Can VHF radars at polar latitudes measure mean vertical winds in the presence of PMSE?

Mean vertical velocity measurements obtained from radars at polar latitudes using polar mesosphere summer echoes (PMSEs) as an inert tracer have been considered to be non-representative of the mean vertical winds over the last couple of decades. We used PMSEs observed with the Middle Atmosphere Alomar Radar System (MAARSY) over Andøya, Norway (69.30°N, 16.04°E), during summers of 2016 and 2017 to derive mean vertical winds in the upper mesosphere. The 3-D vector wind components (zonal, meridional and vertical) are based on a Doppler beam swinging experiment using five beam directions (one vertical and four oblique). The 3-D wind components are computed using a recently developed wind retrieval technique. The method includes full non-linear error propagation, spatial and temporal regularisation, and beam pointing corrections and angular pointing uncertainties. Measurement uncertainties are used as weights to obtain seasonal weighted averages and characterise seasonal mean vertical velocities. Weighted average values of vertical velocities reveal a weak upward behaviour at altitudes ∼ 84-87 km after eliminating the influence of the speed of falling ice. At the same time, a sharp decrease (increase) in the mean vertical velocities at the lower (upper) edges of the summer mean altitude profile, which are attributed to the sampling issues of the PMSE due to disappearance of the target corresponding to the certain regions of motions and temperatures, prevails. Thus the mean vertical velocities can be biased downwards at the lower edge, and the mean vertical velocities can be biased upwards at the upper edge, while at the main central region the obtained mean vertical velocities are consistent with expected upward values of mean vertical winds after considering ice particle sedimentation. © 2019 Author(s). This work is distributed under the Creative Commons Attribution 4.0 License

Can VHF radars at polar latitudes measure mean vertical winds in the presence of PMSE?

Mean vertical velocity measurements obtained from radars at polar latitudes using polar mesosphere summer echoes (PMSEs) as an inert tracer have been considered to be non-representative of the mean vertical winds over the last couple of decades. We used PMSEs observed with the Middle Atmosphere Alomar Radar System (MAARSY) over Andøya, Norway (69.30∘&thinsp;N, 16.04∘&thinsp;E), during summers of 2016 and 2017 to derive mean vertical winds in the upper mesosphere. The 3-D vector wind components (zonal, meridional and vertical) are based on a Doppler beam swinging experiment using five beam directions (one vertical and four oblique). The 3-D wind components are computed using a recently developed wind retrieval technique. The method includes full non-linear error propagation, spatial and temporal regularisation, and beam pointing corrections and angular pointing uncertainties. Measurement uncertainties are used as weights to obtain seasonal weighted averages and characterise seasonal mean vertical velocities. Weighted average values of vertical velocities reveal a weak upward behaviour at altitudes ∼84–87&thinsp;km after eliminating the influence of the speed of falling ice. At the same time, a sharp decrease (increase) in the mean vertical velocities at the lower (upper) edges of the summer mean altitude profile, which are attributed to the sampling issues of the PMSE due to disappearance of the target corresponding to the certain regions of motions and temperatures, prevails. Thus the mean vertical velocities can be biased downwards at the lower edge, and the mean vertical velocities can be biased upwards at the upper edge, while at the main central region the obtained mean vertical velocities are consistent with expected upward values of mean vertical winds after considering ice particle sedimentation.</p

Different long-term trends of the oxygen red 630.0 nm line nightglow intensity as the result of lowering the ionosphere F2 layer

Long-term observations of total nightglow intensity of the atomic oxygen red 630.0 nm line at Abastumani (41.75&amp;deg; N, 42.82&amp;deg; E) in 1957–1993 and measurements of the ionosphere F2 layer parameters from the Tbilisi ionosphere station (41.65&amp;deg; N, 44.75&amp;deg; E) in 1963–1986 have been analyzed. It is shown that a decrease in the long-term trend of the mean annual red 630.0 nm line intensity from the pre-midnight value (+0.770&amp;plusmn;1.045 R/year) to its minimum negative value (&amp;minus;1.080&amp;plusmn;0.670 R/year) at the midnight/after midnight is a possible result of the observed lowering of the peak height of the ionosphere F2 layer electron density &lt;I&gt;hm&lt;/I&gt;F2 (&amp;minus;0.455&amp;plusmn;0.343 km/year). A theoretical simulation is carried out using a simple Chapman-type layer (damping in time) for the height distribution of the F2 layer electron density. The estimated values of the lowering in the &lt;I&gt;hm&lt;/I&gt;F2, the increase in the red line intensity at pre-midnight and its decrease at midnight/after midnight are close to their observational ones, when a negative trend in the total neutral density of the upper atmosphere and an increase in the mean northward wind (or its possible consequence – a decrease in the southward one) are assumed

Mode and site of action of therapies targeting CGRP signaling

Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed

Mode and site of action of therapies targeting CGRP signaling

Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed.</p

Mode and site of action of therapies targeting CGRP signaling

Abstract Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed