vulvar region suggestive of Buschke-Lowenstein Tumour. Treatment included wide local excision with electrosurgery and CO2 vaporization of recurrent focal lesions. Histopathological analysis confirmed the expected diagnosis. Surgery went without complications and the patient is lesion-free at the 12th month of follow-up. Conclusion: There is a lack of consistent trials regarding optimal treatment of BLT. Surgery, when feasible, remains the mainstay of treatment. It allows quick lesion size reduction, with fewer side effects and more rapid return to daily living activities, when compared to other treatment options

Reflexões sobre o Status de Ciência para o Saber Jurídico: De Volta à Discussão de Paradigma

The text board the formation period of modern scientific think during an affirmation while Paradigm Modernity. It`s affirm an existence of juridical theory heiress of this modern tradition, the normative Kelsen, marked of inductive logic, characterize marked the way to produce modern Science knowledge. But the exigencies of the objective falls down in front of the perception that knowledge juridical is especially an interpretative practice and the Hermeneutic shows one field work that make possible put the knowledge juridical in a privileged position next to general science, although one knowledge was fixed of non science.O texto aborda o período de formação do pensamento científico moderno durante a afirmação da Modernidade enquanto paradigma. Afirma a existência de uma teoria jurídica herdeira dessa  tradição  moderna,  o  normativismo  kelseniano,  marcado  pela  lógica  indutiva, característica marcante da maneira de produzir conhecimento da Ciência Moderna. Mas as exigências  de  objetividade  quedam-se  diante  da  percepção  de  que  o  saber  jurídico  é sobretudo uma prática interpretativa, e a Hermenêutica se mostra um campo de trabalho que torna possível colocar o conhecimento jurídico numa posição privilegiada ao lado das ciências em geral, ainda que um tal saber fosse taxado de não científico